International journal of hygiene and environmental health最新文献

{"title":"Estimation of BPA, BPS, and BPF exposure levels in the general Korean population using the physiologically-based toxicokinetic model and human urinary biomonitoring for risk assessment","authors":"Min-Ju Kim ,&nbsp;Yong-Kook Kwon ,&nbsp;Hyung-Jun Kim ,&nbsp;Dong-Gyun Han ,&nbsp;In-Soo Yoon ,&nbsp;Seungyoung Park ,&nbsp;Gunyoung Lee ,&nbsp;Hye Young Lee","doi":"10.1016/j.ijheh.2025.114623","DOIUrl":"10.1016/j.ijheh.2025.114623","url":null,"abstract":"<div><div>Bisphenol A (BPA) is a well-known endocrine disruptor, and its risk levels are regulated by various authorities. In response to regulatory policies, industrial substitutes for BPA, such as bisphenol S (BPS) and bisphenol F (BPF), have been introduced, raising concerns about their potential toxicity. Owing to the limited information on these new alternatives, using only traditional scenario-based risk assessments is insufficient. The use of human biomonitoring (HBM) data with physiologically based toxicokinetic (PBTK) models has increased. We estimated exposure to BPA, BPS, and BPF among Koreans using HBM (2015–2020) from the Korea National Environmental Health Survey (KoNEHS) and PBTK models. BPA model parameters were adjusted based on clinical evidence to enhance accuracy. We estimated external exposure to BPA and substitutes BPS and BPF using HBM data and PBTK model. Risk assessment used HbGV and POD values. Trends in BP exposure among Koreans from 2015 to 2020 were identified through HBM data. Risk characterization used exposure estimation by reverse dosimetry. BPA levels decreased by 43.8 % from 16.2 to 9.2 ng/kg BW/day in the population. BPS exposure increased 2.3-fold (0.52 → 1.23 ng/kg BW/day) in Cycle 4 compared to Cycle 3 (2018–2020). BPF levels showed a decreasing trend but doubled in the 13–18 age group, emphasizing monitoring needs. The risk concerns for BPA, BPS, and BPF in the Korean population were low, with all three within safe exposure limits. The changes in BP exposure were influenced by regulations, and exposure estimation using HBM-based PBTK modeling effectively evaluates regulatory impact.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114623"},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Municipal sewage as a pathway for multidrug-resistant KPC-producing Klebsiella pneumoniae from hospital effluent to urban stream: challenges for wastewater management","authors":"Guilherme Sgobbi Zagui ,&nbsp;Natália Columbaro Moreira ,&nbsp;Joseane Cristina Ferreira ,&nbsp;Marília Vasconcellos Agnesini ,&nbsp;Patrícia Orlandi Barth ,&nbsp;Afonso Luís Barth ,&nbsp;Ana Lúcia Costa Darini ,&nbsp;Leonardo Neves Andrade ,&nbsp;Susana Inés Segura-Muñoz","doi":"10.1016/j.ijheh.2025.114640","DOIUrl":"10.1016/j.ijheh.2025.114640","url":null,"abstract":"<div><div>Carbapenemase-producing <em>Klebsiella pneumoniae</em> is among the mainly reasons for death from bacterial infection associated with antibiotic resistance. Its widespread dissemination, especially due to KPC enzyme, is one of the main challenges in One Health perspective. Here, we studied 42 KPC-producing <em>K. pneumoniae</em> isolates from hospital wastewater, municipal wastewater from wastewater treatment plant (WWTP), and urban stream which receives treated municipal effluent. The isolates presented broad resistance to β-lactams antibiotics, as well as to fluoroquinolones, and show antibiotic resistance profile very similar, even those from out-of-hospital settings. Along to <em>bla</em>_KPC gene, <em>bla</em>_CTX-M-1 (33,3 %, <em>n</em> = 14), <em>bla</em>_CTX-M-8 (19 %, <em>n</em> = 8), <em>qnrB</em> (52,3 %, <em>n</em> = 22), <em>qnrS</em> (2,38 %, <em>n</em> = 1), and <em>rmtB</em> (19 %, <em>n</em> = 8) were detected. There was a predominance of gene that confers tolerance to silver and copper metals, as well as to virulence factor related to enterobactin and colibactin production. Macrorestriction genomic analysis by <em>Xba</em>I enzyme demonstrated several pulsotype, but some ones are related. Isolates from hospital wastewater were detected after 4 months at the same sampling point, as well as similar to those detected in WWTP and urban stream demonstrating the effluents role as spreaders of antibiotic resistance. This study provides data on the characterization of KPC-producing <em>K. pneumoniae</em>, which contributes to the epidemiological characterization of human pathogens transmitted by aquatic matrices. In view of the universal sanitation and control of antimicrobial resistance in the One Health perspective, greater investment in effluent treatment is necessary to avoid contamination and environmental dissemination of antibiotic-resistant bacteria.