International Journal of Hypertension最新文献

{"title":"Assessment of Serum Magnesium Mean Levels at Pre- and Postmagnesium Sulfate Uptake for Eclampsia Prevention: A Cross-Sectional Study.","authors":"Tuan Minh Vo, Du Van Tran, Dat Quoc Nguyen, Toan Thi Nguyen, Mo Ha Nguyen, Thanh Tan Nguyen, Liem Ba Le","doi":"10.1155/ijhy/5541651","DOIUrl":"https://doi.org/10.1155/ijhy/5541651","url":null,"abstract":"<p><p><b>Objective:</b> To assess serum magnesium mean levels in pregnant women with severe preeclampsia at three landmarks: prior to MgSO₄ intake, 30 min, and 6 h postintake of loading dose plus maintenance dose. <b>Methodology:</b> This cross-sectional study collected blood samples over a timeframe of 0-6 h from 64 pregnant women diagnosed with severe preeclampsia who were receiving MgSO₄ therapy at the emergency management department of Hung Vuong Hospital, Vietnam, in the period of November 2023 to April 2024. Serum magnesium levels were measured three times in the timeframe. <b>Results:</b> Prior to MgSO₄ intake, the serum magnesium mean level was 0.75 ± 0.13 mmol/L. At 30 min postloading dose intake plus maintenance, the level increased to 1.65 ± 0.32 mmol/L, and at 6 h, 1.6 ± 0.34 mmol/L, where 17.2% of patients had a serum magnesium level of 2 mmol/L or higher. <b>Conclusion:</b> There were no eclampsia incidents in patients with severe preeclampsia treated with a regimen of a loading dose of 4.5 g MgSO₄ followed by a 1 g-hourly maintenance. Nevertheless, about 17% of participants achieved the desired threshold of 2 mmol/L, indicating a need for additional research to refine the loading and maintenance doses of MgSO₄ for better management of severe preeclampsia in Vietnamese women.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"5541651"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effects of Sustained Regular Medication in Hypertensive Patients in Yunnan, China: A Cohort Study of 5 Years' Follow-Up.","authors":"Min Ma, Huadan Wang, Linhong Pang, Zihong Guo, Manli Sun, Yajing Zhao, Yi Shi, Xia Wu, Junjie Song, Qiuyan Zhu, Lin Duo, Zhongjie Wang, Yu Xia, Liping He, Mingjing Tang","doi":"10.1155/ijhy/4505824","DOIUrl":"https://doi.org/10.1155/ijhy/4505824","url":null,"abstract":"<p><p><b>Background:</b> The relationship between different grades of compliance to antihypertensive medication and blood pressure (BP) control rate remains unclear. This study highlighted the Chinese Basic Public Health Service (BPHS) program upgraded antihypertension medication compliance to improve the blood pressure control rate contributing to the UN sustainable development goal of lowering chronic illness fatalities by one-third by 2030. <b>Methods:</b> In 2015, 1254 hypertensive patients aged ≥ 35 years were selected in the baseline survey in Yunnan Province by a multistage stratified random sampling method and followed up from 2018 to 2022. Then, they were divided into three groups by tertiles as antihypertensive medicine compliance \"poor,\" \"intermittent,\" and \"sustained\" groups. Then, the robust variance Poisson regression models were performed to estimate the association between three groups and the number of referrals. Kaplan-Meier curves calculated the cumulative risk of onset and survival probability of cardiovascular events from three medication compliance groups. <b>Results:</b> A total of 1254 hypertension patients were included in the study; 992, 1218, 1121, 1066, and 999 hypertension patients were followed up annually. From the baseline to last follow-up, systolic BP declined with the largest decrease in the sustained group (2015: 152.88 ± 21.64 mmHg vs. 2022: 134.61 ± 10.49 mmHg, <i>p</i> < 0.05) and the least decrease in the poor group (2015: 157.07 ± 15.37 mmHg vs. 2022: 140.33 ± 12.04 mmHg, <i>p</i> < 0.05). Under the management of BPHS, the BP control rate of all three groups increased significantly. Compared with the baseline, the control rate in the sustained group reached 70% in 2022 (<i>p</i> < 0.01). The number of referrals from the poor group was 11.5%, higher compared with the sustained group (IRR = 1.115 and 95% CI: 1.043-1.193). The poor group also had the highest probability of cardiovascular disease (CVD). The survival probability in the sustained group was the highest and kept at 0.950 at the end of 5 years. <b>Conclusions:</b> High-grade compliance to antihypertensive drugs significantly improves BP control rate and reduces the risk of CVD events and mortality. The decline of medication compliance grades is closely related to decreasing BP control rate and increased risk of CVD and mortality.