International Journal of Molecular and Cellular Medicine最新文献

{"title":"Regulation of Osteoblast Differentiation by miR-214 and miR-206 Through EphrinA2 Signaling: Emerging Therapeutic Insights in Orthodontic Tooth Movement.","authors":"Hossein Salehivaziri, Amir Ali Didar, Maryam Sobhani, Ali Narimani, Moslem Karimzadeh, Yasaman Bathaei","doi":"10.22088/IJMCM.BUMS.14.4.1110","DOIUrl":"10.22088/IJMCM.BUMS.14.4.1110","url":null,"abstract":"<p><p>Orthodontic tooth movement (OTM) is a complex biological process involving the precise remodeling of alveolar bone in response to mechanical forces. This remodeling is mediated by the coordinated activities of osteoblasts (responsible for bone formation) and osteoclasts (responsible for bone resorption) within the periodontal ligament (PDL). Mechanical stimuli are transduced into biochemical signals, which regulate cellular behavior through key signaling pathways such as RANKL/RANK/OPG and Wnt/β-catenin. MicroRNAs (miRNAs), as crucial post-transcriptional regulators of gene expression, play significant roles in skeletal development and bone homeostasis. They influence essential signaling cascades that govern the differentiation, function, and survival of osteoblasts and osteoclasts. Among them, miR-214 and miR-206 have emerged as potent negative regulators of osteoblast differentiation. This review focuses on how their common target, EphrinA2, plays a pivotal role in bone remodeling. EphrinA2 is a membrane-bound ligand critical for osteoclast-osteoblast communication. Upon binding to its receptor EphA2 on osteoblasts, EphrinA2 promotes osteoblast differentiation and bone formation. Dysregulation of the miR-214/miR-206-EphrinA2 axis impairs osteoblast function, disrupts bone remodeling, and can adversely affect the rate and stability of OTM. In conclusion, elucidating the regulatory functions of miR-214 and miR-206 and their modulation of EphrinA2 provides valuable insights into bone remodeling dynamics during OTM. Targeted manipulation of this pathway holds promise for developing novel molecular therapies that aim to enhance the efficacy, speed, and long-term stability of orthodontic treatments, while also addressing broader skeletal pathologies associated with disrupted bone remodeling.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 4","pages":"1110-1128"},"PeriodicalIF":1.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phage Cocktail against <i>Acinetobacter baumannii</i> biofilm on Endotracheal Tube: An in vitro study.","authors":"Susan Khanjani, Farhad Nikkhahi, Fatemeh Zeynali Kelishomi, Amir Javadi, Sara Sadeghi, Behzad Bijani, Hamid Sadeghi, Hediyeh Saghi Sarabi, Seyed Mahmoud Amin Marashi","doi":"10.22088/IJMCM.BUMS.14.4.1059","DOIUrl":"10.22088/IJMCM.BUMS.14.4.1059","url":null,"abstract":"<p><p>Although biofilms on endotracheal tube (ET) surfaces represent a major clinical challenge, studies addressing the effect of lytic bacteriophages on these biofilms are relatively scarce. This study focused on examining the anti-biofilm capability of three specific phage against an XDR isolate of <i>Acinetobacter baumannii</i> in a 48-hour pre-formed biofilm on an ET surface. For this purpose, crystal violet staining, colony counting, and scanning electron microscopy (SEM) were employed. The results demonstrated a significant decrease in biofilm mass and bacterial count after 24 hours of exposure to the phage cocktail. SEM images confirmed a dramatic reduction in the biofilm. Based on these findings, phage therapy has the potential to reduce and disrupt biofilms on ET surfaces.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 4","pages":"1045-1058"},"PeriodicalIF":1.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cross Talk of MicroRNAs and SATB2 Signaling Pathway in Osteogenesis in the Context of Dental Implants.","authors":"Saad Alsaif, Mousa Alrashidy, Saeed Al Dossary","doi":"10.22088/IJMCM.BUMS.14.4.1099","DOIUrl":"10.22088/IJMCM.BUMS.14.4.1099","url":null,"abstract":"<p><p>Dental implant integration is dependent on osteogenesis driven by the transcription factor SATB2, which regulates osteogenic genes. MicroRNAs (miRNAs) modulate SATB2 and influence bone formation. This review evaluates miRNA-SATB2 interactions, non-coding RNAs, and biomaterials in dental implant osseointegration. A critical review of studies from 2015 to 2025 was conducted to elucidate miRNA-SATB2 interactions and their impact on osteogenesis. Inhibitory miRNAs (e.g., miR-31, miR-140-5p) suppress SATB2 via the Wnt/β-catenin or SIRT1/Smad3 pathways and reduce osteoblast differentiation. Promoter miRNAs (e.g., miR-17-5p, miR-27a-5p) enhance SATB2 through BMP/Smad signaling. Non-coding RNAs (e.g., lncRNA H19, hsa_circ_0007292) inhibit miRNAs affecting cancellous bone and promote osteogenesis. Biomaterials such as collagen/nanohydroxyapatite (Col/nHA) scaffolds and comorbidities (e.g., osteoporosis) influence outcomes. Inconsistent miRNA roles and limited in vivo data are key gaps. miRNA- SATB2 interactions are critical for implant success. Patient-specific miRNA profiling and targeted therapies hold promise, pending clinical validation.