Olivia P. Stoddard , Kimberly Berger , Brenda Eskenazi , Katherine Kogut , Nina T. Holland , Stephen Rauch , Kim G. Harley
{"title":"子宫内接触邻苯二甲酸酯、对羟基苯甲酸酯和其他酚类化合物与青少年月经周期特征的关系","authors":"Olivia P. Stoddard , Kimberly Berger , Brenda Eskenazi , Katherine Kogut , Nina T. Holland , Stephen Rauch , Kim G. Harley","doi":"10.1016/j.ijheh.2025.114612","DOIUrl":null,"url":null,"abstract":"<div><div>Phthalates, parabens, and other phenols are present in consumer products humans use every day, including personal care products and food packaging. Exposure to these chemicals may have endocrine disrupting effects. The menstrual cycle is guided by the rise and fall of hormones, which may be disrupted by exposure to these chemicals. Urinary concentrations of metabolites of phthalates, parabens, and phenols in mothers during pregnancy and several menstrual cycle characteristics in their daughters at age 16 were examined in a predominantly Latino farmworker cohort. The association between the chemicals and each outcome was examined using logistic regression. Bayesian hierarchical modeling was used to model the chemical mixture's associations with each outcome. All models were adjusted for poverty level during pregnancy, maternal pre-pregnancy BMI, and fast-food consumption at adolescent age 9. Results showed a positive association between mono (3-carboxypropyl) phthalate, propylparaben, and bisphenol-A and heavy menstrual flow. Exposure to 2,4-dichlorophenol was positively associated with short cycle length. Mono(3-carboxypropyl) phthalate and di (2-ethylhexyl) phthalate were positively associated with long cycle length. These results suggest <em>in utero</em> exposure to phthalates, parabens, and other phenols may be associated with abnormal menstrual cycle characteristics in adolescents.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"268 ","pages":"Article 114612"},"PeriodicalIF":4.5000,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In utero exposure to a mixture of phthalates, parabens, and other phenols and menstrual cycle characteristics in adolescents\",\"authors\":\"Olivia P. Stoddard , Kimberly Berger , Brenda Eskenazi , Katherine Kogut , Nina T. Holland , Stephen Rauch , Kim G. Harley\",\"doi\":\"10.1016/j.ijheh.2025.114612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Phthalates, parabens, and other phenols are present in consumer products humans use every day, including personal care products and food packaging. Exposure to these chemicals may have endocrine disrupting effects. The menstrual cycle is guided by the rise and fall of hormones, which may be disrupted by exposure to these chemicals. Urinary concentrations of metabolites of phthalates, parabens, and phenols in mothers during pregnancy and several menstrual cycle characteristics in their daughters at age 16 were examined in a predominantly Latino farmworker cohort. The association between the chemicals and each outcome was examined using logistic regression. Bayesian hierarchical modeling was used to model the chemical mixture's associations with each outcome. All models were adjusted for poverty level during pregnancy, maternal pre-pregnancy BMI, and fast-food consumption at adolescent age 9. Results showed a positive association between mono (3-carboxypropyl) phthalate, propylparaben, and bisphenol-A and heavy menstrual flow. Exposure to 2,4-dichlorophenol was positively associated with short cycle length. Mono(3-carboxypropyl) phthalate and di (2-ethylhexyl) phthalate were positively associated with long cycle length. These results suggest <em>in utero</em> exposure to phthalates, parabens, and other phenols may be associated with abnormal menstrual cycle characteristics in adolescents.</div></div>\",\"PeriodicalId\":13994,\"journal\":{\"name\":\"International journal of hygiene and environmental health\",\"volume\":\"268 \",\"pages\":\"Article 114612\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-06-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of hygiene and environmental health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S143846392500094X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of hygiene and environmental health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S143846392500094X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
In utero exposure to a mixture of phthalates, parabens, and other phenols and menstrual cycle characteristics in adolescents
Phthalates, parabens, and other phenols are present in consumer products humans use every day, including personal care products and food packaging. Exposure to these chemicals may have endocrine disrupting effects. The menstrual cycle is guided by the rise and fall of hormones, which may be disrupted by exposure to these chemicals. Urinary concentrations of metabolites of phthalates, parabens, and phenols in mothers during pregnancy and several menstrual cycle characteristics in their daughters at age 16 were examined in a predominantly Latino farmworker cohort. The association between the chemicals and each outcome was examined using logistic regression. Bayesian hierarchical modeling was used to model the chemical mixture's associations with each outcome. All models were adjusted for poverty level during pregnancy, maternal pre-pregnancy BMI, and fast-food consumption at adolescent age 9. Results showed a positive association between mono (3-carboxypropyl) phthalate, propylparaben, and bisphenol-A and heavy menstrual flow. Exposure to 2,4-dichlorophenol was positively associated with short cycle length. Mono(3-carboxypropyl) phthalate and di (2-ethylhexyl) phthalate were positively associated with long cycle length. These results suggest in utero exposure to phthalates, parabens, and other phenols may be associated with abnormal menstrual cycle characteristics in adolescents.
期刊介绍:
The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.