International Journal of Pharmaceutics最新文献

{"title":"Alpha to omega for molybdenum disulfide (MoS2)-based antibacterial nanomaterials","authors":"Barlina Konwar ,&nbsp;Sukrit Kashyap ,&nbsp;Srimathi Raghavan,&nbsp;Kwang-sun Kim","doi":"10.1016/j.ijpharm.2025.125531","DOIUrl":"10.1016/j.ijpharm.2025.125531","url":null,"abstract":"<div><div>Addressing antimicrobial resistance is crucial in microbial studies, especially in creating alternative drug candidates vital for protecting human health from multidrug-resistant microorganisms. Nanomaterials (NMs) have emerged as a potential solution, drawing considerable interest owing to their unique structural and functional characteristics that render them effective against microbes. Two-dimensional NMs, particularly those based on molybdenum disulfide (MoS₂), have shown promise as antimicrobial agents owing to their exceptional properties. Although research has advanced in exploring and applying MoS₂ NMs for antimicrobial purposes, strategies for optimizing and modifying their use as antimicrobial agents remain in their early developmental stages. This review presents a comprehensive overview of the current MoS₂ NMs for antimicrobial applications, including their synthesis, properties, optimization techniques, and modifications, as well as their mechanisms of action. This review also addresses the limitations of the individual materials and proposes future directions for overcoming these challenges. This compilation serves as an invaluable resource for scientists working on the development of targeted antimicrobial agents.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125531"},"PeriodicalIF":5.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “An improved experimental model of osteosarcoma lung metastases to investigate innovative therapeutic interventions and sex as a biological variable” [Int. J. Pharm. 673 (2025) 125372]","authors":"Fatemah S. Sunbul ,&nbsp;Rashed M. Almuqbil ,&nbsp;Hanming Zhang ,&nbsp;Sulaiman S. Alhudaithi ,&nbsp;Matthew E. Fernandez ,&nbsp;Raneem R. Aldaqqa ,&nbsp;Victoria A. Garcia ,&nbsp;Valentina Robila ,&nbsp;Matthew S. Halquist ,&nbsp;Sarah W. Gordon ,&nbsp;Paula D. Bos ,&nbsp;Sandro R.P. da Rocha","doi":"10.1016/j.ijpharm.2025.125497","DOIUrl":"10.1016/j.ijpharm.2025.125497","url":null,"abstract":"","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125497"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision-targeted explosion of biomimetic nanoparticles for the effective treatment of uveal melanoma","authors":"Xiaoshuang Bi ,&nbsp;Yaxin Deng ,&nbsp;Chenxiao Chu ,&nbsp;Mingli Wei ,&nbsp;Jiansong Zhao ,&nbsp;Jiaqi Zhao ,&nbsp;Yuying Wang ,&nbsp;Tian Yin ,&nbsp;JingXin Gou ,&nbsp;Haibing He ,&nbsp;Xing Tang ,&nbsp;Guofei Li ,&nbsp;Yu Zhang","doi":"10.1016/j.ijpharm.2025.125543","DOIUrl":"10.1016/j.ijpharm.2025.125543","url":null,"abstract":"<div><div>Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, originating from the melanocytes within the uvea. Currently, the treatment of ocular tumors predominantly relies on conventional approaches such as brachytherapy and enucleation. Despite the limited pharmaceutical treatment options for uveal melanoma (UM), the effectiveness of ocular drug delivery is hindered by the ocular barrier to local drug administration and the complex tumor microenvironment (TME). In response, biomimetic low-density lipoprotein nanoparticles (LD-DPVP NPs) with active targeting capabilities were designed. This nanodrug system combined photosensitizer (verteporfin, VP) with the tumor vascular normalization drug (dexamethasone, DEX) to achieve low-toxicity, high-efficacy treatment of intraocular tumors. After intravenous injection, the nanoparticles selectively targeted the tumor site and induced VP to produce reactive oxygen species (ROS) that killed tumor cells under near-infrared laser stimulation. The produced ROS could also trigger the cleavage of the DEX prodrug (DPD) and rapid release of DEX via breakage of the thioether bond (TK). Additionally, DEX could modulate the TME, improving the delivery of nanoparticles to the tumor and further enhancing the efficacy of LD-DPVP NPs. We believe the biomimetic nanoparticles designed in this study have a potential clinical application value in inhibiting UM growth and provided a promising strategy for addressing other ocular malignancies.