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114640"},"PeriodicalIF":4.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of urban residential environment and biological agents on childhood allergic diseases: Insights from the Greater Taipei area","authors":"Yohane V.A. Phiri ,&nbsp;Yi-Hua Chen ,&nbsp;Ming-Lun Zou ,&nbsp;Gary Adamkiewicz ,&nbsp;Chuen-Bin Jiang ,&nbsp;Chih-Da Wu ,&nbsp;Shih-Chun Candice Lung ,&nbsp;Ling-Chu Chien ,&nbsp;Hsing Jasmine Chao ,&nbsp;John D. Spengler ,&nbsp;Francine Laden","doi":"10.1016/j.ijheh.2025.114626","DOIUrl":"10.1016/j.ijheh.2025.114626","url":null,"abstract":"<div><div>Pediatric allergic diseases pose a significant global public health concern, with environmental factors playing a crucial role in their development. Investigating these determinants, particularly during early childhood, is crucial. This study, part of the Longitudinal Examination Across Prenatal and Postnatal Health in Taiwan (LEAPP-HIT) project, focused on children under 5 years old in the Greater Taipei Area. We collected data on household environments, and children's medical histories related to allergic diseases using standardized questionnaires. Additionally, we examined outdoor factors such as air pollution, land use, and points of interest. Indoor environmental sampling assessed concentrations of air pollutants, microbes, and allergens. Using logistic regression, we analyzed the relationships between indoor and outdoor environmental factors and allergic diseases in 136 children. Our findings revealed that the acquisition of new furniture and less frequent household cleaning were positively associated with allergic rhinitis and eczema, respectively. Using carpets, moldy odors in bedrooms, and Der f 1 concentrations in bed dust were significantly correlated with an increased risk of allergic conjunctivitis. Furthermore, exposure to ambient particulate matter with an aerodynamic diameter of ≤10μm and the presence of certain points of interest (e.g., night markets and restaurants) significantly impacted the occurrence of allergic rhinitis, conjunctivitis, and eczema. These results underscore the complexity of allergic disease development in children and highlight the importance of considering both clean home environments and ambient environmental characteristics when providing public health guidance to families affected by allergic diseases.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114626"},"PeriodicalIF":4.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bioadditive effectiveness at reducing sludge accumulation and E. coli in latrine systems in informal settlements in Lebanon","authors":"Marine Ricau ,&nbsp;Mayssam Nasser ,&nbsp;Nour Ghuneim ,&nbsp;Rida Jomaa ,&nbsp;Baptiste Lecuyot ,&nbsp;Daniele Lantagne","doi":"10.1016/j.ijheh.2025.114639","DOIUrl":"10.1016/j.ijheh.2025.114639","url":null,"abstract":"<div><div>As protracted humanitarian emergencies are increasing, effective fecal sludge management solutions are needed to prevent disease spread. One fecal sludge management solution often promoted is adding bioadditives to reduce fecal sludge volume. However, scientific evidence documenting bioadditive effectiveness is weak. In this study, we evaluated the effectiveness of Sanipit® bioadditive in latrine containment systems in Syrian informal settlements in Lebanon with and without bioadditive. Systems were connected to flush latrines, and were three watertight holding tanks and a soak pit in series. Each week for 28 weeks, we measured sludge volume, <em>E. coli</em> concentration, and odor/fly presence in systems with and without bioadditives. Monthly, we conducted household surveys. Data from 21 systems were analyzed, with no statistical differences in sludge volume and <em>E. coli</em> concentration between systems (p &gt; 0.05), and &lt;12 % difference in reporting ‘no odor’. We found Sanipit® bioadditive had no significant influence on sludge accumulation, <em>E. coli</em> concentration, or odor. Additionally, due to flooding and/or maintenance needs, only four systems remained operational throughout the 28-week study. Our work highlights the difficulties in conducting programs and research in protracted humanitarian contexts, and the need to focus on improved design, construction, and operation of sanitation infrastructure and services in protracted humanitarian settings.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114639"},"PeriodicalIF":4.