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"4505824"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Renin-Angiotensin-Aldosterone System (RAAS) Gene Polymorphism in Essential Hypertension and Antihypertensive Drug Therapy: A Review.","authors":"Archana Adhikari, Chandrakala Sharma, Mingma Lhamu Sherpa, Gauthaman Karaunakran, Mona Dhakal, Anita Sharma","doi":"10.1155/ijhy/5530265","DOIUrl":"https://doi.org/10.1155/ijhy/5530265","url":null,"abstract":"<p><p>Genetic, demographic and environmental factors all play a role in the frequency of an intricate multifactorial condition known as hypertension. Approximately 30% and 50% of BP fluctuation are influenced by genetic variability. Many genetic studies have confirmed the link between genetic variability and susceptibility to essential hypertension; hence, identifying genes associated with essential hypertension susceptibility will aid in understanding the pathophysiology and their influence on how an individual responds towards the antihypertensive therapy. There are also controversial results highlighted in some reports. This review summarises genetic variants of the renin-angiotensin-aldosterone system (RAAS), angiotensinogen (AGT) (M235T), angiotensin converting enzyme (ACE) (insertion/deletion), angiotensin II type 1 receptor (AT1R) (A1166C) and aldosterone synthase (C344T) that are known and might contribute towards the pathophysiology of essential hypertension. Furthermore, the review highlights the response of certain RAAS gene polymorphisms (renin, ACE and AT1R genes) to antihypertensive drugs.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"5530265"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12061529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Adherence Status and Influencing Factors Among Middle-Aged and Elderly Hypertension Patients in Rural Areas of Northeast China.","authors":"Xinyuan Lu, Jiwei Wang, Sikun Chen, Lin Lv, Jinming Yu","doi":"10.1155/ijhy/9954099","DOIUrl":"https://doi.org/10.1155/ijhy/9954099","url":null,"abstract":"<p><p>Hypertension remains a major public health challenge globally, with suboptimal adherence to treatment and lifestyle modifications exacerbating cardiovascular risks. This study evaluates multidimensional adherence (medication, diet, and behavior) and its determinants among hypertensive patients in rural Northeast China. A cross-sectional study enrolled 6352 adults aged ≥ 40 years with diagnosed and poorly controlled hypertension from rural villages across five cities (Benxi, Chaoyang, Dandong, Donggang, and Fuxin) in Liaoning Province, Northeast China, using multistage cluster sampling. Adherence was assessed via standardized questionnaires, with logistic regression analyzing sociodemographic, clinical, and behavioral predictors. Medication adherence was reported by 73.7% of participants, while dietary and behavioral adherence rates were 10.5% and 29.3%, respectively. Ethnic disparities emerged, with Han Chinese exhibiting lower medication adherence (aOR = 0.485, 95% CI: 0.377-0.624). Cohabiting with children enhanced dietary adherence (aOR = 2.184, 95% CI: 1.854-2.573), whereas widowed status reduced both dietary (aOR = 0.698, 95% CI: 0.528-0.924) and behavioral adherence (aOR = 0.726, 95% CI: 0.595-0.887). Higher hypertension knowledge scores positively influenced all adherence domains (<i>p</i> < 0.05). Adherence among rural hypertensive patients is multidimensional, shaped by cultural, socioeconomic, and behavioral factors. Targeted interventions addressing dietary sodium reduction, family-based support, and health literacy improvement are urgently needed. This study underscores the importance of integrating region-specific strategies into hypertension management programs to mitigate cardiovascular morbidity in high-risk populations.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"9954099"},"PeriodicalIF":1.