International journal of hygiene and environmental health最新文献

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Prenatal exposure to polycyclic aromatic hydrocarbons and phthalate acid esters and gestational diabetes mellitus: A prospective cohort study 产前接触多环芳烃和邻苯二甲酸酯与妊娠糖尿病:一项前瞻性队列研究。
IF 4.5 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-07-04 DOI: 10.1016/j.ijheh.2024.114419
Minghao Guo , Yiwei Fang , Meilin Peng , Chao He , Jin Chen , Borui Sun , Chunyan Liu , Yuanzhong Zhou , Huiping Zhang , Kai Zhao
{"title":"Prenatal exposure to polycyclic aromatic hydrocarbons and phthalate acid esters and gestational diabetes mellitus: A prospective cohort study","authors":"Minghao Guo ,&nbsp;Yiwei Fang ,&nbsp;Meilin Peng ,&nbsp;Chao He ,&nbsp;Jin Chen ,&nbsp;Borui Sun ,&nbsp;Chunyan Liu ,&nbsp;Yuanzhong Zhou ,&nbsp;Huiping Zhang ,&nbsp;Kai Zhao","doi":"10.1016/j.ijheh.2024.114419","DOIUrl":"10.1016/j.ijheh.2024.114419","url":null,"abstract":"<div><h3>Background</h3><p>Polycyclic aromatic hydrocarbons and phthalate acid esters (PAHs &amp; PAEs), known as endocrine disrupting chemicals (EDCs), widely exist in daily life and industrial production. Previous studies have suggested that PAHs &amp; PAEs may modify the intrauterine homeostasis and have adverse effects on fetal development. However, epidemiological evidence on the associations between PAHs &amp; PAEs and gestational diabetes mellitus (GDM) is still limited.</p></div><div><h3>Objective</h3><p>To investigate the effects of prenatal PAHs &amp;PAEs exposure on the risk of GDM and hyperglycemia in pregnant women.</p></div><div><h3>Methods</h3><p>The study population was a total of 725 pregnant women from a prospective birth cohort study conducted from December 2019 to December 2021. Blood glucose levels were collected by the hospital information system. Urinary PAHs &amp; PAEs concentrations were determined by gas chromatography tandem mass spectrometry. The Poisson regression in a generalized linear model (GLM), multiple linear regression, quantile-based g-computation method (qgcomp), and Bayesian kernel machine regression (BKMR) were applied to explore and verify the individual and overall effects of PAHs &amp; PAEs on glucose homeostasis. Potential confounders were adjusted in all statistical models.</p></div><div><h3>Results</h3><p>A total of 179 (24.69%) women were diagnosed with GDM. The Poisson regression suggested that a ln-unit increment of 4-OHPHE (4-hydroxyphenanthrene) (adjusted Risk Ratio (aRR) = 1.13; 1.02–1.26) was associated with the increased GDM risk. Mixed-exposure models showed similar results. We additionally found that MBZP (mono-benzyl phthalate) (aRR = 1.19; 1.02–1.39) was positively related to GDM risk in qgcomp model. Although neither model demonstrated that 2-OHNAP (2-hydroxynaphthalene) and 9-OHFLU (9-hydroxyfluorene) increased the risk of GDM, 2-OHNAP and 9-OHFLU exposure significantly increased blood glucose levels. BKMR model further confirmed that overall effects of PAHs &amp; PAEs were significantly associated with the gestational hyperglycemia and GDM risk.</p></div><div><h3>Conclusions</h3><p>Our study presents that environmental exposure to PAHs &amp; PAEs was positively associated with gestational glucose levels and the risks of developing GDM. In particular, 2-OHNAP, 9-OHFLU, 4-OHPHE and MBZP may serve as important surveillance markers to prevent the development of GDM.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114419"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts 三个欧洲队列中产前接触邻苯二甲酸盐和合成酚与青春期发育的关系。
IF 4.5 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-07-04 DOI: 10.1016/j.ijheh.2024.114418
Carmen Freire , Francesca Castiello , Izaro Babarro , Augusto Anguita-Ruiz , Maribel Casas , Martine Vrijheid , Blanca Sarzo , Andrea Beneito , Manik Kadawathagedara , Claire Philippat , Cathrine Thomsen , Amrit Kaur Sakhi , Maria-Jose Lopez-Espinosa
