Normal rate of3H norepinephrine uptake by isolated iris of rabbits injected with reserpine and pargyline

Abstract

The rapid uptake of³HNE exhibitedin vitro by rabbit irises depends on the presence of sympathetic nerves and the NE concentration in the incubation medium. Pretreatment of the animals with reserpine and pargyline fails to inhibit the efficiency of this neuronal uptake process, thus confirming previous reports in the literature that the depletion of neuronal NE elicited by reserpine is not the result of the blockade of the uptake of NE by sympathetic neurons.