International journal of hygiene and environmental health最新文献

{"title":"Prenatal mercury exposure and body mass index at 2 and 4 years: The Japan Environment and Children's Study","authors":"Daisuke Kurogochi ,&nbsp;Kohei Hasegawa ,&nbsp;Yuji Inaba ,&nbsp;Takumi Shibazaki ,&nbsp;Miyuki Iwai-Shimada ,&nbsp;Shin Yamazaki ,&nbsp;Michihiro Kamijima ,&nbsp;Teruomi Tsukahara ,&nbsp;Tetsuo Nomiyama ,&nbsp;the Japan Environment and Children's Study (JECS) Group","doi":"10.1016/j.ijheh.2025.114566","DOIUrl":"10.1016/j.ijheh.2025.114566","url":null,"abstract":"<div><div>Whether prenatal mercury (Hg) exposure may increase obesity among children remains unclear. We here investigated the association between cord blood methylmercury (MeHg) and inorganic mercury (IHg) concentration and body mass index (BMI) z-scores, as well as overweight or obesity at the ages of 2 and 4 years.</div><div>We used 3147 mother–child pairs data from the Japan Environment and Children's Study. The levels of MeHg and IHg in cord blood were quantified by liquid chromatography coupled with inductively coupled plasma mass spectrometry. Pediatric physicians examined the children's height and weight at ages 2 and 4, and BMI z-scores were calculated. Linear or logistic regression models were employed to examine the association between Hg concentrations and BMI outcomes.</div><div>After adjusting for potential confounders, our findings indicated that a 2-fold increase in IHg concentrations was associated with increases in BMI z-scores of 0.05 (95% CI: 0.01, 0.09; p = 0.021) and 0.05 (95% CI: 0.02, 0.09; p = 0.0046) at ages 2 and 4, respectively. Conversely, no significant associations were observed for MeHg. When overweight or obesity was employed as an outcome, we did not observe consistent associations for either MeHg or IHg.</div><div>In this birth cohort study, an increase in cord blood IHg, but not MeHg, was associated with a slight increase in BMI z-score in children at 2 and 4 years of age. However, the observed associations were weak and inconsistent, suggesting that the results might be due to residual confounding or mere chance rather than indicative of a causal relationship.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114566"},"PeriodicalIF":4.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying fomite hotspots and targeted hygiene impacts in a hotel lobby","authors":"Mary E. Spitzer ,&nbsp;Yoonhee Jung ,&nbsp;Jonathan D. Sexton ,&nbsp;Amanda M. Wilson ,&nbsp;J. Lance Picton ,&nbsp;Brandon Toshio Miura-Akagi ,&nbsp;Carolyn Buckley ,&nbsp;Sophie E. Upson ,&nbsp;Lisa M. Ackerley ,&nbsp;Lucas Gent ,&nbsp;Adrian C. Paskey ,&nbsp;Stephanie Cooper ,&nbsp;Kelly A. Reynolds","doi":"10.1016/j.ijheh.2025.114586","DOIUrl":"10.1016/j.ijheh.2025.114586","url":null,"abstract":"<div><div>Environmental surfaces in public settings serve as reservoirs for microbial pathogens, including norovirus, rhinovirus, and adenovirus, which can persist and spread through hand-to-fomite contact. Despite limited evidence of SARS-CoV-2 fomite transmission, hygiene protocols were widely intensified during the pandemic. This study evaluates viral spread and infection risks in a hotel lobby and assesses the efficacy of a Targeted Hygiene intervention designed to reduce contamination while minimizing excessive chemical use. A viral tracer study, using bacteriophage Phi X174, and human behavior observations were utilized to monitor surface contamination patterns, followed by Quantitative Microbial Risk Assessment (QMRA) to estimate infection probabilities. Tracer organisms seeded on high-touch surfaces spread to 50 % of sampled fomites within 4 h. A subsequent Targeted Hygiene intervention, using disinfecting wipes, sprays, or aerosols tailored to surface types, resulted in a statistically significant 97.36 % reduction in viral concentrations (1.57 log₁₀ reduction, p &lt; 0.0001). The proportion of cross-contaminated surfaces (i.e., non-seeded sites testing positive) decreased from 13 % to 2 %, and the overall percentage of positive surfaces dropped from 50 % to 42 %. QMRA modeling demonstrated that infection risks from a single fomite-hand-face contact were highest for rhinovirus, rotavirus, and adenovirus. Following intervention, infection risk was reduced by over 97 % for all modeled pathogens. Risk levels for all viruses and bacteria met the U.S. EPA and WHO benchmark of less than 1 infection per 10,000 exposures used in drinking water guidelines. Notably, bacterial infection risks, already low pre-intervention, were further reduced to meet the more stringent 1 infection per 1,000,000 risk threshold. This is the first study to integrate real-world human behavior, viral tracer data, and QMRA modeling to assess Targeted Hygiene in a hospitality setting. Findings support the implementation of evidence-based hygiene protocols that prioritize high-risk surfaces and timing, offering a sustainable approach to reducing infection risks in public environments.