International Journal of Colorectal Disease最新文献

{"title":"Prognostic value of routine blood biomarkers in 3-year survival of resectable colorectal cancer patients: a prognostic nomogram for clinical practice.","authors":"David Moro-Valdezate, José Martín-Arévalo, Coral Cózar-Lozano, Stephanie García-Botello, Leticia Pérez-Santiago, David Casado-Rodrigo, Carolina Martínez-Ciarpaglini, Noelia Tarazona, Vicente Pla-Martí","doi":"10.1007/s00384-025-04848-3","DOIUrl":"https://doi.org/10.1007/s00384-025-04848-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a prognostic model for colorectal cancer (CRC) patients using biomarkers from routine preoperative peripheral blood examinations combined with clinical factors.</p><p><strong>Methods: </strong>This observational study comprised CRC patients (stages I-III) who underwent curative surgery between January 2011 and December 2019. Study variables included patient demographics, tumour characteristics, and immune/inflammatory markers from preoperative blood tests. Cut-off thresholds for continuous variables were determined using maximally selected rank statistics. Univariate and multivariate analyses identified variables associated with 3-year cancer-specific survival (CSS) and disease-free survival (DFS). Cox regression models were developed and validated using a random split-sample approach. Nomograms based on these models were constructed, and receiver operating characteristic (ROC) curves were generated for 12, 24 and 36 months.</p><p><strong>Results: </strong>A total of 764 patients were included. Independent factors for 3-year DFS included laparoscopic surgery, prognostic nutritional index (PNI), neutrophil count, lymphocyte count, and Charlson comorbidity index. The DFS prediction model showed AUC values of 66.6%, 64.8%, and 69% for years 1, 2, and 3, respectively. For CSS, independent factors included age, systemic immune-inflammation index (SII), serum albumin, and platelet count, with AUC values of 89.2%, 76.8%, and 71% for years 1, 2, and 3. The most significant contributors to the CSS model were SII and platelet cut-off values.</p><p><strong>Conclusion: </strong>Inflammatory biomarkers combined with clinical parameters robustly predict 3-year survival outcomes in CRC patients undergoing curative resection. These findings highlight the importance of systemic inflammation in CRC prognosis and support its inclusion in preoperative risk stratification.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"58"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrysin ameliorates dextran sulfate-induced ulcerative colitis in mice by modulating inflammation and gut microbiota.","authors":"Xin Yao, Yao Chen, Yang Li, Jieyu Mo, Xia Liu, Peng Wang, Daqi Jia, Huaqiang Li, Chunfang Guo","doi":"10.1007/s00384-025-04843-8","DOIUrl":"10.1007/s00384-025-04843-8","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) encompasses chronic inflammation of the colon and rectum, posing significant health challenges. Previous studies have shown potential therapeutic effects of natural compounds on IBD. Chrysin, a naturally occurring flavonoid, has been suggested to modulate inflammatory pathways and gut microbiota, but its comprehensive impact on ulcerative colitis remains inadequately explored.</p><p><strong>Methods: </strong>This study employed a dextran sulfate sodium (DSS)-induced ulcerative colitis model in mice to investigate the effects of Chrysin. Using network pharmacology, we identified key signaling pathways potentially influenced by Chrysin. Experimental approaches included measuring disease activity index scores, serum levels of TNF-α, and assessing colon damage histologically. Transcriptomic and microbiome analyses were conducted to examine changes in gene expression and gut bacterial populations, respectively. Additionally, metabolomic profiling was used to identify alterations in colon metabolites.</p><p><strong>Results: </strong>Chrysin treatment significantly mitigated weight loss and reduced disease activity index scores in DSS-induced mice. There was a notable decrease in serum TNF-α levels and less histological damage in the colon. Transcriptomic analysis revealed significant alterations in gene expression within the NF-κB and IL-17 signaling pathways. Microbiome analysis showed significant shifts in the populations of Bacteroidetes and Firmicutes. Metabolomics analysis identified changes in 298 colon metabolites, implicating several essential metabolic pathways.</p><p><strong>Conclusions: </strong>The findings suggest that Chrysin exerts a dual-action therapeutic effect on ulcerative colitis by reducing inflammation and modulating the gut microbiota. These multifaceted impacts highlight Chrysin's potential utility as a novel therapeutic agent in the clinical management of IBD, offering valuable insights into its mechanisms of action and paving the way for future clinical trials.