International Journal of Critical Illness and Injury Science最新文献

{"title":"Heister mouth gag aided endotracheal intubation in patients with maxillofacial trauma: A case report.","authors":"Karan Singla,&nbsp;Tanvir Samra,&nbsp;Kajal Jain","doi":"10.4103/ijciis.ijciis_15_22","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_15_22","url":null,"abstract":"<p><p>Securing the airway in patients with maxillofacial trauma is challenging for the anesthesiologist. Pain and facial deformities limit mouth opening and hence direct laryngoscopy. Fractured bone segments, blood, oral secretions, and tissue edema preclude the use of fiber-optic bronchoscopes for intubation of the trachea. We report a successful attempt of orotracheal intubation with a Macintosh blade in a 25-year-old patient with restricted mouth opening with the use of a Heister mouth gag.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 3","pages":"177-179"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10393404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential effect of iopamidol contrast on renal function in patients infected with SARS-CoV-2 virus: A retrospective cohort study.","authors":"Sarven Tersakyan,&nbsp;Monica Chappidi,&nbsp;Ankit Patel,&nbsp;Kenneth Hainsworth,&nbsp;Abdalhai Alshoubi","doi":"10.4103/ijciis.ijciis_92_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_92_21","url":null,"abstract":"<p><strong>Background: </strong>Many types of computed tomography (CT) scans require the use of contrast. Acute kidney injury (AKI) is a known adverse effect of intravenous contrast administration. To our knowledge, the effects of low-osmolar contrast agents such as iopamidol on renal function in patients infected with the SARS-CoV-2 virus have never been studied. This study investigates the incidence of AKI following iopamidol contrast administration in patients infected with the SARS-CoV-2 virus.</p><p><strong>Methods: </strong>This retrospective cohort study included two groups: patients who received CT pulmonary angiography who were infected with SARS-CoV-2 virus and those who tested negative for SARS-CoV-2. Data were collected from the electronic medical record of a single hospital from January 1, 2020, to September 15, 2020. AKI was defined using the Kidney Disease: Improving Global Outcomes definition: increase in serum creatinine by ≥0.3 mg/dL (≥26.5 mcmol/L) within 48 h, or increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior 7 days, or urine volume <0.5 mL/kg/h for 6 h.</p><p><strong>Results: </strong>AKI occurred in 13.51% of patients in the SARS-CoV-2 positive group and 16.92% of patients in the negative group. Using a two-sample test to compare the equality of proportions (with continuity correction factor), we found there is no significant difference in the two proportions (<i>P</i> = 0.3735).</p><p><strong>Conclusion: </strong>There was no significant difference in the incidence of AKI between SARS-CoV-2 positive and negative groups. Given the limitations of this study, further work must be done on this topic.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 3","pages":"155-159"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10393405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of central venous-to-arterial carbon dioxide difference to arterial-central venous oxygen difference ratio to lactate clearance and prognosis in patients with septic shock: A prospective observational cohort study.","authors":"Kavya Sindhu,&nbsp;Deepak Malviya,&nbsp;Samiksha Parashar,&nbsp;Chandrakant Pandey,&nbsp;Soumya Sankar Nath,&nbsp;Shilpi Misra","doi":"10.4103/ijciis.ijciis_10_22","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_10_22","url":null,"abstract":"<p><strong>Background: </strong>To assess the relationship between the ratio of difference of venoarterial CO₂ tension (P (v-a) CO₂) and difference of arterio-venous oxygen content (C (a-cv) O₂), i.e., ΔPCO₂/ΔCaO₂ with lactate clearance (LC) at 8 and 24 h, to define a cutoff for the ratio to identify LC >10% and >20% at 8 and 24 h, respectively, and its association with prognosis in septic shock.</p><p><strong>Methods: </strong>Adult patients with septic shock were included in this prospective, observational cohort study. Blood samples for arterial lactate, arterial, and central venous oxygen and carbon dioxide were drawn simultaneously at time zero (T0), 8 h (T8), and 24 h (T24). At T8, patients were divided into Group 8A (LC ≥10%) and Group 8B (LC <10%). At T24, patients were divided into Group 24A (LC ≥20%) and Group 24B (LC <20%).</p><p><strong>Results: </strong>Ninty-eight patients were included. The area under the curve of ΔPCO₂/ΔCaO₂ at T8 (0.596) and T24 (0.823) was the highest when compared to P(v-a) CO₂ and C(a-v) O₂. The best cutoff of P(v-a) CO₂/C (a-v) O₂ as predictor of LC >10% was 1.31 (sensitivity 70.6% and specificity 53.3%) and for LC >20% was 1.37 (sensitivity 100% and specificity 50%). At both T8 and T24, P(v-a) CO₂/C (a-v) O₂ showed a significant negative correlation with LC. Groups 8A and 24A showed lower intensive care unit mortality than 8B and 24B, respectively. Values of P(v-a) CO₂/C (a-v) O₂ at T8 were comparable, but at T24, there was a significant difference between the survivors and nonsurvivors (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>ΔPCO₂/ΔCaO₂ predicts lactate clearance, and its 24 h value appears superior to the 8-h value in predicting LC and mortality in septic shock patients.