International journal of neuropharmacology最新文献_第3页

Eeg patterns during the behavioural desensitization to scopolamine in rats 大鼠东莨菪碱行为脱敏过程中的脑电图模式

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90057-4

V. Florio, G. Bignami, V.G. Longo

引用次数: 9

Effects of 5-hydroxytryptamine, LSD and related compounds on electrical activities evokedin vitro in thin sections from the superior colliculus 5-羟色胺、LSD及相关化合物对上丘离体薄切片电活性的影响

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90060-4

N. Kawai, C. Yamamoto

{"title":"Effects of 5-hydroxytryptamine, LSD and related compounds on electrical activities evokedin vitro in thin sections from the superior colliculus","authors":"N. Kawai, C. Yamamoto","doi":"10.1016/0028-3908(69)90060-4","DOIUrl":"10.1016/0028-3908(69)90060-4","url":null,"abstract":"<div><p>Effects of 5-hydroxytryptamine (5-HT), lysergic acid diethylamide (LSD) and other psychotomimetics upon the potentials induced in thin sections from the superior colliculus of the guinea pig were studied<em>in vitro</em>. The postsynaptic field potential (PSR) evoked by optic tract stimulation was suppressed by 5-HT in concentrations of 10<sup>−7</sup>–10<sup>−6</sup><em>M</em>. Single neuron discharges induced by optic tract stimulation were also suppressed by 5-HT but spontaneous cell firings were not affected. By higher concentrations of 5-HT (more than 10<sup>−4</sup><em>M</em>) PSR was once suppressed but gradually recovered. LSD, lysergic acid ethylamide (LAE) and other related compounds potentiated the 5-HT suppressing action in relatively low concentrations but blocked it in higher ones. Morphine and 2-bromolysergic acid ethylamide (BOL) did not antagonize the 5-HT action. When two shocks were delivered to the optic tract at short intervals and the time course of suppression of the second PSR was studied, it was found that LSD and related compounds accelerated the recovery of the test PSR. Physiological roles of 5-HT in the superior colliculus are discussed.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90060-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16429851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Cardiovascular effects of sympathomimetic amines injected into the cerebral ventricles of rabbits 兔脑室注射拟交感神经胺对心血管的影响

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90061-6

N. Toda, Y. Matsuda, K. Shimamoto

{"title":"Cardiovascular effects of sympathomimetic amines injected into the cerebral ventricles of rabbits","authors":"N. Toda, Y. Matsuda, K. Shimamoto","doi":"10.1016/0028-3908(69)90061-6","DOIUrl":"10.1016/0028-3908(69)90061-6","url":null,"abstract":"<div><p>Adrenaline (10–200 μg) and noradrenaline (50 μg) when injected into the lateral cerebral ventricle of pentobarbital-anesthetized rabbits produced a fall in systemic blood pressure, a decrease in spontaneous heart rate and a stimulation of spontaneous respiration. Isoproterenol (50–200 μg) caused a fall in blood pressure and an acceleration of heart rate, whereas phenylephrine (200 μg) caused a slight rise in blood pressure in association with a decrease in heart rate. The hypotension and bradycardia induced by adrenaline were not significantly affected by bilateral vagotomy. Pretreatment of rabbits with intravenous reserpine reversed the adrenaline-induced hypotension to a hypertension and abolished the bradycardia induced, but did not affect the respiratory stimulation. The cardiovascular responses to intraventricular adrenaline were abolished by transection of the spinal cord. In unanesthetized rabbits adrenaline produced presser and cardio-stimulatory effects followed by depressor and cardio-inhibitory effects. These findings would suggest a centrally mediated hypotensive action of adrenaline in anesthetized rabbits but a hypertensive action in unanesthetized rabbits. Furthermore, changes in the cardiac function might be associated with changes in local blood flow, as postulated by<span>Kaneko</span><em>et al</em>. (1960).</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90061-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16346861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Pharmacological properties of feline red nucleus 猫红核的药理性质

