International Journal of Hypertension最新文献

{"title":"Platelet Indices and Hypertension: Results from Shahedieh Cohort Study, Yazd, Iran","authors":"Fateme Shakeri Shamsi, Moslem Taheri Soodejani","doi":"10.1155/2024/3705771","DOIUrl":"https://doi.org/10.1155/2024/3705771","url":null,"abstract":"<i>Introduction</i>. Hypertension is one of the most important diseases worldwide. In this study, we aim to demonstrate the relationship between platelet indices and hypertension. <i>Materials and Methods</i>. We studied 9448 people in the age range of 30 to 70 years. We assessed their hypertension status, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), smoking, cardiovascular disease history, diabetes status, body mass index, and creatinine levels. Hypertension status was assessed qualitatively. All platelet indices were categorized by quartiles. We then used logistic regression to predict the relationship between these indices and hypertension. <i>Results</i>. PDW index and hypertension had a statistically significant relationship in the second quartile (16.2 fL &lt; PDW ≤ 16.7 fL) in 30 to 40 years old (AOR: 0.225, 95% CI: 0.063–0.806), in the fourth quartile in 50 to 60 years old (AOR = 1.532, 95% CI: 1.048–2.238), and in all the quartiles of the age range of over 60 years. PLT index had a positive relationship (AOR = 3.147, 0.95% CI: 1.163–8.516) in 30 to 40 years old in the fourth quartile vs. the first quartile. A positive relationship was obtained in the third and fourth quartiles of PLT and the age range of 40 to 50 years, respectively (AOR = 2.063, 0.95% CI: 1.162–3.662) and (AOR = 2.204, 0.95% CI: 1.220–3.981). <i>Conclusion</i>. According to the results of this study, some platelet indices could be correlated with hypertension, so we may be able to reduce the burden of this disease.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"18 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139753230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats","authors":"Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan","doi":"10.1155/2024/2226143","DOIUrl":"https://doi.org/10.1155/2024/2226143","url":null,"abstract":"<i>Background</i>. Da-Chuan-Xiong Decoction (DCXD) is an aqueous extract from a classic Chinese herbal formula composed of dried rhizomes of Ligusticum chuanxiong Hort and <i>Gastrodia elata</i> Bl. in the mass ratio of 4 : 1. It has been long used to treat chronic cardiovascular disease caused by blood stasis and wind pathogen in the clinic. This experimental study aimed to investigate the blood pressure (BP)-lowering effect of DCXD treatment on hypertension and underlying mechanisms. <i>Methods</i>. Male Sprague–Dawley rats were used in the experiment, and the hypertensive models were created by administering deoxycorticosterone acetate (DOCA) in conjunction with a high salt intake in uninephrectomized rats. DCXD was administered to hypertensive rats by oral gavage daily at a dose of 5 g/kg or 2.5 g/kg bodyweight for 28 days. The brain sodium sensitivity, ENaC function, superoxide anion level, NADPH oxidase activity, and expression of ENaC, p67phox, p47phox, and Rac1 in the paraventricular nucleus were assessed by using the appropriate methods. <i>Results</i>. The 28 days of DCXD (5 g/kg) treatment significantly reduced the increased BP effectively, inhibited the enhanced heart index, kidney index, and 24 h urinary protein, and improved the progressive pathological changes of heart and kidney, which was comparable to that of the positive control amlodipine. DCXD treatment also caused a marked reduction in plasma norepinephrine and induced a significant improvement in brain sodium sensitivity and ENaC function in DOCA-salt hypertensive rats. Rats in DCXD-treated groups also exhibited decreased superoxide anion levels and NADPH oxidase activity in the paraventricular nucleus. The level of ENaC, p67phox, and Rac1 protein expression in the paraventricular nucleus was significantly downregulated by DCXD treatment in DOCA-salt hypertensive rats. <i>Conclusions</i>. These findings indicate that the depressor action and sympathetic inhibition of DCXD on salt-sensitive hypertension may be by ameliorating brain sodium sensitivity, modulating ENaC function, and inhibiting the expression of ENaC and NADPH oxidase in the hypothalamic paraventricular nucleus.