International journal of hygiene and environmental health最新文献

{"title":"Pyrethroid exposure biomarker 3-phenoxybenzoic acid (3-PBA) binds to transthyretin and is positively associated with free T3 in pregnant women","authors":"Stine Søgaard Normann ,&nbsp;Yanying Ma ,&nbsp;Helle Raun Andersen ,&nbsp;Maria João Valente ,&nbsp;Kostja Renko ,&nbsp;Selina Arnold ,&nbsp;Richard Christian Jensen ,&nbsp;Marianne Skovsager Andersen ,&nbsp;Anne Marie Vinggaard","doi":"10.1016/j.ijheh.2024.114495","DOIUrl":"10.1016/j.ijheh.2024.114495","url":null,"abstract":"<div><div>Pyrethroids constitute a large group of insecticides widely used in agriculture, indoor environments, and in vector control. Structurally, pyrethroids resemble thyroid hormones, and have been suggested to be thyroid hormone disruptors based on experimental studies. During pregnancy, even minor disturbances in maternal levels can affect fetal brain development. Therefore, we aimed to investigate whether three commonly used pyrethroids and their common metabolite, 3-PBA, were able to trigger thyroid disrupting effects on thyroid hormone production and transport, activation or deactivation of thyroid hormones, recycling of iodine, or on iodide uptake into the thyroid. Furthermore, we investigated associations between urinary 3-PBA concentrations (as biomarker of pyrethroid exposure) and serum concentrations of thyroid hormones in early pregnancy in the large prospective Odense Child Cohort (OCC).</div><div>We found that the generic metabolite, 3-PBA, was capable of binding to transthyretin (TTR) at low concentrations, comparable to those reported in human cord blood. Among pregnant women in OCC, we found urinary 3-PBA concentrations to be positively associated with free triiodothyronine (fT3) serum levels. Displacement of thyroid hormones from TTR by pyrethroid exposure in early pregnancy may disturb the transplacental transport of thyroid hormones to the fetus during a very vulnerable window of development, including neural maturation. We did not find any evidence for thyroid disrupting effects <em>in vitro</em> for the three pyrethroids: Deltamethrin, α-cypermethrin, and etofenprox.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"264 ","pages":"Article 114495"},"PeriodicalIF":4.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human biomonitoring health-based guidance values: A case study of the HB2GV Dashboard and DEHP","authors":"Kristin Macey ,&nbsp;Rosa Lange ,&nbsp;Petra Apel ,&nbsp;Devika Poddalgoda ,&nbsp;Antonia M. Calafat ,&nbsp;Marike Kolossa-Gehring ,&nbsp;Judy S. LaKind ,&nbsp;Lisa Jo Melnyk ,&nbsp;Shoji F. Nakayama ,&nbsp;Annie St-Amand ,&nbsp;Tyler Pollock","doi":"10.1016/j.ijheh.2024.114490","DOIUrl":"10.1016/j.ijheh.2024.114490","url":null,"abstract":"<div><div>In 2022, the International Society of Exposure Science (ISES) International Human Biomonitoring (i-HBM) Working Group launched a free, online repository of biomonitoring guidance values referred to as the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard. The goal of the Dashboard is to assist global human biomonitoring data users (e.g., risk assessors, risk managers) and human biomonitoring programs with a readily available compilation of guidance values for the general population. The Dashboard contains approximately 600 HB2GVs for over 150 chemicals or their metabolites. Although there are many different types of HB2GVs, most are Biomonitoring Equivalents (BEs), Human Biomonitoring (HBM-I and HBM-II) values, or Human Biomonitoring Guidance Values (HBM-GVs). For users new to human biomonitoring, understanding how the different types of HB2GVs are derived and how to interpret those values in the context of human biomonitoring data can be difficult. Therefore, there is a need to inform users of the differences among available guidance values and to help users identify the HB2GV that could be most suitable for their purposes. Here, we summarize the derivation of HB2GVs for a case study chemical, di-(2-ethylhexyl) phthalate (DEHP). We selected DEHP as there are 36 unique HB2GVs available from three of the most common types of guidance values (i.e., BE, HBM-I value, HBM-GV). We also compare the available HB2GVs with a focus on the differences among their derivation methods, relative quality and confidence, and interpretation. This case study provides guidance on the use of existing HB2GVs for health-based interpretation of human biomonitoring data that may be applied to other chemicals. As with any other type of guidance or regulatory value (e.g., RfDs, MRLs), thoughtful selection and use are strongly encouraged. Appropriately interpreting HBM data with the aid of guidance values can result in improved decision making which, ultimately, could lead to better protection of public health.