International journal of hygiene and environmental health最新文献

{"title":"Association between ambient air pollution a week prior to delivery and preterm birth using a nationwide study in Sweden","authors":"Nabeel Aziz ,&nbsp;Massimo Stafoggia ,&nbsp;Olof Stephansson ,&nbsp;Nathalie Roos ,&nbsp;Sari Kovats ,&nbsp;Matthew Chersich ,&nbsp;Veronique Filippi ,&nbsp;Cherie Part ,&nbsp;Britt Nakstad ,&nbsp;Shakoor Hajat ,&nbsp;Petter Ljungman ,&nbsp;Jeroen de Bont","doi":"10.1016/j.ijheh.2024.114443","DOIUrl":"10.1016/j.ijheh.2024.114443","url":null,"abstract":"<div><h3>Background</h3><p>Air pollution exposure has been linked with increased risk of preterm birth, which is one of the leading causes of infant mortality. Limited studies have attempted to explore these associations in low-polluted areas. In this study, we aimed to assess the association between short-term exposure to ambient air pollution and preterm birth in Sweden.</p></div><div><h3>Method</h3><p>In this population-based study we included preterm births between 2014 and 2019 from the Swedish Pregnancy Register. We applied a spatiotemporal model to estimate daily levels of particulate matter &lt;2.5 μm (PM_2.5), PM &lt; 10 μm (PM₁₀), nitrogen dioxide (NO_2), and ozone (O₃) at the residential address of each participant. We applied a time-stratified case-crossover design with conditional logistic regression analysis to estimate odds ratios (OR) of preterm birth per 10 μg/m³ (PM₁₀, NO₂, O₃) and 5 μg/m³ (PM_2.5) increase in air pollution exposure at 0–6-day lag. Two-pollutant models were applied to evaluate the independent association of each exposure on preterm birth. We also stratified by maternal characteristics to identify potential effect modifiers.</p></div><div><h3>Results</h3><p>28,216 (4.5%) preterm births were included. An increase in O₃ exposure was associated with increased odds of preterm birth [OR = 1.06 per 10 μg/m³ (95% CI, 1.02; 1.10]. PM_2.5 and PM₁₀ were not significantly associated with preterm birth, and NO₂ displayed a negative nonlinear association with preterm birth. We did not observe any notable effect modification, but we found suggestive larger associations between O₃ and preterm birth when stratifying by male sex, spontaneous delivery, and spring season.</p></div><div><h3>Conclusions</h3><p>Increased O₃ exposure one week before delivery was associated with an increased risk of preterm birth in Sweden, a country with levels of air pollution below the current World Health Organization air quality guidelines. Increases in O₃ levels with climate change make these findings especially concerning.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S143846392400124X/pdfft?md5=d1da12df51d788611e737041cfbd83ea&pid=1-s2.0-S143846392400124X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature, relative humidity and elderly type 2 diabetes mortality: A spatiotemporal analysis in Shandong, China","authors":"Wenxiu Zheng ,&nbsp;Jie Chu ,&nbsp;Hilary Bambrick ,&nbsp;Ning Wang ,&nbsp;Kerrie Mengersen ,&nbsp;Xiaolei Guo ,&nbsp;Wenbiao Hu","doi":"10.1016/j.ijheh.2024.114442","DOIUrl":"10.1016/j.ijheh.2024.114442","url":null,"abstract":"<div><h3>Background</h3><p>The mortality of type 2 diabetes mellitus (T2DM) can be affected by environmental factors. However, few studies have explored the effects of environmental factors across diverse regions over time. Given the vulnerability observed in the elderly group in previous research, this research applied Bayesian spatiotemporal models to assess the associations in the elderly group.</p></div><div><h3>Methods</h3><p>Data on T2DM death in the elderly group (aged over 60 years old) at the county level were collected from the National Death Surveillance System between 1^st January 2013 and 31^st December 2019 in Shandong Province, China. A Bayesian spatiotemporal model was employed with the integrated Nested Laplace Approach to explore the associations between socio-environmental factors (i.e., temperatures, relative humidity, the Normalized Difference Vegetation Index (NDVI), particulate matter with a diameter of 2.5 μm or less (PM_2.5) and gross domestic product (GDP)) and T2DM mortality.