International Journal of Hypertension最新文献

{"title":"Occupational Specific Heavy Metal Exposure: Association With Age and Anthropometric Characteristics Relative to Hypertension.","authors":"Godwin Chinedu Uzomba, Collins Nwafor, Chibuike Ugah, Henry Ogbodo, Chukwuka Amaku, Ken Onwe, Tamuno-Ibelema Cookey-Gam, Godwin Sunday Obaje, Ejikeme Mbajiorgu","doi":"10.1155/ijhy/5085833","DOIUrl":"10.1155/ijhy/5085833","url":null,"abstract":"<p><p>The present study aimed at investigating the association between serum heavy metals, anthropometric characteristics, and hypertension among different occupations and analyzing the prediction between heavy metals, anthropometrics, and hypertension among male and female miners, artisans, laborers, and farmers. Body weight, height, and circumferences were measured via the direct standard anthropometric approach. Blood pressure (BP) was measured using a standardized mercury sphygmomanometer with an appropriate cuff size. Blood samples were analyzed using an atomic absorption spectrophotometer. Chi-square and binary logistic regression analysis were conducted at a significance level of <i>p</i> < 0.05 (^∗). For miners, there was no significant association between serum heavy metals, anthropometric characteristics, and hypertension (<i>p</i> > 0.05). Among artisans, age and anthropometric circumferences showed significant association with hypertension (<i>χ</i> ² = 5.266 - 21.206, <i>p</i> < 0.05^∗). Among laborers, age was significantly associated with hypertension (<i>χ</i> ² = 62.548, <i>p</i> < 0.05∗). For farmers, age showed significant association with hypertension (<i>χ</i> ² = 3.925, <i>p</i> < 0.05∗). The derived regression model, which included age as a predictor, showed that increasing age was significantly associated with higher odds of hypertension among miners (aOR: 1.076, 95% CI: 1.029-1.125) and artisans (aOR: 11.938, 95% CI: 3.349-38.621). Furthermore, anthropometric circumferences were significant predictors of hypertension among artisans (aOR: 3,427, 95% CI: 1.205-9.747) and laborers (aOR: 2.50, 95% CI: 1.130-3.207). The study contributes to the understanding of relevant of heavy metals and specific anthropometrics to BP. Understanding the effects of heavy metals and age have implications in occupational health and contribute to the development of public health interventions.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"5085833"},"PeriodicalIF":3.1,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Adiposity to Diastolic Dysfunction: The Integrated Role of Epicardial Fat, Autonomic Dysregulation, and Morning Blood Pressure Surge in Obesity.","authors":"Ayhan Cosgun, Huseyin Oren","doi":"10.1155/ijhy/8528281","DOIUrl":"https://doi.org/10.1155/ijhy/8528281","url":null,"abstract":"<p><strong>Objective: </strong>Although the association between obesity and left ventricular diastolic dysfunction (LVDD) is well established, the concurrent associations of epicardial adipose tissue (EAT), sleep-trough (prewaking) morning blood pressure surge (MBPS), and autonomic imbalance with LVDD have not been fully elucidated. This study aimed to evaluate the associations of EAT thickness, MBPS, and heart rate variability (HRV) parameters with LVDD in obese adults and to assess the cross-sectional discriminatory performance of these multimodal markers.</p><p><strong>Methods: </strong>This cross-sectional study included 240 individuals, comprising 120 obese participants (body mass index ≥ 30 kg/m²) and 120 age- and sex-matched normal-weight controls (body mass index 18.5-24.9 kg/m²). All participants underwent transthoracic echocardiography, 24-h ambulatory blood pressure monitoring, and 24-h Holter electrocardiographic analysis, with HRV data available for the entire cohort (<i>n</i> = 240). EAT thickness was measured echocardiographically, and LVDD was classified using contemporary guideline-based echocardiographic criteria. SDNN was predefined as the primary autonomic marker, while RMSSD and the LF/HF ratio were reported as supportive indices. Associations with LVDD (≥ Grade I) were evaluated using correlation analysis, multivariable logistic regression, and receiver operating characteristic analyses. Cross-sectional discrimination analysis and performance assessment were performed within the obese subgroup (<i>n</i> = 120).