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114490"},"PeriodicalIF":4.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental exposures and fecundability: The Norwegian Mother, Father, and Child Cohort study","authors":"Thea Grindstad ,&nbsp;Siri E. Håberg ,&nbsp;Olga Basso ,&nbsp;Hans Ivar Hanevik ,&nbsp;Ida H. Caspersen ,&nbsp;Lise A. Arge ,&nbsp;Cecilia Høst Ramlau-Hansen ,&nbsp;Mikko Myrskyla ,&nbsp;Maria C. Magnus","doi":"10.1016/j.ijheh.2024.114492","DOIUrl":"10.1016/j.ijheh.2024.114492","url":null,"abstract":"<div><div>Previous studies have linked certain environmental exposures to reduced fecundability, influencing exposure recommendations. We continue to encounter numerous environmental exposures in our everyday lives, and further evidence is needed regarding their effects on fecundability. We evaluated associations between various self-reported environmental exposures and fecundability, measured as time to pregnancy, in 64,942 women and 53,219 men participating in the Norwegian Mother, Father, and Child Cohort study (MoBa). Women reported on 17, and men on 19, environmental exposures, including heavy metals, pesticides, paints, and radiation. Fecundability ratios (FR) were estimated using log-binomial regression, comparing likelihood of conception during a given menstrual cycle between exposed versus unexposed participants. About 50 % of women and 75 % of men reported minimum one environmental exposure. Exposure to any pesticide (FR 0.94 [95 % CI 0.91–0.98]), and frequent exposure to photographic chemicals (FR 0.84 [95 % CI: 0.73–0.96]), was associated with decreased fecundability in women. We also observed a tendency of a slightly higher fecundability among women and men exposed to disinfectants (FR 1.02 [95 % CI: 1.00–1.04] and 1.03 [95 % CI: 1.00–1.06], respectively). Our results suggests that exposure to pesticides and photographic chemicals could affect women's fecundability.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114492"},"PeriodicalIF":4.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between chronic long-term exposure to airborne dioxins and breast cancer","authors":"Delphine Praud ,&nbsp;Amina Amadou ,&nbsp;Thomas Coudon ,&nbsp;Margaux Duboeuf ,&nbsp;Benoît Mercoeur ,&nbsp;Elodie Faure ,&nbsp;Lény Grassot ,&nbsp;Aurélie MN. Danjou ,&nbsp;Pietro Salizzoni ,&nbsp;Florian Couvidat ,&nbsp;Laure Dossus ,&nbsp;Gianluca Severi ,&nbsp;Francesca Romana Mancini ,&nbsp;Béatrice Fervers","doi":"10.1016/j.ijheh.2024.114489","DOIUrl":"10.1016/j.ijheh.2024.114489","url":null,"abstract":"<div><div>Breast cancer is the most common type of cancer among women. Environmental pollutants, specifically those with endocrine disrupting properties like dioxins, may impact breast cancer development. Current epidemiological studies on the association between exposure to dioxins and the risk of breast cancer show inconsistent results. To address these uncertainties, our objective was to investigate the impact of airborne dioxin exposure on breast cancer risk within the E3N cohort, encompassing 5222 cases identified during the 1990–2011 follow-up and 5222 matched controls. Airborne dioxin exposure was assessed using a Geographic Information System-based metric considering residential proximity to dioxin emitting sources, their technical characteristics, exposure duration and wind direction. Additional analyses were performed using dioxin concentrations estimated by a chemistry transport model, CHIMERE. The results suggest a slightly increased risk between cumulative dioxin exposure at the residential address and overall breast cancer risk (adjusted odds ratio (OR) = 1.03, 95% confidence interval (CI): 0.99–1.07, for a one standard deviation (SD) increment among controls (14.47 log-μg-TEQ/m²). The associations remained consistent for sources within 3, 5, and 10 km, and when restricting exposure to dioxin emissions from household waste incinerators. Similar OR estimates (OR = 1.02, 95% CI: 0.97–1.07, for a one SD increment) were obtained using the CHIMERE model. The findings of this study suggest the possibility of an increased risk of breast cancer associated with long-term residential exposure to dioxins and emphasize the importance of efforts to mitigate air pollution exposure.