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 4","pages":"1099-1109"},"PeriodicalIF":1.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achillea biebersteinii-Mediated Gold Nanoparticles on Oocyte Gene Expression and Follicular Development in Mice.","authors":"Mohammadreza Abdollahi, Mohammad Zangooei, Parishad Ghorbani, Reihaneh Alsadat Mahmoudian, Atena Mansouri","doi":"10.22088/IJMCM.BUMS.14.4.1072","DOIUrl":"10.22088/IJMCM.BUMS.14.4.1072","url":null,"abstract":"<p><p>This study investigated the effects of chemically synthesized gold nanoparticles (GNPs) and green gold nanoparticles (gGNPs) derived from <i>Achillea biebersteinii</i> extract on antrum diameter and the expression of genes associated with follicular development in NMRI mice. Female mice were treated with GNPs and gGNPs at concentrations of 10, 50, and 100 µg/mL. Antrum diameter in ovarian follicles was measured using ImageJ software. Gene expression levels of BMP-15, GDF-9, SOD, and GPx were quantified via real-time PCR.Treatment with gGNPs at 100 µg/mL significantly increased the antrum diameter of secondary follicles compared to GNPs (p ≤ 0.05), while no significant changes were observed in grafted follicles. A dose-dependent upregulation of BMP-15, GDF-9, GPx, and SOD was observed in both GNP and gGNP groups, with gGNPs eliciting stronger effects across all genes (p ≤ 0.05). The findings suggest that <i>A. biebersteinii</i>-mediated green synthesis enhances the biological activity of GNPs, particularly in promoting follicular development and antioxidant gene expression. Although mechanistic pathways were not explored in this study, future research should address these gaps and evaluate long-term safety and therapeutic potential.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 4","pages":"1072-1083"},"PeriodicalIF":1.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Pluripotency to Patients: Making Induced pluripotent stem cell (iPSC) Therapies Safer.","authors":"Monireh Golpour, Hadi Prsian","doi":"10.22088/IJMCM.BUMS.14.4.976","DOIUrl":"10.22088/IJMCM.BUMS.14.4.976","url":null,"abstract":"","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 4","pages":"976-979"},"PeriodicalIF":1.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine Modulates Cell Death and Telomerase Activity in Triple-negative Breast Cancer Cells.","authors":"Qanita Hana Amira, Shadira Anindieta Irdianto, Fadilah Fadilah, Retno Lestari, Fadhillah Fadhillah, Anom Bowolaksono, Astari Dwiranti","doi":"10.22088/IJMCM.BUMS.14.2.606","DOIUrl":"10.22088/IJMCM.BUMS.14.2.606","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is an aggressive subtype defined by the lack of estrogen receptors (ER), progesterone receptors (PR), and HER2 expression, resulting in limited therapeutic options. Given this challenge, this study explores caffeine, a widely consumed stimulant, as a potential anticancer agent, particularly for TNBC. Although caffeine has demonstrated stimulatory and inhibitory effects on telomerase in other cancer types, its influence on telomerase activity in TNBC remains uncharacterized. This study investigates the impact of caffeine concentrations (10, 15, and 20 mM) on cell viability, proliferation, apoptosis, ultrastructure, and the expression of apoptosis-related genes (<i>BAX, BCL2, CASP8</i>) and telomerase activity (<i>hTERT</i>) in MDA-MB-231 cells. Our findings showed that caffeine significantly reduces cell viability and induces early apoptosis with a dose-dependent effect. Morphological changes consistent with early apoptosis were observed, and an increased <i>BAX/BCL2</i> ratio indicated the activation of the intrinsic apoptosis pathway. Additionally, caffeine exhibited upregulation of <i>hTERT</i> mRNA expression, which may reflect a compensatory response to cellular stress induced by caffeine. These results underscore the multifaceted effects of caffeine on TNBC cells, highlighting its potential not only as an apoptosis inducer but also as a modulator of telomerase activity. Given its accessibility, low toxicity, and established safety profile, caffeine presents an exciting avenue for further research as a complementary or standalone therapeutic strategy for TNBC.