</p></div><div><h3>Results</h3><p>T2DM mortality in the elderly group was found to be associated with temperature and relative humidity (i.e., temperature: Relative Risk (RR) = 1.41, 95% Credible Interval (CI): 1.27–1.56; relative humidity: RR = 1.05, 95% CI:1.03–1.06), while no significant associations were found with NDVI, PM_2.5 and GDP. In winter, significant impacts from temperature (RR = 1.18, 95% CI: 1.06–1.32) and relative humidity (RR = 0.94, 95% CI: 0.89–0.99) were found. Structured and unstructured spatial effects, temporal trends and space-time interactions were considered in the model.</p></div><div><h3>Conclusions</h3><p>Higher mean temperatures and relative humidities increased the risk of elderly T2DM mortality in Shandong Province. However, a higher humidity level decreased the T2DM mortality risk in winter in Shandong Province. This research indicated that the spatiotemporal method could be a useful tool to assess the impact of socio-environmental factors on health by combining the spatial and temporal effects.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001238/pdfft?md5=e0e2010b677afa38371b310fed9b3388&pid=1-s2.0-S1438463924001238-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141990840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconception mitochondrial DNA copy number plays a crucial role in linking prenatal air pollution with the risk of preterm birth","authors":"Qiuming Wang ,&nbsp;Yalong Wang ,&nbsp;Panpan Sun ,&nbsp;Yanan He ,&nbsp;Xi Yan ,&nbsp;Lifang Jiang ,&nbsp;Yuting Zeng ,&nbsp;Jingjing Wu ,&nbsp;Junxi Zhang ,&nbsp;CuiPing Wu ,&nbsp;Fangfang Yu ,&nbsp;Yue Ba ,&nbsp;Jian Chai ,&nbsp;Guoyu Zhou","doi":"10.1016/j.ijheh.2024.114441","DOIUrl":"10.1016/j.ijheh.2024.114441","url":null,"abstract":"<div><p>The relationship between maternal peripheral blood mitochondrial DNA and adverse pregnancy outcomes, specifically preterm birth (PTB), remains uncertain. To investigate the effects of preconception mitochondrial DNA copy number (mtDNAcn) on the association between prenatal air pollutants exposure and PTB risk, a total of 1871 expectant mothers from six regions in Henan Province were recruited. Information regarding air pollutants was obtained from 151 environmental monitoring sites, and relative mtDNAcn was evaluated using real-time PCR analysis. After adjusting for potential confounding variables, it was determined that the risk of PTB increased with elevated levels of inhalable particulate matter (PM₁₀), fine particulate matter (PM_2.5), sulfur dioxide (SO₂), carbon monoxide (CO) and ozone (O₃) exposure (<em>P</em> &lt; 0.05) but decreased with higher nitrogen dioxide (NO₂) exposure (0.05 &lt; <em>P</em> &lt; 0.10) during the entire pregnancy. Additionally, the preconception relative mtDNAcn was lower in the PTB group (0.82 ± 0.23) compared to the term group (0.92 ± 0.29). Furthermore, for each 0.1-unit increase in preconception mtDNAcn, the risk of PTB decreased by 14.8%. Stratified analyses revealed that the risk of PTB rose with increasing O₃ concentrations, regardless of the relative mtDNAcn. Moreover, the study found a significant association between PTB risk and prenatal exposure to elevated PM₁₀, PM_2.5, SO₂, and CO, particularly in mothers with low mtDNAcn (≤0.88) (<em>P</em> &lt; 0.05). Conversely, a decrease in the PTB risk was observed with elevated NO₂ exposure in mothers with high mtDNAcn (&gt;0.88). Interaction analysis revealed that exposure to PM₁₀, PM_2.5, SO₂, NO₂, and CO interacted with mtDNAcn, respectively, affecting PTB risk (<em>P</em>_-interaction&lt;0.05). These findings indicate a noteworthy association between PTB risk and prenatal air pollutants exposure, which is influenced by the preconception mtDNAcn.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical and haematological effects of serum PFOA, ADV and cC6O4 in workers of a chemical company producing fluoropolymers, Italy, 2013–2022","authors":"Dario Consonni ,&nbsp;Silvia Fustinoni","doi":"10.1016/j.ijheh.2024.114440","DOIUrl":"10.1016/j.ijheh.2024.114440","url":null,"abstract":"<div><h3>Introduction</h3><p>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in the manufacture of fluoropolymers. We evaluated biochemical and haematological effects of three PFAS, serum perfluorooctanoic acid (PFOA), ADV, and cC₆O₄ in workers of a fluoropolymer company.</p></div><div><h3>Methods</h3><p>Using data (2013–2022), we fitted random intercept regression models adjusted for several covariates and reciprocal adjustment between the three PFAS.