International journal of hygiene and environmental health最新文献

{"title":"Occupational electromagnetic field exposure and sleep disturbances: The predominant role of high-frequency electric fields","authors":"Matej Soumillion,&nbsp;Viviane Fiona Mathilde Remy,&nbsp;Dusan Petrovic,&nbsp;J. Hugo Dil,&nbsp;Irina Guseva Canu","doi":"10.1016/j.ijheh.2026.114886","DOIUrl":"10.1016/j.ijheh.2026.114886","url":null,"abstract":"<div><div>Electromagnetic fields (EMFs) are ubiquitous and include low-frequency magnetic fields (LF-MF) from alternating currents, low-frequency electric fields (LF-EF) from wiring and equipment, and high-frequency electric fields (HF-EF) from wireless technologies and broadcast antennas. Bus drivers are exposed to an EMF mixture and report higher rates of sleep disorders than the general population. This study aimed to examine associations between sleep disturbances and cumulative occupational EMF exposure over 12 months, considering individual components and the mixture.</div><div>EMF exposure estimates from the Swiss bus-exposure matrix were matched to the occupational history of 351 TRAPHEAC study bus drivers. Sleep quality, insomnia, and excessive daytime sleepiness (EDS) were assessed using the Global Sleep Assessment Questionnaire. Associations with cumulative EMF exposure were evaluated using multivariable linear regression controlled for age, sex, occupational noise, and nightshift work, and heat exposure. Mixture effects were analyzed with Bayesian Kernel Machine Regression (BKMR), and the influence of non-occupational EMF exposure was examined via stratification.</div><div>Multivariable linear regression showed positive associations of HF-EF, but not LF-EF or LF-MF, with insomnia and EDS, although models explained little variance. BKMR confirmed the predominance of HF-EF in the mixture effect, with a positive but statistically non-significant dose-response for the EMF mixture. Stratified analyses suggested stronger associations among drivers with low non-occupational EMF exposure.</div><div>These findings suggest a dose-response relationship between occupational EMF mixture exposure and sleep disturbances, primarily driven by HF-EF. However, the overall variance explained by EMF exposure is small, highlighting the role of other risk factors in sleep disturbances among bus drivers<strong>.</strong></div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114886"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy lifestyle modifies the association between per- and polyfluoroalkyl substances and hyperlipidemia: A propensity score-matched case-control study","authors":"Peiwen Li,&nbsp;Lianlong Yu,&nbsp;Xiao Zhang,&nbsp;Yinglin Du,&nbsp;Yuanyuan Jiang,&nbsp;Yanxin Gao,&nbsp;Yan Wang","doi":"10.1016/j.ijheh.2026.114880","DOIUrl":"10.1016/j.ijheh.2026.114880","url":null,"abstract":"<div><div>The impact of per- and polyfluoroalkyl substances (PFAS) on hyperlipidemia and the potential modifying role of overall lifestyle remain underexplored. We examined six serum PFAS and a composite lifestyle score among 192 propensity score-matched case-control pairs. Individual and joint associations were evaluated using conditional logistic regression, quantile g-computation, and Bayesian kernel machine regression. A composite healthy lifestyle score was constructed based on smoking, alcohol drinking, physical activity, body shape, and diet. Per interquartile range (IQR) increase in ln-transformed concentrations, perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), and perfluoroundecanoic acid (PFUnDA) were associated with 89%, 110%, 67%, 49%, and 42% higher odds of hyperlipidemia, respectively. Mixture analyses revealed a joint positive association (OR = 1.57; 95% CI: 1.22, 2.02), driven predominantly by PFNA, the emerging alternative 6:2 Cl-PFESA, and PFHxS. Among participants with an unhealthy lifestyle (defined as a composite score ≤2 based on the population median), higher levels of PFOA, PFHxS, and PFNA were associated with significantly elevated odds of hyperlipidemia. However, for 6:2 Cl-PFESA, perfluorodecanoic acid (PFDA), and PFUnDA, these associations were generally weaker in participants adhering to a relatively healthy lifestyle, as supported by significant multiplicative interactions. Negative additive interactions were also observed for 6:2 Cl-PFESA and PFNA. Our findings demonstrate that adherence to a healthy lifestyle was associated with substantially weaker associations between 6:2 Cl-PFESA and PFDA exposures and hyperlipidemia, highlighting lifestyle modification may serve as a potential public health strategy to reduce environmental metabolic hazards.