{"title":"Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts","authors":"Carmen Freire ,&nbsp;Francesca Castiello ,&nbsp;Izaro Babarro ,&nbsp;Augusto Anguita-Ruiz ,&nbsp;Maribel Casas ,&nbsp;Martine Vrijheid ,&nbsp;Blanca Sarzo ,&nbsp;Andrea Beneito ,&nbsp;Manik Kadawathagedara ,&nbsp;Claire Philippat ,&nbsp;Cathrine Thomsen ,&nbsp;Amrit Kaur Sakhi ,&nbsp;Maria-Jose Lopez-Espinosa","doi":"10.1016/j.ijheh.2024.114418","DOIUrl":"10.1016/j.ijheh.2024.114418","url":null,"abstract":"<div><h3>Background</h3><p>There is limited epidemiological evidence on the association of prenatal exposure to phthalates and synthetic phenols with altered pubertal timing.</p></div><div><h3>Objective</h3><p>To examine the association of prenatal exposure to phthalates, bisphenol A (BPA), parabens, benzophenone 3 (BP-3), and triclosan (TCS) with pubertal development in girls and boys from three European cohorts.</p></div><div><h3>Methods</h3><p>Urinary metabolites of six different phthalate diesters (DEP, DiBP, DnBP, BBzP, DEHP, and DiNP), BPA, methyl- (MePB), ethyl- (EtPB), propyl- (PrPB), and butyl-paraben (BuPB), BP-3, and TCS were quantified in one or two (1st and 3rd trimester) urine samples collected during pregnancy (1999–2008) from mothers in three birth cohorts: INMA (Spain), EDEN (France), and MoBa (Norway). Pubertal development of their children was assessed at a single visit at age 7–12 years (579 girls, 644 boys) using the parent-reported Pubertal Development Scale (PDS). Mixed-effect Poisson and g-computation and Bayesian Kernel Machine Regression (BKMR) were employed to examine associations of individual and combined prenatal chemical exposure, respectively, with the probability of overall pubertal onset, adrenarche, and gonadarche (stage 2+) in girls and boys. Effect modification by child body mass index (BMI) was also assessed.</p></div><div><h3>Results</h3><p>Maternal concentrations of the molar sum of DEHP and of DiNP metabolites were associated with a slightly higher probability of having started puberty in boys (relative risk, RR [95% CI] = 1.13 [0.98–1.30] and 1.20 [1.06–1.34], respectively, for a two-fold increase in concentrations), with a stronger association for DiNP in boys with overweight or obesity. In contrast, BPA, BuPB, EtPB, and PrPB were associated with a lower probability of pubertal onset, adrenarche, and/or gonadarche in all boys (<em>e.g.</em> overall puberty, BPA: RR [95% CI] = 0.93 [0.85–1.01] and BuPB: 0.95 [0.90–1.00], respectively), and the association with BPA was stronger in boys with underweight/normal weight. In girls, MEHP and BPA were associated with delayed gonadarche in those with underweight/normal weight (RR [95% CI] = 0.86 [0.77–0.95] and 0.90 [0.84–0.97], respectively). Most of these associations were trimester specific. However, the chemical mixture was not associated with any pubertal outcome in boys or girls.</p></div><div><h3>Conclusions</h3><p>Prenatal exposure to certain phthalates and synthetic phenols such as BPA may impact the pubertal development of boys, and weight status may modify this effect. BPA may also alter the pubertal development of girls.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114418"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924000993/pdfft?md5=ac171343a92a8e90deda08695602e71b&pid=1-s2.0-S1438463924000993-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer incidence in Swedish oil refinery workers exposed to benzene 接触苯的瑞典炼油厂工人的癌症发病率。
IF 4.5 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-07-04 DOI: 10.1016/j.ijheh.2024.114420
E.M. Andersson , L. Barregard , M. Akerstrom , G. Sallsten , B. Järvholm , R.I. Nilsson