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114489"},"PeriodicalIF":4.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wastewater surveillance of Candida auris in Baltimore","authors":"Daniel A. Nwaubani,&nbsp;Rakshya Baral,&nbsp;Tamunobelema Solomon,&nbsp;Oladele Idris,&nbsp;Samendra P. Sherchan","doi":"10.1016/j.ijheh.2024.114486","DOIUrl":"10.1016/j.ijheh.2024.114486","url":null,"abstract":"<div><div><em>Candida auris (C. auris)</em>, an opportunistic fungus causing disease, poses a growing global health concern due to its significant mortality rate, resistance to antifungal treatment, and ability to persist in healthcare settings. Over a span of 47 weeks, untreated wastewater samples were regularly gathered from two wastewater treatment plants (referred to as WWTP-A and WWTP-B) in Baltimore, from July 27, 2022, to June 23, 2023. Throughout the study period, 110 primary influent (PI) samples were collected from both WWTP-A and WWTP-B. A quantitative polymerase chain reaction (qPCR) method was used to analyze <em>C. auris</em> captured on filters (0.45 μm) from these samples. Positive <em>C. auris</em> detection (11.81%) occurred in the influent samples, with a higher frequency of detection in WWTP-B. Influent wastewater concentrations ranged from 1.2 to 7.9 log10 gene copies per liter (gc/L). Interestingly, seasonal analysis showed that <em>C. auris</em> presence in wastewater was more pronounced during the spring season, indicating a sustained existence of the pathogen as seasons changed. Integration of wastewater surveillance and clinical data reveals temporal correlations in <em>C. auris</em> dynamics. The resulting Pearson correlation coefficient of 0.27 reveals a weak positive correlation between the number of new <em>C. auris</em> cases in Baltimore and the quantity of detected gene copies in wastewater. This study marks the first instance of detecting <em>C. auris</em> in Baltimore's wastewater. The results emphasize that wastewater monitoring could serve as an additional early warning tool for anticipating and managing future outbreaks of <em>C. auris</em>.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114486"},"PeriodicalIF":4.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of exposure to endocrine disruptors and other environmental chemicals on breast development in girls: A systematic review of human studies","authors":"Alicia Olivas-Martínez ,&nbsp;Paula Sol Ventura-Wischner ,&nbsp;Mariana F. Fernandez ,&nbsp;Carmen Freire","doi":"10.1016/j.ijheh.2024.114487","DOIUrl":"10.1016/j.ijheh.2024.114487","url":null,"abstract":"<div><h3>Background</h3><div>Age at thelarche has decreased over recent decades. This change in female puberty timing may be influenced by exposure to endocrine disrupting chemicals (EDCs) during critical periods of development.</div></div><div><h3>Objective</h3><div>To review the scientific literature for evidence on the association of exposure to EDCs and other environmental chemicals with the timing of thelarche in girls.</div></div><div><h3>Methods</h3><div>A systematic search for original peer-reviewed articles published up to July 2023 was conducted in three databases (Medline/PubMed, Scopus, and Web of Science), following the PECO strategy and PRISMA guidelines. The quality of evidence and reporting and the risk of bias were evaluated using GRADE, STROBE, and ROBINS-E tools.</div></div><div><h3>Results</h3><div>Out of 3094 articles retrieved in the search, 67 met the review inclusion criteria. Data from 10 out of the 14 studies offering high-quality suggest that <em>in utero</em> and/or childhood exposure to certain synthetic and natural chemicals is associated with earlier breast development in girls; 8 of these 10 studies described a relationship with exposure to organohalogenated compounds <em>in utero</em> and to phthalates in childhood.