</p></div><div><h3>Results</h3><p>We analysed data of 814 workers (698 men, 116 women), 607 from the chemical plant, 207 from the research centre, for a total of 4912 blood samples (2065 with all three PFAS measured). Median levels of PFOA and ADV were 21.3 and 120 μg/L. Most (65.5%) cC₆O₄ measurements were below the limits of quantification (which varied over time from 5 to 0.1 μg/L). For PFOA, we observed positive associations with total cholesterol (+1.1% increase per ln(PFOA) increase) and apolipoprotein B (+1.4%) and negative associations with alkaline phosphatase (−1.5%); suggestive associations were also found with RBC (−0.4%), IgA (−1.5%), IgM (−1.4%). ADV was positively associated with total and LDL cholesterol (+1.0% and +1.6% per ln(ADV) increase), apolipoprotein B (+1.0%), GGT (+2.1%), IgM (+1.4%), and WBC (+1.5%) and negatively associated with direct bilirubin (−2.3%) and alpha-2-globulins (−0.7%); suggestive associations were found for indirect bilirubin (−2.0%), oestradiol (−2.1%), ad CRP (+6.0%). For samples with detectable cC₆O₄ levels we observed higher values of ALP (+2.3%), proteins (+0.5%), IgG (+0.7%) and platelets (+1.6%) and suggestively increased total bilirubin (+3.9%), RBC (+0.6%), and oestradiol (+5.8%). Some associations (total cholesterol, apolipoprotein B, WBC, total bilirubin, and alkaline phosphatase showed reverse time trends in parallel with the strong decrease of serum PFOA and ADV over the study period.</p></div><div><h3>Discussion</h3><p>We found associations of serum PFOA and ADV with lipid metabolism, liver function, and immunoglobulins. The reverse time trends of some endpoints in parallel with decrease of serum PFOA and ADV reinforce causal interpretation of results. cC₆O₄ showed a different pattern of associations.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001214/pdfft?md5=35d89cad3fdc9c42db718226eb561b2b&pid=1-s2.0-S1438463924001214-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between air temperature and self-perceived health status in Southern Germany: Results from KORA FIT study","authors":"Hasan Sohail ,&nbsp;Siqi Zhang ,&nbsp;Ute Kraus ,&nbsp;Santtu Mikkonen ,&nbsp;Susanne Breitner ,&nbsp;Kathrin Wolf ,&nbsp;Nikolaos Nikolaou ,&nbsp;Annette Peters ,&nbsp;Timo Lanki ,&nbsp;Alexandra Schneider","doi":"10.1016/j.ijheh.2024.114431","DOIUrl":"10.1016/j.ijheh.2024.114431","url":null,"abstract":"<div><h3>Background</h3><p>Short-term exposure to low and high air temperatures can cause serious harmful effects on human health. Existing literature has mostly focused on associations of ambient air temperature with mortality and the need for health care in population-level studies. Studies that have considered self-perceived health status as an outcome when examining the effects of air temperature on health are scarce. In this study, we explored the short-term association of daily mean air temperature with various measures of self-perceived health status.</p></div><div><h3>Methods</h3><p>This cross-sectional analysis is based on the Cooperative Health Research in the Region of Augsburg (KORA) FIT study conducted in 2018/2019 and included participants from the Augsburg region of Southern Germany. Health-related quality of life (HRQOL) was evaluated by using the 5-level EuroQol Five Dimension (EQ-5D-5L) questionnaire, including the EuroQol visual analog scale (EQ-VAS). Self-rated health (SRH) and comparative self-rated health (CSRH) were each assessed using a single question. Daily mean air temperature data was estimated using a spatiotemporal model and assigned to participants' home addresses at a resolution of 1 × 1 km. Regression models with a Distributed Lag Non-linear Modeling (DLNM) approach were used to investigate the associations between daily mean air temperature and self-perceived health measures.</p></div><div><h3>Results</h3><p>We found no association of heat or cold with the HRQOL, SRH or CSRH. Nevertheless, there was a significant protective association of low air temperature with the EQ-5D-5L dimension “usual activities.”</p></div><div><h3>Conclusion</h3><p>There was no evidence of daily mean air temperature adversely affecting participants' self-perceived health status.