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114880"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual expectation reaction time and attentional control associated with prenatal maternal biomarkers of organophosphate and pyrethroid exposures in a Thai birth cohort","authors":"Pimjuta Nimmapirat,&nbsp;Zimeng Ren,&nbsp;Margaret Wolan Sullivan,&nbsp;Wathoosiri Promduang,&nbsp;Nattapon Chaikittipornlert,&nbsp;Tippawan Prapamontol,&nbsp;Warangkana Naksen,&nbsp;Parinya Panuwet,&nbsp;Dana Boyd Barr,&nbsp;Brittney O. Baumert,&nbsp;Pamela Ohman-Strickland,&nbsp;Panrapee Suttiwan,&nbsp;Nancy Fiedler","doi":"10.1016/j.ijheh.2026.114884","DOIUrl":"10.1016/j.ijheh.2026.114884","url":null,"abstract":"<div><h3>Background</h3><div>Maternal biomarkers of organophosphates (OPs) and pyrethroids (PYR) have been associated with compromised child cognitive development. Visual expectation (VExP) evaluates infant processing speed as a foundation for subsequent cognition. Prenatal exposures to pesticides among children of Thai farmworkers are significantly higher than those in the US.</div></div><div><h3>Objective</h3><div>We evaluated the association of prenatal urinary OP and PYR metabolites with VExP reaction time (RT), intraindividual variability in reaction time (SDRT), and percent off task and anticipatory responses.</div></div><div><h3>Methods</h3><div>We analyzed urinary metabolites of OPs and PYR in composited urine samples representing each trimester of pregnancy in 306 Thai farmworkers. Offspring completed VExP at 7, 12, and 18 months. In adjusted regression models, we tested the associations of OP and PYR metabolites with VExP outcomes.</div></div><div><h3>Results</h3><div>Prenatal OP metabolites were not associated with RT at 7 or 18 months. Females aged 12 months had significantly slower RT associated with first and third trimester OP metabolites and significantly higher SDRT at 12 and 18 months associated with first trimester OPs. Significantly faster RT and lower percent off task were associated with the PYR metabolite concentration in 18-month old females. Significantly higher anticipatory and lower off task rates were associated with concentrations of OP metabolites among 12 and 18 month old males.</div></div><div><h3>Discussion</h3><div>Increased intraindividual variability among females is consistent with previous parental reports of attention symptoms associated with prenatal OP metabolites. No consistent adverse associations with PYR were observed. Faster processing and learning were also associated with higher OPs and PYR metabolites at different ages.PP</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114884"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148740737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial species contributions to the inflammatory potential of occupational bioaerosol exposures from biomass-based energy production","authors":"Victor Carp Kofoed,&nbsp;Akila Muthalagu,&nbsp;Jeppe Lund Nielsen,&nbsp;Anne Mette Madsen","doi":"10.1016/j.ijheh.2026.114889","DOIUrl":"10.1016/j.ijheh.2026.114889","url":null,"abstract":"<div><div>The production of reactive oxygen species (ROS) by neutrophils and other immune cells is essential for host defense and contributes to inflammatory responses to inhaled microorganisms. Elevated occupational exposure to bioaerosols and particles, has been shown to induce ROS production in cell-based assays. This study aimed to investigate how individual fungal and bacterial species and overall species composition contribute to ROS production induced by complex mixed bioaerosol exposures. Using a cell assay with neutrophil-like differentiated HL-60 cells, ROS production was measured after challenge with personal exposure samples from workers (n = 129) at 22 Danish biomass plants combusting straw, wood chips, wood pellets, or a combination thereof. The measured ROS production is here referred to as the total inflammatory potential (TIP) of the complex exposure samples. Associations between TIP and levels of exposures and the species of microorganisms, as identified with MALDI-TOF MS, were assessed. A mixed model including all measured exposure levels showed that TIP was associated with exposure to endotoxin, inhalable dust, and bacteria cultured aerobically at 25 °C. Analysis using constrained ordination showed that TIP was associated with the composition of bacteria cultured anaerobically at 37 °C. Finally, the species <em>Paenibacillus barengoltzii</em>, <em>Pantoea agglomerans</em>, and <em>Aspergillus montevidensis</em> showed positive associations with TIP, while <em>Staphylococcus capitis</em> was negatively associated with TIP. The results indicate that in addition to concentrations of microorganisms, microbial species may influence the capacity of mixed exposures to induce ROS production in a human cell line, and thus potentially affect the inflammatory potential of exposures.