{"title":"Cancer incidence in Swedish oil refinery workers exposed to benzene","authors":"E.M. Andersson ,&nbsp;L. Barregard ,&nbsp;M. Akerstrom ,&nbsp;G. Sallsten ,&nbsp;B. Järvholm ,&nbsp;R.I. Nilsson","doi":"10.1016/j.ijheh.2024.114420","DOIUrl":"10.1016/j.ijheh.2024.114420","url":null,"abstract":"<div><h3>Background</h3><p>Oil refinery workers are exposed to benzene, which is a well-known cause of leukaemia, but results on leukaemia in oil refinery workers have been mixed, and the data on workers’ exposure is limited. Oil refinery workers are also exposed to asbestos and several studies have shown increased risk of mesothelioma.</p></div><div><h3>Aim</h3><p>The objective was to investigate cancer incidence, especially leukaemia, at low to moderate exposure to benzene in an update of a previous study of employees at three Swedish oil refineries.</p></div><div><h3>Methods</h3><p>Cancer incidence was followed up in 2264 men (1548 refinery operators) employed at three oil refineries in Sweden for at least one year. Job types and employment times were collected from complete company files. A retrospective assessment of the benzene exposure was performed by occupational hygienists in collaboration with the refineries using historic measurements as well as detailed information on changes in the industrial hygiene and technological developments. Cases of cancer were retrieved by a linkage with the Swedish Cancer Register through 35–47 years of follow-up and standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated.</p></div><div><h3>Results</h3><p>In total, 258 tumors had occurred versus 240 expected (SIR 1.07; 95% CI 0.95–1.21). There were 10 cases of leukaemia, all in refinery operators (SIR 2.4; 95% CI 1.18–4.51). There were three cases of pleural mesothelioma, two of which in refinery operators. The mean estimated cumulative benzene exposure for the cases of leukaemia was 7.9 ppm-years (median 4.9, range 0.1–31.1).</p></div><div><h3>Discussion</h3><p>The study suggests that low to moderate average cumulative benzene exposure increases the risk of leukaemia. Limitations include the modest number of cases and potential misclassification of exposure.</p></div><div><h3>Conclusion</h3><p>The present study indicated an increased risk of leukaemia in male oil refinery workers with low to moderate exposure to benzene.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114420"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001019/pdfft?md5=d38eff61ad991bfd1b0aafb2a4b78489&pid=1-s2.0-S1438463924001019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outbreak of cholera due to contaminated pond water utilisation in a rural area of West Bengal, India, 2021 2021 年,印度西孟加拉邦农村地区因使用受污染的池塘水而爆发霍乱。
IF 4.5 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-28 DOI: 10.1016/j.ijheh.2024.114409
Dhiraj Roy , Tanima Roy Mondal , Pallavi Indwar
{"title":"Outbreak of cholera due to contaminated pond water utilisation in a rural area of West Bengal, India, 2021","authors":"Dhiraj Roy ,&nbsp;Tanima Roy Mondal ,&nbsp;Pallavi Indwar","doi":"10.1016/j.ijheh.2024.114409","DOIUrl":"10.1016/j.ijheh.2024.114409","url":null,"abstract":"<div><h3>Background</h3><p>On March 31, 2021, an outbreak of diarrhoeal disease was reported in Dangapara village of Purba Bardhaman district, West Bengal, India. The outbreak was investigated to estimate the magnitude, identify aetiological agents and source of infection, and guide prevention control measures.</p></div><div><h3>Methods</h3><p>We did an active search for case patients at Dangapara village. We excluded children under five years of age from the epidemiological analysis. We described the outbreak by time, place, and person. We conducted a case control study with 133 controls and 65 cases. Water samples from different sources and rectal swabs from case patients were collected and sent for laboratory investigations.</p></div><div><h3>Results</h3><p>We identified 95 case patients among 330 residents of Dangapara village (attack rate 29 %). Three stool samples were positive for <em>Vibrio cholerae</em>, and two pond water samples were contaminated with coliform organisms. Washing utensils [adjusted odds ratio (AOR): 69.8, (95% confidence interval (CI) 6.5–749.5)] and taking a bath in pond water [AOR: 3.4, (95% CI 1.2–9)] were associated with increased risk of illness. About 97% of cases were attributed to washing utensils in pond water. Washing hands before taking food was associated with a lower risk of developing disease with AOR: 0.1 (95% CI 0.03–0.33).</p></div><div><h3>Conclusion</h3><p>A cholera outbreak occurred among residents of Dangapara village due to theuse of contaminated pond water for washing utensils and bathing. Prompt management of cases and immediate discontinuation of pond water use stopped the outbreak.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114409"},"PeriodicalIF":4.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of metals with early postnatal gut microbiota among infants admitted to the neonatal intensive care unit 新生儿重症监护室收治的婴儿中金属与产后早期肠道微生物群的关系。
