International Journal of Critical Illness and Injury Science最新文献

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A retrospective observational study of injury patterns associated with powered circular saw in subjects presenting to the emergency department of a tertiary care hospital. 对一家三甲医院急诊科就诊者与电动圆锯相关的伤害模式进行回顾性观察研究。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_34_23
Mantu Jain, Rakesh Vadakkethil Radhakrishnan, Chitta Ranjan Mohanty, Ijas Muhammed Shaji, Sangeeta Sahoo, Ajitesh Sahu, Narayan Prasad Mishra, Pramod Kumar Palai, Ruby Nahan Siddique
{"title":"A retrospective observational study of injury patterns associated with powered circular saw in subjects presenting to the emergency department of a tertiary care hospital.","authors":"Mantu Jain, Rakesh Vadakkethil Radhakrishnan, Chitta Ranjan Mohanty, Ijas Muhammed Shaji, Sangeeta Sahoo, Ajitesh Sahu, Narayan Prasad Mishra, Pramod Kumar Palai, Ruby Nahan Siddique","doi":"10.4103/ijciis.ijciis_34_23","DOIUrl":"10.4103/ijciis.ijciis_34_23","url":null,"abstract":"<p><strong>Background: </strong>Powered circular saw-related injuries (PCSRIs) are responsible for a sizable proportion of occupational injuries presented to the emergency department (ED). The present study portrays the mechanisms, injury patterns, epidemiological parameters, and outcomes among subjects presenting with PCSRI to the ED.</p><p><strong>Methods: </strong>This retrospective observational study was conducted in the ED of a tertiary care hospital in eastern India. Clinical records of subjects with PCSRI from June 2019 to June 2022 were reviewed. Data pertaining to patients' demographic profiles and the patterns and mechanisms of injury were retrieved. The Modified Hand Injury Severity Score (MHISS) and the Injury Severity Score (ISS) were calculated. Statistical analysis was performed using R version 4.1.0.</p><p><strong>Results: </strong>A total of 175 subjects' data were analyzed. The median age was 34.5 years, and all subjects were men. The mean year of experience of the subjects was 6.2. The most common job category was carpentry (<i>n</i> = 63 [36%]), followed by \"do it yourself work\" (<i>n</i> = 26 [14.8%]). One hundred twenty-two (69.7%) subjects had hand injuries (HIs), and the left hand was involved in 85 (69.6%) subjects. The index finger was involved in 36 (29.5%) subjects, followed by the thumb (<i>n</i> = 31 [25.4%]). Laceration (<i>n</i> = 155 [88.5%]) was the most common injury pattern. The subjects' mean ISS and mean MHISS were 8.52 and 45, respectively.</p><p><strong>Conclusion: </strong>PCSRI is associated with moderate-to-severe HIs that are most common in occupational settings. Young male carpenters involved in wood and plywood work are more prone to injuries.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"165-172"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for hearing loss using the electronic whisper test: A prospective cross-sectional study. 使用电子耳语测试筛查听力损失:前瞻性横断面研究
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_21_23
Nyilo Purnami, Rian Waraney Palandeng, Puguh Setyo Nugroho, Rosa Falerina, H M S Wiyadi, Dhany Arifianto, In Seok Moon
{"title":"Screening for hearing loss using the electronic whisper test: A prospective cross-sectional study.","authors":"Nyilo Purnami, Rian Waraney Palandeng, Puguh Setyo Nugroho, Rosa Falerina, H M S Wiyadi, Dhany Arifianto, In Seok Moon","doi":"10.4103/ijciis.ijciis_21_23","DOIUrl":"10.4103/ijciis.ijciis_21_23","url":null,"abstract":"<p><strong>Background: </strong>Hearing screening is a method for early identification of hearing loss. Hearing screening is widely used in hospitals as part of physical examination. However, some of them are difficult to operate outside the hospitals regarding portability and user-friendliness. Therefore, we developed a simple yet easy-to-use portable electronic whisper test (EWT) for field deployment, particularly on many subjects. The EWT validity is a hearing screening method compared to pure-tone audiometry.