</p><p><strong>Results: </strong>Compared with controls, obese participants exhibited greater EAT thickness (6.5 ± 1.7 vs. 4.0 ± 1.2 mm), higher MBPS (33 ± 10 vs. 21 ± 7 mmHg), increased LF/HF ratio, and lower SDNN and RMSSD values (all <i>p</i> < 0.001). The prevalence of LVDD was significantly higher in obese individuals than in controls (45% vs. 15%, <i>p</i> < 0.001). In multivariable analysis, EAT thickness (odds ratio [OR] = 1.20 per 1 mm; 95% confidence interval [CI] 1.08-1.34), MBPS (OR = 1.35 per 10 mmHg; 95% CI 1.10-1.65), and SDNN (OR = 0.88 per 10 ms; 95% CI 0.80-0.97) were independently associated with LVDD. The parsimonious model demonstrated discrimination and calibration comparable to or superior to the full clinical model (AUC: 0.89 vs. 0.85).</p><p><strong>Conclusion: </strong>In obese adults, increased epicardial adiposity, exaggerated MBPS, and autonomic dysfunction coexist with LVDD. Integrated assessment of structural (EAT), hemodynamic (MBPS), and autonomic (SDNN) markers may facilitate cross-sectional identification of LVDD and improve phenotypic characterization in obesity.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"8528281"},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension Among Medical Students in Lubumbashi, Democratic Republic of the Congo: Prevalence, Associated Factors and Comparison of the 2025 ACC/AHA and JNC 7 Classifications.","authors":"Jacques Mbaz Musung, Emmanuel Kiyana Muyumba, Phillipe Bianga Katchunga, Placide Kambola Kakoma, Yves Idi Isango, Marcellin Bugeme, Berthe Mwad Kon Kamalo, Orly Muyumba Ngungwa, Harvey Kabulo Kapya, Didier Lez Malamba, Olivier Mukuku","doi":"10.1155/ijhy/7252722","DOIUrl":"https://doi.org/10.1155/ijhy/7252722","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is increasingly recognised among young adults, but its estimated prevalence varies substantially according to the diagnostic criteria used. This study assessed the prevalence and factors associated with hypertension among medical students in Lubumbashi, Democratic Republic of the Congo (DRC), using the 2025 American College of Cardiology/American Heart Association (ACC/AHA) criteria, and compared the findings with the JNC 7 classification.</p><p><strong>Methods: </strong>We conducted a cross-sectional study among students aged ≥ 18 years at the Faculty of Medicine, University of Lubumbashi, from July to August 2023. Blood pressure and anthropometric measurements were obtained using standardised procedures, and sociodemographic, behavioural and family-history data were collected using a structured questionnaire. Hypertension was defined according to the 2025 ACC/AHA criteria and, for sensitivity analysis, according to JNC 7. Factors associated with hypertension were assessed using logistic regression, with adjusted odds ratios (aORs) and 95% confidence intervals (CIs). The agreement between the two classifications was assessed using Cohen's <i>κ</i> and McNemar's test.</p><p><strong>Results: </strong>Among 3505 medical students, 1171 (33.4%) were classified as hypertensive according to the 2025 ACC/AHA criteria. In multivariable analysis, hypertension was independently associated with a family history of hypertension (aOR 1.31, 95% CI 1.09-1.59), higher BMI (aOR 1.02 per kg/m², 95% CI 1.00-1.04), alcohol consumption (aOR 1.32, 95% CI 1.09-1.62) and physical inactivity (aOR 1.22, 95% CI 1.02-1.46). Using JNC 7, only 168 students (4.8%) were classified as hypertensive. In the sensitivity analysis, older age, higher academic level and a family history of hypertension were associated with JNC 7-defined hypertension. The agreement between the two classifications was 71.4% (<i>κ</i> = 0.18, <i>p</i> < 0.001), while McNemar's test indicated a significant difference in paired classifications (<i>χ</i> ² = 1003.0, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Hypertension was highly prevalent among medical students when classified according to the 2025 ACC/AHA criteria, although the prevalence was substantially lower using JNC 7. The limited agreement between the two classifications highlights the considerable impact of diagnostic thresholds on the estimated burden of hypertension among young adults. Early identification of modifiable and familial factors may support targeted cardiovascular risk prevention in university populations.