International journal of neuropharmacology最新文献_第2页

Effect of reserpine and p-chlorophenylalanine on the electrocorticogram of unrestrained rats during short and long recording sessions 利血平和对氯苯丙氨酸对无约束大鼠短、长记录期间皮质电图的影响

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90071-9

J.H. Pirch

{"title":"Effect of reserpine and p-chlorophenylalanine on the electrocorticogram of unrestrained rats during short and long recording sessions","authors":"J.H. Pirch","doi":"10.1016/0028-3908(69)90071-9","DOIUrl":"10.1016/0028-3908(69)90071-9","url":null,"abstract":"<div><p>The effect of reserpine and <em>p</em>-chlorophenylalanine (PCPA) on the integrated voltage of the electrocorticogram (ECoG) of unrestrained rats was examined during 15 min and 2½ hr recording sessions. As previously reported, reserpine caused an increase in the ECoG voltage during 15 min sessions. This effect was slightly enhanced by PCPA pretreatment. PCPA treatment alone produced an increase in the ECoG voltage and an increase in synchronized activity similar to that induced by reserpine. Thus, it appears that the ECoG effect of reserpine during 15 min recording sessions does not depend upon increased “free” 5-HT. During 2½ hr sessions, PCPA produced a decrease in voltage with decreased slow-wave activity. A consistent increase in ECoG voltage was observed 4 hr after reserpine injection using the long recording time. By 24 hr, the voltage had returned to the control levels and was lower than the control at 48 hr and later. α-Methyltyrosine restored the decreased voltage to the control levels. PCPA pretreatment antagonized the reserpine-induced increase in ECoG voltage and instead of a return to the control at 24 hr after reserpine, a marked decrease in voltage was seen in the PCPA-pretreated animals at this time period. These results are discussed in terms of reciprocally acting “catecholaminergic” and “serotoninergic” systems.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 6","pages":"Pages 535-548"},"PeriodicalIF":0.0,"publicationDate":"1969-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90071-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16443855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Experimental alteration of tryptophan metabolism by methionine: Neuropharmacologic implications 蛋氨酸对色氨酸代谢的实验改变:神经药理学意义

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90078-1

H. Sprince, C.M. Parker, Dorothy Jameson, J.A. Josephs Jr.

{"title":"Experimental alteration of tryptophan metabolism by methionine: Neuropharmacologic implications","authors":"H. Sprince, C.M. Parker, Dorothy Jameson, J.A. Josephs Jr.","doi":"10.1016/0028-3908(69)90078-1","DOIUrl":"10.1016/0028-3908(69)90078-1","url":null,"abstract":"<div><p>The amino acids tryptophan and methionine are known to be involved in behavioral alterations and their metabolites have been implicated in mental illness. To learn more about the metabolic interrelationships of these two amino acids, rats were placed on amino acid diets deficient in nicotinic acid and nicotinamide and pair-fed with and without intestinal-antibiotics. Excess methionine (4%) added to such diets resulted in rats showing a decrease in body weight and urinary N<sup>1</sup>-methylnicotinamide (MNA) and an increase in urinary xanthurenic acid (XA) and total indoleacetic acid (TIAA) in comparison with controls. Urinary creatinine (CR) was relatively unchanged. Intestinal-antibiotics did not affect the overall methionine effect. The overall results demonstrate that excess-dietary methionine alters the tissue metabolism of tryptophan, and gives rise to urinary excretion patterns of tryptophan metabolites claimed to occur in mental illness. The observed data point to a metabolic alteration involving vitamin B<sub>6</sub>. A natural competition may exist between methionine and tryptophan for vitamin B<sub>6</sub> which is utilized in the metabolic pathways of both amino acids. Our work suggests that tolerance load tests of methionine and tryptophan in behavioral alteration studies must take into account the metabolic competition between these two amino acids for vitamin B<sub>6</sub>, as well as the formation of psychotogenic metabolites by N-methylation and O-methylation reactions.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 6","pages":"Pages 615-626"},"PeriodicalIF":0.0,"publicationDate":"1969-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90078-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15348605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hypothalamic stimulation of preganglionic autonomic activity and its modification by chlorpromazine, diazepam and pentobarbital 氯丙嗪、地西泮和戊巴比妥对下丘脑神经节前自主神经活动的刺激及其影响

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90073-2

E.B. Sigg, T.D. Sigg

引用次数: 40

Effect of haloperidol on monoamines in brain and heart 氟哌啶醇对大脑和心脏单胺的影响

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90080-X

Bengt Falck, Lars Nordgren, Evald Rosengren

引用次数: 9

Lowered thresholds to flurothyl seizures after lateral geniculate lesions in rats 降低大鼠外侧膝状病变后氟醚发作的阈值

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90055-0

M.W. Adler

引用次数: 7

The effect of sodium barbitone, alone and together with acth and amphetamine, on the behaviour of the rat in the multiple “T” maze 巴比妥钠单独及与acth和安非他明联合使用对大鼠多重“T”迷宫行为的影响

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90059-8

B.E. Leonard

引用次数: 16

Studies on the central antinociceptive action of cholinomimetic agents 胆碱类药物中枢抗感觉作用的研究

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90058-6

J. Metysˇ , N. Wagner, J. Metyˇová , A. Herz

{"title":"Studies on the central antinociceptive action of cholinomimetic agents","authors":"J. Metysˇ , N. Wagner, J. Metyˇová , A. Herz","doi":"10.1016/0028-3908(69)90058-6","DOIUrl":"10.1016/0028-3908(69)90058-6","url":null,"abstract":"<div><p>The inhibition of nociceptive reactions by cholinomimetic agents was studied in mice, rats and rabbits using systemic, intraventricular and intracerebral drug application. Tertiary amines (oxotremorine, arecoline and RS 86) as well as a quaternary ammonium compound (carbachol) were used. Various nociceptive reactions showed considerable differences in sensitivity. However, no clear-cut relation to the proposed level of integration of these reactions in the CNS could be found. Carbachol, which hardly passes the blood-brain barrier, was found after systemic administration to be ineffective against nociception but highly effective when injected intraventricularly in rats and rabbits. Oxotremorine too revealed a high antinociceptive activity when injected in this way. This points to a periventricular site of the antinociceptive action of cholinomimetics. Intracerebral microinjection of cholinomimetics into various brain structures of rats was very effective when injection was made into certain diencephalic and mesencephalic areas, but was much less effective when applied to the caudate nucleus. Similarities and differences between the antinociceptive action of cholinomimetics and morphine-like analgesics are discussed in view of the hypothesis that both groups of substances interfere with different links of periventricular nociceptive systems.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 5","pages":"Pages 413-425"},"PeriodicalIF":0.0,"publicationDate":"1969-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90058-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16429850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77

Cholinesterase in the feline red nucleus 猫红核中的胆碱酯酶

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90065-3

H. McLennan

引用次数: 8

The effect of orphenadrine hydrochloride on the acetylcholine concentration in rat brain 盐酸奥非那林对大鼠脑内乙酰胆碱浓度的影响

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90063-X

W. Hespe, M.J.E. Ernsting, W.Th. Nauta

引用次数: 3

Normal rate of3H norepinephrine uptake by isolated iris of rabbits injected with reserpine and pargyline 利血平和帕格林对家兔离体虹膜3h去甲肾上腺素正常摄取率的影响

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90062-8

B. Herr , E. Costa

引用次数: 7