International Journal of Critical Illness and Injury Science最新文献_第5页

A prospective observational study to correlate lung ultrasound with clinical severity and prognosis score in patients with primary pulmonary pathology on invasive ventilatory support. 一项前瞻性观察研究，旨在将接受有创呼吸支持的原发性肺部病变患者的肺部超声与临床严重程度和预后评分联系起来。

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_31_23

Sulagna Basu, Rishiraj Narayan Verma, Aditya Joshi, Deepak Dwivedi, Mohammad Abdul Mateen, Jagdeep Singh Bhatia

{"title":"A prospective observational study to correlate lung ultrasound with clinical severity and prognosis score in patients with primary pulmonary pathology on invasive ventilatory support.","authors":"Sulagna Basu, Rishiraj Narayan Verma, Aditya Joshi, Deepak Dwivedi, Mohammad Abdul Mateen, Jagdeep Singh Bhatia","doi":"10.4103/ijciis.ijciis_31_23","DOIUrl":"10.4103/ijciis.ijciis_31_23","url":null,"abstract":"Background: Lung ultrasound (LUS) is a known imaging modality employed for monitoring patients in an intensive care unit. This study evaluates, LUS in assessing disease severity and prognosis, by correlating its score with the three commonly used clinical severity scoring systems (CSSS), namely, sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation (APACHE) II score, and simplified acute physiology score (SAPS) II.Methods: This single-center prospective observational study included 54 adult patients of primary lung disease-induced acute respiratory distress syndrome (ARDS), on invasive ventilation. The primary objective was to correlate LUS score with SOFA score. Secondary objectives were to correlate LUS score with APACHE II and SAPS II scores. LUS score was also correlated with the estimated mortality derived from the above-mentioned scores. A subgroup analysis on COVID-19-positive cases was also carried out. All scores were calculated on the initiation of mechanical ventilation, daily for 7 days or mortality, whichever was earlier.Results: A significant positive correlation (P < 0.001) was found between LUS and all three severity scores, as well as their corresponding estimated mortality percentages, for all days of the study period, in both non-COVID-19 ARDS patients and in COVID-19 patients. The merit of all four scores in differentiating between the survivor and mortality group for the duration of study also showed significant (P < 0.05) to very significant (P < 0.001) results.Conclusion: Point-of-care LUS in conjunction with CSSS is a reliable tool for assessing the severity and progression of primary lung disease.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"151-158"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective analysis of the 5-year trends of antimicrobial resistance in gram-negative bacterial isolates from an intensive care unit at a tertiary care hospital. 对一家三甲医院重症监护室革兰氏阴性细菌分离物抗菌药耐药性 5 年趋势的回顾性分析。

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_30_23

Nikhil Raj, Jyotsna Agarwal, Vikramjeet Singh, Soumya Sankar Nath, Anupam Das, Manodeep Sen

{"title":"A retrospective analysis of the 5-year trends of antimicrobial resistance in gram-negative bacterial isolates from an intensive care unit at a tertiary care hospital.","authors":"Nikhil Raj, Jyotsna Agarwal, Vikramjeet Singh, Soumya Sankar Nath, Anupam Das, Manodeep Sen","doi":"10.4103/ijciis.ijciis_30_23","DOIUrl":"10.4103/ijciis.ijciis_30_23","url":null,"abstract":"Background: Intensive care units (ICUs) in developing countries constitute a high risk for patients acquiring infection by multidrug-resistant organisms (MDROs). The rise in antimicrobial resistance (AMR) threatens the effective prevention and treatment of an increasing range of infections. The present study analyzed the local trends of AMR in Gram-negative isolates of ICU patients from a tertiary care facility in North India.Methods: This retrospective study was conducted over 5 years (January 2018-December 2022). All bacterial isolates from patients admitted to ICU during the study period were included in the study, and their AMR pattern was analyzed. In addition, sensitivity trends of different antimicrobials against the common Gram-negative bacteria were analyzed, and AMR trends were analyzed over the study period.Results: Klebsiella spp. was the most common isolate in samples received from ICU. A rise of carbapenem-resistant microorganisms was observed over the study period. Escherichia coli and Klebsiella spp. showed around 10% and a 17% decrease in susceptibility to carbapenems, respectively. In contrast, a marked 29% decrease in sensitivity to carbapenems was observed in Acinetobacter spp.Conclusion: The inception of integrated stewardship measures has shown a rising trend in susceptibility and is the need of the hour to prevent the spread of MDROs. Surveillance studies help us understand the impact of AMR in hospitals and help plan prevention programs.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"178-183"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical utility of i-gel^® and BlockBuster™ supraglottic devices for airway management in postburn injury contracture neck patients under general anesthesia: A randomized controlled trial. i-gel® 和 BlockBuster™ 声门上装置对全身麻醉下烧伤后挛缩颈部患者气道管理的临床实用性：随机对照试验。

