Adrien A. Wilkie , Alison K. Krajewski , Fanny Njie , Kevin Park , Sarah Zelasky , Kristen M. Rappazzo , Thomas J. Luben
{"title":"Long-term exposure to criteria air pollutants and infant mortality: a systematic review and meta-analysis","authors":"Adrien A. Wilkie , Alison K. Krajewski , Fanny Njie , Kevin Park , Sarah Zelasky , Kristen M. Rappazzo , Thomas J. Luben","doi":"10.1016/j.ijheh.2025.114587","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>We conducted a systematic review/meta-analysis for epidemiologic evidence of the association between long-term criteria air pollution (nitrogen dioxide (NO<sub>2</sub>), sulfur dioxide (SO<sub>2</sub>), coarse particulate matter (PM<sub>10</sub>), fine particulate matter (PM<sub>2.5</sub>), ozone (O<sub>3</sub>), carbon monoxide (CO)) exposure and all-cause, respiratory, and sudden infant death syndrome (SIDS) infant mortality.</div></div><div><h3>Methods</h3><div>Studies were identified through PubMed/Web of Science databases using comprehensive search terms, then screened using predefined criteria. For studies eligible for inclusion in meta-analyses, we applied a systematic rubric for evaluating study quality across domains: participant selection, outcome, exposure, confounding, analysis, selective reporting, sensitivity, overall quality. When ≥3 eligible studies provided effect estimates, we performed meta-analyses to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI) for air pollutants and infant mortality.</div></div><div><h3>Results</h3><div>Of the 701 initial studies, we excluded 678 studies in the abstract screening and full text screening phases, leaving 23 studies for inclusion. Four studies included extractable effect estimates for PM<sub>10</sub> and seven for PM<sub>2.5</sub>. We could not conduct meta-analyses for CO, O<sub>3</sub>, NO<sub>2</sub>, or SO<sub>2</sub> because each had <3 eligible studies. The pooled OR (95% CI) for a 10-μg/m<sup>3</sup> increase in PM<sub>10</sub> concentration was 1.04 (1.02, 1.06) for all-cause, 1.11 (1.02, 1.21) for respiratory, and 1.05 (0.98, 1.13) for SIDS infant mortality. The pooled OR for a 5-μg/m<sup>3</sup> increase in PM<sub>2.5</sub> concentration was 1.02 (0.98, 1.05) for all-cause, 0.83 (0.30, 2.27) for respiratory, and 0.97 (0.88, 1.08) for SIDS infant mortality.</div></div><div><h3>Conclusions</h3><div>Long-term exposure to PM<sub>10</sub> is associated with all-cause and respiratory infant mortality across studies.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"267 ","pages":"Article 114587"},"PeriodicalIF":4.5000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of hygiene and environmental health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1438463925000690","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Aim
We conducted a systematic review/meta-analysis for epidemiologic evidence of the association between long-term criteria air pollution (nitrogen dioxide (NO2), sulfur dioxide (SO2), coarse particulate matter (PM10), fine particulate matter (PM2.5), ozone (O3), carbon monoxide (CO)) exposure and all-cause, respiratory, and sudden infant death syndrome (SIDS) infant mortality.
Methods
Studies were identified through PubMed/Web of Science databases using comprehensive search terms, then screened using predefined criteria. For studies eligible for inclusion in meta-analyses, we applied a systematic rubric for evaluating study quality across domains: participant selection, outcome, exposure, confounding, analysis, selective reporting, sensitivity, overall quality. When ≥3 eligible studies provided effect estimates, we performed meta-analyses to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI) for air pollutants and infant mortality.
Results
Of the 701 initial studies, we excluded 678 studies in the abstract screening and full text screening phases, leaving 23 studies for inclusion. Four studies included extractable effect estimates for PM10 and seven for PM2.5. We could not conduct meta-analyses for CO, O3, NO2, or SO2 because each had <3 eligible studies. The pooled OR (95% CI) for a 10-μg/m3 increase in PM10 concentration was 1.04 (1.02, 1.06) for all-cause, 1.11 (1.02, 1.21) for respiratory, and 1.05 (0.98, 1.13) for SIDS infant mortality. The pooled OR for a 5-μg/m3 increase in PM2.5 concentration was 1.02 (0.98, 1.05) for all-cause, 0.83 (0.30, 2.27) for respiratory, and 0.97 (0.88, 1.08) for SIDS infant mortality.
Conclusions
Long-term exposure to PM10 is associated with all-cause and respiratory infant mortality across studies.
期刊介绍:
The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.