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Care Behaviors and Associated Factors Among Hypertensive Patients at Dessie Referral Hospital, Northeast Ethiopia.","authors":"Assen Muhe, Mesfin Haile Kahissay, Mohammed K Ali, Solveig A Cunningham, Bruck Messele Habte","doi":"10.1155/ijhy/1774636","DOIUrl":"https://doi.org/10.1155/ijhy/1774636","url":null,"abstract":"<p><p><b>Introduction:</b> Hypertension poses a significant global health challenge, leading to serious health conditions and premature death. Effective blood pressure control is often hindered by patients' nonadherence to self-care behaviors. This study evaluates these behaviors and their influencing factors among hypertensive patients at Dessie Referral Hospital, Ethiopia. <b>Methods:</b> Conducted from October 20 to November 30, 2019, this mixed-methods study involved 370 hypertensive patients from the hospital's outpatient clinic. Data were collected via structured questionnaires and analyzed using multivariable logistic regression. Additionally, 14 in-depth interviews provided qualitative insights, analyzed thematically. <b>Results:</b> Only 29.4% of patients fully adhered to self-care recommendations. Urban dwellers showed 70% less adherence than rural counterparts. Adherence varied with the duration since diagnosis, with medium-duration patients being less likely to adhere. Interviews revealed personal strategies for managing diet, exercise, medication, and lifestyle, highlighting the struggle with adherence and innovative solutions to challenges. <b>Conclusion:</b> Adherence to self-care among hypertensive patients is alarmingly low, influenced by diagnosis duration, residency, and BMI. Addressing hindrances like living conditions, work, cultural norms, and peer influence is vital. Healthcare providers must focus on education that promotes behavior change and support. Patient engagement in self-care is essential. Future research should investigate healthcare organizational and provider influences. Implementing these strategies could markedly improve hypertension management and patient outcomes.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"1774636"},"PeriodicalIF":1.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Ultra-Processed Food Consumption and Hypertension Incidence: Findings From RaNCD Cohort Project.","authors":"Parsa Amirian, Mahsa Zarpoosh, Yahya Pasdar","doi":"10.1155/ijhy/2495258","DOIUrl":"https://doi.org/10.1155/ijhy/2495258","url":null,"abstract":"<p><p><b>Background:</b> Ultra-processed food (UPF) consumption is increasing rapidly due to large-scale food production. Being a public health issue, hypertension is affecting 1.28 billion adults globally. This study investigates the link between UPF consumption and hypertension. <b>Methods:</b> We included 8150 participants at the risk of hypertension in the final analysis. UPF consumption was assessed using data from the available Food Frequency Questionnaire (FFQ), and the amount of UPF consumption of each participant in a day was assessed. Cox proportional models with covariates including age, sex, residence type, marital status, socioeconomic status, physical activity, familial history of hypertension, and fasting blood sugar were used to assess the association between UPF consumption and hypertension in the main model and sensitivity analysis. Age, residence type, and the third tertile of UPF interacted with time in our model, which was addressed accordingly. <b>Results:</b> The mean participant age was 46.25 years (47.58% male) with a mean follow-up of 7.65 years. The mean daily UPF intake was 88.07 g. During follow-up, 862 hypertension cases were recorded. After adjusting the main model for confounders, the hazard ratios for the second and third tertiles of UPF consumption were 1.13 (95% CI, <i>p</i> value) (0.96-1.32, 0.13) and 0.65 (95% CI, <i>p</i> value) (0.46-0.91, 0.01), respectively, compared to the first tertile. <b>Conclusion:</b> We found significant association between the third tertile of UPF intake and hypertension; moreover, we identified significant associations between hypertension incidence and some demographic factors, warranting further investigation.