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greenness exposure mitigate PM2.5-associated congenital heart defects in China: A mediation analysis of chemical composition and seasonal-spatial vulnerability","authors":"Die Li ,&nbsp;Tiezheng Li ,&nbsp;Yunyan Wang ,&nbsp;Feixia Pan ,&nbsp;Jiajia Chen ,&nbsp;Jinghua Ruan ,&nbsp;Weize Xu","doi":"10.1016/j.ijheh.2025.114624","DOIUrl":"10.1016/j.ijheh.2025.114624","url":null,"abstract":"<div><div>While prenatal PM_2.5 exposure constitutes an established risk factor for congenital heart defects (CHDs), the modifying role of greenness exposure in this association remains underexplored. We conducted a retrospective cohort study analyzed 1,356,420 birth records (11,803 CHD cases) from Zhejiang Province, China (2018–2023). Prenatal exposure to PM₂.₅ and its major constituents was estimated using satellite-derived speciation models, and greenness was assessed via the normalized difference vegetation index (NDVI). Generalized additive models (GAMs) with a quasibinomial logit link and restricted maximum likelihood were used to model non-linear associations and interactions. Mixture effects and joint exposure–response surfaces were estimated using fast Bayesian kernel machine regression (fbKMR). Causal mediation analysis under a counterfactual framework was used to assess indirect effects of PM₂.₅ in the greenness–CHD relationship. We identified predominantly J-shaped exposure–response relationships between key PM₂.₅ constituents and CHD risk, with organic matter (OM) and black carbon (BC) exhibiting the steepest risk increases. Mixture modeling via fbKMR revealed a monotonic increase in CHD risk with joint pollutant exposure. NDVI showed a robust U-shaped association with CHDs, with lowest risk at moderate greenness. Seasonal analysis highlighted strong BC and OM effects in autumn and winter, sulfate in spring and winter, and a threshold pattern for ammonium in summer. Spatial heterogeneity was evident, with eastern coastal cities (e.g., Ningbo, Jiaxing) showing pronounced risk increases above 35 μg/m³. Septal-type CHDs exhibited consistent positive associations with PM₂.₅, while complex subtypes showed weaker patterns. Mediation analysis indicated that PM₂.₅ accounted for 5.6–15.7 % of the greenness–CHD association, with BC showing the strongest mediation effect. Our findings underscore the cumulative toxicity of PM₂.₅ mixtures and the protective yet nonlinear role of greenness. Region- and season-specific strategies that integrate pollution control and green infrastructure may help mitigate CHD risk.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114624"},"PeriodicalIF":4.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive interaction of maternal early pregnancy exposure to particulate matter and residential greenness on congenital heart disease in the Offspring: Mediation of DNA methylation in placental tissue","authors":"Honglu Zhang ,&nbsp;Lei Pan ,&nbsp;Chengjie Pan ,&nbsp;Zhao Ma ,&nbsp;Hongyue Sun ,&nbsp;Zinuo Wang ,&nbsp;Wei Gao ,&nbsp;Yiqing Wang ,&nbsp;Weiqin Li ,&nbsp;Ying Chang ,&nbsp;Wen Li ,&nbsp;Wei Zhang ,&nbsp;Zhiyu Wang ,&nbsp;Qiang Zhang ,&nbsp;Xueli Yang ,&nbsp;Jing Wei ,&nbsp;Nai-jun Tang ,&nbsp;Junhong Leng","doi":"10.1016/j.ijheh.2025.114625","DOIUrl":"10.1016/j.ijheh.2025.114625","url":null,"abstract":"<div><div>We aim to assess the interactive effect of greenness with particulate matter(PM) on congenital heart disease(CHD), and estimate the mediation of DNA methylation in PM on CHD. A case-control study of 1540 CHD mother-child pairs and one-to-one, age±2 years and gravidity-matched controls was organized in Tianjin, China during 2018–2021. And we further collected placental tissue(30 CHD mother-child pairs and 30 controls). We calculated maternal average PM and normalized difference vegetation index(NDVI) exposure at 3–8 gestation weeks. Conditional logistic regressions were performed to test associations between PM and NDVI, and CHD. Additive interactions were used to examine interactive effects of PM and NDVI on CHD. Quantile-based g-computation was performed to identify the main contributors. We further estimated the mediation of DNA methylation in PM on CHD. High PM exposure at 3–8 weeks of gestation increased CHD risk, whereas high NDVI decreased CHD risk. Low NDVI greatly enhanced the OR(95 % CI) of PM₁≥vs.&lt;25 μg/m³ exposure for CHD from 4.479(2.933,6.841) to 7.335(4.888,11.006). Similar results were found in the additive interaction of NDVI with PM_2.5 and PM₁₀. PM_2.5 mixture(OR: 2.022, 95 % CI: 1.788,2.289) increased CHD risk and sulfate(SO₄²⁻) was the main contributor(weight = 0.533). After further adjusting for methylation level of cg13438944/cg12145624 in addition to PM₁/SO₄²⁻ on CHD, the effects of PM₁(OR:1.120, 95 % CI: 0.989, 1.269) and SO₄²⁻(OR:1.530, 95 % CI: 0.992, 2.362) on CHD were no longer significant, indicating DNA methylation potentially might mediate the effect of PM on CHD. We recommend strict control of PM, especially SO₄²⁻, and increase residential greenness.