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 3","pages":"146-154"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10393865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk factors of the functional status, quality of life, and family psychological status in children with postintensive care syndrome: A cohort study.","authors":"Saptadi Yuliarto, Kurniawan Taufik Kadafi, Sri Fauziah, Takhta Khalasha, William Prayogo Susanto","doi":"10.4103/ijciis.ijciis_7_22","DOIUrl":"10.4103/ijciis.ijciis_7_22","url":null,"abstract":"<p><strong>Background: </strong>Intensive care treatment has a side effect of several impairments after hospital discharge, known as postintensive care syndrome (PICS). PICS in children must be well evaluated because PICS can affect their global development and quality of life. Our specific aims are to determine the impact of intensive care treatment and the risk factors which contribute to PICS.</p><p><strong>Methods: </strong>In this observational cohort study, we identified critically ill children treated in intensive care units (ICUs) for more than 24 h and survived. We evaluated the internal and external risk factors of the patients in the intensive care. We interviewed their parents to define the functional status and quality of life of the patients in 7 days before ICU admission and the psychological status of the family at the time of intensive care admission. The interview was repeated in 3 months after the intensive care discharge.</p><p><strong>Results: </strong>There was a significant decrease in functional status and quality of life after intensive care treatment (<i>P</i> < 0.001). However, none of the internal risk factors were significantly associated with PICS. Neurologic involvement in the disease was associated with the significantly reduced functional status of patients, while the severity of the disease was significantly associated with both functional status and quality of life. Our study also showed a significant psychological disorder of the family in the intensive care.</p><p><strong>Conclusion: </strong>The occurrence of PICS in children was associated with the severity of the disease, decreased the functional status and quality of life, and contributed to psychological disorders for the family.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 3","pages":"165-173"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10393866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point prevalence of delirium among critically ill patients in Saudi Arabia: A multicenter observational study.","authors":"Nada S Alqadheeb,&nbsp;Mai S Hashhoush,&nbsp;Abdulrahman M Alharthy,&nbsp;Nasir Nasim Mahmood,&nbsp;Zahra A Alfardan,&nbsp;Rashid Amin,&nbsp;Khalid A Maghrabi,&nbsp;Mohammed A Almaani,&nbsp;Mahmoud S Alyamany,&nbsp;Farhan Zayed Alenezi,&nbsp;Abdulrahman R Alruwaili,&nbsp;Kasim H Alkhatib,&nbsp;Asia S Rugaan,&nbsp;Faisal S Eltatar,&nbsp;Haifa M Algethamy,&nbsp;Abdullah M Abudayah,&nbsp;Alaa E Ghabashi,&nbsp;Galal B ElRakaiby,&nbsp;Khalid F Alkatheeri,&nbsp;Mohammed I Alarifi,&nbsp;Yousef A Al Mubarak,&nbsp;Nadia H Ismail,&nbsp;Israa H Alnajdi,&nbsp;Mohammed Elrazi I Ahmed,&nbsp;Mariam A Alansari,&nbsp;Ahmed O Alenazi,&nbsp;Osama M Almuslim","doi":"10.4103/ijciis.ijciis_76_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_76_21","url":null,"abstract":"<p><strong>Background: </strong>Delirium in critically ill patients is independently associated with poor clinical outcomes. There is a scarcity of published data on the prevalence of delirium among critically ill patients in Saudi Arabia. Therefore, we sought to determine, in a multicenter fashion, the prevalence of delirium in critically ill patients in Saudi Arabia and explore associated risk factors.</p><p><strong>Methods: </strong>A cross-sectional point prevalence study was conducted on January 28, 2020, at 14 intensive care units (ICUs) across 3 universities and 11 other tertiary care hospitals in Saudi Arabia. Delirium was screened once using the Intensive Care Delirium Screening Checklist. We excluded patients who were unable to participate in a valid delirium assessment, patients admitted with traumatic brain injury, and patients with documented dementia in their medical charts.</p><p><strong>Results: </strong>Of the 407 screened ICU patients, 233 patients were enrolled and 45.9% were diagnosed with delirium. The prevalence was higher in mechanically ventilated patients compared to patients not mechanically ventilated (57.5% vs. 33.6%; <i>P</i> < 0.001). In a multivariate model, risk factors independently associated with delirium included age (adjusted odds ratio [AOR], 1.021; 95% confidence interval [CI], 1.01-1.04; <i>P</i> = 0.008), mechanical ventilation (AOR, 2.39; 95% CI, 1.34-4.28; <i>P</i> = 0.003), and higher severity of illness (AOR, 1.01; 95% CI, 1.001-1.021; <i>P</i> = 0.026).