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125543"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orodispersible films prepared by hot-melt extrusion versus solvent casting","authors":"Mathieu Reuther ,&nbsp;Nicolas Rollet ,&nbsp;Frédéric Debeaufort ,&nbsp;Odile Chambin","doi":"10.1016/j.ijpharm.2025.125536","DOIUrl":"10.1016/j.ijpharm.2025.125536","url":null,"abstract":"<div><div>This study investigated the influence of solvent casting and hot-melt extrusion manufacturing methods on the physical, chemical, and functional properties of orodispersible films with the same composition and incorporating a poorly soluble active pharmaceutical ingredient (API). Both techniques produced films that met pharmaceutical standards for disintegration and dissolution times. Solvent casting, the most used method, yielded films with homogeneous distribution of plasticizer, smoother textures, and greater flexibility. In contrast, hot melt extrusion, a solvent-free process, resulted in slightly brittle films due to uneven plasticizer integration, highlighting the impact of manufacturing parameters on film structure. Despite these differences, both methods exhibited similar chemical stability under varying humidity conditions, with API recrystallization occurring at higher humidity, particularly in films prepared by solvent casting. Increased humidity significantly reduced tensile strength, as water acted as a plasticizer, promoting API recrystallization and weakening the structure. Stability tests revealed that hot melt extrusion films retained their structural and chemical integrity over 12 months when stored in impermeable packaging bags. This study confirms the suitability of hot melt extrusion for industrial-scale ODF production, offering advantages such as a solvent-free process, reduced environmental impact, and adaptability for modern pharmaceutical manufacturing, provided formulation and process parameters could be carefully optimized.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125536"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled PAMAM-G4 dendrimer nanoparticles with Phloxine B as photosensitizer for antimicrobial photodynamic therapy","authors":"David E. Ybarra ,&nbsp;Camila Quezada ,&nbsp;Yuly A. Guarín ,&nbsp;Gerardo A. Cabello ,&nbsp;Jorge Montanari ,&nbsp;Fernando C. Alvira ,&nbsp;Silvia del Valle Alonso ,&nbsp;Manuel F. Meléndrez ,&nbsp;Luis F. Barraza","doi":"10.1016/j.ijpharm.2025.125534","DOIUrl":"10.1016/j.ijpharm.2025.125534","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) represents a critical global health challenge, driving the need for innovative therapeutic strategies. This study introduces self-assembled nanoparticles based on fourth-generation polyamidoamine (PAMAM-G4) dendrimers and Phloxine B (PhB), forming G4-PhB nanoparticles as an advanced platform for antimicrobial photodynamic therapy (aPDT). The optimal dendrimer:dye molar ratio was determined through dynamic light scattering (DLS) titration experiments, yielding a 1:15 G4:PhB ratio. The resulting G4-PhB nanoparticles were spherical, with a hydrodynamic diameter of 260 ± 15 nm, a narrow polydispersity index (PDI) of 0.264 ± 0.085, and a positive zeta potential of 8.71 ± 2.88 mV, indicating monodispersity and colloidal stability. These features were corroborated by morphological analyses using TEM and AFM. Cytotoxicity assays conducted on murine fibroblasts (3 T3 cell line), using MTT, neutral red uptake, and crystal violet staining revealed that G4-PhB nanoparticles are intrinsically non-toxic, contrasting with the EDTA-PhB complex, which exhibited significant cytotoxic effects. Antibacterial activity was evaluated against <em>Staphylococcus aureus</em> (SA) and <em>Pseudomonas aeruginosa</em> (PA). While free PhB demonstrated bactericidal effects exclusively against SA, the G4-PhB nanoparticles exhibited enhanced activity against both bacterial strains, notably overcoming the limitations of free PhB against PA. These findings highlight the versatility and effectiveness of G4-PhB nanoparticles as a biocompatible and non-invasive system for localized aPDT, with potential applications in wound healing for immunocompromised patients. This work provides a robust foundation for future research into dendrimer-based photosensitizers as innovative solutions to pressing biomedical challenges.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125534"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on design rules for formulating amorphous solid dispersions based on drug-polymer interactions in aqueous environment","authors":"Gayathri Ramachandran ,&nbsp;Indhu Annie Chacko ,&nbsp;M.G. Mishara ,&nbsp;Ajay Jaysingh Khopade ,&nbsp;M. Sabitha ,&nbsp;M.S. Sudheesh","doi":"10.1016/j.ijpharm.2025.125541","DOIUrl":"10.1016/j.ijpharm.2025.125541","url":null,"abstract":"<div><div>Amorphous solid dispersions (ASDs) are multi-component formulations in which a drug is molecularly dispersed in a carrier. ASDs undergo complex dissolution mechanisms to generate and sustain a supersaturated state of poorly soluble drugs. The link between enhanced solubility, supersaturation stability and drug-polymer interaction (DPI) is critical for the rational design of ASDs. The key mechanism responsible for a high