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"9 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139661924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Antihypertensive Drug-Related Gene Polymorphisms with Stroke in the Chinese Hypertensive Population","authors":"Huixia Liu, Hua Zhong, Ying Lin, Linzhi Han, Mengshi Chen, Tao Tang, Jing Deng","doi":"10.1155/2024/5528787","DOIUrl":"https://doi.org/10.1155/2024/5528787","url":null,"abstract":"<i>Background</i>. Antihypertensive therapy is crucial for preventing stroke in hypertensive patients. However, the efficacy of antihypertensive therapy varies across individuals, partially due to therapy-related genetic variations among individuals. We investigated the association of antihypertensive drug-related gene polymorphism with stroke in patients with hypertension. <i>Methods</i>. Demographic information, medication, and outcome data were obtained from a hypertensive patient management system, and a PCR fluorescence probe technique was used to detect 7 gene polymorphic loci (<i>CYP2D6</i><svg height=\"6.01072pt\" style=\"vertical-align:-0.04980993pt\" version=\"1.1\" viewbox=\"-0.0498162 -5.96091 7.75925 6.01072\" width=\"7.75925pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g></svg><i>10</i>, <i>ADRB1</i>, <i>CYP2C9</i><svg height=\"6.01072pt\" style=\"vertical-align:-0.04980993pt\" version=\"1.1\" viewbox=\"-0.0498162 -5.96091 7.75925 6.01072\" width=\"7.75925pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-43\"></use></g></svg><i>3</i>, <i>AGTR1</i>, <i>ACE</i>, <i>CYP3A5</i><svg height=\"6.01072pt\" style=\"vertical-align:-0.04980993pt\" version=\"1.1\" viewbox=\"-0.0498162 -5.96091 7.75925 6.01072\" width=\"7.75925pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-43\"></use></g></svg><i>3</i>, and <i>NPPA</i>), and these loci were compared between patients with and without stroke. Logistic regression was performed to analyze the association of these genetic variations with stroke risk in hypertensive patients while controlling for potential factors. <i>Results</i>. The prevalence of stroke in the hypertensive population in Changsha County of Hunan Province was 2.75%. The mutation frequencies of <i>ADRB1</i> (<i>1165G</i> &gt; <i>C</i>), <i>CYP2D6</i><svg height=\"6.01072pt\" style=\"vertical-align:-0.04980993pt\" version=\"1.1\" viewbox=\"-0.0498162 -5.96091 7.75925 6.01072\" width=\"7.75925pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-43\"></use></g></svg><i>10</i>, <i>CYP2C9</i><svg height=\"6.01072pt\" style=\"vertical-align:-0.04980993pt\" version=\"1.1\" viewbox=\"-0.0498162 -5.96091 7.75925 6.01072\" width=\"7.75925pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-43\"></use></g></svg><i>3</i>, <i>AGTR1</i> (<i>1166A</i> &gt; <i>C</i>), <i>ACE</i> (<i>I</i>/<i>D</i>), <i>NPPA</i> (<i>2238T</i> &gt; <i>C</i>), and <i>CYP3A5</i><svg height=\"6.01072pt\" style=\"vertical-align:-0.04980993pt\" version=\"1.1\" viewbox=\"-0.0498162 -5.96091 7.75925 6.01072\" width=\"7.75925pt\" xmlns=\"http://www.w3.org/2000/svg\" xml","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"4 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139560646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Link between Overweight/Obesity and Noncommunicable Diseases in Ethiopia: Evidences from Nationwide WHO STEPS Survey 2015.","authors":"Bedilu Alamirie Ejigu, Fentanesh Nibret Tiruneh","doi":"10.1155/2023/2199853","DOIUrl":"https://doi.org/10.1155/2023/2199853","url":null,"abstract":"<p><strong>Background: </strong>Noncommunicable diseases (NCDs) are the leading cause of death worldwide. Each year, 15 million adults die from NCDs; more than 85% of these premature deaths occur in low- and middle-income nations. Evidence indicates that overweight and obesity are the main risk factors for NCDs. Although the literature indicates that the burden of NCDs is increasing in Ethiopia, no research has been conducted to demonstrate a link between overweight/obesity and NCDs. Therefore, the aim of this study is to examine the association between overweight/obesity and the common NCDs while adjusting for other important factors.