</p><p><strong>Conclusion: </strong>In our study, delirium remains a prevalent complication, with distinct risk factors. Further studies are necessary to investigate long-term outcomes of delirium in critically ill patients in Saudi Arabia.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 2","pages":"70-76"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance study of bloodstream infections, antimicrobial use, and resistance patterns among intensive care unit patients: A retrospective cross-sectional study.","authors":"Mera A Ababneh,&nbsp;Mohammad Al Domi,&nbsp;Abeer M Rababa'h","doi":"10.4103/ijciis.ijciis_70_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_70_21","url":null,"abstract":"<p><strong>Background: </strong>Bloodstream infections (BSIs) are one of the most critical illnesses requiring intensive care unit (ICU) admission. This study assessed patterns of antimicrobial use and resistance in ICU patients with BSIs.</p><p><strong>Methods: </strong>Inpatients admitted to the ICU and who received at least one antimicrobial agent between January 1, 2017, and December 31, 2019, were included in the study. Electronic patients' medical records were used to collect patients' demographic, clinical, and microbiological data.</p><p><strong>Results: </strong>A total of 1051 patients were enrolled in the study, where 650 patients (61.84%) were treated with three or more antimicrobial agents. The most frequently used antimicrobials were piperacillin/tazobactam followed by teicoplanin, meropenem, and levofloxacin. The most predominant multidrug-resistant pathogens were <i>Acinetobacter baumannii</i>, followed by <i>Escherichia coli, Methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumonia,</i> and <i>Pseudomonas aeruginosa</i>.</p><p><strong>Conclusions: </strong>The administration of the antimicrobials among ICU patients was highly based on a combination of three or more broad-spectrum agents. MDR pathogens were found to be highly prevalent among ICU patients with BSI. Therefore, we suggest recommending that hospital policies should apply the antimicrobial stewardship protocols, infection control, and implement antimicrobial de-escalation protocol to reduce the harm pressure of antimicrobial resistance.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 2","pages":"82-90"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to new-onset facial nerve palsy in a critically ill patient: A case report.","authors":"Saumitra Misra,&nbsp;Saurabh Kumar,&nbsp;Nitin Rai,&nbsp;Sai Saran","doi":"10.4103/ijciis.ijciis_94_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_94_21","url":null,"abstract":"<p><p>Lower motor type of facial nerve palsy (Bell's palsy) is one of the most common types of facial nerve palsy, with well-defined management with steroids and antivirals for patients attending outpatient clinics. The diagnosis and management of facial nerve palsy in critically ill patients require an individualized approach, as there may be many other causes like soft-tissue compression due to facial edema which can occur as a complication of prone ventilation and severe subcutaneous emphysema. This report highlights the challenges in the management of new-onset facial nerve palsy diagnosed in the intensive care unit (ICU) for a patient on mechanical ventilation, and creates a necessity for a standard operating protocol for the management of such scenarios in ICU.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 2","pages":"115-117"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational management of Grade II or higher blunt traumatic thoracic aortic injury: 15 years of experience at a single suburban institution.","authors":"Jin Bong Ye,&nbsp;Jin Young Lee,&nbsp;Jin Suk Lee,&nbsp;Se Heon Kim,&nbsp;Hanlim Choi,&nbsp;Yook Kim,&nbsp;Soo Young Yoon,&nbsp;Young Hoon Sul,&nbsp;Jung Hee Choi","doi":"10.4103/ijciis.ijciis_89_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_89_21","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the outcomes after delayed management of ≥ Grade II blunt traumatic thoracic aortic injury (BTAI).</p><p><strong>Methods: </strong>Between January 2005 and December 2019, we retrospectively reviewed the medical records of 21 patients with ≥ Grade II thoracic aortic injury resulting from blunt trauma. Twelve patients underwent observation for the injury, whereas nine patients were transferred immediately after the diagnosis. Patients were divided into a nonoperative management group (<i>n</i> = 7) and delayed repair group (<i>n</i> = 5) based on whether they underwent thoracic endovascular aneurysm repair or surgery.</p><p><strong>Results: </strong>The most common dissection type was DeBakey classification IIIa (<i>n</i> = 9). Five patients underwent delayed surgery (including aneurysm repair), with observation periods ranging from 1 day to 36 months. The delayed repair group exhibited higher injury severity scores than the nonoperative management group (<i>n</i> = 7). The nonoperative management group was followed-up with blood pressure management without a change in status for a period ranging from 3 to 96 months.