IF 4.5 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-25 DOI: 10.1016/j.ijheh.2024.114410
Shi-ting Xiang , Changci Zhou , Kunyan Zhao , Ye Ma , Ruiwen Huang , Yunlong Peng , Yan Tang , Fei Yang , Jun Qiu
{"title":"Association of metals with early postnatal gut microbiota among infants admitted to the neonatal intensive care unit","authors":"Shi-ting Xiang ,&nbsp;Changci Zhou ,&nbsp;Kunyan Zhao ,&nbsp;Ye Ma ,&nbsp;Ruiwen Huang ,&nbsp;Yunlong Peng ,&nbsp;Yan Tang ,&nbsp;Fei Yang ,&nbsp;Jun Qiu","doi":"10.1016/j.ijheh.2024.114410","DOIUrl":"10.1016/j.ijheh.2024.114410","url":null,"abstract":"<div><p>The gut microbiota is closely related to infant health. However, the impact of environmental factors on the gut microbiota has not been widely investigated, particularly in vulnerable populations such as infants admitted to the neonatal intensive care unit (NICU). This study investigated the association between exposure to 12 metals and the composition of the gut microbiota in infants admitted to the NICU. Metal concentrations were determined in serum samples obtained from 107 infants admitted to the NICU at Hunan Children's hospital, China. Gut microbiota data were derived from 16S rRNA sequencing using stool samples. Generalized linear regression (GLR) models and Bayesian kernel machine regression (BKMR) analyses were used to estimate the associations between metals and both alpha-diversity indices and bacterial taxa. The GLR models showed that tin correlated negatively with the Shannon index (β = −0.55, 95% conficence interval [CI]: −0.79, −0.30, <em>P</em><sub>FDR</sub>&lt; 0.001) and positively with the Simpson index (β = 0.26, 95% CI: 0.13, 0.39, <em>P</em><sub>FDR</sub>&lt; 0.001). The BKMR analysis yielded similar results, showing that tin had the largest posterior inclusion probability for both the Shannon (0.986) and the Simpson (0.796) indices. Tin, cadmium, mercury, lead, and thallium were associated with changes in one or more taxa at the genus level. The BKMR analysis also revealed a negative correlation between metal mixtures and <em>Clostridium_sensu_stricto</em>, and tin contibuted mostly to the negative correlation. Early postnatal exposure to metals were associated with differences in the microbiome among infants admitted to the NICU. However, as the study was cross-sectional, these relationships must be confirmed in further studies.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114410"},"PeriodicalIF":4.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal and childhood exposure to bisphenols and bone mineral density in 7-year-old children from the Odense Child Cohort 欧登塞儿童队列中 7 岁儿童的产前和童年双酚暴露与骨矿物质密度
IF 6 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-18 DOI: 10.1016/j.ijheh.2024.114408
Annika Sigvaldsen , Hanne Frederiksen , Frederik Damsgaard Højsager , Anna-Maria Andersson , Anders Juul , Henriette Boye , Marianne Skovsager Andersen , Tina Kold Jensen
{"title":"Prenatal and childhood exposure to bisphenols and bone mineral density in 7-year-old children from the Odense Child Cohort","authors":"Annika Sigvaldsen ,&nbsp;Hanne Frederiksen ,&nbsp;Frederik Damsgaard Højsager ,&nbsp;Anna-Maria Andersson ,&nbsp;Anders Juul ,&nbsp;Henriette Boye ,&nbsp;Marianne Skovsager Andersen ,&nbsp;Tina Kold Jensen","doi":"10.1016/j.ijheh.2024.114408","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114408","url":null,"abstract":"<div><h3>Background</h3><p>Bisphenol A (BPA) is a well-known endocrine disrupter used in several consumer products. Restricted use of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). While previous studies found no associations between prenatal BPA and BPF exposure and bone mineral density (BMD), two recent cohort studies found that prenatal BPS exposure was negatively associated with bone mineral density in the offspring.