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114586"},"PeriodicalIF":4.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure to criteria air pollutants and infant mortality: a systematic review and meta-analysis","authors":"Adrien A. Wilkie ,&nbsp;Alison K. Krajewski ,&nbsp;Fanny Njie ,&nbsp;Kevin Park ,&nbsp;Sarah Zelasky ,&nbsp;Kristen M. Rappazzo ,&nbsp;Thomas J. Luben","doi":"10.1016/j.ijheh.2025.114587","DOIUrl":"10.1016/j.ijheh.2025.114587","url":null,"abstract":"<div><h3>Aim</h3><div>We conducted a systematic review/meta-analysis for epidemiologic evidence of the association between long-term criteria air pollution (nitrogen dioxide (NO₂), sulfur dioxide (SO₂), coarse particulate matter (PM₁₀), fine particulate matter (PM_2.5), ozone (O₃), carbon monoxide (CO)) exposure and all-cause, respiratory, and sudden infant death syndrome (SIDS) infant mortality.</div></div><div><h3>Methods</h3><div>Studies were identified through PubMed/Web of Science databases using comprehensive search terms, then screened using predefined criteria. For studies eligible for inclusion in meta-analyses, we applied a systematic rubric for evaluating study quality across domains: participant selection, outcome, exposure, confounding, analysis, selective reporting, sensitivity, overall quality. When ≥3 eligible studies provided effect estimates, we performed meta-analyses to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI) for air pollutants and infant mortality.</div></div><div><h3>Results</h3><div>Of the 701 initial studies, we excluded 678 studies in the abstract screening and full text screening phases, leaving 23 studies for inclusion. Four studies included extractable effect estimates for PM₁₀ and seven for PM_2.5. We could not conduct meta-analyses for CO, O₃, NO₂, or SO₂ because each had &lt;3 eligible studies. The pooled OR (95% CI) for a 10-μg/m³ increase in PM₁₀ concentration was 1.04 (1.02, 1.06) for all-cause, 1.11 (1.02, 1.21) for respiratory, and 1.05 (0.98, 1.13) for SIDS infant mortality. The pooled OR for a 5-μg/m³ increase in PM_2.5 concentration was 1.02 (0.98, 1.05) for all-cause, 0.83 (0.30, 2.27) for respiratory, and 0.97 (0.88, 1.08) for SIDS infant mortality.</div></div><div><h3>Conclusions</h3><div>Long-term exposure to PM₁₀ is associated with all-cause and respiratory infant mortality across studies.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114587"},"PeriodicalIF":4.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new approach for simultaneous measurement of aerosol respiratory deposition and its chemical composition: Health risk assessment of metal engineered nanomaterials in consumer spray aerosols","authors":"Jinho Lee ,&nbsp;Wei-Chung Su","doi":"10.1016/j.ijheh.2025.114588","DOIUrl":"10.1016/j.ijheh.2025.114588","url":null,"abstract":"<div><h3>Background</h3><div>Conventional methods for studying aerosol deposition face limitations when applied to aerosols with irregular shapes and diverse physical properties.</div></div><div><h3>Objective</h3><div>This study aimed to develop the MALDA (Mobile Aerosol Lung Deposition Apparatus)-MOUDI tandem system to simultaneously estimate the size-specific deposition fraction of aerosols and their chemical constituents. Using this innovative approach, we investigated the respiratory deposition of aerosols generated from selected consumer spray products and evaluated the inhalation risks of engineered nanomaterials (ENMs), specifically metals, in these aerosols.</div></div><div><h3>Methods</h3><div>Aerosols were generated from two common types of consumer spray products—trigger and propellant sprays. The size-segregated respiratory deposition fraction and mass proportions of target metals in the aerosols were measured. Occupational exposure scenarios were then designed to estimate the non-cancer and cancer risks associated with inhalation of ENMs (metals) in these aerosols.