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"7252722"},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Associated Factors of Hypertension Among Diabetic Individuals in the Sylhet Region of Bangladesh.","authors":"Abu Taher, Nurshad Ali","doi":"10.1155/ijhy/9276454","DOIUrl":"10.1155/ijhy/9276454","url":null,"abstract":"<p><strong>Background: </strong>Hypertension commonly coexists with diabetes and substantially increases the risk of cardiovascular and renal complications. However, data on the prevalence of hypertension and its associated factors among people with diabetes in Bangladesh remain limited. This study aimed to determine the prevalence of hypertension and identify factors associated with hypertension among adults with diabetes in the Sylhet region of Bangladesh.</p><p><strong>Methods: </strong>A total of 295 adults with diabetes were enrolled in this cross-sectional study. Data on anthropometric measurements, lifestyle factors, and sociodemographic characteristics were collected using a structured questionnaire and a review of medical records. Diabetes and hypertension were defined according to standard guidelines. Blood glucose and lipid profile parameters were measured using standard colorimetric methods. Multivariable logistic regression analysis was performed to identify factors associated with hypertension.</p><p><strong>Results: </strong>The overall prevalence of hypertension was 61.4% (181/295). Hypertension prevalence increased with age and adiposity, reaching 69.4% among participants aged > 55 years and 70.0% among those with obesity. In the multivariable logistic regression analysis, participants aged > 55 years had higher odds of hypertension than those aged 30-40 years (AOR = 2.09, 95% CI: 1.10-3.97). Compared with participants with normal BMI, overweight (AOR = 1.82, 95% CI: 1.03-3.20) and obesity (AOR = 2.46, 95% CI: 1.24-4.88) were significantly associated with hypertension. Abdominal obesity was also independently associated with hypertension (AOR = 2.57, 95% CI: 1.41-4.65). No significant associations were observed for sex, education level, dyslipidemia, lipid parameters, physical activity, or smoking status.</p><p><strong>Conclusions: </strong>Hypertension was highly prevalent among adults with diabetes in the Sylhet region of Bangladesh. Older age and both general and abdominal obesity were independently associated with hypertension, underscoring the importance of regular blood pressure screening and comprehensive weight management as integral components of diabetes care.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"9276454"},"PeriodicalIF":3.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13548778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncontrolled Hypertension in Cardio-Renal-Metabolic Diseases: Real-World Insights on Patient Profiles and Management Patterns From iCaReMe Global Registry.","authors":"Kamlesh Khunti, Mustafa Arici, Carol Pollock, Chien-Ning Huang, Rubén Silva-Tinoco, Adel A El Sayed, Esteban Coto, Karim Salama, Hardik Vasnawala, Ahmed Hadaoui","doi":"10.1155/ijhy/9668123","DOIUrl":"10.1155/ijhy/9668123","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is a leading risk factor for cardiovascular (CV) and renal morbidity and mortality, yet blood pressure (BP) control remains suboptimal worldwide. Understanding management patterns, especially among patients with coexisting Type 2 diabetes mellitus (T2DM), chronic kidney diseases (CKDs), or heart failure (HF), and assessing uncontrolled HTN burden across diverse health systems are critical to inform guideline-concordant strategies to improve care.</p><p><strong>Methods: </strong>Cross-sectional analysis includes participants with HTN, with or without comorbid T2DM, CKD, or HF enrolled in iCaReMe Global Registry across 29 countries. Demographic and clinical characteristics, antihypertensive treatment patterns, prevalence of uncontrolled HTN (defined as SBP ≥ 130 mmHg or DBP ≥ 80 mmHg), and its associated factors were assessed.