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"2495258"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Body Composition Measures to the Increased Left Ventricular Mass Index in Young Adult Black and White Females.","authors":"Jordan Sill, Jessica G Woo, Elaine M Urbina","doi":"10.1155/ijhy/8274623","DOIUrl":"10.1155/ijhy/8274623","url":null,"abstract":"<p><p><b>Objective:</b> We aimed to determine the contribution of various types of body composition measures to the increased left ventricular mass index (LVMI) in young adult females. <b>Methods:</b> Data from the National Growth and Health Study (NGHS), including dual-energy x-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), and echocardiogram, were analyzed (<i>N</i> = 589, 54.8% Black, mean age: 24.9 ± 0.7 years). Logistic and linear regressions were conducted to assess for the contribution of fat mass (FM) and fat-free mass (FFM) by DEXA and subcutaneous abdominal adipose tissue (SAT) mass and visceral adipose tissue (VAT) volume by MRI in relation to the increased LVMI or left ventricular hypertrophy (LVH; LVMI ≥ 38.6 g/m^2.7). <b>Results:</b> FM (<i>β</i> ± SE: 0.025 ± 0.002, <i>p</i> < 0.01, adjusted <i>R</i> ² = 0.313), FFM (0.059 ± 0.003, <i>p</i> < 0.01, adjusted <i>R</i> ² = 0.374), SAT (0.054 ± 0.005, <i>p</i> < 0.01, adjusted <i>R</i> ² = 0.291), and VAT (0.194 ± 0.019, <i>p</i> < 0.01, adjusted <i>R</i> ² = 0.256) were each significantly associated with the increased LVMI, with FFM having the greatest association. Black race was associated with the increased LVMI in models involving individual fat mass types (0.055 ± 0.020, <i>p</i> < 0.01 for FM; 0.054 ± 0.021, <i>p</i> = 0.01 for SAT; 0.119 ± 0.021, <i>p</i> < 0.01 for VAT). In logistic models considering all mass types, FFM (OR [95% CI]: 1.62 [1.46-1.79], <i>p</i> < 0.01) and systolic blood pressure (SBP) (1.04 [1.01-1.07], <i>p</i> < 0.01) were significant contributors to LVH (area under the receiver-operator characteristic curve 0.847), and only FFM was a significant contributor in the corresponding linear regression (<i>β</i> ± SE: 0.059 ± 0.003, <i>p</i> < 0.01, adjusted <i>R</i> ² = 0.374). <b>Conclusions:</b> FFM had the greatest association with LVH and LVMI, confirming previously published data. Through the use of MRI, we found that neither subtype of abdominal fat mass (SAT and VAT) better explained the variance in LVMI than FFM.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"8274623"},"PeriodicalIF":1.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-34a Mediates the Aldosterone-Induced Acceleration of Endothelial Senescence.","authors":"Minyue Jia, Liya Lin, Boyun Yang, Hanxiao Yu, Shan Zhong, Xiaohong Xu, Xiaoxiao Song","doi":"10.1155/ijhy/2339598","DOIUrl":"https://doi.org/10.1155/ijhy/2339598","url":null,"abstract":"<p><p>Inappropriate aldosterone production relative to sodium status is known to induce arterial hypertension and cause detrimental effects on endothelium and vascular remodeling. This study investigated whether microRNAs (miRs) serve as key mediators of aldosterone's effects on endothelial dysfunction. Using human umbilical vein endothelial cells (HUVECs) as a model system, we demonstrated that aldosterone treatment suppressed cellular proliferation and migration while promoting senescence. Mechanistically, we observed that aldosterone exposure significantly upregulated miR-34a expression in HUVECs. The functional significance of miR-34a was confirmed when specific inhibitors reversed aldosterone's antiproliferative and prosenescence effects. To elucidate the underlying molecular pathway, we performed comprehensive biological analyses, which revealed that miR-34a target genes were predominantly associated with the Notch signaling pathway. Western blot analysis further validated that miR-34a promotes senescence in HUVECs through negative regulation of NOTCH1. Collectively, our findings identify miR-34a as a crucial mediator of aldosterone-induced endothelial cell senescence via the NOTCH1 signaling pathway, suggesting its potential as a therapeutic target for aldosterone-related vascular diseases.