</div></div><div><h3>Conclusions</h3><div>This systematic review provides the first overview of available human data on the association of EDCs/environmental chemicals with the timing of thelarche. Further high-quality research is urgently needed to fully elucidate the influence of this exposure on breast development timing in girls.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114487"},"PeriodicalIF":4.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells","authors":"Naruporn Pedklang ,&nbsp;Panida Navasumrit ,&nbsp;Chalida Chompoobut ,&nbsp;Jeerawan Promvijit ,&nbsp;Potchanee Hunsonti ,&nbsp;Mathuros Ruchirawat","doi":"10.1016/j.ijheh.2024.114488","DOIUrl":"10.1016/j.ijheh.2024.114488","url":null,"abstract":"<div><div>Traffic-related particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) have been linked to respiratory diseases and cancer risk in humans. Genomic damage, including benzo[a]pyrene diolepoxide (BPDE)-DNA adducts as well as alterations in telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) are associated with respiratory diseases. This study aimed to investigate the association between exposure to traffic-related particulate pollutants and genomic damage in exhaled breath condensate (EBC) in human subjects and a bronchial epithelial cell line (BEAS-2B). Among the 60 healthy recruited subjects, residents living in high-traffic-congested areas were exposed to higher concentrations of PM_2.5 (1.66-fold, p &lt; 0.01), UFPs (1.79-fold, p &lt; 0.01), PM_2.5-PAHs (1.50-fold, p &lt; 0.01), and UFPs-PAHs (1.35-fold, p &lt; 0.05), than those in low-traffic-congested areas. In line with increased exposure to particulate air pollution, the high-traffic-exposed group had significantly increased BPDE-DNA adducts (1.40-fold, p &lt; 0.05), TL shortening (1.24-fold, p &lt; 0.05), and lower mtDNA-CN (1.38-fold, p &lt; 0.05) in EBC. The observations in the human study linking exposure to PM_2.5, UFPs, PM_2.5-PAHs, and UFPs-PAHs with the aforementioned biological effects were confirmed by an <em>in vitro</em> cell-based study, in which BEAS-2B cells were treated with diesel exhaust particulate matter (DEP) containing fine and ultrafine PM and PAHs. Increased BPDE-DNA adducts levels, shortened TL, and decreased mtDNA-CN were also found in treated BEAS-2B cells. The shortened TL and decreased mtDNA-CN were in part mediated by decreased transcript levels of h<em>TERT</em>, and <em>SIRT1</em>, which are involved in telomerase activity and mitochondrial biogenesis, respectively. These results suggest that exposure to traffic-related particulate pollutants can cause genomic instability in respiratory cells, which may increase the health risk of respiratory diseases and the development of cancer.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114488"},"PeriodicalIF":4.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper and zinc status in cord blood and breast milk and child's neurodevelopment at 18 months: Results of the Italian PHIME cohort","authors":"Fabiano Barbiero ,&nbsp;Valentina Rosolen ,&nbsp;Dario Consonni ,&nbsp;Marika Mariuz ,&nbsp;Maria Parpinel ,&nbsp;Luca Ronfani ,&nbsp;Liza Vecchi Brumatti ,&nbsp;Maura Bin ,&nbsp;Luigi Castriotta ,&nbsp;Francesca Valent ,&nbsp;D'Anna Little ,&nbsp;Janja Snoj Tratnik ,&nbsp;Darja Mazej ,&nbsp;Ingrid Falnoga ,&nbsp;Milena Horvat ,&nbsp;Fabio Barbone","doi":"10.1016/j.ijheh.2024.114485","DOIUrl":"10.1016/j.ijheh.2024.114485","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Trace elements, including zinc (Zn) and copper (Cu), although toxic at higher concentrations are known to play important roles in the maintenance of human health and neurodevelopment. Few epidemiological studies have investigated the association between prenatal or early postnatal Cu and Zn levels and child neurodevelopment. The aim of this research is to assess the association between child neurodevelopment at 18 months of age and cord blood and breast milk concentrations of Cu and Zn in Italian mother-child pairs enrolled in the Italian Northern Adriatic Cohort II (NAC-II), a part of the “Public health impact of long-term, low-level, mixed element exposure in susceptible population strata” project PHIME.