{"title":"盐酸奥非那林对大鼠脑内乙酰胆碱浓度的影响","authors":"W. Hespe, M.J.E. Ernsting, W.Th. Nauta","doi":"10.1016/0028-3908(69)90063-X","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of orphenadrine hydrochloride on the concentration of acetylcholine in the rat brain was investigated. An i.p. dose of 50<em>mgkg</em> caused a significant reduction of the acetylcholine concentration, as shown by determinations at 15 min—where the effect was maximal—and at 30 and 60 min after administration. These findings are discussed in relation to the orphenadrine concentration in the rat brain as a function of time and to other effects of the compound on brain biochemistry as previously established.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 5","pages":"Pages 471-474"},"PeriodicalIF":0.0000,"publicationDate":"1969-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90063-X","citationCount":"3","resultStr":"{\"title\":\"The effect of orphenadrine hydrochloride on the acetylcholine concentration in rat brain\",\"authors\":\"W. Hespe, M.J.E. Ernsting, W.Th. Nauta\",\"doi\":\"10.1016/0028-3908(69)90063-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of orphenadrine hydrochloride on the concentration of acetylcholine in the rat brain was investigated. An i.p. dose of 50<em>mgkg</em> caused a significant reduction of the acetylcholine concentration, as shown by determinations at 15 min—where the effect was maximal—and at 30 and 60 min after administration. These findings are discussed in relation to the orphenadrine concentration in the rat brain as a function of time and to other effects of the compound on brain biochemistry as previously established.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":\"8 5\",\"pages\":\"Pages 471-474\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90063-X\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/002839086990063X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/002839086990063X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of orphenadrine hydrochloride on the acetylcholine concentration in rat brain
The effect of orphenadrine hydrochloride on the concentration of acetylcholine in the rat brain was investigated. An i.p. dose of 50mgkg caused a significant reduction of the acetylcholine concentration, as shown by determinations at 15 min—where the effect was maximal—and at 30 and 60 min after administration. These findings are discussed in relation to the orphenadrine concentration in the rat brain as a function of time and to other effects of the compound on brain biochemistry as previously established.
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