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114625"},"PeriodicalIF":4.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal exposure to ambient air pollution and risk of congenital heart defects in offspring: A population-based cohort study in Wuhan, China","authors":"Dan Zhang ,&nbsp;Yu Zhang ,&nbsp;Huan Feng ,&nbsp;Liu Nie,&nbsp;Yifan Yang,&nbsp;Xin Wang,&nbsp;Yafei Tan","doi":"10.1016/j.ijheh.2025.114627","DOIUrl":"10.1016/j.ijheh.2025.114627","url":null,"abstract":"<div><h3>Background</h3><div>Existing evidence on maternal ambient air pollutants exposure during pregnancy and the risk of congenital heart defects (CHDs) and its subtypes in offspring is inconsistent, and few studies have focused on preconception exposure. The critical susceptibility window for air pollutants linked to CHDs remains poorly answered.</div></div><div><h3>Objective</h3><div>We aimed to explore whether maternal exposure to ambient air pollutants before and after conception were associated with the risk of CHDs and its subtypes, and determined the critical susceptibility windows and potential modifiers for air pollutants exposure on CHDs.</div></div><div><h3>Methods</h3><div>We conducted a population-based cohort through the Wuhan Maternal and Child Health Management Information System in Wuhan, China, and heart defects data and daily air pollutants concentrations were collected from 2011 to 2017. Individual exposure concentrations of air pollutants were estimated through the inverse distance weighted method. The associations between maternal air pollutants exposure and the risk of CHDs were evaluated using logistic regression models with controlling for covariates.</div></div><div><h3>Results</h3><div>A total of 510,857 infants participated, with 1055 diagnosed with CHDs. Maternal exposure to PM_2.5 in the three months before conception (OR = 1.022, 95 % CI: 1.004–1.039), second and third month of conception (OR = 1.042, 95 % CI: 1.024–1.060; OR = 1.039, 95 % CI: 1.021–1.057, separately) were significantly related to CHDs. The associations of PM_2.5 exposure with CHDs were modified by maternal parity and infant sex. For CHD subtypes, we observed the positively relationships between PM_2.5 exposure and ventricular septal defect and tetralogy of Fallot. No significant association between exposure to SO₂, NO₂, CO, and O₃ and the risk of CHDs and its subtypes was observed. The second month of conception might be the potential critical susceptibility window of air pollutants with CHDs.</div></div><div><h3>Conclusion</h3><div>Our findings have revealed that maternal exposure to PM_2.5 before and after conception increased the risk of CHDs and its subtypes in offspring, as well as identified the modifications of individual characteristics and potential critical susceptibility windows. These results provide potential evidence for improving air quality and focusing on individual characteristics to prevent CHDs.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114627"},"PeriodicalIF":4.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying differences in U.S. exposure to ubiquitous carcinogens","authors":"Adam Theising,&nbsp;Tina Bardot ,&nbsp;Ann Wolverton","doi":"10.1016/j.ijheh.2025.114611","DOIUrl":"10.1016/j.ijheh.2025.114611","url":null,"abstract":"<div><div>Cancer is a leading cause of death in the United States, and substantial race-, ethnicity-, sex-, and income-based differences in cancer incidence and mortality persist despite declining overall trends. Underlying differences in exposure to carcinogenic chemicals are often cited as a contributing factor to persistent differences in the incidence of certain cancer types. In this exploratory analysis, we construct a novel database of actual or potential exposure to ubiquitous carcinogenic chemicals based on nationally-representative biomonitoring and environmental data to produce demographically-differentiated exposure statistics, where possible. Despite major data gaps – one or more measures of direct or indirect exposure were available for only 37% of these 622 carcinogens – our results show evidence of notable differences in exposure for at least 28 carcinogens. We also review readily-available information on associated exposure pathways and cancer types for carcinogens with differences in exposure to identify common pathways through which households may be exposed, and explore correlations between relative exposure levels and cancer incidence rates. We end the paper with a discussion of key data gaps and limitations that future data gathering and research could address.