bioavailability is the evolution of supersaturation during the dissolution of ASDs which is also the driving force for drug precipitation. A critical determinant of robust supersaturation generation and stability during dissolution is the molecular interaction between the drug and polymer. Characterization of DPI in a solution state is, however, challenging because of the poor hydrodynamic resolution of the techniques, traditionally used in solid-state analysis. Further, the dissolution conditions, such as the choice of buffer, pH and ionic strength may complicate the analyses and predictions. The role of DPI is a poorly understood aspect of ASD dissolution and therefore is an active area of research. DPI is critical for understanding the design rules for formulating an optimal ASD formulation. The review focuses on different aspects of DPI to stabilize the supersaturated state of a drug during the dissolution of ASDs.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125541"},"PeriodicalIF":5.3,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-induced microstructural evolution in risperidone loaded PLGA microspheres","authors":"Andrew G. Clark ,&nbsp;Jeffery Wong ,&nbsp;Ruifeng Wang ,&nbsp;Yan Wang ,&nbsp;Bin Qin ,&nbsp;Diane J. Burgess ,&nbsp;Shawn Zhang","doi":"10.1016/j.ijpharm.2025.125512","DOIUrl":"10.1016/j.ijpharm.2025.125512","url":null,"abstract":"<div><div>This study demonstrates the application of innovative imaging-based characterization techniques to quantify structural changes as a function of ageing for poly (lactic-co glycolic acid) (PLGA) microspheres. Aging of polymers can potentially alter the performance of polymer-based therapeutics and therefore an understanding of the impact of aging on microsphere structure is important. Correlative focused ion beam scanning electron microscopy (FIB-SEM) and X-ray microscopy (XRM) were used to quantify the change in structural critical quality attributes (CQAs) of risperidone loaded microspheres at the single microsphere scale and overall batch scale. One batch of microspheres was aged one year beyond its shelf life while the other batch was within its shelf life, providing a robust comparison between an aged and fresh sample. Comparison of the aged and fresh microspheres revealed an increase in porosity and pore size following aging at the nanoscale, anticipated with physical relaxation of the PLGA. A novel XRM-based method to determine the material density of the microsphere batches was employed to assess the batch level changes induced by aging. A decrease in density in the aged microsphere batch was observed, that was consistent with the porosity increase seen in the FIB-SEM study. These results reveal aging produces an increase in porosity through polymer relaxation that widens the existing pores within the microspheres. The increased porosity was correlated to the in vitro release performance of the two microsphere batches, providing a novel method to assess the impact of polymer aging on the downstream performance of PLGA microsphere systems.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125512"},"PeriodicalIF":5.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural deep eutectic solvents (NADES) in drug delivery systems: Characteristics, applications, and future perspectives","authors":"Hui Li ,&nbsp;Kaining Yang ,&nbsp;Yumin Yang ,&nbsp;Liqin Ding ,&nbsp;Xiaoxia Li","doi":"10.1016/j.ijpharm.2025.125509","DOIUrl":"10.1016/j.ijpharm.2025.125509","url":null,"abstract":"<div><div>Deep eutectic solvents (DESs) are a class of low-melting mixtures formed by the hydrogen-bond interactions between hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) in specific molar ratios. Their unique physicochemical properties enable DESs to significantly enhance drug solubility and permeability, while also serving as carriers to facilitate efficient drug delivery. A subclass of DESs, natural deep eutectic solvents (NADESs), is found in the metabolites of natural organisms, such as plants. With low toxicity and biodegradability, NADESs possess distinct advantages for applications in the pharmaceutical field.The therapeutic efficacy of drugs is often limited by imprecise release mechanisms, leading to the metabolism or degradation of a portion of the drug before it reaches the target site, thereby reducing its effectiveness. Moreover, many drugs exhibit poor solubility and stability, resulting in low efficiency during absorption and metabolism, which further diminishing their therapeutic impact. NADESs, with their excellent tunability and biocompatibility, have demonstrated great potential in drug delivery systems.This paper first provides an overview of the fundamental characteristics of NADESs, followed by a detailed summary of recent advancements and applications of NADESs across various administration routes, including transdermal, mucosal, and inhalation drug delivery. Finally, the paper explores the prospects of NADESs in novel drug delivery systems and proposes strategies for optimizing their performance to promote clinical applications.