</p><p><strong>Methods: </strong>We analysed data from the 2015 Ethiopia WHO STEPS survey, which was conducted in 2015. A total weighted sample of 9,800 participants (15-69 years) was included. The relationship between nutritional status and NCDs was assessed using bivariate and multivariable logistic regression models while adjusting for covariates.</p><p><strong>Results: </strong>Among the 9,800 participants, 2053 (21% with (95% CI: 19.8-22.1) had hypertension and 1368 (14% with (95% CI: 13.1-15.0) had high cholesterol levels. According to the multivariable logistic regression analysis, being overweight/obese (AOR = 2.0; 95% CI: 1.7-2.3), alcohol consumption, received lifestyle advice, being female, living in urban areas, increased age, having government occupation, and living in SNNP region were positively associated with hypertension. While being underweight (AOR = 0.6; 95% CI: 0.5-0.7), living in the Afar, Somali, and Tigray regions were negatively associated with hypertension. Being overweight/obese (AOR = 1.4; 95% CI: 1.1-1.7), being female, having older age, and living in Somali region were positively associated with a high cholesterol level. Whereas being underweight (AOR = 0.7; 95% CI: 0.6-0.9), received lifestyle advice, reside in rural areas, being farmer, student, and housewife, and living in Gambela region were negatively associated with a high cholesterol level.</p><p><strong>Conclusion: </strong>This study found a statistically positive association between the common NCDs, namely, overweight/obesity, hypertension, and high cholesterol levels. Our findings imply that there is a need for effective interventions to prevent overweight/obesity by encouraging people to increase physical activity, minimize sedentary behavior, and maintain a healthy dietary pattern in order to reduce the risk of hypertension and high cholesterol levels.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2023 ","pages":"2199853"},"PeriodicalIF":1.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138459862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Consequences of Blood Pressure Management and Blood Homocysteine Levels with Perindopril in Newly Diagnosed Hypertensive Patients in the Vietnamese Population.","authors":"Son Kim Tran,&nbsp;An Bao Truong,&nbsp;Phi Hoang Nguyen,&nbsp;Toan Hoang Ngo,&nbsp;Tuyen Long Vu,&nbsp;Khoa Dang Dang Tran,&nbsp;Phuong Minh Vo,&nbsp;Bao The Nguyen,&nbsp;Tuong Le Trong Huynh,&nbsp;Kien Trung Nguyen,&nbsp;Hung Do Tran","doi":"10.1155/2023/1933783","DOIUrl":"10.1155/2023/1933783","url":null,"abstract":"<p><strong>Background: </strong>Perindopril is an ACE inhibitor that aids in both blood pressure regulation and homocysteine reduction.</p><p><strong>Objectives: </strong>Our study aimed to evaluate the results of controlling blood pressure and blood homocysteine levels by perindopril in patients with primary hypertension.</p><p><strong>Materials and methods: </strong>A cross-sectional descriptive study with a longitudinal follow-up was conducted on 105 primary hypertensive patients treated with perindopril.</p><p><strong>Results: </strong>The results of our study showed that after 6 weeks of treatment with perindopril, the proportion of patients with the target blood pressure (BP) level accounted for 70.5%, the rate of grade 1 hypertension decreased from 61.0% to 25.7%, grade 2 blood pressure decreased from 17.1% to 3.8%, and there was no case of grade 3 hypertension. At the same time, we also found that the rate of BP control in the group of patients who controlled Hcy below a threshold of 15 <i>μ</i>mol/L was significantly higher than in the other group (<i>p</i>  <  0.05). Concerning the efficacy of decreasing homocysteine in blood, we discovered that after 6 weeks of treatment with perindopril, the proportion of patients with elevated homocysteine reduced considerably from 74.3% to 40% (<i>p</i>  <  0.05). In addition, the homocysteine concentration was 4.33 mol/L lower after treatment than before treatment (95% CI: 3.69-4.97) (<i>p</i>  <  0.05).