</p><p><strong>Conclusions: </strong>Our findings indicated that conservative management may be appropriate for select patients with Grade II/III BTAI, especially those exhibiting hemodynamic stability with anti-impulse therapy and minimally sized pseudoaneurysms. However, further studies are required to identify the risk factors for injury progression and long-term outcomes.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 2","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in patients receiving prolonged invasive mechanical ventilation time in the emergency department: A retrospective cohort study.","authors":"Sorravit Savatmongkorngul,&nbsp;Chaiyaporn Yuksen,&nbsp;Napathom Sunsuwan,&nbsp;Pungkawa Sricharoen,&nbsp;Chetsadakon Jenpanitpong,&nbsp;Konwachira Maijan,&nbsp;Sorawich Watcharakitpaisan,&nbsp;Parama Kaninworapan","doi":"10.4103/ijciis.ijciis_69_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_69_21","url":null,"abstract":"<p><strong>Background: </strong>Patients waiting for intensive care unit (ICU) admission cause emergency department (ED) crowding and have an increased risk of mortality and length of stay (LOS) in hospital, which increase the hospitalization cost. This study aimed to investigate the correlation between mortality and invasive mechanical ventilation (IMV) time in patients in the ED.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted in patients who received IMV in the ED of Ramathibodi Hospital. The correlation between mortality at 28 days after intubation and IMV time in the ED was analyzed. The cutoff time was analyzed to determine prolonged and nonprolonged IMV times. ICU ventilation time, length of ICU stay, and LOS in the hospital were also analyzed to determine their correlations between IMV time in the ED.</p><p><strong>Results: </strong>In this study, 302 patients were enrolled, 71 died, and 231 survived 28 days after receiving IMV in the ED. We found that the duration of >12 h of IMV in the ED increased the 28-day mortality rate by 1.98 times (<i>P</i> = 0.036). No correlations were found between IMV time in the ED and ventilation time in the ICU, length of ICU stay, and LOS in the hospital.</p><p><strong>Conclusion: </strong>More than 12 h of IMV time in the ED correlated with mortality at 28 days after initiation of IMV. No associations were found between prolonged IMV time in the ED with ventilation time in the ICU, length of ICU stay, and LOS in the hospital.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 2","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive care unit delirium in patients with severe COVID-19: A prospective observational cohort study.","authors":"Ryan J Smith,&nbsp;Christian Lachner,&nbsp;Vijay P Singh,&nbsp;Rodrigo Cartin-Ceba","doi":"10.4103/ijciis.ijciis_93_21","DOIUrl":"https://doi.org/10.4103/ijciis.ijciis_93_21","url":null,"abstract":"<p><strong>Background: </strong>Delirium is common in patients with severe coronavirus disease-19 (COVID-19). The purpose of our study was to determine whether severe COVID-19 is an independent risk factor for the development of delirium in patients treated in the intensive care unit (ICU).</p><p><strong>Methods: </strong>This prospective observational cohort study involved 162 critically ill patients admitted to a multidisciplinary ICU during 2019 and 2020. A validated screening tool was used to diagnose delirium. Multiple delirium risk factors were collected daily including clinical characteristics, hospital course, lab values, vital signs, surgical exposure, drug exposure, and COVID-19 characteristics. After univariate analysis, a multivariate logistic regression analysis was performed to determine independent risk factors associated with the development of delirium.</p><p><strong>Results: </strong>In our study population, 50 (31%) patients developed delirium. A total of 39 (24.1%) tested positive for COVID-19. Initial analysis showed COVID-19 to be more prevalent in those patients that developed delirium (40% vs. 17%; <i>P</i> = 0.003). Multivariate analysis showed opioid use (odds ratio [OR]: 24 [95% confidence intervals (CI): 16-27]; <i>P</i> ≤ 0.001), benzodiazepine use (OR: 23 [95% CI: 16-63] <i>P</i> = 0.001), and estimated mortality based on acute physiology and chronic health evaluation IV score (OR: 1.04 [95% CI: 1.01-1.07] <i>P</i> = 0.002) to be independently associated with delirium development. COVID-19 (OR: 1.44 [95% CI: 0.13-10.6]; <i>P</i> = 0.7) was not found to be associated with delirium.</p><p><strong>Conclusion: </strong>Delirium is prevalent in critically ill patients admitted to the ICU, including those with COVID-19. However, after adjustment for important covariates, we found in this cohort that COVID-19 was not an independent risk factor for delirium.</p>","PeriodicalId":13938,"journal":{"name":"International Journal of Critical Illness and Injury Science","volume":"12 2","pages":"61-69"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}