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_35_23

Manish Kumar Tripathi, Tanmay Tiwari, Bhavya Naithani, Divya Narain Upadhyaya, Prem Raj Singh, Ila Tripathi

{"title":"Clinical utility of i-gel® and BlockBuster™ supraglottic devices for airway management in postburn injury contracture neck patients under general anesthesia: A randomized controlled trial.","authors":"Manish Kumar Tripathi, Tanmay Tiwari, Bhavya Naithani, Divya Narain Upadhyaya, Prem Raj Singh, Ila Tripathi","doi":"10.4103/ijciis.ijciis_35_23","DOIUrl":"10.4103/ijciis.ijciis_35_23","url":null,"abstract":"Background: Post burn injury contracture (PBC) neck patients pose a unique challenge for the anesthesiologists. The use of supraglottic device (SGDs) for managing such patients is being increasingly used. We compared i-gel® and LMA BlockBuster™ in PBC adult patients under general anesthesia (GA).Methods: The study included 63 subjects with mild/moderate PBC neck of either sex with American Society of Anesthesiologists Physical Status I and II under GA. Patients with intraoral pathology, mouth opening <2.5 cm, and severe contracture were excluded. Patients were randomly assigned to i-gel® (I) and BlockBuster™ (B) groups. The primary objective of the study was the time for successful insertion. First attempt success rate, oropharyngeal leak pressures (OLP), and complications were also assessed.Results: Mean insertion time was significantly less in Group I as compared to Group B (17.35 ± 1.43 vs. 21.32 ± 1.10 s; P < 0.001), OLP in Group B was significantly higher as compared to Group I (34.03 ± 1.33 vs. 25.23 ± 3.04 cm of H2O; P < 0.001). Group I was found to be statistically easier to insert as compared to Group B (P = 0.011) with reduced requirement of airway maneuvering to insert the device (P = 0.017). Groups were similar in terms of complications.Conclusion: SGDs are attractive option for airway management in mild/moderate degree of PBC neck. i-gel® having shorter insertion time with easier insertion can be favorable at times of emergency while use of LMA BlockBuster™ can be preferred to reduce the risk of aspiration owing to higher OLP.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posterior reversible encephalopathy syndrome secondary to malignancy-associated hypercalcemia: A case report. 继发于恶性肿瘤相关性高钙血症的后可逆性脑病综合征：病例报告。

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_8_23

Mansoor C Abdulla

引用次数: 0

A narrative review on tofacitinib: The properties, function, and usefulness to treat coronavirus disease 2019. 关于托法替尼的叙述性综述：特性、功能和治疗冠状病毒疾病的实用性 2019.