</div></div><div><h3>Results</h3><div>The MALDA-MOUDI tandem system was successfully developed and validated. Results demonstrated that the non-cancer and cancer risks of inhaled metals due to occupational exposure to the target spray aerosols were below established safety thresholds.</div></div><div><h3>Significance</h3><div>The MALDA-MOUDI tandem system provides an innovative and systematic approach to assess size-specific aerosol deposition in major human airway regions. This method can be applied to broader environmental and occupational aerosol exposure research to evaluate health risks from toxic substances in aerosols. Findings from this study also offer valuable insights for environmental and occupational health research and propose an improved method for health risk assessment.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114588"},"PeriodicalIF":4.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between air quality and neurodegenerative diseases in River Sacco Valley: A retrospective cohort study in Latium, central Italy","authors":"Alessandro Trentalange,&nbsp;Chiara Badaloni,&nbsp;Daniela Porta,&nbsp;Paola Michelozzi,&nbsp;Matteo Renzi","doi":"10.1016/j.ijheh.2025.114578","DOIUrl":"10.1016/j.ijheh.2025.114578","url":null,"abstract":"<div><div>Research on the relationship between air pollution and neurodegenerative diseases is growing. However, few studies focus on this association in contaminated sites.</div><div>We investigated the association between long-term air pollution exposure and dementia/Parkinson's disease (PD) incidence in the River Sacco Valley, a contaminated site in central Italy.</div><div>Through a retrospective cohort study, we enrolled 298,919 40+ years-old residents in 95 municipalities across the study area from 2007 to 2018. Residential exposure to benzene (C₆H₆), NO₂, O₃, PM₁₀, PM_2.5 and SO₂ was estimated through FARM dispersion models with 1–4 km² resolution. Risks were computed for interquartile range (IQR) increases of each pollutant. Incidence of dementia and PD was determined combining electronic health records. We used Cox proportional hazard regression with age as time axis and sex, socio-economic position (SEP) and municipality of residence as covariates.</div><div>Study population was formed by 53 % females, 65 % 40–64 years old, 32 % medium-low SEP. Among 40+ years-old individuals, increased risks (HR; 95 % CIs) of dementia resulted from IQR increases of C₆H₆ (1.15; 1.11–1.18), NO₂ (1.17; 1.14–1.21), PM₁₀ (1.08; 1.04–1.11) and PM_2.5 (1.10; 1.07–1.13). Increased risks of PD resulted from IQR increases of O₃ (1.17; 1.14–1.21) and PM_2.5 (1.02; 1.00–1.05). Vascular dementia's risk increases resulted from IQR increases of NO₂ and PM_2.5.</div><div>Results for dementia and PD varied based on the pollutant analyzed. Our results concord with previous literature and the biological mechanisms that link air pollution to neurodegeneration. Air pollution might be a risk factor for dementia and PD.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114578"},"PeriodicalIF":4.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between air pollution and telomere length: Baseline findings from a comprehensive ambispective cohort study","authors":"Dagmar Kramna ,&nbsp;Ondrej Machaczka ,&nbsp;Petra Riedlova ,&nbsp;Tereza Janulkova ,&nbsp;Silvie Ostrizkova ,&nbsp;Grzegorz Siemiatkowski ,&nbsp;Leszek Osrodka ,&nbsp;Ewa Krajny ,&nbsp;Vitezslav Jirik","doi":"10.1016/j.ijheh.2025.114577","DOIUrl":"10.1016/j.ijheh.2025.114577","url":null,"abstract":"<div><h3>Background</h3><div>Telomere length is a biomarker of cellular aging, influenced by various environmental and lifestyle factors. Air pollution is a known environmental stressor that may impact telomere dynamics. This study aimed to investigate the effect of age, lifetime exposure to air pollution, inflammatory parameters and selected lifestyle factors on telomere length.</div></div><div><h3>Methods</h3><div>The study included 356 participants aged 35–65 living in two regions with varying pollution. Telomere length was measured using qPCR. Individual lifetime exposures to PM₁₀, PM_2.5, NO₂, benzo(a)pyrene and benzene were calculated based on historical air quality data. Statistical analysis of age, pollution exposure, inflammatory parameters, and lifestyle factors on telomere length was performed using logistic regression and generalized linear models, with odds ratios calculated.