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 2","pages":"606-619"},"PeriodicalIF":0.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral squamous cell carcinoma pharmacological treatment; A long non-coding RNAs (long ncRNAs) story.","authors":"Azita Sadeghzade, Ali Jafarian, Amir Hossein Davodpour, Mohsen Pouresmaeliyan Roumani, Meysam Mohammadikhah, Sarah Qutaiba Badraldeen, Sajad Ataei Azimi","doi":"10.22088/IJMCM.BUMS.14.2.736","DOIUrl":"10.22088/IJMCM.BUMS.14.2.736","url":null,"abstract":"<p><p>Oral squamous cell cancer (OSCC) is a major global health issue, ranking sixth in prevalence, particularly in Asia. The diagnosis often occurs late due to inadequate early screening, resulting in a dismal five-year survival rate of around 50%. This document provides a comprehensive analysis of drug-based treatments for oral cavity carcinoma, focusing on chemotherapy, immune modulation, and novel approaches like nanoparticle therapies. Despite advancements in these methods, drug resistance remains a significant obstacle that adversely affects patient outcomes. The research highlights the critical role of long ncRNAs in the progression and treatment of OSCC. These long ncRNAs, which are over 200 nucleotides long, play essential roles in gene regulation and tumor growth, including mechanisms of drug resistance. Some long ncRNAs may promote or inhibit tumor development and influence the effectiveness of anti-cancer drugs like cisplatin. Additionally, the review explores how the tumor microenvironment and immune responses interact, suggesting that inflammation may accelerate the progression of oral cancer. By synthesizing insights from extensive literature, this review clarifies the complex relationship between long ncRNAs and OSCC treatment. The study aimed to improve treatment efficacy and increase survival rates for patients with oral squamous cell carcinoma by identifying potential therapeutic targets. The findings underscore the importance of integrating molecular insights into treatment strategies to combat drug resistance and enhance patient outcomes in oral cancer therapy.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 2","pages":"736-752"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Production Conditions of a Caspian Sea <i>Actinomycete</i> Exhibiting Promising Antibacterial Activity Against Clinically-important Pathogens Using the Two-Factor Interaction/ Minimum Run Resolution IV Method.","authors":"Zeinab Jan, Hamed Norouzi Taheri, Abolghasem Danesh","doi":"10.22088/IJMCM.BUMS.14.2.666","DOIUrl":"10.22088/IJMCM.BUMS.14.2.666","url":null,"abstract":"<p><p>Natural products recovered from marine sediment have the potential for the treatment of various diseases. <i>Streptomyces</i> sp., strain MN38 which was previously isolated from the Caspian Sea of Iran was at first characterized based on its 16srRNA analysis and morphological properties. Two-factor Interaction/ Minimum Run Resolution IV method was employed to evaluate the influence of various potential factors on the strain's antibacterial activity using cost-effective substrates. Twelve variables were considered effective for investigation, with an emphasis on assessing the antibacterial activity against <i>Staphylococcus aureus</i> and <i>Enterococcus faecalis</i> via the micro-dilution method. The findings indicate that a quadratic model and a second-order polynomial equation are statistically significant at the 95% confidence level due to a low P-value (< 0.0001) in this context. As a result, A1BFe+C agar medium, incubated at 28°C for three days with a shaking speed of 200 rpm, using specific concentrations of starch (5.0 g/l), yeast extract (6.0 g/l), peptone (4.0 g/l), KBr (0.5 g/l), CaCO₃ (0.2 g/l), sea salt (15 g/l), and Fe₂(SO₄)₃ (0.003 g/l), along with an inoculum size of 3.0% v/v at a pH of 6, exhibits the enhanced antibacterial activity against <i>Staphylococcus aureus</i> and <i>Enterococcus faecalis</i> reached up to 69 and 166 (Bu/ml). It could be concluded that the MN38 of Caspian Sea sediments was a potent source of antimicrobial agent production and the production process was significantly optimized using mathematical methods.