</p><p><strong>Conclusion: </strong>Perindopril helps control blood pressure and reduces blood homocysteine levels in patients with primary hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2023 ","pages":"1933783"},"PeriodicalIF":1.9,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hypertension and Associated Factors among Residents Aged ≥18 Years in Ganzhou, China: A Cross-Sectional Study.","authors":"Junwang Gu,&nbsp;Qi Wang,&nbsp;Wei Qiu,&nbsp;Fen Lin,&nbsp;Chunmei Wu,&nbsp;Ming Hao,&nbsp;Ping Wu","doi":"10.1155/2023/5486139","DOIUrl":"10.1155/2023/5486139","url":null,"abstract":"<p><strong>Background: </strong>Reliable epidemiologic data on the present burden of hypertension are needed in developing region-specific strategies since previous studies have suggested that China is lagging in risk factor management.</p><p><strong>Objective: </strong>The study aimed at exploring the prevalence of hypertension and its associated factors among adult residents in Ganzhou, China. <i>Methodology</i>. A multistage, stratified, and cluster random sampling method was used to conduct the cross-sectional survey. The study selected four county-level districts in Ganzhou City, China, as the investigation area. Permanent residents aged ≥18 years who have settled in the area for 6 months or more were selected. A total of 7430 residents were involved in the study. Univariate and multivariate logistic regression analysis was carried out to identify predictors of hypertension.</p><p><strong>Results: </strong>The prevalence of hypertension in Ganzhou was 28.5%, and the age-standardized prevalence of hypertension was 22.4%. Univariate logistic regression analysis revealed that multiple variables have a statistically significant effect on the prevalence of hypertension. The elderly (odds ratio [95% CI]: 2.791 [2.594-3.004]), men (1.805 [1.583-2.058]), lower educated (0.848 [0.805-0.893]), a family history of hypertension (4.575 [3.900-5.368]), higher body mass index (1.344 [1.215-1.488]), central obesity (1.532 [1.304-1.799]), and less vegetable intake (1.150 [1.023-1.294]) were the major risk factors for hypertension.</p><p><strong>Conclusion: </strong>Hypertension is a major public health problem in Ganzhou and requires much effort to reduce its prevalence. An effective multifaceted implementation strategy is highly desirable to combat the emerging burden of hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2023 ","pages":"5486139"},"PeriodicalIF":1.9,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41235190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Mean Platelet Volume in Children with Hypertension.","authors":"Ismail Yildiz,&nbsp;Ozgur Kizilca","doi":"10.1155/2023/5731260","DOIUrl":"https://doi.org/10.1155/2023/5731260","url":null,"abstract":"<p><strong>Background: </strong>Childhood hypertension, a disease with increasing prevalence, can lead to severe health problems. With the increased pressure on the vascular endothelium in hypertension, lesions in the endothelium result in endothelial activation and a process of inflammation, which causes platelet activation and in the bone marrow the release of platelet precursor cells into the peripheral blood stream. During inflammation, changes in the number and size of platelets are observed. With the release of platelet precursors into the peripheral blood stream due to platelet activation, an increase in mean platelet volume (MPV) is also seen.</p><p><strong>Aim: </strong>Our aim in this study is the evaluation of MPV changes in the hemogram of children suffering from hypertension, a condition causing severe cardiovascular problems. <i>Material and Methods</i>. This research is a descriptive retrospective cross-sectional study. It consists of a patient group diagnosed with hypertension and a control group of children presenting for routine check-ups with no diagnosed hypertension. Demographic characteristics, arterial pressure values, and hemogram parameters have been evaluated.