</p><p><strong>Methods: </strong>This study was a cross-sectional comparative with a prospective approach. The subjects were outpatients at the Audiology Clinic of Dr. Soetomo Academic Medical Center, Surabaya, Indonesia, who met the inclusion and exclusion criteria. Statistical analysis made sensitivity and specificity tables using a 2 × 2 table, positive and negative predictive values.</p><p><strong>Results: </strong>Samples of 50 participants (100 ears) obtained a sensitivity value of 83%, specificity of 78%, positive predictive value of 45%, and negative predictive value of 95%.</p><p><strong>Conclusions: </strong>The EWT is valid for use as a hearing screening method.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"173-177"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac tamponade and basilar artery aneurysm following leptospirosis: A case report. 钩端螺旋体病引发的心脏填塞和基底动脉瘤:病例报告。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_26_23
Saumitra Misra, Syed Nabeel Muzaffar, Shubhajeet Roy, Shashank Prajapati
{"title":"Cardiac tamponade and basilar artery aneurysm following leptospirosis: A case report.","authors":"Saumitra Misra, Syed Nabeel Muzaffar, Shubhajeet Roy, Shashank Prajapati","doi":"10.4103/ijciis.ijciis_26_23","DOIUrl":"10.4103/ijciis.ijciis_26_23","url":null,"abstract":"<p><p>Complications involving the heart are rare in leptospirosis, and cardiac tamponade is still rarer. We report the case of a 42-year-old hypertensive woman who presented with complaints of cough for 2 months and breathlessness for 1 month. One month later, she developed shortness of breath and loss of consciousness. The patient had a history of hemiparesis. Serum anti-<i>Leptospira</i> immunoglobulin M ELISA was positive. Ultrasound showed pericardial tamponade and hemorrhagic collection. Two-dimensional echocardiography showed minimal effusion posterior to the left ventricle and no effusion present to the right ventricle. High-resolution computerized tomography revealed patchy areas of ground glass opacities in bilateral upper and bilateral lower lobes, prominent bronchovascular markings bilaterally, and minimal pericardial thickening. Magnetic resonance imaging of the brain showed small chronic infarcts in bilateral corona radiata and basal ganglia. A magnetic resonance angiogram of the brain showed a basilar top aneurysm, which was an incidental finding. No signs of rupture of the aneurysm were seen. Digital subtraction angiography showed 50%-70% stenosis at the junction of the V3-V4 segments of the vertebral artery. The right lower limb immobilization, along with ecosprin, ivabradine, amlodipine, and fluconazole, was started, to which the patient responded well.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"202-205"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prospective observational study to correlate lung ultrasound with clinical severity and prognosis score in patients with primary pulmonary pathology on invasive ventilatory support. 一项前瞻性观察研究,旨在将接受有创呼吸支持的原发性肺部病变患者的肺部超声与临床严重程度和预后评分联系起来。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_31_23
Sulagna Basu, Rishiraj Narayan Verma, Aditya Joshi, Deepak Dwivedi, Mohammad Abdul Mateen, Jagdeep Singh Bhatia
{"title":"A prospective observational study to correlate lung ultrasound with clinical severity and prognosis score in patients with primary pulmonary pathology on invasive ventilatory support.","authors":"Sulagna Basu, Rishiraj Narayan Verma, Aditya Joshi, Deepak Dwivedi, Mohammad Abdul Mateen, Jagdeep Singh Bhatia","doi":"10.4103/ijciis.ijciis_31_23","DOIUrl":"10.4103/ijciis.ijciis_31_23","url":null,"abstract":"<p><strong>Background: </strong>Lung ultrasound (LUS) is a known imaging modality employed for monitoring patients in an intensive care unit. This study evaluates, LUS in assessing disease severity and prognosis, by correlating its score with the three commonly used clinical severity scoring systems (CSSS), namely, sequential organ failure assessment (SOFA) score, acute physiology and chronic health evaluation (APACHE) II score, and simplified acute physiology score (SAPS) II.