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Projections of mortality attributable to hot ambient temperatures in Cyprus under moderate and extreme climate change scenarios","authors":"Mingyue Ma ,&nbsp;Panayiotis Kouis ,&nbsp;Anderson Paulo Rudke ,&nbsp;Maria Athanasiadou ,&nbsp;Vasos Scoutellas ,&nbsp;Filippos Tymvios ,&nbsp;Kleanthis Nikolaidis ,&nbsp;Petros Koutrakis ,&nbsp;Panayiotis K. Yiallouros ,&nbsp;Barrak Alahmad","doi":"10.1016/j.ijheh.2024.114439","DOIUrl":"10.1016/j.ijheh.2024.114439","url":null,"abstract":"<div><h3>Background</h3><p>Heat-related mortality has become a growing public health concern in light of climate change. However, few studies have quantified the climate-attributable health burden in Cyprus, a recognized climate change hotspot. This study aims to estimate the heat-related mortality in Cyprus for all future decades in the 21st century under moderate (SSP2-4.5) and extreme (SSP5-8.5) climate scenarios.</p></div><div><h3>Methods</h3><p>We applied distributed lag non-linear models to estimate the baseline associations between temperature and mortality from 2004 to 2019 (data obtained from Department of Meteorology of the Ministry of Agriculture, Rural Development and Environment and the Health Monitoring Unit of the Cyprus Ministry of Health). The relationships were then extrapolated to future daily mean temperatures derived from downscaled global climate projections from General Circulation Models. Attributable number of deaths were calculated to determine the excess heat-related health burden compared to the baseline decade of 2000–2009 in the additive scale. The analysis process was repeated for all-cause, cardiovascular, and respiratory mortality and mortality among males, females, and adults younger or older than 65. We assumed a static population and demographic structure, no adaptation to hot temperatures over time, and did not evaluate potential interaction between temperature and humidity.</p></div><div><h3>Results</h3><p>Compared to 2000–2009, heat-related total mortality is projected to increase by 2.7% (95% empirical confidence interval: 0.6, 4.0) and 4.75% (2.2, 7.1) by the end of the century in the moderate and extreme climate scenarios, respectively. Cardiovascular disease is expected to be an important cause of heat-related death with projected increases of 3.4% (0.7, 5.1) and 6% (2.6, 9.0) by the end of the century. Reducing carbon emission to the moderate scenario can help avoid 75% of the predicted increase in all-cause heat-related mortality by the end of the century relative to the extreme scenario.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that climate change mitigation and sustainable adaptation strategies are crucial to reduce the anticipated heat-attributable health burden, particularly in Cyprus, where adaptation strategies such as air conditioning is nearing capacity.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinant Factors of Children's Blood Lead Levels in Java, Indonesia","authors":"Muchtaruddin Mansyur ,&nbsp;Dewi Yunia Fitriani ,&nbsp;Ari Prayogo ,&nbsp;Ade Mutiara ,&nbsp;Asep ,&nbsp;Ratih Fadhillah ,&nbsp;Rifka Aini ,&nbsp;Winda Widyaning Putri ,&nbsp;Sarah Edna Fadilah Ramadhani ,&nbsp;Agus Kharmayana Rubaya ,&nbsp;Sarjito Eko Windarso ,&nbsp;Herman Santjoko ,&nbsp;Sigid Sudaryanto ,&nbsp;Haryono ,&nbsp;Budi Susilorini ,&nbsp;Nickolaus Hariojati ,&nbsp;Alfonso Rodriguez ,&nbsp;Stephan Bose-O’Reilly","doi":"10.1016/j.ijheh.2024.114426","DOIUrl":"10.1016/j.ijheh.2024.114426","url":null,"abstract":"<div><h3>Introduction</h3><p>Lead poisoning contributes to a significant burden of disease as a toxic substance found in air, soil, and water. In Indonesia, the risk of exposure is high due to the inappropriate recycling of used lead batteries. The objective was to investigate the factors that influence lead levels in children's blood.</p></div><div><h3>Methods</h3><p>This cross-sectional study assessed blood lead levels (BLLs) in children aged 12–59 months in four communities exposed to used lead-acid batteries (ULABs) recycling activities, comparing them to a control area. The study employed a threshold level of 20 μg/dL to identify high BLLs and utilized a sample size of 324 children from exposed sites and 240 from control sites. Questionnaires, blood lead tests and a home-based assessment for environmental exposures were applied.