</p></div><div><h3>Aim</h3><p>To determine possible associations between maternal and child urinary bisphenol concentrations, BMD and bone mineral content (BMC) in 7-year-old healthy children.</p></div><div><h3>Methods</h3><p>Pregnant women were recruited in 2010–2012 to participate in the Odense Child Cohort (OCC), Denmark. Maternal urine samples were collected in gestational week 28 and urinary BPA concentration was measured by isotope diluted LC-MS/MS. The children delivered a urine sample at age 7 years in which BPA, BPF and BPS were measured by an extended LS-MS/MS method based on the original method. At age 7 years DXA scans were performed and BMC and Z-score for BMD calculated. Associations between osmolality adjusted urinary maternal BPA and child BPA, BPF and BPS concentrations and BMC and BMD Z-score were examined by multiple linear regression analysis adjusted for potential confounders. Additionally, a combined effect of the bisphenols were evaluated by including the sum of child urinary BPA, BPF and BPS concentrations in the statistical analyses.</p></div><div><h3>Results</h3><p>A total of 546 mothers and 453 children aged 7 years participated. BPA was detected in 84% and 96% of the maternal and child urine samples, respectively. We found no significant association between maternal urinary BPA concentration during pregnancy and BMC and BMD Z-score in 7-year-old children. In addition, no association between current bisphenol exposure in tertiles and bone density was found, interestingly, current BPA and summed bisphenol exposure in the highest 10% was associated with lower BMD Z-score at age 7-years, statistically significant for boys.</p></div><div><h3>Conclusion</h3><p>In these low exposed children we found no association between prenatal or current bisphenol exposure in tertiles and BMD in healthy children, however, the highest 10% exposed children had lower BMD, significant for boys, suggesting a negative impact with high bisphenol exposure. The short half-lives of bisphenols and the cross-sectional nature of the child exposure prompt more longitudinal studies to further clarify this topic.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"260 ","pages":"Article 114408"},"PeriodicalIF":6.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924000890/pdfft?md5=99b644321315e41d77d27c86d2297db2&pid=1-s2.0-S1438463924000890-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study 产前接触多环芳烃与学龄时的执行功能:一项合并队列研究的结果
IF 6 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-15 DOI: 10.1016/j.ijheh.2024.114407
Yu Ni , Adam A. Szpiro , Christine T. Loftus , Tomomi Workman , Alexis Sullivan , Erin R. Wallace , Anne M. Riederer , Drew B. Day , Laura E. Murphy , Ruby H.N. Nguyen , Sheela Sathyanarayana , Emily S. Barrett , Qi Zhao , Daniel A. Enquobahrie , Christopher Simpson , Shaikh I. Ahmad , Jessica A. Arizaga , Brent R. Collett , Karen J. Derefinko , Kurunthachalam Kannan , Catherine J. Karr
{"title":"Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study","authors":"Yu Ni ,&nbsp;Adam A. Szpiro ,&nbsp;Christine T. Loftus ,&nbsp;Tomomi Workman ,&nbsp;Alexis Sullivan ,&nbsp;Erin R. Wallace ,&nbsp;Anne M. Riederer ,&nbsp;Drew B. Day ,&nbsp;Laura E. Murphy ,&nbsp;Ruby H.N. Nguyen ,&nbsp;Sheela Sathyanarayana ,&nbsp;Emily S. Barrett ,&nbsp;Qi Zhao ,&nbsp;Daniel A. Enquobahrie ,&nbsp;Christopher Simpson ,&nbsp;Shaikh I. Ahmad ,&nbsp;Jessica A. Arizaga ,&nbsp;Brent R. Collett ,&nbsp;Karen J. Derefinko ,&nbsp;Kurunthachalam Kannan ,&nbsp;Catherine J. Karr","doi":"10.1016/j.ijheh.2024.114407","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114407","url":null,"abstract":"<div><h3>Background</h3><p>Executive functions develop rapidly in childhood, enabling problem-solving, focused attention, and planning. Exposures to environmental toxicants in pregnancy may impair healthy executive function development in children. There is increasing concern regarding polycyclic aromatic hydrocarbons (PAHs) given their ability to transfer across the placenta and the fetal blood-brain barrier, yet evidence from epidemiological studies is limited.