</p><p><strong>Results: </strong>A total of 90 cases were enrolled in the study, including a patient group of 45 cases with hypertension (19 females, 26 males) and a control group of 45 cases (27 females, 18 males). The median age was 15 years in the hypertension group and 13 years in the control group. In the hypertension cases, the thickness of the carotis intima media was statistically significantly greater than in the control group (<i>p</i> < 0.001). Echocardiographic findings (IVSd, LVDd, LVPWd, IVSs, LVDs, LVPWs, and LV mass) were significantly higher in the hypertension group compared to the control group (<i>p</i> < 0.001). A statistically significant difference in platelet count and MPV values between the groups was not found (<i>p</i> = 0.151, <i>p</i> = 0.405, respectively).</p><p><strong>Conclusion: </strong>While MPV is hypothesized to be higher in hypertensive individuals, there was no statistically significant difference between the hypertensive and non-hypertensive groups in this study.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2023 ","pages":"5731260"},"PeriodicalIF":1.9,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41124338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans","authors":"Jonathan N. Katsukunya, Nyarai D. Soko, Jashira Naidoo, Brian Rayner, Dirk Blom, Phumla Sinxadi, Emile R. Chimusa, Michelle Dandara, Kevin Dzobo, Erika Jones, Collet Dandara","doi":"10.1155/2023/9919677","DOIUrl":"https://doi.org/10.1155/2023/9919677","url":null,"abstract":"In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90 mmHg. Current hypertension guidelines recommend the use of antihypertensives belonging to the following classes: calcium channel blockers (CCB), angiotensin converting inhibitors (ACEI), angiotensin receptor blockers (ARB), diuretics, <i>β</i>-blockers, and mineralocorticoid receptor antagonists (MRAs), to manage hypertension. Still, a considerable number of hypertensives in Africa have their BP uncontrolled due to poor drug response and remain at the risk of CVD events. Genetic factors are a major contributing factor, accounting for 20% to 80% of individual variability in therapy and poor response. Poor response to antihypertensive drug therapy is characterised by elevated BPs and occurrence of adverse drug reactions (ADRs). As a result, there have been numerous studies which have examined the role of genetic variation and its influence on antihypertensive drug response. These studies are predominantly carried out in non-African populations, including Europeans and Asians, with few or no Africans participating. It is important to note that the greatest genetic diversity is observed in African populations as well as the highest prevalence of hypertension. As a result, this warrants a need to focus on how genetic variation affects response to therapeutic interventions used to manage hypertension in African populations. In this paper, we discuss the implications of genetic diversity in <i>CYP11B2, GRK4, NEDD4L, NPPA, SCNN1B, UMOD, CYP411, WNK, CYP3A4/5, ACE, ADBR1/2, GNB3, NOS3, B2, BEST3, SLC25A31, LRRC15</i> genes, and chromosome 12q loci on hypertension susceptibility and response to antihypertensive therapy. We show that African populations are poorly explored genetically, and for the few characterised genes, they exhibit qualitative and quantitative differences in the profile of pharmacogene variants when compared to other ethnic groups. We conclude by proposing prioritization of pharmacogenetics research in Africa and possible adoption of pharmacogenetic-guided therapies for hypertension in African patients. Finally, we outline the implications, challenges, and opportunities these studies present for populations of non-European descent.