</div></div><div><h3>Results</h3><div>Unexpectedly, higher air pollutants lifetime exposures were associated with longer telomeres, particularly for PM₁₀ 51–55 μg/m³ (OR = 5.67, p &lt; 0.001), PM_2.5 42–45 μg/m³ (OR = 6.56, p &lt; 0.001), B(a)P 6.9–8.3 ng/m³ (OR = 5.25, p = 0.002), NO₂ 26–27 μg/m³ (OR = 5.22, p = 0.001) and benzene 2.45–2.75 μg/m³ (OR = 6.13, p &lt; 0.001). Age significantly affected telomere length, with older individuals having shorter telomeres. Socioeconomic factors such as college education were positively associated with longer telomeres, while lifestyle factors did not show significant associations. IL-8 was identified as a significant inflammatory marker negatively associated with very long telomeres.</div></div><div><h3>Conclusion</h3><div>These baseline findings bring new perspective to the relationship between air pollution and telomere length. Contrary to traditional views, the results suggest potential adaptive responses, highlighting the need for further longitudinal research to explore telomere dynamics over time in conjunction with other factors.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114577"},"PeriodicalIF":4.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of coexposure to per- and polyfluoroalkyl substances and heavy metals with thyroid function across varied age pregnant women and the potential role of hemoglobin","authors":"Fang Wang ,&nbsp;Xinyu Zhang ,&nbsp;Yuxin Hu ,&nbsp;Gang Wang ,&nbsp;Jingbo Pi ,&nbsp;Tingyu Wang ,&nbsp;Haina Guo ,&nbsp;Mingqi Zhang ,&nbsp;Lijuan Zhang ,&nbsp;Yuanyuan Xu","doi":"10.1016/j.ijheh.2025.114574","DOIUrl":"10.1016/j.ijheh.2025.114574","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have examined the relationship between exposure to one chemical mixture type and thyroid function in pregnant women; however, the combined impact of coexposure to two or more chemical mixture types is limited. Additionally, age-specific studies are insufficient.</div></div><div><h3>Objectives</h3><div>This study aimed to confirm the relationships between coexposure to nine per- and polyfluoroalkyl substances (PFAS) and heavy metals (HMs) mixtures and thyroid function in pregnant women in different age groups, and to explore the potential role of hemoglobin in these association.</div></div><div><h3>Methods</h3><div>A total of 156 pregnant women from a cross-sectional study at one hospital in Liaoning Province, China, were included in this study. High-performance liquid chromatography-electrospray tandem mass spectrometry and inductively coupled plasma-tandem mass spectrometry were used to measure the levels of PFAS and HMs, respectively, in cord blood. Generalized linear regression (GLR), quantile-based g-computation (qgcomp), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were performed to assess the individual and combined effects of PFAS and HMs on thyroid hormones levels. Furthermore, mediation analyses were used to estimate whether these combined effects were mediated by hemoglobin levels.</div></div><div><h3>Results</h3><div>Mixed analysis revealed that coexposure to nine PFAS and HMs was negatively correlated with FT3 in the GLR, qgcomp, WQS and BKMR models for all participants, and similar results were obtained for the nonadvanced age group. Single analysis explored significantly negative associations between exposure to Co, Ba or Pb and FT3 levels in all participants by GLR analysis. In the nonadvanced age groups, further single analysis explored that PFOA was significantly and negatively associated with FT3 by GLR and BKMR analysis, and contributed most substantially (PIP = 0.90). It also had the largest negative weight (0.36) by further qgcomp analysis. Moreover, hemoglobin masked almost 15 % of the correlation between coexposure to PFAS and HMs and FT3 in the nonadvanced age group.</div></div><div><h3>Conclusions</h3><div>Our study demonstrated a negative association between PFAS and HMs coexposure and FT3 levels, which was even more pronounced and partly masked by hemoglobin in the nonadvanced age group of pregnant women. PFOA was the primary pollutant affecting this association. Focusing on hemoglobin as a potential target for reducing the harmful effects of exposure to PFAS and HMs mixtures on thyroid function in pregnant women might be valuable.