</p><p><strong>Results: </strong>Among 23,063 participants, comorbidities included T2DM (71.4%), CKD (38.2%), and HF (14.6%). Key CV risk factors were family history of CV disease (34.3%), obesity (40.5%), and dyslipidemia (51.0%). Echocardiography (available in 28.6%) revealed left ventricular hypertrophy (LVH) in 30.6% and diastolic dysfunction in 42.4%. Overall, 88.7% were prescribed antihypertensive drugs: renin-angiotensin system (RAS) blockers (76.6%), calcium channel blockers (CCBs, 42.0%), beta-blockers (41.4%), diuretics (23.7%), with a majority (62.3%) on combination regimens. Uncontrolled HTN was prevalent in 75.4%, who were younger (59.8 vs 61.8 years) and exhibited higher burden of obesity (42.5% vs 34.6%), CKD (39.3% vs 33.1%), LVH (32.9% vs 24.8%), and treated less intensively with antihypertensives (60.2% vs 88.7%) and combinations (46.2% vs 61.8%) when compared to the controlled HTN group. Multivariate analysis confirmed independent association of non-use of RAS blockers/CCB/diuretics combinations (dual/triple therapy), obesity, and comorbid CKD, with uncontrolled HTN (OR [95% CI], 2.8 [2.44-3.18]/2.3 [1.66-3.16], 1.5 [1.38-1.65], and 1.4 [1.27-1.53], respectively, <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>This study uncovers alarming rates of uncontrolled HTN in real-world settings, exacerbated by comorbid T2DM/CKD/HF, underscoring the need to identify HTN management gaps and tailor innovative strategies to mitigate CV risk. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03549754.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"9668123"},"PeriodicalIF":3.1,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of the Association Between Obesity and Albuminuria in Asian People.","authors":"Maria Riastuti Iryaningrum, Louis Fabio Jonathan Jusni, Rivaldi Ruby, Ria Bandiara, Yunia Sribudiani, Nanny Natalia Mulyani Soetedjo, Rudi Supriyadi","doi":"10.1155/ijhy/5660680","DOIUrl":"10.1155/ijhy/5660680","url":null,"abstract":"<p><p>Obesity-related renal dysfunction is largely attributed to hemodynamic alterations and insulin resistance. Among individuals with overweight or obesity, albuminuria has been shown to be independently and inversely associated with circulating adiponectin levels in the absence of diabetes. Accordingly, this study aimed to evaluate and quantify the independent association between obesity and the risk of kidney disease, as assessed by the presence of albuminuria in the Asian Population. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive and systematic search strategy was applied across multiple electronic databases, including PubMed, ProQuest, Taylor & Francis, and Wiley, to identify relevant studies meeting the eligibility criteria. Data synthesis and statistical analyses were carried out using Review Manager (RevMan) software Version 5.4, and the methodological rigor of the included studies was independently assessed using the Newcastle-Ottawa Scale (NOS). The pooled analysis demonstrated that obesity was significantly associated with albuminuria in the general population as well as in sex-specific subgroups. Specifically, the odds of albuminuria were higher among individuals with obesity in the overall population (OR = 1.76; 95% CI: 1.09-2.83; <i>p</i> = 0.02, <i>I</i> ² = 78%), in men (OR = 1.34; 95% CI: 1.05-1.71; <i>p</i> = 0.02, <i>I</i> ² = 63%), and in women (OR = 1.16; 95% CI: 1.05-1.28; <i>p</i> = 0.004, <i>I</i> ² = 19%). Obesity was associated with albuminuria in Asian Populations.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"5660680"},"PeriodicalIF":3.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Weekend Catch-Up Sleep and Hypertension: Insights From the National Health and Nutrition Examination Survey, 2017-2023.","authors":"Han Chen, Qiang Tong, Lu Chai, Yongqi Shan","doi":"10.1155/ijhy/1755790","DOIUrl":"10.1155/ijhy/1755790","url":null,"abstract":"<p><strong>Objective: </strong>Sleep deprivation is associated with an increased risk of hypertension (HTN), and many individuals practice weekend catch-up sleep (WCS). However, evidence of an association between WCS and HTN in adults in the United States remains limited. This study examines this relationship using a nationally representative sample.</p><p><strong>Methods: </strong>Data from NHANES 2017-2023 (16,268 adults aged ≥ 20 years) were analyzed. The WCS was defined as weekend sleep minus weekday sleep. Multivariate logistic regression was used to adjust for sociodemographic, lifestyle, and metabolic factors. WCS was examined as a binary (> 0 vs. ≤ 0 h), continuous, and categorical (≤ 0, 0-1, 1-2, 2-3, and ≥ 3 h) variable. Subgroup analyses were exploratory and not corrected for multiple testing.