</p></div><div><h3>Methods</h3><p>We examined associations between prenatal PAH exposure and executive functions in 814 children of non-smoking mothers from two U.S. cohorts in the ECHO-PATHWAYS Consortium. Seven mono-hydroxylated PAH metabolites were measured in mid-pregnancy urine and analyzed individually and as mixtures. Three executive function domains were measured at age 8–9: cognitive flexibility, working memory, and inhibitory control. A composite score quantifying overall performance was further calculated. We fitted linear regressions adjusted for socio-demographics, maternal health behaviors, and psychological measures, and examined modification by child sex and stressful life events in pregnancy. Bayesian kernel machine regression was performed to estimate the interactive and overall effects of the PAH mixture.</p></div><div><h3>Results</h3><p>The results from primary analysis of linear regressions were generally null, and no modification by child sex or maternal stress was indicated. Mixture analyses suggested several pairwise interactions between individual PAH metabolites in varied directions on working memory, particularly interactions between 2/3/9-FLUO and other PAH metabolites, but no overall or individual effects were evident.</p></div><div><h3>Conclusion</h3><p>We conducted a novel exploration of PAH-executive functions association in a large, combined sample from two cohorts. Although findings were predominantly null, the study carries important implications for future research and contributes to evolving science regarding developmental origins of diseases.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"260 ","pages":"Article 114407"},"PeriodicalIF":6.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924000889/pdfft?md5=a697c0c6051e2f1c88cd69c59eabbf2d&pid=1-s2.0-S1438463924000889-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational noise and genetic variants in stress hormone biosynthesis-based genes and rates of blood lipid changes in China: A five-year longitudinal study 中国的职业噪声和基于应激激素生物合成的基因的遗传变异与血脂变化率:五年纵向研究
IF 6 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-14 DOI: 10.1016/j.ijheh.2024.114404
Xiayun Dai , Fan Wang , Lei Ni, Jinfeng Jiang, Jiaojun Liang, Tian Xu, Zhiteng Min, Siqi Chen, Yong Yao, Guilin Yi, Yongbin Luo, Zhiwei Pan, Zhenlong Chen
{"title":"Occupational noise and genetic variants in stress hormone biosynthesis-based genes and rates of blood lipid changes in China: A five-year longitudinal study","authors":"Xiayun Dai ,&nbsp;Fan Wang ,&nbsp;Lei Ni,&nbsp;Jinfeng Jiang,&nbsp;Jiaojun Liang,&nbsp;Tian Xu,&nbsp;Zhiteng Min,&nbsp;Siqi Chen,&nbsp;Yong Yao,&nbsp;Guilin Yi,&nbsp;Yongbin Luo,&nbsp;Zhiwei Pan,&nbsp;Zhenlong Chen","doi":"10.1016/j.ijheh.2024.114404","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114404","url":null,"abstract":"<div><p><em>Lipid profiles are influenced by both noise and genetic variants. However, little is known about the associations of occupational noise and genetic variants with age-related changes in blood lipids, a crucial event in the initiation and evolution of atherosclerotic cardiovascular diseases. We aimed to evaluate the associations of blood lipid change rates with occupational noise and genetic variants in stress hormone biosynthesis-based genes. This cohort was established in 2012 and 2013 and was followed up until 2017. A total of 952 participants were included in the final analysis and all of them were categorized to two groups, the exposed group and control group, according to t</em>he exposed noise levels in their working area. Single nucleotide polymorphisms (SNPs) <em>in stress hormone biosynthesis-based genes</em> were genotyped. Five physical examinations were conducted from 2012 to 2017 and lipid measurements were repeated five times. The estimated annual changes (EACs) of blood