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"266 ","pages":"Article 114574"},"PeriodicalIF":4.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational exposure to wildland firefighting and its effects on systemic DNA damage","authors":"Filipa Esteves ,&nbsp;Joana Madureira ,&nbsp;Carla Costa ,&nbsp;Joana Pires ,&nbsp;Bela Barros ,&nbsp;Sara Alves ,&nbsp;Josiana Vaz ,&nbsp;Marta Oliveira ,&nbsp;Klara Slezakova ,&nbsp;Adília Fernandes ,&nbsp;Maria do Carmo Pereira ,&nbsp;Simone Morais ,&nbsp;Vanessa Valdiglesias ,&nbsp;Stefano Bonassi ,&nbsp;João Paulo Teixeira ,&nbsp;Solange Costa","doi":"10.1016/j.ijheh.2025.114576","DOIUrl":"10.1016/j.ijheh.2025.114576","url":null,"abstract":"<div><h3>Background</h3><div>Portugal is among the European Union countries more devastated by forest fires. Wildland firefighters are at the forefront of this battle, facing exposure to a wide range of harmful pollutants. Epidemiological studies have highlighted a potential link between occupational firefighting exposure and several diseases, including cancer. To date, very few studies have explored the biological mechanisms associated with such exposure. The present longitudinal study aims to assess changes in early effect biomarkers following wildland firefighters’ occupational exposure to a real wildfire event.</div></div><div><h3>Methods</h3><div>Paired blood samples from 59 healthy Portuguese wildland firefighters were collected at two different time points: before wildfire season and after a fire event during wildfire season. Sociodemographic variables (e.g., age, sex) and work-related factors (e.g., years of service) were assessed via a self-reported questionnaire. Levels of early effect biomarkers, such as primary DNA damage and oxidative DNA damage (oxidised purines) were assessed via comet assay. DNA double-strand breaks (DSBs) were evaluated by phosphorylated H2AX (γH2AX). Moreover, hydroxylated polycyclic aromatic hydrocarbon metabolites (OHPAHs) and metal(loid)s were quantified in urine samples. The influence of urinary OHPAHs, urinary metal(loid)s, and other exposure-related factors (e.g., firefighting duration) on changes (Δ) in early effect biomarkers (post-vs. baseline levels) was investigated.</div></div><div><h3>Results</h3><div>Firefighting activities led to a significant increase in both primary DNA damage and oxidative DNA damage by 22 % (95 % CI: 1.11–1.35; p &lt; 0.05) and 23 % (95 % CI: 1.04–1.45; p &lt; 0.05), respectively. Results from linear regression revealed that per each unit increase of urinary 2-hydroxyfluorene (2-OHFlu) (μmol/mol creatinine), the risk of ⧍ oxidative DNA damage increased by 20 % [FR: 1.20 (1.09–1.32); p &lt; 0.01]. Additionally, each unit increase in urinary cesium (Cs) (μg/L) resulted in a significant 4 % increase in Δ primary DNA damage [FR: 1.04 (1.01–1.06); p &lt; 0.05] and a 3 % increase in Δ oxidative DNA damage [FR: 1.03 (1.01–1.05); p &lt; 0.05]. Post-exposure levels of γH2AX were significantly correlated with urinary 2-OHFlu levels assessed after firefighting (r = 0.30; p &lt; 0.05). Furthermore, exposure duration and reported breathing difficulties during firefighting were significantly associated with increased levels of primary DNA damage.</div></div><div><h3>Conclusion</h3><div>Results obtained provide insights into the potential human health effects of wildland firefighting occupational exposure at the genetic and molecular levels, offering new and important mechanistic data. These findings are crucial for implementing health and safety measures, recommendations, and best practices to mitigate occupational risks and protect the health of wildland firefighters.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"266 ","pages":"Article 114576"},"PeriodicalIF":4.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term and lagged effects of ambient air pollutants on CVD hospitalization: A two-decade population-based study in Tehran","authors":"Alireza Khajavi ,&nbsp;Navid Ebrahimi ,&nbsp;Soroush Masrouri ,&nbsp;Mitra Hasheminia ,&nbsp;Fereidoun Azizi ,&nbsp;Davood Khalili ,&nbsp;Farzad Hadaegh","doi":"10.1016/j.ijheh.2025.114573","DOIUrl":"10.1016/j.ijheh.2025.114573","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the relationship between short-term exposure to ambient air pollutants and cardiovascular disease (CVD) hospitalizations.