</p><p><strong>Results: </strong>In the fully adjusted models, neither the binary nor continuous WCS duration was significantly associated with HTN (<i>p</i> > 0.05). Among categorical analyses, only the 0-1 h WCS group showed lower odds of HTN compared with the ≤ 0 h group (OR = 0.814, 95% CI: 0.666-0.995, <i>p</i> = 0.033); all other WCS categories (1-2 h, 2-3 h, and ≥ 3 h) were nonsignificant. No dose-response relationship was observed. Subgroup analyses suggested potential effect modification by sex and education, but these results are hypothesis-generating given the lack of correction for multiple comparisons.</p><p><strong>Conclusion: </strong>In this large cross-sectional study, the WCS was not robustly associated with HTN. The isolated finding of 0-1 h of WCS requires confirmation in prospective studies and should not be interpreted as evidence for a preventive or therapeutic strategy.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"1755790"},"PeriodicalIF":3.1,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chicken Protein Hydrolysate Supplementation Alone or Combined With Concurrent Training on Arterial Stiffness in Adults With Hypertension: A Randomized Controlled Trial.","authors":"Piyaporn Tumnark, Sarunrat Hirunrattanathum, Pakaporn Sathalalai, Tantawan Pirak, Jatuporn Phoemsapthawee","doi":"10.1155/ijhy/8962082","DOIUrl":"10.1155/ijhy/8962082","url":null,"abstract":"<p><p>Hypertension (HT) is associated with vascular dysfunction, chronic low-grade inflammation, and increased arterial stiffness, all of which contribute to elevated cardiovascular risk. Lifestyle-based interventions incorporating nutritional and exercise strategies may provide complementary vascular benefits. This study investigated the effects of chicken protein hydrolysate supplementation, administered alone or combined with concurrent training (CT), on arterial stiffness, blood pressure (BP), inflammatory markers, and physical fitness in adults with HT. In this randomized controlled trial, adults with HT who completed the study were included in the analysis: control (CON, n = 12), chicken protein hydrolysate supplementation alone (PRO, n = 10; 28 g/day), and supplementation combined with CT (PRO + CT, n = 12) following the 8-week intervention. BP, brachial-ankle pulse wave velocity (baPWV), high-sensitivity C-reactive protein (hs-CRP), and physical fitness outcomes-including peak oxygen consumption (V̇O₂peak) and upper- and lower-body muscular endurance-were assessed at baseline and postintervention. Significant group × time interactions were observed for baPWV (<i>p</i> < 0.01), hs-CRP (<i>p</i> < 0.01), V̇O₂peak (<i>p</i> < 0.01), and upper- and lower-body muscular endurance (<i>p</i> < 0.01). Both PRO and PRO + CT demonstrated greater reductions in baPWV compared with CON (<i>p</i> < 0.05). Significant reductions in hs-CRP were observed in both PRO and PRO + CT groups (<i>p</i> < 0.01); however, only PRO + CT demonstrated a significantly greater reduction compared with CON (<i>p</i> < 0.05). Improvements in V̇O₂peak and muscular endurance occurred exclusively in the PRO + CT group (<i>p</i> < 0.01), whereas changes in BP were modest across intervention groups. Chicken protein hydrolysate supplementation, particularly when combined with CT, was associated with improvements in arterial stiffness, while the combined intervention further improved inflammatory status and physical fitness outcomes. These findings suggest a potential role for combined nutritional and exercise-based lifestyle interventions in improving vascular function in adults with HT. <b>Trial Registration:</b> Thai Clinical Trials Registry: TCTR20251210008.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"8962082"},"PeriodicalIF":3.1,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Hypertension in Pediatric Patients With Systemic Lupus Erythematosus: A Historical Study.","authors":"Mohamed Husein Aldokhi, Noosha Samieefar, Fatemeh Tahghighi, Behnaz Bazargani, Arash Abbasi, Daryoush Fahimi, Fahimeh Askarian, Mastaneh Moghtaderi","doi":"10.1155/ijhy/1352079","DOIUrl":"10.1155/ijhy/1352079","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood-onset systemic lupus erythematosus (cSLE) primarily affects children and adolescents and is a potentially life-threatening condition. In contrast to adult-onset SLE, children with cSLE tend to have a more severe and aggressive course of disease. One of the most prevalent and concerning comorbidities in SLE patients is hypertension (HTN). This study evaluates diverse aspects of HTN in pediatric patients afflicted with cSLE at a tertiary hospital.