</p><p><strong>Methods: </strong>This single-center prospective observational study included 54 adult patients of primary lung disease-induced acute respiratory distress syndrome (ARDS), on invasive ventilation. The primary objective was to correlate LUS score with SOFA score. Secondary objectives were to correlate LUS score with APACHE II and SAPS II scores. LUS score was also correlated with the estimated mortality derived from the above-mentioned scores. A subgroup analysis on COVID-19-positive cases was also carried out. All scores were calculated on the initiation of mechanical ventilation, daily for 7 days or mortality, whichever was earlier.</p><p><strong>Results: </strong>A significant positive correlation (<i>P</i> < 0.001) was found between LUS and all three severity scores, as well as their corresponding estimated mortality percentages, for all days of the study period, in both non-COVID-19 ARDS patients and in COVID-19 patients. The merit of all four scores in differentiating between the survivor and mortality group for the duration of study also showed significant (<i>P</i> < 0.05) to very significant (<i>P</i> < 0.001) results.</p><p><strong>Conclusion: </strong>Point-of-care LUS in conjunction with CSSS is a reliable tool for assessing the severity and progression of primary lung disease.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"151-158"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A retrospective analysis of the 5-year trends of antimicrobial resistance in gram-negative bacterial isolates from an intensive care unit at a tertiary care hospital. 对一家三甲医院重症监护室革兰氏阴性细菌分离物抗菌药耐药性 5 年趋势的回顾性分析。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_30_23
Nikhil Raj, Jyotsna Agarwal, Vikramjeet Singh, Soumya Sankar Nath, Anupam Das, Manodeep Sen
{"title":"A retrospective analysis of the 5-year trends of antimicrobial resistance in gram-negative bacterial isolates from an intensive care unit at a tertiary care hospital.","authors":"Nikhil Raj, Jyotsna Agarwal, Vikramjeet Singh, Soumya Sankar Nath, Anupam Das, Manodeep Sen","doi":"10.4103/ijciis.ijciis_30_23","DOIUrl":"10.4103/ijciis.ijciis_30_23","url":null,"abstract":"<p><strong>Background: </strong>Intensive care units (ICUs) in developing countries constitute a high risk for patients acquiring infection by multidrug-resistant organisms (MDROs). The rise in antimicrobial resistance (AMR) threatens the effective prevention and treatment of an increasing range of infections. The present study analyzed the local trends of AMR in Gram-negative isolates of ICU patients from a tertiary care facility in North India.</p><p><strong>Methods: </strong>This retrospective study was conducted over 5 years (January 2018-December 2022). All bacterial isolates from patients admitted to ICU during the study period were included in the study, and their AMR pattern was analyzed. In addition, sensitivity trends of different antimicrobials against the common Gram-negative bacteria were analyzed, and AMR trends were analyzed over the study period.</p><p><strong>Results: </strong><i>Klebsiella</i> spp. was the most common isolate in samples received from ICU. A rise of carbapenem-resistant microorganisms was observed over the study period. <i>Escherichia</i> <i>coli</i> and <i>Klebsiella</i> spp. showed around 10% and a 17% decrease in susceptibility to carbapenems, respectively. In contrast, a marked 29% decrease in sensitivity to carbapenems was observed in <i>Acinetobacter</i> spp.</p><p><strong>Conclusion: </strong>The inception of integrated stewardship measures has shown a rising trend in susceptibility and is the need of the hour to prevent the spread of MDROs. Surveillance studies help us understand the impact of AMR in hospitals and help plan prevention programs.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"178-183"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical utility of i-gel® and BlockBuster™ supraglottic devices for airway management in postburn injury contracture neck patients under general anesthesia: A randomized controlled trial. i-gel® 和 BlockBuster™ 声门上装置对全身麻醉下烧伤后挛缩颈部患者气道管理的临床实用性:随机对照试验。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_35_23
