同时测量气溶胶呼吸沉积及其化学成分的新方法：消费喷雾气溶胶中金属工程纳米材料的健康风险评估

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health Pub Date : 2025-04-27 DOI:10.1016/j.ijheh.2025.114588

Jinho Lee , Wei-Chung Su

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引用次数: 0

摘要

传统的气溶胶沉积研究方法在应用于具有不规则形状和不同物理性质的气溶胶时面临局限性。目的建立移动气溶胶肺沉积仪(MALDA)-MOUDI串联系统，同时测定气溶胶的粒径沉积分数及其化学成分。使用这种创新的方法，我们研究了由选定的消费喷雾产品产生的气溶胶的呼吸沉积，并评估了这些气溶胶中工程纳米材料（enm），特别是金属的吸入风险。方法从两种常见的消费喷雾产品——触发喷雾和推进剂喷雾中产生气溶胶。测量了气溶胶中目标金属的大小分离呼吸沉积分数和质量比例。然后设计了职业暴露情景，以估计与吸入这些气溶胶中的enm（金属）相关的非癌症和癌症风险。结果MALDA-MOUDI串联系统研制成功并得到验证。结果表明，由于职业暴露于目标喷雾气溶胶而吸入金属的非癌症和癌症风险低于既定的安全阈值。MALDA-MOUDI串联系统提供了一种创新和系统的方法来评估人类主要气道区域的特定尺寸气溶胶沉积。该方法可应用于更广泛的环境和职业气溶胶暴露研究，以评估气溶胶中有毒物质的健康风险。本研究结果为环境与职业健康研究提供了有价值的见解，并提出了一种改进的健康风险评估方法。

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A new approach for simultaneous measurement of aerosol respiratory deposition and its chemical composition: Health risk assessment of metal engineered nanomaterials in consumer spray aerosols

Background

Conventional methods for studying aerosol deposition face limitations when applied to aerosols with irregular shapes and diverse physical properties.

Objective

This study aimed to develop the MALDA (Mobile Aerosol Lung Deposition Apparatus)-MOUDI tandem system to simultaneously estimate the size-specific deposition fraction of aerosols and their chemical constituents. Using this innovative approach, we investigated the respiratory deposition of aerosols generated from selected consumer spray products and evaluated the inhalation risks of engineered nanomaterials (ENMs), specifically metals, in these aerosols.

Methods

Aerosols were generated from two common types of consumer spray products—trigger and propellant sprays. The size-segregated respiratory deposition fraction and mass proportions of target metals in the aerosols were measured. Occupational exposure scenarios were then designed to estimate the non-cancer and cancer risks associated with inhalation of ENMs (metals) in these aerosols.

Results

The MALDA-MOUDI tandem system was successfully developed and validated. Results demonstrated that the non-cancer and cancer risks of inhaled metals due to occupational exposure to the target spray aerosols were below established safety thresholds.

Significance

The MALDA-MOUDI tandem system provides an innovative and systematic approach to assess size-specific aerosol deposition in major human airway regions. This method can be applied to broader environmental and occupational aerosol exposure research to evaluate health risks from toxic substances in aerosols. Findings from this study also offer valuable insights for environmental and occupational health research and propose an improved method for health risk assessment.

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来源期刊

International journal of hygiene and environmental health 医学-传染病学

CiteScore

11.50

自引率

5.00%

发文量

151

审稿时长

22 days

期刊介绍： The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.