</p><p><strong>Method: </strong>This historical study includes medical records of all patients with cSLE referred to Children's Medical Hospital for two years (2020-2022). Data were collected on various clinical features and laboratory findings and were analyzed by SPSS software.</p><p><strong>Results: </strong>A total of 76 patients with cSLE were included, of whom 59.2% had lupus nephritis at diagnosis. Forty-one patients (53.9%) had normal blood pressure, while 35 patients (46.1%) were diagnosed with HTN. Although the mean age of the HTN group was higher than that of the non-HTN group, the difference, however, was not statistically significant (<i>p</i> value = 0.548). Similarly, the gender distribution between the HTN and non-HTN groups was not significantly different (<i>p</i> value = 0.350), suggesting that neither age nor sex is a major determinant of HTN in this population. Significant differences were observed between the HTN and non-HTN groups in hemoglobin, hematocrit, polymorphonuclear cell count, complement Component 3, creatinine, blood urea nitrogen, sodium, and calcium levels.</p><p><strong>Conclusion: </strong>Laboratory changes associated with increased disease activity, including lower C3 levels, lower hemoglobin, and higher BUN and Cr were reported in cSLE patients with HTN. Given the high prevalence of HTN among cSLE patients, early diagnosis and treatment of HTN and renal involvement are crucial in the long-term outcomes of these patients.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"1352079"},"PeriodicalIF":3.1,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Prediction of Incident Hypertension in Australian Men: Integrating Survey, Pharmaceutical and Healthcare Utilisation Data From the Ten to Men Cohort.","authors":"Ebenezer Afrifa-Yamoah, Emmanuel Peprah-Yamoah, Victor Opoku-Yamoah, Eric Adua","doi":"10.1155/ijhy/3041345","DOIUrl":"10.1155/ijhy/3041345","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a leading modifiable contributor to cardiovascular disease. We developed and evaluated machine learning models to predict incident hypertension in Australian men using baseline survey data linked to pharmaceutical (PBS) and healthcare utilisation (MBS) administrative records from the Ten to Men cohort.</p><p><strong>Methods: </strong>Among 13,519 men free of hypertension at baseline (2014), incident hypertension over 10 years was ascertained from PBS antihypertensive dispensing. Twenty-five baseline features spanning sociodemographic, anthropometric, lifestyle, clinical and administrative domains were used to train logistic regression, random forest, gradient boosting and XGBoost models, evaluated by five-fold cross-validation with out-of-fold prediction. Discrimination, calibration and threshold-based operating characteristics were reported with 95% confidence intervals.</p><p><strong>Results: </strong>Incident hypertension occurred in 1310 men (9.7%). All algorithms achieved comparable discrimination (AUROC ≈ 0.77; XGBoost 0.771, 95% CI: 0.756-0.784), with no material advantage for flexible tree-based methods over regularised logistic regression. Age, administrative markers of healthcare engagement and BMI were the leading predictors, and a parsimonious six-variable model recovered almost all the discrimination of the full model. The model showed high negative predictive and low positive predictive values across decision thresholds, consistent with the 9.7% event rate. Incorporating measured blood pressure history from intervening waves increased apparent discrimination, but this gain was attributable to information contemporaneous with the outcome and is reported only as a concurrent surveillance benchmark.</p><p><strong>Conclusions: </strong>Routinely collected survey and administrative data can identify Australian men at low risk of incident hypertension with high negative predictive value, supporting population-level risk stratification rather than individual diagnosis. Predictive performance was driven by feature availability and quality rather than algorithm choice.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2026 ","pages":"3041345"},"PeriodicalIF":3.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148827959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}