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138533993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covariates of Knowledge, Attitude, Practice, and Burdens among the Caregivers of Hypertensive Patients.","authors":"Sudipta Deb Nath,&nbsp;Afrin Sultana Chowdhury,&nbsp;Susmita Dey Pinky,&nbsp;Kazi Mahmuda Akter,&nbsp;Nishat Anjum Nourin,&nbsp;Tonmoy Chowdhury,&nbsp;Hossain Ahmed Fahid,&nbsp;K M Shailah Sharmin,&nbsp;Md Mashud Rana,&nbsp;Nazmul Alam,&nbsp;Md Moinul Ahsan,&nbsp;Adnan Mannan","doi":"10.1155/2023/8866231","DOIUrl":"https://doi.org/10.1155/2023/8866231","url":null,"abstract":"<p><p>Caregivers of hypertensive patients play a significant role in ensuring adequate patient care and lowering the risk of hypertension-relatedcomplications. Caregivers are ideal study subjects for identifying gaps in hypertension management. Our study aimed to assess the knowledge, attitude, and practice (KAP) of hypertensive patients' caregivers, to identify their extent of involvement in patients' care, and to assess their care-related attributes. A descriptive cross-sectional study was conducted from August 2020 to February 2021 in the eight largest tertiary care medical college hospitals and all eight divisions of Bangladesh, with 949 caregivers enrolled. Data were collected using a pretested interviewer-administered questionnaire through snowball sampling and analyzed using a one-way ANOVA, independent-sample <i>T</i>-test, and chi-square test. Among the 949 interviewed caregivers, 541 (57.0%) were female, and 479 (50.5%) were aged 18 to 25 years. The percentage scores regarding overall knowledge, attitude, and practice of the caregivers were 54.83 ± 17.95, 47.95 ± 24.05, and 61.26 ± 17.50, respectively. Caregivers' education, history of hypertension, residence, age, relationship with the patient, occupation, and caregiving duration were significantly associated with the KAP scores. In addition, factors such as relationship with the patient, age, educational status, occupation, residence, and caregiving duration/day had significant correlations with all types of burden. Findings of this study suggest the necessity for awareness programs for the caregivers of hypertensive patients to diminish the gap in their KAP and improve their mental and physical health.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2023 ","pages":"8866231"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10111522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Association between Hemoglobin Concentration and Blood Pressure in Adults: A Cross-Sectional Study Based on Rafsanjan Cohort Study.","authors":"Gholamreza Bazmandegan,&nbsp;Mitra Abbasifard,&nbsp;Hamid Ostadebrahimi,&nbsp;Mohammadreza Gholamrezapour,&nbsp;Zahra Kamiab","doi":"10.1155/2023/6283711","DOIUrl":"https://doi.org/10.1155/2023/6283711","url":null,"abstract":"<p><strong>Introduction: </strong>Identification of factors associated with blood pressure (BP), including hemoglobin, can be used in diagnosing, controlling, and predicting the prognosis of patients. This study aims to investigate the cross-sectional association between hemoglobin concentration and BP in people aged 35-70 years in a cohort study of Rafsanjan, Iran.</p><p><strong>Method: </strong>This cross-sectional study was conducted on 9398 urban and rural population of Rafsanjan adult cohort study as a part of the prospective epidemiological research studies in Iran (PERSIAN). Demographic information, medical history, history of smoking and alcohol intake, systolic and diastolic BP, and hemoglobin concentration were collected. A logistic regression test was performed to evaluate the relationship between hemoglobin concentration and BP in 4 unadjusted and adjusted models based on demographic indicators, clinical and laboratory findings using SPSS.24 software and SAS software version 9.2.</p><p><strong>Results: </strong>The mean age of the participants was 49.78 ± 9.53 years, and 53.2% (5002 people) were women. Adjusted models 3 and 4 showed a positive association between BP and hemoglobin. For each unit increase in hemoglobin, the odds ratio (OR) of BP in the adjusted model 3 was 1.062 (95% CI: 1.005-1.121), and in the adjusted model 4, it was 1.090 (95% CI: 1.031-1.153).</p><p><strong>Conclusion: </strong>Based on the results, the positive trend of BP and hemoglobin levels may indicate the need to pay more attention to these people as higher-risk groups for hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2023 ","pages":"6283711"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9275266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}