</p></div><div><h3>Results</h3><p>The study participants comprised 295 boys and 269 girls, with an average age of 35 months. Significant disparities in soil lead concentrations median: Q1-Q3 were found between exposed (6581.7 : 2432.6–16647.1) ppm and control areas (253.5 : 158.8–417.1) ppm. Children in exposed areas had 3.9 times higher odds of BLL ≥20 μg/dL. Fathers with BLL ≥20 μg/dL had children with similarly elevated BLLs. Multivariate analysis identified socioeconomic status, study areas, environmental factors (cookware, food ware, spices, house cleaning), and children's behavior (breastfeeding duration) as determinants of elevated BLLs. Reported environmental factors had notable impact on BLLs, with aluminum cookware (aOR = 1.4, 95%CI [1.2–1.6]), food ware materials (aOR = 1.15, 95%CI [1.0–1.3]), type of spices (aOR = 2.7, 95%CI [1.7–48.0]), and house cleaning method (aOR = 2.9, 95%CI [1.2–7.1]).</p></div><div><h3>Conclusion</h3><p>This study highlighted key risk factors affecting children's blood lead levels (BLL) and emphasized the urgency of employing effective strategies to remediate lead-contaminated soils in exposed regions. The findings underscore the need for prompt medical intervention and monitoring for children in these areas, with additional research essential to fully understand lead poisoning pathways in the environment.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to endocrine disrupting chemicals including phthalates, phenols, and parabens in infancy: Associations with neurodevelopmental outcomes in the MARBLES study","authors":"Jennie Sotelo-Orozco ,&nbsp;Antonia M. Calafat ,&nbsp;Julianne Cook Botelho ,&nbsp;Rebecca J. Schmidt ,&nbsp;Irva Hertz-Picciotto ,&nbsp;Deborah H. Bennett","doi":"10.1016/j.ijheh.2024.114425","DOIUrl":"10.1016/j.ijheh.2024.114425","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Endocrine disrupting chemicals (EDCs) are widely used compounds with the potential to affect child neurodevelopmental outcomes including autism spectrum disorders (ASD). We aimed to examine the urinary concentrations of biomarkers of EDCs, including phthalates, phenols, and parabens, and investigate whether exposure during early infancy was associated with increased risk of later ASD or other non-typical development (Non-TD) or adverse cognitive development.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;This analysis included infants from the Markers of Autism Risks in Babies—Learning Early Signs (MARBLES) study, a high-risk ASD cohort (n = 148; corresponding to 188 urine samples). Thirty-two EDC biomarkers were quantified in urine among infants 3 and/or 6 months of age. Trends in EDC biomarker concentrations were calculated using least square geometric means. At 36 months of age, children were clinically classified as having ASD (n = 36), nontypical development (Non-TD; n = 18), or typical development (TD; n = 81) through a clinical evaluation. Trinomial logistic regression analysis was used to test the associations between biomarkers with ASD, or Non-TD, as compared to children with TD. In single analyte analysis, generalized estimating equations were used to investigate the association between each EDC biomarkers and longitudinal changes in cognitive development using the Mullen Scales of Early Learning (MSEL) over the four assessment time points (6, 12, 24, and 36 months of age). Additionally, quantile g-computation was used to test for a mixture effect.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;EDC biomarker concentrations generally decreased over the study period, except for mono-2-ethyl-5-carboxypentyl terephthalate. Overall, EDC biomarkers at 3 and/or 6 months of age were not associated with an increased risk of ASD or Non-TD, and a few showed significant inverse associations. However, when assessing longitudinal changes in MSEL scores over the four assessment time points, elevated monoethyl phthalate (MEP) was significantly associated with reduced scores in the composite score (β = −0.16, 95% CI: 0.31, −0.02) and subscales of fine motor skills (β = −0.09, 95%CI: 0.17, 0.00), and visual reception (β = −0.11, 95% CI: 0.23, 0.01). Additionally, the sum of metabolites of di (2-ethylhexyl) terephthalate (ƩDEHTP) was associated with poorer visual reception (β = −0.09, 95% CI: 0.16, −0.02), and decreased composite scores (β = −0.11, 95% CI: 0.21, −0.01). Mixtures analyses using quantile g-computation analysis did not show a significant association between mixtures of EDC biomarkers and MSEL subscales or composite scores.