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114889"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148777922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing additive interactions of heat wave, fine particulate matter, and ozone on cardiovascular mortality in a typical cold region of China: A time-stratified case-crossover study","authors":"Jinghao Wan,&nbsp;Mingzhao She,&nbsp;Hanhan Wang,&nbsp;Lixin Zheng,&nbsp;Xinyue Yu,&nbsp;Yuqian Song,&nbsp;Zhongran Wang,&nbsp;Min Li,&nbsp;Xu Han,&nbsp;Haibo Zhou,&nbsp;Zhifeng Xing,&nbsp;Xiao Bai,&nbsp;Shichun Yan,&nbsp;Wenjing Tian","doi":"10.1016/j.ijheh.2026.114887","DOIUrl":"10.1016/j.ijheh.2026.114887","url":null,"abstract":"<div><div>Under the background of climate change, concurrent exposure to fine particulate matter (PM_2.5), ozone (O₃), and heat wave is becoming increasingly prevalent; however, their combined cardiovascular associations remain insufficiently characterized. We conducted a time-stratified case-crossover study including 499,996 cardiovascular disease (CVD) deaths during the warm season (May to September) in Heilongjiang Province, China, from 2013 to 2022. Conditional logistic regression models were applied to estimate short-term associations. Meteorological data and air pollutant concentrations were obtained from validated gridded datasets based on residential addresses. Under the P95_3d heat wave definition, the odds ratio (OR) of CVD mortality associated with heat wave-only exposure was 1.119 (95%CI: 1.103, 1.136). For heat wave-PM_2.5 co-exposure, the relative excess odds due to interaction (REOI) was 0.048 (95%CI: 0.015, 0.080). For heat wave-O₃ co-exposure, the REOI was 0.110 (95%CI: 0.078, 0.142). For heat wave-O₃-PM_2.5 triple co-exposure, the REOI was −0.023 (95%CI: −0.090, 0.044). Stratified analyses suggested higher co-exposure ORs among adults aged 65 years and older and females, although sex differences in additive interaction were not statistically significant. These findings suggest that compound exposure to heat wave and air pollution may be associated with an increased short-term CVD mortality burden in cold-region populations.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114887"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Per- and polyfluoroalkyl substances and type 2 diabetes risk: Evidence from metabolomics and triglyceride-glucose index-related pathways","authors":"Jun Zhu,&nbsp;Yu Xia,&nbsp;Ningbin Dai,&nbsp;Wanying Wang,&nbsp;Zeyuan Chen,&nbsp;Weiyi Cao,&nbsp;Haibing Yang,&nbsp;Jing Shi,&nbsp;Fang Zhou,&nbsp;Liuqing Zhao,&nbsp;Lei Li,&nbsp;Zhan Zhang","doi":"10.1016/j.ijheh.2026.114881","DOIUrl":"10.1016/j.ijheh.2026.114881","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS), including emerging alternatives, have been implicated in type 2 diabetes (T2D), but epidemiological evidence remains inconsistent and the underlying mechanisms are unclear. We aimed to investigate the associations of individual and mixed PFAS exposure with T2D risk and to explore the roles of triglyceride-glucose (TyG)-related indices and metabolomic alterations. A total of 1647 participants (749 participants with T2D and 898 controls) were included. Multivariable logistic regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single PFAS and mixed PFAS with T2D risk, respectively. Mediation analyses were conducted for TyG-related indices, and untargeted metabolomics and sequential mediation analyses were further performed in a nested case-control subset. Most individual PFAS were positively associated with T2D risk. Mixed-exposure analyses consistently showed that PFAS mixture was associated with increased T2D risk, with 6:2 FTS, PFNS, and PFPeS identified as the main contributors. Mediation analyses indicated that TyG-related indices (TyG, TyG-BMI, TyG-WC, and TyG-WHtR) were significantly associated with both PFAS mixture and T2D. Metabolomic analyses identified 35 shared metabolites associated with both PFAS mixture and T2D, mainly enriched in lipid-related pathways. Sequential mediation analyses further suggested that palmitic acid, stearic acid, and glutamine, together with TyG, might be involved in the pathways in the association between PFAS exposure and T2D risk. PFAS exposure was associated with T2D, with TyG-related indices and metabolites potentially involved in this association.