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90064-1

R. Davis , P.C. Vaughan

{"title":"Pharmacological properties of feline red nucleus","authors":"R. Davis , P.C. Vaughan","doi":"10.1016/0028-3908(69)90064-1","DOIUrl":"10.1016/0028-3908(69)90064-1","url":null,"abstract":"<div><p>Biogenic amines and related compounds, and certain amino acids were applied by microelectrophoresis onto single red nucleus neurons. The cats were either lightly anesthetized or specially prepared in the unanesthetized state.<span>l</span>-Glutamic and<span>dl</span>-homoeysteic acids were potent excitants while gamma-aminobutyric acid was a strong depressant of neuronal activity. Acetylcholine and carbamylcholine, 5-hydroxytryptamine and lysergic acid diethylamide, noradrenaline and dopamine and other phenylethylamines stopped brachio-rubral synaptic transmission, reduced “spontaneous” firing and amino-acid evoked firing of RN neurons. Parenterally administered drugs which disturb motor coordination, such as lysergic acid diethylamide, bufotenine and mephenesin depress directly or indirectly rubral neuronal activity. 4-Methoxyphenylethylamine when applied locally did depress rubral neurons. However, when applied intravenously 4-methoxyphenylethylamine caused a hypokinetic rigid syndrome to develop; parallel to the increases in muscle tension and electromyogram activity were increases in rubral neuronal firing. The evidence presented and from a Preliminary Note (<span>H. McLennan</span>) indicates that the transmitter released from the brachium fibers to excite rubral neurons is not acetylcholine. The rubro-cerebellar fibers may be cholinergic.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90064-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15414318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90066-5

Israel Hanin

引用次数: 0

Study of the nerve endings in the vas deferens and seminal vesicle of the guinea pig 豚鼠输精管和精囊神经末梢的研究

International journal of neuropharmacology Pub Date : 1969-09-01 DOI: 10.1016/0028-3908(69)90056-2

F. Clementi, Kabir M. Naimzada , P. Mantegazza

引用次数: 15

Mechanism of action of antihistamines in laboratory antidepressant tests 抗组胺药在实验室抗抑郁试验中的作用机制

International journal of neuropharmacology Pub Date : 1969-07-01 DOI: 10.1016/0028-3908(69)90021-5

A. Barnett , R.I. Taber , D.D. Greenhouse

{"title":"Mechanism of action of antihistamines in laboratory antidepressant tests","authors":"A. Barnett , R.I. Taber , D.D. Greenhouse","doi":"10.1016/0028-3908(69)90021-5","DOIUrl":"10.1016/0028-3908(69)90021-5","url":null,"abstract":"<div><p>Dose-response curves for the prevention of tetrabenazine-induced ptosis in mice by antihistamines such as dexchlorpheniramine, are shifted to the right in parallel fashion by raising the dose of tetrabenazine, whereas the dose-response curves for imipramine-like antidepressants are relatively unaffected. Another difference between dexchlorpheniramine and imipramine is that the antihistamine reverses α-methyl-tyrosine-induced ptosis whereas imipramine is ineffective. In both procedures, methamphetamine produces effects similar to dexchlorpheniramine, suggesting that dexchlorpheniramine has a central sympathomimetic effect. Additional evidence for this hypothesis is that dexchlorpheniramine-indueed lethality is enhanced by aggregation (ten mice per cage vs. five mice per cage) and that this aggregate lethality can be prevented by phenoxybenzamine but not by α-methyl-tyrosine. The central sympathomimetic effect of dexchlorpheniramine may be similar to the direct effect of methamphetamine, which has been demonstrated in the present studies by reversal of both tetrabenazine- and α-methyl-tyrosine-induced ptosis. The present studies have not ruled out the possibility that antihistamines such as dexchlorpheniramine can antagonize ptosis in part by inhibition of norepinephrine uptake.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90021-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15492772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Acetylcholine depolarization of the dorsal root nerve terminals in the amphibian spinal cord 两栖动物脊髓背根神经末梢的乙酰胆碱去极化

International journal of neuropharmacology Pub Date : 1969-07-01 DOI: 10.1016/0028-3908(69)90018-5

K. Koketsu , A.G. Karczmar , R. Kitamura

引用次数: 33

Effects of cardiac glycosides on spontaneous efferent activity in vagus and sympathetic nerves of cats 心脏糖苷对猫迷走神经和交感神经自发传出活动的影响

International journal of neuropharmacology Pub Date : 1969-07-01 DOI: 10.1016/0028-3908(69)90025-2

P.L. McIain

引用次数: 40

Evidence for peripheral cholinergic components in thirst-induced water consumption 外周胆碱能成分在口渴引起的饮水中的证据

International journal of neuropharmacology Pub Date : 1969-07-01 DOI: 10.1016/0028-3908(69)90019-7

M.C. Gerald , R.P. Maickel

引用次数: 26