lipid were calculated as the difference in blood lipid levels between any 2 adjacent examinations divided by their time interval (year). The generalized estimating equations for repeated measures analyses with exchangeable correlation structures were used to evaluate the influence of exposing to noise (versus being a control) and the SNPs mentioned above on the EACs of blood lipids. We found that the participants experienced accelerated age-related decline in high-density lipoprotein cholesterol (HDL-C) levels as they were exposed to noise (<em>β</em> = −0.38, 95% confidence interval (<em>CI</em>), −0.66 to −0.10, <em>P</em> = 0.007), after adjusting for work duration, gender, smoking, alcohol consumption, and pack-years. This trend was only found in participants with <em>COMT</em>-rs165815 TT genotype (<em>β</em> = −1.19, 95% <em>CI</em>, −1.80 to −0.58, <em>P</em> &lt; 0.001), but not in those with the CC or CT genotypes. The interaction of noise exposure and rs165815 was marginally significant (<em>P</em><sub>interaction</sub> = 0.010) after multiple adjustments. Compared with <em>DDC</em>-rs11978267 AA genotype carriers, participants carrying rs11978267 GG genotype had decreased EAC of triglycerides (TG) (<em>β</em> = −5.06, 95% <em>CI</em>, −9.07 to −1.05, <em>P</em> = 0.013). Participants carrying <em>DBH</em>-rs4740203 CC genotype had increased EAC of total cholesterol (TC) (<em>β</em> = 1.19, 95% <em>CI</em>, 0.06 to 2.33, <em>P</em> = 0.039). However, these findings were not statistically significant after multiple adjustments. These results indicated that Occupational noise exposure was associated with accelerated age-related decreases in HDL-C levels, and the <em>COMT</em>-rs165815 genotype appeared to modify the effect of noise exposure on HDL-C changes among the occupational population.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"260 ","pages":"Article 114404"},"PeriodicalIF":6.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between mycoestrogen exposure and sex steroid hormone concentrations in maternal serum and cord blood in the UPSIDE pregnancy cohort UPSIDE 妊娠队列中雌激素暴露与母体血清和脐带血中性激素浓度之间的关系
IF 6 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-14 DOI: 10.1016/j.ijheh.2024.114405
Carolyn W. Kinkade , Lauren M. Aleksunes , Anita Brinker , Brian Buckley , Jessica Brunner , Christina Wang , Richard K. Miller , Thomas G. O'Connor , Zorimar Rivera-Núñez , Emily S. Barrett
{"title":"Associations between mycoestrogen exposure and sex steroid hormone concentrations in maternal serum and cord blood in the UPSIDE pregnancy cohort","authors":"Carolyn W. Kinkade ,&nbsp;Lauren M. Aleksunes ,&nbsp;Anita Brinker ,&nbsp;Brian Buckley ,&nbsp;Jessica Brunner ,&nbsp;Christina Wang ,&nbsp;Richard K. Miller ,&nbsp;Thomas G. O'Connor ,&nbsp;Zorimar Rivera-Núñez ,&nbsp;Emily S. Barrett","doi":"10.1016/j.ijheh.2024.114405","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114405","url":null,"abstract":"<div><p>Zearalenone (ZEN) is a fungal-derived toxin found in global food supplies including cereal grains and processed foods, impacting populations worldwide through diet. Because the chemical structure of ZEN and metabolites closely resembles 17β-estradiol (E2), they interact with estrogen receptors α/β earning their designation as ‘mycoestrogens’. In animal models, gestational exposure to mycoestrogens disrupts estrogen activity and impairs fetal growth. Here, our objective was to evaluate relationships between mycoestrogen exposure and sex steroid hormone concentrations in maternal circulation and cord blood for the first time in humans. In each trimester, pregnant participants in the UPSIDE study (n = 297) provided urine for mycoestrogen analysis and serum for hormone analysis. At birth, placental mycoestrogens and cord steroids were measured. We fitted longitudinal models examining log-transformed mycoestrogen concentrations in relation to log-transformed hormones, adjusting for covariates. Secondarily, multivariable linear models examined associations at each time point (1st, 2nd, 3rd