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"57"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term functional and prognostic outcomes of robotic intersphincteric resection for treating low rectal cancer: a single-center retrospective study.","authors":"Yang Bo, Wang Yigao, Zheng Mingye, Jian Zhao, Yongxiang Li","doi":"10.1007/s00384-025-04844-7","DOIUrl":"10.1007/s00384-025-04844-7","url":null,"abstract":"<p><strong>Objective: </strong>Intraoperative and postoperative data collected from patients with low rectal cancer who had undergone robotic and laparoscopic intersphincteric resection (ISR) procedures were retrospectively analyzed to evaluate factors linked to anastomotic leakage and postoperative recovery of urinary function, bowel control, and long-term prognosis.</p><p><strong>Method: </strong>This single-center study enrolled patients with low rectal cancer who had undergone robotic ISR (n = 150) or laparoscopic ISR (n = 150) from January 2016 to July 2019.</p><p><strong>Result: </strong>The respective mean tumor distances from the anal margin in the robotic and laparoscopic ISR groups were 3.94 ± 0.48 cm and 5.66 ± 0.47 cm, while the mean times to postoperative catheter removal in these respective groups were 4.9 ± 1.4 days and 5.3 ± 1.6 days (P = 0.007). Binary logistic regression analyses indicated that a higher BMI (≥ 25 kg/m²), diabetes, the absence of left colic artery presentation, T3 pathological T stage, the absence of temporary ileostomy, and DRM (distal resection margin) < 1 cm were linked to a greater likelihood of postoperative anastomotic leakage. Relative to patients in the laparoscopic group, those in the robotic ISR group exhibited better anal and urinary function from 6 months postoperatively, as indicated by a lower frequency of bowel movements, reduced LARS (The Low Anterior Resection Syndrome) severity, and lower IPSS (the International Prostate Symptom Score) scores. Five-year overall and disease-free survival did not differ significantly between the groups.</p><p><strong>Conclusion: </strong>These results highlight the promise of robotic ISR as an approach to managing cases of low and ultra-low rectal tumors, providing a safe and feasible alternative to conventional laparoscopic ISR treatment.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"56"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis on the efficacy of botulinum toxin alone versus combined botulinum toxin and topical diltiazem.","authors":"Cigdem Arslan, Emre Karagoz, Tansu Altintas, Caglar Pekuz, Yasemin Yildirim, Mustafa Oncel","doi":"10.1007/s00384-025-04823-y","DOIUrl":"10.1007/s00384-025-04823-y","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the short- and long-term outcomes of botulinum toxin (BT) alone versus BT combined with topical diltiazem (TD) in the treatment of chronic anal fissures (CAF).</p><p><strong>Design: </strong>The study is designed as a retrospective analysis, reviewing data from 1296 patients diagnosed with anal fissures who presented to our clinic between 2017 and 2022.</p><p><strong>Setting: </strong>Single center (University hospital).</p><p><strong>Patients: </strong>A total of 217 patients who met the inclusion criteria were analyzed, with 143 receiving BT alone and 74 receiving the combination of BT + TD.</p><p><strong>Interventions: </strong>BT was administered as 100 IU injected into four quadrants. TD was applied twice daily for 10 days immediately following the BT injection.</p><p><strong>Main outcome measures: </strong>Primary outcome measures were fissure healing at 2 months and days to pain-free defecation. Secondary outcome measures were complete healing and recurrence rates at 24 months.</p><p><strong>Results: </strong>There were no significant differences in demographic characteristics and symptom duration between the BT and BT + TD groups. The median time to pain-free defecation was 7 days across the entire series, with no statistical difference between groups. At 2 months, complete healing was observed in 74.4% of patients, with no significant difference between groups: 74.8% for BT and 74.3% for BT + TD. During a median follow-up of 53 (22-101) months, a recurrence rate of 26.3% was observed, and TD showed no effect on complete healing and recurrence rates.</p><p><strong>Limitations: </strong>The most significant limitation of our study is its retrospective design and the absence of a placebo control for TD.