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"269 ","pages":"Article 114611"},"PeriodicalIF":4.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First application of enterophages for monitoring faecal pollution in the temperate Baltic region of Northern Poland","authors":"Agata Jurczak-Kurek ,&nbsp;Joanna Całkiewicz ,&nbsp;Ewa Kotlarska","doi":"10.1016/j.ijheh.2025.114622","DOIUrl":"10.1016/j.ijheh.2025.114622","url":null,"abstract":"<div><div>This study investigates the abundance of enterophages, a novel faecal indicator, in raw and treated sewage at two Wastewater Treatment Plants (WWTPs) in Pomerania, Poland, serving a population of 1.2 million inhabitants. Using the ISO-standardized double agar layer (DAL) method, we compared enterophages with other biological indicators, including coliphages, <em>Escherichia coli</em>, and enterococci. We observed that, although enterophages were present, they formed smaller plaques than coliphages, which complicated detection. Despite this, the study identified a strong presence of <em>E. coli</em> in both raw and treated wastewater, with lower concentrations of enterophages, consistent with other global studies. Enterophages were found to be less abundant than bacterial indicators and coliphages, suggesting a potentially more specific human source. The concentration of enterophages in treated sewage decreased significantly, supporting their potential as indicators of untreated sewage contamination in water bodies. Our results also revealed that enterophages counts in raw sewage were higher than those reported in tropical regions, possibly due to differences in methodology and bacterial strains used. Furthermore, correlation analyses indicated that microbial indicators in raw sewage were linked with chemical parameters such as temperature and orthophosphates, which may influence their presence. The study concludes that while enterophages are viable alternative faecal indicators, their low abundance in treated wastewater highlights the need for further research, including survivability studies and the development of molecular detection methods. This research contributes to the understanding of enterophages in temperate climates and underscores the importance of regional collaboration in optimizing faecal contamination monitoring methodologies.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"268 ","pages":"Article 114622"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans among population living in a contaminated area in Lausanne, Switzerland","authors":"Christelle Oltramare ,&nbsp;David Vernez ,&nbsp;Valentin Rousson ,&nbsp;Markus Zennegg ,&nbsp;Yves Henchoz ,&nbsp;Murielle Bochud ,&nbsp;Aurélie Berthet","doi":"10.1016/j.ijheh.2025.114619","DOIUrl":"10.1016/j.ijheh.2025.114619","url":null,"abstract":"<div><div>Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) are ubiquitous in the environment and the main route of exposure for humans is food. A widespread soil contamination was discovered in 2021 in Lausanne city. Previous human exposure assessment study showed that consumption of home-produced eggs and cucurbits were dominant exposure scenarios. In the absence of recent biomonitoring data on PCDD/Fs in the Swiss general population, we conducted a cross-sectional study in 2023 to assess the difference between control (n = 50) and exposed (n = 51) groups, living in the contaminated area and reporting to consume selected home-produced foods (eggs and cucurbits). We compared the two groups using multivariable modelling. The geometric mean serum PCDD/Fs concentration was 6.1 (Interquartile range (IQR): 4.2) and 6.9 (IQR: 5.0) pg TEQ₀₅/g lipid in the control and exposed groups, respectively. In the exposed group, the serum concentrations were 7.7 (IQR: 4.6) and 6.4 (IQR: 3.8) pg TEQ₀₅/g lipid for those who consumed home-produced eggs or cucurbit, respectively. In unadjusted analysis, control and exposed groups did not significantly differ. However, multivariable analyses showed that older age, female sex, higher body fat mass and consumption of home-produced eggs from contaminated areas were independently and significantly associated with higher PCDD/F concentrations. Health risk for humans living on contaminated areas depends on the land use. These results confirm the importance of dietary factors of animal origin as an important route of PCDD/Fs exposure. Unlike cucurbits, home-produced eggs from contaminated areas represent an important source of exposure to PCDD/Fs, which helps guiding public health recommendations.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"268 ","pages":"Article 114619"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}