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The study population consisted of 632 children, and their mothers, born within the NAC-II, who were tested with the Bayley Scales of Infant and Toddler Development third edition (BSID-III) at age 18 months. Cu and Zn concentrations were measured in cord blood and breast milk samples. Only children born at term (≥37 gestational week), who completed the BSID-III test and had at least 1 measure of Cu and Zn concentrations were included in the analysis. Information about socio-demographics and lifestyles were collected through questionnaires at different phases of follow-up. Cu and Zn concentrations were log&lt;sub&gt;2&lt;/sub&gt; transformed because of their skewed distribution. Multiple linear regression models were performed to study the association between each BSID-III composite score (cognitive, motor and language) and each metal concentration. Separate models were applied for each biological sample. The β coefficient (β) and its 95% confidence interval (95% CI) were estimated. Stratified analyses by child's sex were also conducted.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The mean ± standard deviation (SD) of cognitive, motor and language composite scores were respectively: 106 ± 8, 101 ± 5 and 97 ± 8. The mean ± SD of Cu and Zn concentrations (ng/g) were respectively 699.2 ± 129.0 and 2538 ± 589 in cord blood and 607 ± 498 and 3226 ± 1428 in breast milk. No association between metal concentration and cognitive composite score was found. A higher motor composite score was associated with higher Cu concentrations in cord blood (β = 4.31 95% CI 2.03; 6.59). No associations were found between language composite score and metal concentrations. The effect of Cu cord blood concentration on motor composite score was confirmed when stratified by sex: males (β = 5.49 95% CI 2.15; 8.36) and females (β = 3.11; 95% CI 0.00; 6.22). A direct association, in females only, was found between language composite score and Cu concentration in cord blood (β = 5.60 95% CI 0.63; 10.57) and in breast milk (β = 3.04 95% CI 1.06; 5.03), respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The results from this cohort study showed a strong direct association between prenatal Cu levels and child motor neurodevelopment","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114485"},"PeriodicalIF":4.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent organic pollutants among seafood processing workers in West Greenland","authors":"Maria Wielsøe ,&nbsp;Manhai Long ,&nbsp;Jakob Hjort Bønløkke ,&nbsp;Rossana Bossi ,&nbsp;Niels E. Ebbehøj ,&nbsp;Kurt Rasmussen ,&nbsp;Torben Sigsgaard ,&nbsp;Eva Cecilie Bonefeld-Jørgensen","doi":"10.1016/j.ijheh.2024.114484","DOIUrl":"10.1016/j.ijheh.2024.114484","url":null,"abstract":"<div><div>The Greenlandic population is highly exposed to persistent organic pollutants (POPs) through the consumption of traditional marine food, including marine mammals. Central to Greenland's economy and cultural identity, the fishing industry employes about 15% of the working population.</div><div>This study investigated POP exposure, including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFASs), among seafood processing workers at the Greenlandic west coast. We examined determinants for the POPs including age, smoking habits, ethnicity, and working place. Additionally, we explored the association between POPs and the prevalence of asthma, allergy, and lung function.</div><div>With samples taken during 2016–2018, the study encompassed 382 workers, primarily of Inuit descent (93%), employed across three large factories located in Nuuk, Sisimiut, and Ilulissat, four smaller factories in settlements (Kangaatsiaq, Ikerasaarsuk, Sarfannguaq, Qeqertarsuaq), and four factory trawlers. Data collected include clinical examinations, questionnaires on ethnicity, occupational exposure status, health indicators, and smoking habits, and serum selenium and POP analyses. We used ANCOVA with adjustment for relevant confounders to assess differences in POPs between groups (e.g. ethnic groups and working place), and multiple linear and logistic regressions were used to assess associations between POPs and lung function, allergy and asthma.