Manish Kumar Tripathi, Tanmay Tiwari, Bhavya Naithani, Divya Narain Upadhyaya, Prem Raj Singh, Ila Tripathi
{"title":"Clinical utility of i-gel<sup>®</sup> and BlockBuster™ supraglottic devices for airway management in postburn injury contracture neck patients under general anesthesia: A randomized controlled trial.","authors":"Manish Kumar Tripathi, Tanmay Tiwari, Bhavya Naithani, Divya Narain Upadhyaya, Prem Raj Singh, Ila Tripathi","doi":"10.4103/ijciis.ijciis_35_23","DOIUrl":"10.4103/ijciis.ijciis_35_23","url":null,"abstract":"<p><strong>Background: </strong>Post burn injury contracture (PBC) neck patients pose a unique challenge for the anesthesiologists. The use of supraglottic device (SGDs) for managing such patients is being increasingly used. We compared i-gel<sup>®</sup> and LMA BlockBuster™ in PBC adult patients under general anesthesia (GA).</p><p><strong>Methods: </strong>The study included 63 subjects with mild/moderate PBC neck of either sex with American Society of Anesthesiologists Physical Status I and II under GA. Patients with intraoral pathology, mouth opening <2.5 cm, and severe contracture were excluded. Patients were randomly assigned to i-gel<sup>®</sup> (I) and BlockBuster™ (B) groups. The primary objective of the study was the time for successful insertion. First attempt success rate, oropharyngeal leak pressures (OLP), and complications were also assessed.</p><p><strong>Results: </strong>Mean insertion time was significantly less in Group I as compared to Group B (17.35 ± 1.43 vs. 21.32 ± 1.10 s; <i>P</i> < 0.001), OLP in Group B was significantly higher as compared to Group I (34.03 ± 1.33 vs. 25.23 ± 3.04 cm of H<sub>2</sub>O; <i>P</i> < 0.001). Group I was found to be statistically easier to insert as compared to Group B (<i>P</i> = 0.011) with reduced requirement of airway maneuvering to insert the device (<i>P</i> = 0.017). Groups were similar in terms of complications.</p><p><strong>Conclusion: </strong>SGDs are attractive option for airway management in mild/moderate degree of PBC neck. i-gel<sup>®</sup> having shorter insertion time with easier insertion can be favorable at times of emergency while use of LMA BlockBuster™ can be preferred to reduce the risk of aspiration owing to higher OLP.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterior reversible encephalopathy syndrome secondary to malignancy-associated hypercalcemia: A case report. 继发于恶性肿瘤相关性高钙血症的后可逆性脑病综合征:病例报告。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_8_23
Mansoor C Abdulla
{"title":"Posterior reversible encephalopathy syndrome secondary to malignancy-associated hypercalcemia: A case report.","authors":"Mansoor C Abdulla","doi":"10.4103/ijciis.ijciis_8_23","DOIUrl":"10.4103/ijciis.ijciis_8_23","url":null,"abstract":"<p><p>Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical syndrome usually characterized by a range of neurological manifestations and distinctive neuroimaging findings reflecting vasogenic edema. PRES has been described in the context of various clinical settings including: renal failure, blood pressure fluctuations, use of cytotoxic drugs, autoimmune disorders and eclampsia. Hypercalcemia is rarely associated with PRES. We report a patient with lung cancer presenting as PRES secondary to hypercalcemia.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"199-201"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A narrative review on tofacitinib: The properties, function, and usefulness to treat coronavirus disease 2019. 关于托法替尼的叙述性综述:特性、功能和治疗冠状病毒疾病的实用性 2019.
