The effect of orphenadrine hydrochloride on the acetylcholine concentration in rat brain

Abstract

The effect of orphenadrine hydrochloride on the concentration of acetylcholine in the rat brain was investigated. An i.p. dose of 50mgkg caused a significant reduction of the acetylcholine concentration, as shown by determinations at 15 min—where the effect was maximal—and at 30 and 60 min after administration. These findings are discussed in relation to the orphenadrine concentration in the rat brain as a function of time and to other effects of the compound on brain biochemistry as previously established.