</p><p><strong>Conclusion: </strong>The study demonstrates that BT is an effective and safe treatment for CAF, with or without the addition of TD. The combination therapy did not show superior outcomes.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"54"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting extensive metastasis in postoperative oligometastatic colorectal cancer.","authors":"Rencai Fan, Chenkai Mao, Jiaqi Zhang, Min Dai, Rong Zhang, Xinran Wang, Jiaxin Dai, Shicheng Li, Zhixiang Zhuang","doi":"10.1007/s00384-025-04841-w","DOIUrl":"10.1007/s00384-025-04841-w","url":null,"abstract":"<p><strong>Purpose: </strong>Oligometastatic colorectal cancer (OMCRC) patients can achieve long-term disease control with multidisciplinary treatment. However, the development of extensive metastasis worsens prognosis and restricts treatment options. This study aims to develop a predictive model for extensive metastasis in OMCRC to assist in clinical decision-making.</p><p><strong>Methods: </strong>Clinical and pathological data for OMCRC patients were collected from the Second Affiliated Hospital of Soochow University. Patients were randomly divided into training and testing cohorts. Risk factors for extensive metastasis were identified through LASSO regression analysis and COX regression analysis. Three predictive models were developed in the training cohort and validated in the testing cohort: COX regression analysis, Extreme Gradient Boosting (XGBoost), and Survival Support Vector Machine (SurvSVM). Finally, the optimal model was visualized with the nomogram.</p><p><strong>Results: </strong>A total of 214 patients with OMCRC were enrolled in the study. Four independent risk factors were identified: whether surgery has been undertaken following oligometastasis (WST), histological type (HT), carcinoembryonic antigen at the last follow-up (CAE at last-FU), and preoperative albumin to globulin ratio (Preop-AGR). In the testing cohort, the COX model (1-year AUC = 0.82, 3-year AUC = 0.72, 5-year AUC = 0.85, mean AUC = 0.80) performed best. Decision curve analysis (DCA) confirmed the net benefit of the Cox model, and the nomogram provided accurate predictions of metastasis risk.</p><p><strong>Conclusion: </strong>CAE at last-FU, Preop-AGR, HT, and WST are independent risk factors for extensive metastasis in OMCRC. The nomogram model incorporating risk factors can assist clinicians in developing optimal treatment for OMCRC patients.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"53"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal cutpoint of preoperative neutrophil-lymphocyte ratio and associated postoperative prognosis in colorectal cancer patients.","authors":"Tai-Jan Chiu, Ting-Ting Liu, Ching-Di Chang, Wan-Hsiang Hu","doi":"10.1007/s00384-025-04839-4","DOIUrl":"10.1007/s00384-025-04839-4","url":null,"abstract":"<p><strong>Purpose: </strong>As the role of systemic inflammation in cancer progression, the neutrophil-to-lymphocyte ratio (NLR) is easily evaluated and predicts prognosis in solid cancers. However, the optimal cutpoint for NLR in colorectal cancer patients remains unclear.</p><p><strong>Methods: </strong>This retrospective cohort study was based on the Chang Gung Research Database. Participants included colorectal cancer patients who received operation and preoperative complete blood counts with differentiation from 2007 to 2017. The cutpoint of NLR was calculated by SAS macro (%FINGCUT).</p><p><strong>Results: </strong>A total of 16,990 colorectal patients were included, and 4961 (29.1%) were identified as the high NLR group (≥ 3.59). Poor clinical characteristics were significantly predominant in the patients with high NLR. The patients with high NLR were associated with worse 5-year disease-free survival and overall survival (p < 0.0001). Multivariate Cox regression survival analysis still showed poor 5-year disease-free survival (HR = 1.319, p < 0.0001) and overall survival (HR = 1.611, p < 0.0001) in the high NLR group after adjustment. Patients with high NLR and hypoalbuminemia had the worst disease-free survival and overall survival (p < 0.0001). In subgroup analysis, stage II colon cancer patients with low NLR had better survival than those with high NLR (p < 0.0001). The hazard ratios of without chemotherapy in disease-free survival and overall survival were higher in the patients with high NLR.</p><p><strong>Conclusions: </strong>High NLR was associated with worse clinical characteristics and an independent predictor of poor survival. After adjuvant chemotherapy for stage II colon cancer, more benefits of improving survival were demonstrated in the patients with high NLR.