International journal of neuropharmacology最新文献

Alteration of centrally mediated cardiovascular manifestations by intraventricular pronethalol and phentolamine 脑室内前乙醇和酚妥拉明对中枢介导的心血管表现的改变

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90075-6

D.J. Gagnon , K.I. Melville

引用次数: 13

Electroencephalographic analyses of amphetamine and its methoxy derivatives with reference to their sites of EEG alerting in the rabbit brain 安非他明及其甲氧基衍生物的脑电图分析及其在兔脑中的脑电图报警部位

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90077-X

M. Fujimori, H.E. Himwich

引用次数: 18

Action of intracerebroventricular epinephrine on gross behavior, locomotor activity and hexobarbital sleeping times in rats 脑室内肾上腺素对大鼠粗大行为、运动活动和六巴比妥睡眠时间的影响

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90074-4

L.R. Grunden

{"title":"Action of intracerebroventricular epinephrine on gross behavior, locomotor activity and hexobarbital sleeping times in rats","authors":"L.R. Grunden","doi":"10.1016/0028-3908(69)90074-4","DOIUrl":"10.1016/0028-3908(69)90074-4","url":null,"abstract":"<div><p><span>l</span>-Epinephrine administered via the lateral cerebral ventricle was found to decrease exploratory locomotor activity and potentiate hexobarbital sleeping time in rats. Both effects were dose-dependent and occurred with microgram quantities (3·3–125 μg) of epinephrine. Additional signs of a central depressant effect were noted in gross behavior. Although subcutaneous injections of <span>l</span>-epinephrine (0·025 and 1·0 mg/kg) also depressed locomotor activity, intraventricular injections proved much more effective. Lethality of <span>l</span>-epinephrine was enhanced by the intraventricular route, but the observed depressant effects occurred at doses well below the <span>ld</span><sub>50</sub> and were observed to be completely reversible. The importance of the catechol moiety for the central depressant effects of epinephrine was emphasized by the results obtained from studying the effect on locomotor activity of a series of sympathomimetic amines. The parent compound, phenylethylamine, which is devoid of hydroxyl groups on the benzene ring and aliphatic side chain, was found to be excitant rather than depressant. Rank order of potency studies indicated that the depressant effect of catecholamines on locomotor activity might be mediated through central adrenergic receptors of the β-type. Studies with adrenergic blocking agents did not support this idea, however, and suggested that the central receptors involved are not identical to either the classical α or β adrenergic receptor.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90074-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16443857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Nicholas Giarman 尼古拉斯Giarman

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90068-9

Daniel X. Freedman

引用次数: 0

Pentylenetetrazol and Renshaw cell activity 戊四氮和Renshaw细胞活性

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90079-3

H.K. Borys , D.W. Esplin

引用次数: 5

Modification of arterial blood pressure in rats following microinjection of drugs into the posterior hypothalamus 下丘脑后部微量注射药物对大鼠动脉血压的影响

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90076-8

H.E. Brezenoff, D.J. Jenden

引用次数: 69

Evidence for biogenic amine receptors in toad sciatic nerves 蟾蜍坐骨神经中生物胺受体存在的证据

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90069-0

H.C. Sabelli , M. Gorosito

引用次数: 10

Comparative study of the actions of nicotine and succinylcholine on the monosynaptic reflex and spindle afferent activity 尼古丁和琥珀胆碱对单突触反射和纺锤体传入活动影响的比较研究

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90070-7

K.H. Ginzel , E. Eldred , Y. Sasaki

{"title":"Comparative study of the actions of nicotine and succinylcholine on the monosynaptic reflex and spindle afferent activity","authors":"K.H. Ginzel , E. Eldred , Y. Sasaki","doi":"10.1016/0028-3908(69)90070-7","DOIUrl":"10.1016/0028-3908(69)90070-7","url":null,"abstract":"<div><p>Nicotine, in low doses of 20–40 μg/kg i.v., blocked the monosynaptic reflex without influencing spindle afferent activity. In contrast, succinylcholine depressed the monosynaptic reflex only when it enhanced spindle discharge. Abolition of the spindle excitatory effect of succinylcholine by gallamine or deafferentation eliminated the monosynaptic reflex depressant action of succinylcholine but did not affect that of nicotine. Mecamylamine, on the other hand, which blocks the nicotinic synapse at the Renshaw cell, abolished the monosynaptic reflex blocking effect of nicotine but not that of succinylcholine. These results emphasize the basically different mechanisms underlying the blockade of the monosynaptic reflex by nicotine and succinylcholine.</p><p>At intermediate doses of nicotine (40–80 μg/kg i.v.) spindle afferent activity was affected through changes in fusinotor activity consisting of a brief increase followed by prolonged depression. In still higher i.v. doses of nicotine, a direct excitatory effect on the spindle organ was observed. Depression of the monosynaptic reflex through this peripheral effect was revealed when the central action of nicotine was blocked by mecamylamine. Like the action of succinylcholine, it could be blocked by gallamine. Excitation of skin receptors and motor nerve terminals was excluded as a contributory cause of the monosynaptic reflex depression induced by nicotine in the dose range used.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90070-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16443854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The 3rd European symposium on epilepsy 第三届欧洲癫痫研讨会

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90081-1

引用次数: 0

Noradrenaline sensitive cells in cat cerebral cortex 猫大脑皮层的去甲肾上腺素敏感细胞

International journal of neuropharmacology Pub Date : 1969-12-01 DOI: 10.1016/0028-3908(69)90072-0

E.S. Johnson, M.H.T. Roberts , A. Sobieszek , D.W. Straughan

{"title":"Noradrenaline sensitive cells in cat cerebral cortex","authors":"E.S. Johnson, M.H.T. Roberts , A. Sobieszek , D.W. Straughan","doi":"10.1016/0028-3908(69)90072-0","DOIUrl":"10.1016/0028-3908(69)90072-0","url":null,"abstract":"<div><p>Noradrenaline, isoprenaline, 5-hydroxytryptamine, acetylcholine, glutamate and gaba have been applied iontophoretically onto spontaneously active cortical neurones in cats under different anaesthetic conditions. Neurones were predominantly excited by monoamines in halothane anaesthetised cats and <em>encéphale isolé</em> preparations, and excitation was still seen when careful controls for current, pH and anion effects were made.</p><p>Noradrenaline excitations were blocked selectively by α-adrenergic antagonists (dibenamine, thymoxamine and phentolamine) and β-adrenergic antagonists (propranolol, <span>d</span>-INPEA and sotalol) when responses to acetylcholine, 5-hydroxytryptamine and glutamate were unaffected. However, noradrenaline depressions were relatively resistant to these antagonists. Cells tested with both noradrenaline and isoprenaline invariably responded in the same direction, in contrast to cells tested with either noradrenaline and 5-hydroxytryptamine, or noradrenaline and acetylcholine.</p><p>The time-course of noradrenaline, isoprenaline and 5-hydroxytryptamine excitation was similar, though slower than that seen with acetylcholine. The time-course of depression was identical for all four substances. The latency of onset of noradrenaline and 5-hydroxytryptamine excitation, but not depression, was inversely related to the spontaneous neuronal discharge rate. Since most neurones discharged at a low rate, there was usually a long latency for monoamine excitation.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90072-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15496703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 92