trimesters, delivery). We additionally considered effect modification by fetal sex. ZEN and its metabolite, α-zearalenol (α-ZOL), were detected in &gt;93% and &gt;75% of urine samples; &gt;80% of placentas had detectable mycoestrogens. Longitudinal models from the full cohort exhibited few significant associations. In sex-stratified analyses, in pregnancies with male fetuses, estrone (E1) and free testosterone (fT) were inversely associated with ZEN (E1 %Δ: −6.68 95%CI: −12.34, −0.65; fT %Δ: −3.22 95%CI: −5.68, −0.70); while α-ZOL was positively associated with E2 (%Δ: 5.61 95%CI: −1.54, 9.85) in pregnancies with female fetuses. In analysis with cord hormones, urinary mycoestrogens were inversely associated with androstenedione (%Δ: 9.15 95%CI: 14.64, −3.30) in both sexes, and placental mycoestrogens were positively associated with cord fT (%Δ: 37.13, 95%CI: 4.86, 79.34) amongst male offspring. Findings support the hypothesis that mycoestrogens act as endocrine disruptors in humans, as in animal models and livestock. Additional work is needed to understand impacts on maternal and child health.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"260 ","pages":"Article 114405"},"PeriodicalIF":6.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924000865/pdfft?md5=71edc2f93955ae7856000511d54ae880&pid=1-s2.0-S1438463924000865-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclophosphamide exposure factors in family caregivers for pediatric cancer patients 儿科癌症患者家庭护理人员接触环磷酰胺的因素
IF 6 2区 医学
International journal of hygiene and environmental health Pub Date : 2024-06-12 DOI: 10.1016/j.ijheh.2024.114402
Yuko Noda , Yuhki Koga , Kenichiro Yamamura , Junko Miyata , Yuko Hamada , Shouichi Ohga
{"title":"Cyclophosphamide exposure factors in family caregivers for pediatric cancer patients","authors":"Yuko Noda ,&nbsp;Yuhki Koga ,&nbsp;Kenichiro Yamamura ,&nbsp;Junko Miyata ,&nbsp;Yuko Hamada ,&nbsp;Shouichi Ohga","doi":"10.1016/j.ijheh.2024.114402","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114402","url":null,"abstract":"<div><p>The exposure of family caregivers to anticancer drugs for pediatric patients with malignancy is a potential health risk that needs to be minimized. We monitored the amount of cyclophosphamide (CPM) that had adhered to the undershirts of patients and the personal protective equipment (PPE) of family caregivers as well as the caregivers' urine levels of CPM within the first three days after the first and second courses of high-dose CPM therapy. Liquid chromatography/mass spectrometry (LC/MS/MS) detected &gt;0.03 ng/ml of CPM in 26% (23/88) of urine samples from 8 of 11 (72.7%) patients’ family caregivers, with a peak of 0.7 ng/ml from 24 to 48 h after administration. Since urine CPM concentrations in family caregivers varied after the first and second courses, the exposure risk factors were analyzed by scoring the PPE-wearing time index (caring minutes × PPE points from wearing masks, gloves, and/or gowns) and CPM adhesion of PPE items with the caring patterns of diaper change, washing body care, oral care, eating assistance, emotional support, and co-sleeping. The closest association was observed for CPM adhesion between oral care gloves and undershirts (correlation coefficient 0.67, p = 0.001). The mixed-effect model analysis indicated only a significant correlation between the PPE-wearing time index and emotional care (playing, cuddling, and physical contact) (p = 0.016). These results suggest that prolonged emotional support results in poor PPE protection, which increases the risk of exposure in family caregivers. Strict PPE care within 48 h after high-dose CPM controls the exposure to high-risk anticancer drugs in caregivers of pediatric patients.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"260 ","pages":"Article 114402"},"PeriodicalIF":6.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S143846392400083X/pdfft?md5=6de46dce1a6c5705c284fb968f6b88a7&pid=1-s2.0-S143846392400083X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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