脂质地平线:用于口服降压药的 LBDDS 的最新进展和未来展望

IF 1.9 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
undefined Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani
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引用次数: 0

摘要

脂质给药系统(LBDDS)是一种成熟的技术,预计将给制药领域带来全面变革,影响药物的管理和给药,以及治疗和诊断。经证实可作为高血压监测系统有效机制的各种枸橼酸给药系统包括 SEDDS(自纳米乳化给药)、纳米乳液、微乳液、囊泡系统(转运体和脂质体)以及固体脂质纳米颗粒。LBDDS 克服了降压药的缺点,因为约有 50% 的降压药存在一些缺点,包括肝脏首过代谢导致的半衰期短、水溶性差、渗透率低以及不良副作用。本综述强调的是将降压药封装到脂质载体中,以改善其口服生物利用度差的问题。脂质载体结合了纳米技术和靶向给药等尖端技术,有望解决高血压的多因素问题。通过微调药物释放曲线和提高药物在特定部位的吸收,LBDDS 有可能靶向肾素-血管紧张素-醛固酮系统成分、交感神经系统通路和内皮功能障碍,所有这些在高血压病理生理学中都起着至关重要的作用。使用枸橼酸脱氢表皮生长因子治疗高血压的前景十分广阔,目前正在进行的研究主要集中在精准医疗方法、改善生物相容性和降低毒性等方面。随着我们对高血压复杂机制的深入了解,LBDDS 为开发更安全、更有效、更适合患者个体需求的下一代降压疗法提供了一条途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents
The lipid-based drug delivery system (LBDDS) is a well-established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis. Various LBDDSs verified to be an efficacious mechanism for monitoring hypertension systems are SEDDS (self-nano emulsifying drug delivery), nanoemulsion, microemulsions, vesicular systems (transferosomes and liposomes), and solid lipid nanoparticles. LBDDSs overcome the shortcomings that are associated with antihypertensive agents because around fifty percent of the antihypertensive agents experience a few drawbacks including short half-life because of hepatic first-pass metabolism, poor aqueous solubility, low permeation rate, and undesirable side effects. This review emphasizes antihypertensive agents that were encapsulated into the lipid carrier to improve their poor oral bioavailability. Incorporating cutting-edge technologies such as nanotechnology and targeted drug delivery, LBDDS holds promise in addressing the multifactorial nature of hypertension. By fine-tuning drug release profiles and enhancing drug uptake at specific sites, LBDDS can potentially target renin-angiotensin-aldosterone system components, sympathetic nervous system pathways, and endothelial dysfunction, all of which play crucial roles in hypertension pathophysiology. The future of hypertension management using LBDDS is promising, with ongoing reviews focusing on precision medicine approaches, improved biocompatibility, and reduced toxicity. As we delve deeper into understanding the intricate mechanisms underlying hypertension, LBDDS offers a pathway to develop next-generation antihypertensive therapies that are safer, more effective, and tailored to individual patient needs.
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来源期刊
International Journal of Hypertension
International Journal of Hypertension Medicine-Internal Medicine
CiteScore
4.00
自引率
5.30%
发文量
45
期刊介绍: International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
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