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114881"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household-level indicators overestimate sanitation coverage by masking within-household differences in practices and facility quality across 14 countries","authors":"Ryan Cronk,&nbsp;Lisa Fleming,&nbsp;Wren Tracy,&nbsp;Musa Manga,&nbsp;Ben Tidwell,&nbsp;Jamie Bartram,&nbsp;Sarah Lebu","doi":"10.1016/j.ijheh.2026.114883","DOIUrl":"10.1016/j.ijheh.2026.114883","url":null,"abstract":"<div><div>Accurate measurement of sanitation access is essential for tracking progress toward universal sanitation under the Sustainable Development Goals, yet current indicators focus on household-level access and rarely capture how sanitation is used within households or facility quality. We conducted a cross-sectional survey of 36,860 rural households in 14 low- and middle-income countries, assessing differences in open defecation practices among household members and sanitation facility quality. Heads of household reported where adult men, adult women, boys, and girls usually defecated, while enumerators directly observed sanitation facilities. We then developed alternative estimates of sanitation service levels that accounted for these dimensions. Despite access to a sanitation facility, 14.1% of households reported that at least one member practiced open defecation, including 2.9% of households classified as having basic sanitation. Children (12.6%) were more likely than adults (9.2% of men and 8.9% of women) to practice open defecation. Only 2.0% of sanitation facilities met the study's hygiene criteria, largely because 80.1% lacked a nearby handwashing facility with soap and water, 45.4% had visible flies, and 79.9% lacked appropriate anal cleansing materials. Structural deficiencies included cracked or damaged pedestals (26.3%), unusable floors (11.6%), non-functional facilities (5.7%), and lack of privacy (18.8%). Accounting for these factors yielded substantially lower estimates of basic sanitation coverage (2.2%) compared to the standard Joint Monitoring Programme (JMP) classification (31.8%), highlighting a gap between reported access and effective service delivery. Routine collection of disaggregated data on sanitation use and standardized measures of facility quality could improve monitoring of effective sanitation coverage.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114883"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational and off-work recovery predictors of heat-related illness among farmworkers in California: Insights including gender-related differences","authors":"Lena van Selm,&nbsp;Haley Ciborowski,&nbsp;Rietta Wagoner,&nbsp;Brandon Toji-Ruiz,&nbsp;Michelle Solorio,&nbsp;Briana Toji,&nbsp;Ana Solorio,&nbsp;Trent Biggs,&nbsp;Penelope J.E. Quintana,&nbsp;Linda Lara-Jacobo,&nbsp;Nicolas Lopez-Galvez","doi":"10.1016/j.ijheh.2026.114885","DOIUrl":"10.1016/j.ijheh.2026.114885","url":null,"abstract":"<div><h3>Background</h3><div>Farmworkers in the United States are exposed to extreme heat and demanding physical labor, placing them at increased risk for heat-related illnesses (HRI). This study examined individual, occupational, and household factors associated with self-reported HRI among men and women farmworkers in Imperial Valley, California.</div></div><div><h3>Methods</h3><div>This cross-sectional study used a convenience and snowball sampling approach to recruit agricultural workers through a local community organization. Participants were administered an in-person interview on their experience with HRI and potential risk factors. A multivariate regression analysis was conducted to identify variables related to HRI.</div></div><div><h3>Results</h3><div>From 300 participants, 119 (39.7%) experienced HRI, defined as reporting at least three HRI symptoms. In the multivariate regression analysis, HRI odds were significantly increased in women (aOR: 2.36, 95%CI: 1.35-4.15), in those reporting heat-related sleep problems (aOR: 3.25, 95%CI: 1.50-7.02), face covering use (aOR: 1.94, 95%CI: 1.09-3.45) and those working more than 5 days per week (aOR: 2.19, 95%CI: 1.23-3.91). Older age had a modest association with lower odds of HRI (aOR: 0.98, 95%CI: 0.96-0.99) and more than one break per day (aOR: 0.59, 95%CI: 0.35-1.00, p = 0.053) was associated with marginally lower HRI odds.</div></div><div><h3>Conclusions</h3><div>As climate change continues to intensify occupational heat exposure among agricultural workers, interventions should extend beyond purely workplace-focused efforts and address cumulative exposure, non-occupational factors and structural constraints. Report of heat-related sleep problems has been associated with HRI relatively recently. Future research should establish the occupational, structural, and biological pathways contributing to the increased HRI odds for women farmworkers.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"277 ","pages":"Article 114885"},"PeriodicalIF":4.