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 2","pages":"666-681"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Aptamer-HRP Conjugation for Cardiac Troponin I Detection: A Novel ELASA Approach for AMI Diagnostics.","authors":"Mahshid Bahari, Farshid Yeganeh, Ali Kargar","doi":"10.22088/IJMCM.BUMS.14.2.705","DOIUrl":"10.22088/IJMCM.BUMS.14.2.705","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI), a major global cause of mortality, is diagnosed using cardiac troponin I (cTnI). Antibody-based assays face challenges, prompting the exploration of aptamers. This study develops an aptamer-HRP probe and ELASA for improved cTnI detection. Aptamer-based enzyme-linked aptamer assays (ELASA) were developed to detect cTnI using Tro4 and Tro6 aptamers. Molecular docking was performed via the HDOCK web server to confirm aptamer binding affinity to cTnI. Tro4 was biotinylated for use as a capture probe, while Tro6 was conjugated to HRP through sulfo-SMCC crosslinking, followed by size exclusion chromatography and purification. Direct and sandwich ELASA assays were performed using streptavidin-coated plates and clinical serum samples from AMI and non-AMI patients. Data were analyzed using GraphPad Prism10 and SPSS software. Molecular docking confirmed the high binding affinity of Tro4 and Tro6 aptamers to cTnI, with significant interaction energies. Direct ELASA verified aptamer binding, and optimal concentrations were determined as 10μM for Tro4 and 5μM for Tro6. A sandwich ELASA using paired aptamers achieved improved sensitivity and specificity for cTnI detection. The assay displayed a linear response between 0.1-22 ng.mL cTnI (R²=0.94), with a limit of detection (LOD) of 0.10ng.mL. When tested on patient serum samples, results correlated with a commercial antibody-based ELASA kit. This study successfully developed a highly sensitive and specific sandwich ELASA for cTnI detection, utilizing the optimal aptamers Tro4 and Tro6. The results demonstrated excellent sensitivity, specificity, and potential clinical applicability, offering a promising alternative to antibody-based assays.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 2","pages":"705-713"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Candida albicans</i> Impact on the Progression, Morphology, and Cellular Integrity of Biofilm Formation on the Surfaces of Implants; Current Knowledge and Future Perspectives.","authors":"Seçkin Yalçın, Selin Özel, Dilara Çamyar, Emir Farboud Bonabian","doi":"10.22088/IJMCM.BUMS.14.2.620","DOIUrl":"10.22088/IJMCM.BUMS.14.2.620","url":null,"abstract":"<p><p>The capacity of <i>Candida albicans</i> to adhere to diverse oral substrates constitutes a pivotal preliminary phase in the formation of a pathogenic fungal biofilm. Yeast cells demonstrate a considerable ability to bind to host tissues, encompassing dental structures and mucosal surfaces, in addition to synthetic, non-biological materials such as dental appliances. Biomaterials utilized for the restoration of oral functionality are prone to biofilm formation, which can detrimentally affect oral health. Oral microorganisms can adhere to both hydrophobic and hydrophilic surfaces; however, in vivo investigations indicate that hydrophobic surfaces tend to accumulate minimal biofilm due to differential shear forces. Rough surfaces are observed to retain more biofilm compared to their smooth counterparts. The presence of biofilms on composite materials and glass-ionomer cement types results in surface degradation, consequently fostering additional biofilm development. While the leaching of residual monomers from composites has been shown to influence biofilm proliferation in vitro, the effect in vivo appears to be less consequential, likely attributable to the dilution and continual renewal of saliva. Furthermore, research has produced inconsistent findings regarding the influence of fluoride release from glass-ionomer cement types. A comparative analysis is conducted between biomaterial-associated infections in implants and devices situated in other anatomical regions and the formation of oral biofilms. The discourse critically evaluates alterations to biomaterials aimed at diminishing biofilm formation on implants and devices, taking into account their prospective applications within dentistry. The conclusion reached is that for dental applications, antimicrobial coatings that exterminate fungi upon contact are deemed more efficacious than those that gradually release antimicrobial agents.</p>","PeriodicalId":14152,"journal":{"name":"International Journal of Molecular and Cellular Medicine","volume":"14 2","pages":"620-636"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}