</div><div>Significant differences in POPs were observed among ethnic groups; Faroese workers had the highest concentrations of lipophilic POPs (lipPOPs; PCBs and OCPs), while Inuit workers exhibited highest PFASs. All subsequent analyses were focused on the Inuit workers (n = 337). The PFASs were significantly higher in workers at small factories, followed by large factories and trawlers, whereas no differences were seen for lipPOPs. The differences between the working places were most likely due to differences in lifestyle and diet, but occupational exposures cannot be excluded.</div><div>LipPOP and PFAS concentrations associated positively with selenium, and PFASs positively associated with lung function. However, upon adjustment of selenium, the associations between PFASs and lung function became non-significant and attenuated towards null. No significant associations were found between POPs and the prevalence of asthma or allergy.</div><div>Compared to the general population in the same area and period, the seafood processing workers exhibited 2–6 times higher POP levels. The higher exposure level among seafood processing workers, as well as the difference across workplaces, underscore the need for further investigation of environmental and occupational sources of POPs in this population. These findings may contribute to future public health strategies and regulatory measures to reduce POP exposure in Arctic populations.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114484"},"PeriodicalIF":4.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational phthalate exposure and behavioral problems in preschool-aged children with increased likelihood of autism spectrum disorder","authors":"Jeong Weon Choi ,&nbsp;Deborah H. Bennett ,&nbsp;Antonia M. Calafat ,&nbsp;Daniel J. Tancredi ,&nbsp;Meghan Miller ,&nbsp;Rebecca J. Schmidt ,&nbsp;Hyeong-Moo Shin","doi":"10.1016/j.ijheh.2024.114483","DOIUrl":"10.1016/j.ijheh.2024.114483","url":null,"abstract":"<div><h3>Background</h3><div>Experimental studies have shown associations between gestational phthalate exposure and behavioral problems among offspring; however, epidemiological evidence is still mixed. This study aims to investigate whether gestational phthalate exposure is associated with behavioral problems in preschool-aged children.</div></div><div><h3>Methods</h3><div>Participants include 178 mother-child pairs from MARBLES (Markers of Autism Risk in Babies – Learning Early Signs), a cohort with high familial likelihood of autism spectrum disorder (ASD). We quantified 14 phthalate metabolites in multiple maternal urine samples collected during the 2nd and 3rd trimesters. Preschool behavior problems were assessed using the Child Behavioral Checklist (CBCL), a standardized instrument for evaluating behavior problems of children aged 1.5–5 years. To examine associations of CBCL scores with both individual phthalate biomarker concentrations and their mixture, we used negative binomial regression and weighted quantile sum regression.</div></div><div><h3>Results</h3><div>Overall, maternal phthalate biomarker concentrations were not associated with child behavior problems. Monoisobutyl phthalate (MiBP) concentrations were inversely associated with child anxious/depressed symptoms and somatic complaints. Mono-hydroxy-isobutyl phthalate (MHiBP) and monobenzyl phthalate (MBzP) were also inversely associated with somatic complaints. When assessing trimester-specific associations, more behavior problems were associated with the 2nd trimester biomarker concentrations: mono(3-carboxypropyl) phthalate (MCPP) and monocarboxyisononyl phthalate (MCNP) were positively associated with somatic complaints. All associations became non-significant after false discovery rate correction. No association between a mixture of phthalates and CBCL scores was found.</div></div><div><h3>Conclusions</h3><div>Our study observed no clear evidence of gestational phthalate exposure on child behavior problems. However, our findings based on the biomonitoring assessment of multiple samples per participant could improve our understanding of gestational phthalate exposure in association with behavior problems in preschool-aged children.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114483"},"PeriodicalIF":4.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}