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_27_23
Seyed Mohammad Reza Hashemian, Tayebeh Farhadi
{"title":"A narrative review on tofacitinib: The properties, function, and usefulness to treat coronavirus disease 2019.","authors":"Seyed Mohammad Reza Hashemian, Tayebeh Farhadi","doi":"10.4103/ijciis.ijciis_27_23","DOIUrl":"10.4103/ijciis.ijciis_27_23","url":null,"abstract":"<p><p>In coronavirus disease 2019 (COVID-19), the formation of cytokine storm may have a role in worsening of the disease. By attaching the cytokines like interleukin-6 to the cytokine receptors on a cell surface, Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway will be activated in the cytoplasm lead to hyperinflammatory conditions and acute respiratory distress syndrome. Inhibition of JAK/STAT pathway may be useful to prevent the formation of cytokine storm. Tofacitinib is a pan inhibitor of JAKs. In this review, the main characteristics of tofacitinib and its usefulness against COVID-19 pneumonia were reviewed. Tofacitinib may be a hopeful therapeutic candidate against COVID-19 respiratory injury since it inhibits a range of inflammatory pathways. Hence, the agent may be considered a potential therapeutic against the post-COVID-19 respiratory damage. Compared to other JAK inhibitors (JAKi), the administration of tofacitinib in COVID-19 patients may be safer and more effective. Other JAKi such as baricitinib are related to severe adverse events such as thrombotic events compared to more common side effects of tofacitinib.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"192-198"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is new in critical illness and injury science? Lung ultrasound assessment of disease severity and prognosis in patients with acute respiratory distress syndrome. 危重病与损伤科学有何新进展?用肺部超声评估急性呼吸窘迫综合征患者的病情严重程度和预后。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_68_23
Andrew C Miller
{"title":"What is new in critical illness and injury science? Lung ultrasound assessment of disease severity and prognosis in patients with acute respiratory distress syndrome.","authors":"Andrew C Miller","doi":"10.4103/ijciis.ijciis_68_23","DOIUrl":"10.4103/ijciis.ijciis_68_23","url":null,"abstract":"","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"149-150"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review and meta-analysis of randomized controlled trials with trial sequence analysis of remdesivir for COVID-19 treatment. 对用于治疗 COVID-19 的雷米替韦随机对照试验进行系统回顾和荟萃分析,并对试验序列进行分析。
International Journal of Critical Illness and Injury Science Pub Date : 2023-10-01 Epub Date: 2023-12-26 DOI: 10.4103/ijciis.ijciis_23_23
Rupali Patnaik, Tatikonda Chandramouli, Shakti Bedanta Mishra
{"title":"A systematic review and meta-analysis of randomized controlled trials with trial sequence analysis of remdesivir for COVID-19 treatment.","authors":"Rupali Patnaik, Tatikonda Chandramouli, Shakti Bedanta Mishra","doi":"10.4103/ijciis.ijciis_23_23","DOIUrl":"10.4103/ijciis.ijciis_23_23","url":null,"abstract":"<p><p>Remdesivir is one of the proposed therapies for the corona virus disease 2019 (COVID-19). To assess the effect of remdesivir on mortality, need for invasive mechanical ventilation (IMV) and extracorporeal membrane oxygenation (ECMO), time to clinical improvement, and significant adverse effects. The study protocol was prospectively registered with The International Prospective Register of Systematic Reviews (Registration #CRD42021283221). Randomized controlled trials (RCTs) published in English detailing use of remdesivir in hospitalized patients with COVID-19 were included. Primary outcome was in hospital mortality among patients receiving remdesivir. Secondary outcomes were need for IMV and ECMO, time to clinical recovery, and significant adverse effects associated with remdesivir. Odds ratios (ORs) of worse outcome with 95% confidence interval (CI) in a forest plot were used to show the results of random effects meta-analysis. Remdesivir and placebo had similar in hospital mortality in the pooled analysis of five RCTs (OR: 0.93, 95% CI: 0.82-1.06). The remdesivir group needed less IMV/ECMO (OR: 0.59, 95% CI: 0.46-0.76) and recovered 1.06 days faster than placebo. Remdesivir did not affect transaminitis or renal damage. Trial sequence analysis showed that death has not reached the number of instances needed to predict futility. This meta-analysis shows that remdesivir therapy for COVID-19 is not associated with a mortality benefit. However, there is significant reduction in the need for IMV/ECMO.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"13 4","pages":"184-191"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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