</div></div><div><h3>Methods</h3><div>A time-series analysis was conducted using data from the Tehran Lipid and Glucose Study cohort of 3454 residents (1880 women) aged 50–70 from District 13 of Tehran. Follow-up data from January 1999 to March 2018 were analyzed. Daily mean temperatures and air pollution levels (CO, O₃, PM₁₀, NO₂, and SO₂) were recorded, and distributed lag non-linear models (DLNMs) assessed the lagged effects on outcome.</div></div><div><h3>Results</h3><div>Over a median follow-up of 14.7 years, 2200 CVD hospitalizations occurred among 3454 participants (mean age 58.7 years, women = 1880). Among the general population, the DLNM models indicated that PM10 concentrations at 73 μg/m³ was associated with a 12 % increased risk of the outcome, with an RR of 1.12 (95 % CI: 1.01–1.24), and higher PM10 levels corresponded to increasing RRs. PM10 indicated a short-term exposure effect at 1-day lag on the outcome risk. SO₂ concentrations reached significance at 24 μg/m³, with an RR of 1.06 (95 % CI: 1.04–1.07); the effect persisted up to 65 μg/m³, with an increased risk of the outcome observed at a 6-day lag. CO showed the highest RR of 1.92 (95 % CI: 1.65–2.23) for the concentration of 5 mg/m3. Exposure to CO was linked to an increased risk of the outcome with a 1-day lag. Sex as well as presence of metabolic syndrome and CKD did not modify the association between air pollutants with the outcome.</div></div><div><h3>Conclusions</h3><div>Short-term exposure to PM10, SO2 and CO significantly increased risk of CVD hospitalization.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"266 ","pages":"Article 114573"},"PeriodicalIF":4.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of epidemiologic data on infectious disease in relation to exposure to twelve perfluoroalkyl substances (PFAS)","authors":"Emma M. Rosen ,&nbsp;Lori Crawford ,&nbsp;Sebastian Hoffmann ,&nbsp;Becky Skidmore ,&nbsp;Anna K. Porter ,&nbsp;Scott A. Halperin ,&nbsp;Matthew P. Longnecker","doi":"10.1016/j.ijheh.2025.114571","DOIUrl":"10.1016/j.ijheh.2025.114571","url":null,"abstract":"<div><h3>Background</h3><div>While some per- and polyfluoroalkyl substances (PFAS) are immunosuppressants, whether they have an adverse effect on infectious disease morbidity is unclear. We conducted a systematic review and meta-analysis of epidemiologic data on the association between an incremental increase in serum concentration of any of 12 PFAS and the risk or rate of infectious disease (ID).</div></div><div><h3>Methods</h3><div>From 25 reports representing 18 unique study populations, we conducted meta-analyses stratified on exposure type (log-transformed or absolute scale) and outcome type (risk or rate). To synthesize data that could not be combined with meta-analysis due to different exposure or outcome types, we additionally conducted vote counting and calculated combined p-values.</div></div><div><h3>Results</h3><div>A small positive association between PFAS exposure and ID risk or rate was more frequently reported than not, though in the synthesized data statistical significance was present only in a few instances. The meta-analyses and combined p-value analyses had many similar findings. In the combined p-value analyses, statistically significant positive associations were noted between Perfluorononanoic acid and lower respiratory tract infection (LRTI) event rates, Perfluorooctanesulfonamide and LRTI event rates and LRTI risk and rates combined, Perfluorooctanoic acid and Perfluorodecanoic acid with all ID risk and rates combined, and Perfluoroundecanoic acid with all ID risk.</div></div><div><h3>Conclusion</h3><div>We identified moderate evidence of positive associations that were of variable size but usually small; the certainty of evidence was, however, generally low or very low and diminished by the possible influences of multiple testing and covariance among results not accounted for in the analyses.</div></div><div><h3>Prospero registration</h3><div>CRD42024551990.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"266 ","pages":"Article 114571"},"PeriodicalIF":4.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}