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"2339598"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Factors Associated With Uncontrolled Hypertension Using Machine Learning Methods: A Cross-Sectional Study in Western Iran.","authors":"Zahra Cheraghi, Mahboobeh Doosti-Irani, Masoumeh Sohrabi, Amin Doosti-Irani","doi":"10.1155/ijhy/4011397","DOIUrl":"10.1155/ijhy/4011397","url":null,"abstract":"<p><p>Uncontrolled hypertension is a major public health issue globally. This study aimed to uncover the factors contributing to uncontrolled hypertension using machine learning techniques. In this study, 303 adults with hypertension were included in this cross-sectional study. Data were collected using the Standard Health Literacy Questionnaire. Uncontrolled hypertension was defined as systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg on both days. Data were analyzed using percentages and chi-square tests. Four machine learning algorithms were employed in this study. The efficacy of these algorithms was assessed using several performance metrics, including accuracy, positive predictive value, sensitivity, <i>F</i>_Score, and the area under the receiver operating characteristic (ROC) curve (AUC). The analyses were performed utilizing Python version 3.8. Of the four models evaluated, logistic regression exhibited the highest accuracy at 75.4% and the greatest AUC at 0.87. According to the logistic regression algorithm, individuals who did not adhere to their treatment had a significantly lower likelihood of having uncontrolled hypertension (OR = 0.17, <i>p</i> value < 0.001). Number of children (OR = 0.44, <i>p</i> < 0.001), physical activity (OR = 0.94, <i>p</i> < 0.001), and health literacy (OR = 0.29, <i>p</i> = 0.10) were all associated directly, and salt intake (OR = 9.60, <i>p</i> < 0.001) was associated inversely with the odds of having uncontrolled hypertension. Based on variable importance analysis, low physical activity was identified as the most important variable, followed by weak health literacy and nonadherence to drug treatment. Factors such as age, duration of hypertension, chronic disease, and salt consumption were also significant. Adherence to treatment, physical activity, health literacy, and salt intake play crucial roles in uncontrolled hypertension. Interventions targeting these factors could help in managing and preventing uncontrolled hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2025 ","pages":"4011397"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Hydrogen Sulfide on Sympathoinhibition in Obese Pithed Rats and Participation of K⁺ Channel.","authors":"Carolina B Gomez, Araceli Sánchez-López, Karla Carvajal, David Centurión","doi":"10.1155/2024/5848352","DOIUrl":"https://doi.org/10.1155/2024/5848352","url":null,"abstract":"<p><p>Elevated blood pressure is the leading metabolic risk factor in attributable deaths, and hydrogen sulfide (H₂S) regulates vascular tone and blood pressure. Thus, this study aims to evaluate the mechanism by which NaHS (H₂S donor) produces inhibition of the vasopressor sympathetic outflow in obese rats. For that purpose, animals were fed a high-fat diet (HFD) (60% calories from fat) for 12 weeks. They were anesthetized, pithed, and cannulated to evaluate the role of the potassium channel on NaHS-induced sympathoinhibition. Animals received selective electrical stimulation of the vasopressor sympathetic outflow, an intravenous (i.v.) administration of (1) tetraethylammonium (TEA, non-selective K⁺ channel blocker, 16.5 mg/kg), (2) 4-aminopyridine (4-AP, K_V channel blocker, 5 mg/kg), (3) barium chloride (BaCl₂, K_IR channel blocker, 65 <i>μ</i>g/kg), (4) saline solution (vehicle of TEA, 4-AP, and BaCl₂, 1 mL/kg), (5) glibenclamide (K_ATP channel blocker, 10 mg/kg), and (6) glibenclamide vehicle (DMSO + glucose 10% + NaOH, 1 mL/kg), and then a 310 <i>μ</i>g/kg·min NaHS i.v. continuous infusion. We observed that (1) NaHS produced inhibition of the vasopressor sympathetic outflow and (2) the sympathoinhibitory effect by NaHS was reversed by the K_IR channel blocker, BaCl₂, in obese rats. The above data suggest that the potassium channel could be involved in the sympathoinhibition induced by NaHS.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2024 ","pages":"5848352"},"PeriodicalIF":1.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}