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125509"},"PeriodicalIF":5.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-assembly enzyme-like hydrogel with ROS scavenging and immunomodulatory capability for microenvironment-responsive wound healing acceleration","authors":"Xiaohui Jia ,&nbsp;Yuhe Dong ,&nbsp;Jihui Lu ,&nbsp;Zhenyuan Yang ,&nbsp;Ran Xu ,&nbsp;Xiang Zhang ,&nbsp;Jingyi Jiao ,&nbsp;Zixuan Zhang ,&nbsp;Yixuan Lin ,&nbsp;Fuhao Chu ,&nbsp;Penglong Wang ,&nbsp;Tian Zhong ,&nbsp;Haimin Lei","doi":"10.1016/j.ijpharm.2025.125529","DOIUrl":"10.1016/j.ijpharm.2025.125529","url":null,"abstract":"<div><div>On-demand responsive hydrogels are a promising solution for effective wound management as they can adjust their properties in response to changes in the wound environment, allowing them to provide tailored support for the healing process. However, the conventional hydrogels may not fully meet the diverse demands of the intricate healing process. Herein, a novel glycyrrhizic acid (GA) based self-assembly hydrogel coordinated with copper and polyphenol (GCP hydrogel) was developed to exhibit triggered release behavior in response to the microenvironment. The GCP hydrogel coordinated with copper and protocatechuic acid (PA) and self-assembled with GA, also exhibits enzyme-like properties by mimicking the cascade process of superoxide dismutase (SOD) and catalase (CAT), effectively scavenging reactive oxygen species (ROS). Furthermore, the on-demand release of Cu²⁺ at different stages of the wound healing process can not only enhance the antibacterial ability of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) but also intelligently promote angiogenesis with outstanding biocompatibility. In addition, the GCP hydrogel effectively modulated the activity of macrophages in response to inflammatory stimuli, exhibiting remarkable anti-inflammatory abilities and promoting tissue regeneration. The multifunctional GCP hydrogel platform has the potential to create a dynamic microenvironment that is conducive to tissue regeneration, making it an ideal candidate for smart wound management.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125529"},"PeriodicalIF":5.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printing of partially-coated floating systems for controlled release of drugs into the stomach","authors":"Marco Uboldi ,&nbsp;Arianna Chiappa ,&nbsp;Francesco Briatico-Vangosa ,&nbsp;Alice Melocchi ,&nbsp;Lucia Zema","doi":"10.1016/j.ijpharm.2025.125513","DOIUrl":"10.1016/j.ijpharm.2025.125513","url":null,"abstract":"<div><div>This work focused on the development of a retentive drug delivery system (DDS) able to float in the gastric fluids and to ensure prolonged release of drugs over a pre-defined period of time, being then safely emptied from the stomach. To this end, the design step played a pivotal role. The device was thus devised to be composed of a polyvinyl alcohol-based matrix with a tapered geometry, which was partially coated with an insoluble layer of thermoplastic elastomer. This way, release of allopurinol (ALP), used as model drug, could occur only from the uncoated surfaces, while the peculiar geometry of the hydrophilic swellable/erodible matrix was intended to balance the increase in the diffusional path over time with a wider release area. In addition, the coating featured air pockets, whose volume was sized to compensate for the weight force of the DDS once immersed in gastric fluids, thus ensuring its long-lasting buoyancy. By easing the entrance of gastric fluids when the matrix is completely exhausted, such air pockets would also favor sinking and removal of the DDS from the pylorus. Given the multi-layered geometry of the final floating device, including hard-to-fabricate details (<em>e.g.</em> uncoated surfaces, voids), fused deposition modeling 3D printing was identified as the technique of choice for its effectiveness in manufacturing complex shapes. Various formulations were tested for fabricating both the inner matrix and the outer coating, assessing their thermo-mechanical properties, printability and release behavior. The gastro-retentive system demonstrated prolonged buoyancy (&gt; 12 h) and a wide portfolio of ALP release performances, differing in rate and duration, which would make it a promising platform for personalized delivery of drugs in the upper gastrointestinal tract.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"675 ","pages":"Article 125513"},"PeriodicalIF":5.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}