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_27_23

Seyed Mohammad Reza Hashemian, Tayebeh Farhadi

{"title":"A narrative review on tofacitinib: The properties, function, and usefulness to treat coronavirus disease 2019.","authors":"Seyed Mohammad Reza Hashemian, Tayebeh Farhadi","doi":"10.4103/ijciis.ijciis_27_23","DOIUrl":"10.4103/ijciis.ijciis_27_23","url":null,"abstract":"In coronavirus disease 2019 (COVID-19), the formation of cytokine storm may have a role in worsening of the disease. By attaching the cytokines like interleukin-6 to the cytokine receptors on a cell surface, Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway will be activated in the cytoplasm lead to hyperinflammatory conditions and acute respiratory distress syndrome. Inhibition of JAK/STAT pathway may be useful to prevent the formation of cytokine storm. Tofacitinib is a pan inhibitor of JAKs. In this review, the main characteristics of tofacitinib and its usefulness against COVID-19 pneumonia were reviewed. Tofacitinib may be a hopeful therapeutic candidate against COVID-19 respiratory injury since it inhibits a range of inflammatory pathways. Hence, the agent may be considered a potential therapeutic against the post-COVID-19 respiratory damage. Compared to other JAK inhibitors (JAKi), the administration of tofacitinib in COVID-19 patients may be safer and more effective. Other JAKi such as baricitinib are related to severe adverse events such as thrombotic events compared to more common side effects of tofacitinib.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"192-198"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is new in critical illness and injury science? Lung ultrasound assessment of disease severity and prognosis in patients with acute respiratory distress syndrome. 危重病与损伤科学有何新进展？用肺部超声评估急性呼吸窘迫综合征患者的病情严重程度和预后。

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_68_23

Andrew C Miller

引用次数: 0

A systematic review and meta-analysis of randomized controlled trials with trial sequence analysis of remdesivir for COVID-19 treatment. 对用于治疗 COVID-19 的雷米替韦随机对照试验进行系统回顾和荟萃分析，并对试验序列进行分析。

International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_23_23

Rupali Patnaik, Tatikonda Chandramouli, Shakti Bedanta Mishra

{"title":"A systematic review and meta-analysis of randomized controlled trials with trial sequence analysis of remdesivir for COVID-19 treatment.","authors":"Rupali Patnaik, Tatikonda Chandramouli, Shakti Bedanta Mishra","doi":"10.4103/ijciis.ijciis_23_23","DOIUrl":"10.4103/ijciis.ijciis_23_23","url":null,"abstract":"Remdesivir is one of the proposed therapies for the corona virus disease 2019 (COVID-19). To assess the effect of remdesivir on mortality, need for invasive mechanical ventilation (IMV) and extracorporeal membrane oxygenation (ECMO), time to clinical improvement, and significant adverse effects. The study protocol was prospectively registered with The International Prospective Register of Systematic Reviews (Registration #CRD42021283221). Randomized controlled trials (RCTs) published in English detailing use of remdesivir in hospitalized patients with COVID-19 were included. Primary outcome was in hospital mortality among patients receiving remdesivir. Secondary outcomes were need for IMV and ECMO, time to clinical recovery, and significant adverse effects associated with remdesivir. Odds ratios (ORs) of worse outcome with 95% confidence interval (CI) in a forest plot were used to show the results of random effects meta-analysis. Remdesivir and placebo had similar in hospital mortality in the pooled analysis of five RCTs (OR: 0.93, 95% CI: 0.82-1.06). The remdesivir group needed less IMV/ECMO (OR: 0.59, 95% CI: 0.46-0.76) and recovered 1.06 days faster than placebo. Remdesivir did not affect transaminitis or renal damage. Trial sequence analysis showed that death has not reached the number of instances needed to predict futility. This meta-analysis shows that remdesivir therapy for COVID-19 is not associated with a mortality benefit. However, there is significant reduction in the need for IMV/ECMO.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"184-191"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory pancytopenia upon initiation of asciminib in tyrosine kinase inhibitor-resistant chronic myeloid leukemia. 酪氨酸激酶抑制剂耐药的慢性粒细胞白血病中ascimib引发的难治性全血细胞减少症。

International Journal of Critical Illness and Injury Science Pub Date : 2023-04-01 Epub Date: 2023-06-26 DOI: 10.4103/ijciis.ijciis_85_22

Steven Tessier, Mina Aiad, Santo Longo, Melissa Wilson, Yacoub Faroun

引用次数: 0

Evaluation of adherence with lung-protective ventilator strategies in moderate-to-severe acute respiratory distress syndrome in a tertiary care setup in India: A prospective observational study. 印度三级医疗机构对中重度急性呼吸窘迫综合征患者肺保护性呼吸机策略依从性的评估：一项前瞻性观察性研究。

International Journal of Critical Illness and Injury Science Pub Date : 2023-04-01 Epub Date: 2023-06-26 DOI: 10.4103/ijciis.ijciis_66_22