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;These findings highlight the potential importance of infant exposures on cognitive development. Future research can help further investigate whether early infant exposures are associated with longer-term deficits and place special attention on EDCs with increasing temporal trends and whe","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001068/pdfft?md5=35da1bc55dcd8e03c06894ad74e3ab80&pid=1-s2.0-S1438463924001068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological insights into neonatal deaths: The role of cooking fuel pollution in Colombia","authors":"Federico Andrade-Rivas ,&nbsp;Arnold Ikedichi Okpani ,&nbsp;Diego I. Lucumí ,&nbsp;Maria D. Castillo ,&nbsp;Mohammad Ehsanul Karim","doi":"10.1016/j.ijheh.2024.114429","DOIUrl":"10.1016/j.ijheh.2024.114429","url":null,"abstract":"<div><h3>Purpose</h3><p>Household air pollution is one of the leading causes of death and disease globally. Emerging evidence of elevated risk of neonatal death has been reported in Africa and South Asia. However, evidence on the extent of the problem in Latin America is limited despite the persistent use of highly polluting cooking fuels. We assessed whether the use of high-polluting household cooking fuels increases the risk of neonatal death compared to low-polluting fuels in Colombia.</p></div><div><h3>Methods</h3><p>We used cross-sectional data from the 2005–2015 Colombian Demographic Health Survey and performed a survey-featured multivariate logistic regression. We selected adjustment covariates based on a causal diagram, addressed missing data through multiple imputation, and conducted several sensitivity analysis, such as propensity score matching.</p></div><div><h3>Result</h3><p>We found evidence suggesting an increased risk of neonatal death in households using high-polluting fuels (OR: 1.48; 95% CI: 0.91, 2.39). The sensitivity analyses were consistent with the main analysis.</p></div><div><h3>Conclusion</h3><p>We observed increased odds of neonatal death associated with using high-polluting household cooking fuels compared to low-polluting fuels, although this association was not statistically significant. This study contributes evidence to a region where the issue is not yet a priority and should be included in national-level discussions and interventions that impact cooking fuel use patterns.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S143846392400110X/pdfft?md5=9a658a4fe051c393a8e2b177baaf2d64&pid=1-s2.0-S143846392400110X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality risk associated to arsenic exposure after a major disaster. Results from the Manfredonia occupational cohort study 1976–2021","authors":"R. Di Staso ,&nbsp;D. Wollschläger ,&nbsp;M. Blettner ,&nbsp;E. Gianicolo","doi":"10.1016/j.ijheh.2024.114428","DOIUrl":"10.1016/j.ijheh.2024.114428","url":null,"abstract":"<div><h3>Background</h3><p>On September 1976, due to the explosion of an ammonia-washing column at the petrochemical plant in Manfredonia (Italy), 39 tonnes of arsenic were released into the atmosphere, contaminating the plants and the neighbourhoods close to it. The aim of this study is to present the results of a 45-year follow up of exposed workers with a focus on residential exposure.</p></div><div><h3>Methods</h3><p>We contacted Italian General Registries Offices and updated the vital status of persons involved in the clean-up activities following the disaster. The outcome of interest was the overall and cause-specific mortality. An accelerated failure time (AFT) approach was used when appropriate to model the risk of mortality.</p></div><div><h3>Results</h3><p>1772 workers contributing 67,743 person years were considered in the analysis. For overall mortality, results of the age-adjusted AFT model show an accelerator factor of 0.89 (95%CI 0.80–0.99) among contract workers, which means a shortening of survival in comparison to the reference category (plastic area workers). When accounting for latency greater than 20 years, higher mortality rates for lung cancer were observed among workers residing in Manfredonia.</p></div><div><h3>Discussion</h3><p>An increased risk of mortality among workers who were more exposed to arsenic during the clean-up activities has been observed. In fact, a loss of 5 years of life among more exposed workers was calculated. Furthermore, the mortality rates of residents in Manfredonia were higher than those of workers residing elsewhere.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001093/pdfft?md5=00da5237136ef1c1406f4c44c862133e&pid=1-s2.0-S1438463924001093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}