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swine waste stabilization ponds as hotspots for antimicrobial resistance gene accumulation: a longitudinal metagenomic study","authors":"Mariana Costa Torres,&nbsp;Gabriela Merker Breyer,&nbsp;Maria Eduarda Rocha Jacques da Silva,&nbsp;Louise Jank,&nbsp;Fabiano Barreto,&nbsp;Marcio Dorn,&nbsp;Marisa Ribeiro de Itapema Cardoso,&nbsp;Franciele Maboni Siqueira","doi":"10.1016/j.ijheh.2026.114857","DOIUrl":"10.1016/j.ijheh.2026.114857","url":null,"abstract":"<div><div>Using next-generation sequencing, this study provides a comprehensive longitudinal assessment of bacterial communities, antimicrobial resistance genes (ARGs), mobile genetic elements (MGEs), and metabolic pathways in a full-scale swine waste treatment system in Brazil. Samples were collected from the first (WSP1) and final (WSP4) waste stabilization ponds of a farrow-to-finish farm during four sampling events between October 2022 and January 2023. Antibiotic molecules were additionally identified and quantified using solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry. Bacterial community composition remained remarkably stable over time. Similarly, the resistome and mobilome showed pronounced temporal stability, although a consistently higher relative abundance of ARGs and MGEs was observed in the final treatment process (WSP4). Genes encoding resistance markers of human-health relevance were detected in WSP4, including <em>Paer_PhoP_CST</em>, associated with polymyxin (colistin) resistance; <em>PRC-1</em>, linked to resistance to third-generation cephalosporins; and quinolone resistance determinants such as <em>adeF</em>, <em>Paer_parE_FLO</em>, and <em>Mtub_gyrB_FLO</em>. Genes encoding efflux pump complexes associated with multidrug resistance were also identified, including <em>Paer_CpxR</em>, <em>PmpM</em>, <em>YajC</em>, <em>MuxB</em>, and <em>MexW</em>. Supporting these findings, fluoroquinolones (ciprofloxacin and norfloxacin), lincomycin, and tetracycline molecules were detected in the waste ponds, indicating sustained selective pressure within the system. The accumulation of clinically relevant resistance determinants in the final of the waste treatment process, whose effluent is reused for agricultural irrigation, highlights waste stabilization ponds as potential hotspots for the persistence and environmental dissemination of antimicrobial resistance. These findings underscore the urgent need for improved monitoring and management of livestock waste treatment systems to mitigate antimicrobial resistance dissemination across agroecosystems.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"276 ","pages":"Article 114857"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periconceptional ambient temperature and adult atherogenic lipid profile: A life-course study of acute coronary syndrome patients and matched controls","authors":"Antonio Meseguer-Hernández,&nbsp;José Manuel Andreu-Cayuelas,&nbsp;Francisco Buendía-Santiago,&nbsp;Lidia Martínez-Gascón,&nbsp;María Isabel Baños-Maturano,&nbsp;Jaime Merino-Romero,&nbsp;Irene González-Fernández,&nbsp;Claudia Alejandra Azcondo-San Segundo,&nbsp;Leticia Risco-Eres,&nbsp;María Belén Villamarín-Heredia,&nbsp;Alberto Fernández-Reina,&nbsp;Juan Antonio Castillo-Moreno","doi":"10.1016/j.ijheh.2026.114862","DOIUrl":"10.1016/j.ijheh.2026.114862","url":null,"abstract":"<div><h3>Aim</h3><div>Emerging evidence suggests that early-life environmental conditions may induce long-term metabolic programming. We evaluated the association of the season of conception and periconceptional or perinatal climatic conditions with the adult Atherogenic Index of Plasma (AIP) in patients with Acute Coronary Syndrome (ACS) and matched controls.</div></div><div><h3>Methods</h3><div>In this life-course study, we analysed 833 patients with ACS and 833 age- and sex-matched controls. Individual data were linked with historical climatological records to determine mean temperature and diurnal temperature range (DTR) during the estimated month of conception, and sunshine hours during the month of birth. Adjusted multiple linear regression models identified predictors of adult AIP.</div></div><div><h3>Results</h3><div>ACS patients presented higher AIP than controls (0.15 ± 0.28 vs. 0.06 ± 0.29; p &lt; 0.001). Summer conception predicted higher adult AIP in ACS patients (B = 0.042; 95% CI: 0.003–0.081; p = 0.035) and controls (B = 0.051; 95% CI: 0.006–0.097; p = 0.028). Higher mean temperature (B = 0.007; 95% CI: 0.001–0.014; p = 0.030) and wider DTR (B = 0.085; 95% CI: 0.002–0.169; p = 0.045) at conception also predicted higher adult AIP, with consistent findings across cohorts. No association was found with perinatal sunshine hours.</div></div><div><h3>Conclusions</h3><div>Conception in summer and with higher ambient temperatures or wider DTR is associated with a pro-atherogenic lipid phenotype decades later. These findings suggest that environmental conditions at the very beginning of life may induce long-term metabolic programming of cardiovascular risk; an association increasingly important to understand given current global warming trends.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"276 ","pages":"Article 114862"},"PeriodicalIF":4.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}