Simran J Singh, Alex Jude Fonseca, Spandan Rajyaguru

{"title":"Evaluation of adherence with lung-protective ventilator strategies in moderate-to-severe acute respiratory distress syndrome in a tertiary care setup in India: A prospective observational study.","authors":"Simran J Singh, Alex Jude Fonseca, Spandan Rajyaguru","doi":"10.4103/ijciis.ijciis_66_22","DOIUrl":"10.4103/ijciis.ijciis_66_22","url":null,"abstract":"Background: Evaluation of the efficacy and safety of mechanical ventilation settings is a cornerstone of the early phase of the management of acute respiratory distress syndrome (ARDS). This study aimed to evaluate the adherence to currently recommended lung-protective ventilator strategies (tidal volume, plateau pressure, driving pressure, prone positioning, and positive end-expiratory pressure [PEEP]) for adults with moderate-to-severe ARDS in a tertiary care setup, thereby evaluating if lung-protective ventilation is associated with improved outcomes.Methods: This was an observational study over 1 year in ventilated moderate-to-severe ARDS participants. All participants were mechanically ventilated when required using the protocol followed by the ARDS Network low-tidal volume lung-protective ventilation strategy and monitored.Results: The total number of participants in the study was 32. Septic shock was the most common cause of ARDS. The mean duration of intensive care unit (ICU) stay was 6.13 (±5.4) days, mean ventilator days were 3.66 (±3.75) days and mortality rate of 71.8%.Adherence to low-tidal volume was 78.12% with an improvement of 36% in the adherent group (P = 0.06). Adherence to high PEEP was 34.38% with a survival of 73% in the adherent group (P = 0.0004). Adherence to prone ventilation was 18.75% with a survival of 33% in the adherent group (P = 0.7).Conclusion: Intensivists should take an extra effort to focus on evidence-based ventilator strategies and increase adherence to these recommendations in their ICUs to improve patient survival.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 2","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9953329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of spirituality on patient memories of intensive care unit stays: A nationwide cross-sectional study. 精神对重症监护病房住院患者记忆的影响：一项全国性的横断面研究。

International Journal of Critical Illness and Injury Science Pub Date : 2023-04-01 Epub Date: 2023-06-26 DOI: 10.4103/ijciis.ijciis_10_23

Amir Vahedian-Azimi, Mahmood Salesi, Ali A Hssain, Farzaneh Baghernezhad, Andrew C Miller

{"title":"Impact of spirituality on patient memories of intensive care unit stays: A nationwide cross-sectional study.","authors":"Amir Vahedian-Azimi, Mahmood Salesi, Ali A Hssain, Farzaneh Baghernezhad, Andrew C Miller","doi":"10.4103/ijciis.ijciis_10_23","DOIUrl":"10.4103/ijciis.ijciis_10_23","url":null,"abstract":"Background: Absent or delusional memories are experienced by many patients following an intensive care unit (ICU) stay. Up to 70% may have delusional or hallucinatory intrusive memories, which may persist long term. This study aims to investigate how spiritual health (SH) impacts ICU patients' memories and quality of communication (QoC) between patients and physicians (PP) or nurses (PN).Methods: This cross-sectional study was conducted across the country on ICU patients discharged from 45 medical centers in 31 provinces of Iran, to evaluate the direct and indirect effects of SH and ICU characteristics on patients' memory. Two valid and standard ICU memory tools (ICU-MT) and SH questionnaires were administered to patients 1 day post-ICU discharge used.Results: No significant direct effect of SH scores on ICU-MT items was observed. No significant correlation was observed between PP-QoC and PN-QoC variables and primary items of the ICU-MT. Female sex positively correlated with the development of delusional memories (odds ratio [OR]: 1.730, 95% confidence interval [CI]: 1.025-2.915, P < 0.05). Subjects admitted to the medical ICU were less likely to remember being in the ICU (OR: 0.398, 95% CI: 0.159-0.996, P < 0.05), and were less likely to report intrusive memories from their time in the hospital or events that led to their admission (OR: 0.19, 95% CI: 0.086-0.419, P < 0.001).Conclusions: The results of this study indicate that the spiritual health indirectly increased coping with intrusive memories, however, no direct effect was observed on ICU-MT items. The quality of communication between patients and physicians and nurses significantly mediated development of intrusive memories.","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 2","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9955796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0