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"55"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence pattern and mapping of lymph node metastases from rectal neuroendocrine tumors.","authors":"Ayumi Takaoka, Shunsuke Tsukamoto, Yasuyuki Takamizawa, Konosuke Moritani, Jun Imaizumi, Yusuke Kinugasa, Yukihide Kanemitsu","doi":"10.1007/s00384-025-04820-1","DOIUrl":"10.1007/s00384-025-04820-1","url":null,"abstract":"<p><strong>Purpose: </strong>There are as yet no data on the long-term clinical outcomes or the frequency of lymph node metastasis after surgical resection in patients with rectal neuroendocrine tumors (NETs). Our study investigated the long-term clinical outcomes and the frequency of lymph node metastasis in patients with rectal NETs treated by surgical resection.</p><p><strong>Methods: </strong>Fifty-one patients with rectal NETs who underwent rectal resection with total mesorectal excision between January 2000 and July 2020 at our hospital were enrolled. Twenty-eight patients had undergone preoperative endoscopic mucosal resection or endoscopic submucosal dissection before surgical resection. The indication for surgery was determined based on the Japan Neuroendocrine Tumor Society guidelines. Patients diagnosed with neuroendocrine carcinoma were excluded. Main outcome measures are frequency of pathological diagnosis of lymph node metastasis, site of lymph node metastasis, and the long-term prognosis after surgical resection.</p><p><strong>Results: </strong>Lymph node metastasis was observed in 20 patients (39.2%) with lateral lymph node metastasis occurring in 4 patients (7.8%). There was no significant association between lymph node metastasis and 5-year relapse-free survival (90% for metastasis-negative patients vs 58.1% for metastasis-positive patients, p = 0.094).</p><p><strong>Conclusions: </strong>The rate of lymph node metastasis in patients with rectal NETs treated by surgical resection with total mesorectal excision was found to be high. However, a good prognosis was achieved by surgical resection even in patients with lymph node metastasis.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"52"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison study of two anastomosis techniques in right hemicolectomy: a systematic review and pooling up analysis.","authors":"Xiao-Qiang Zhang, Run-Xi Tang, Chao-Fu Zhang, Ming-Yang Xia, Lei-Yuan Shuai, Hua Tang, Guang-Yan Ji","doi":"10.1007/s00384-025-04835-8","DOIUrl":"10.1007/s00384-025-04835-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to compare side-to-side anastomosis (SSA) and end-to-side anastomosis (ESA) in laparoscopic right hemicolectomy from multiple perspectives to guide the selection of the optimal anastomotic technique.</p><p><strong>Methods: </strong>This review was pre-registered with PROSPERO (CRD42024614418). A comprehensive literature search was performed using Embase, PubMed, Cochrane Library, and China Biology Medicine (CBM). The primary outcome was anastomotic complications, and secondary outcomes included non-anastomotic complications, short-term prognosis, and surgical parameters.</p><p><strong>Results: </strong>A total of 18 articles involving 14,555 participants were included in this systematic review and meta-analysis. No significant difference was found between SSA and ESA regarding overall anastomotic complications (OR = 1.14, 95% CI = 0.81 to 1.62, P = 0.45). However, SSA showed advantages in reducing postoperative anastomotic bleeding (OR = 0.64, 95% CI = 0.45 to 0.90, P = 0.01), while ESA appeared more favorable for reducing anastomotic leakage (AL) (OR = 1.29, 95% CI = 0.97 to 1.73, P = 0.08) and intestinal obstruction (OR = 1.20, 95% CI = 0.99 to 1.47, P = 0.07), though these differences were not statistically significant. No significant differences were found in non-anastomotic complications, short-term prognosis, or surgical parameters.</p><p><strong>Conclusion: </strong>Current clinical evidence suggests that SSA is more effective than ESA in reducing postoperative anastomotic bleeding during right hemicolectomy for cancer. However, no significant differences were observed between the two techniques regarding overall anastomotic.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"50"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended mesenteric resection reduces the rate of surgical recurrence in Crohn's disease: a systematic review and meta-analysis.","authors":"Sascha Vaghiri, Ali Alipouriani, Wolfram Trudo Knoefel, Hermann Kessler, Dimitrios Prassas","doi":"10.1007/s00384-025-04845-6","DOIUrl":"10.1007/s00384-025-04845-6","url":null,"abstract":"<p><strong>Purpose: </strong>Mesenteric resection in Crohn's disease (CD) is still controversial and under discussion. We performed a meta-analysis to assess recurrence rates and operative-related morbidity based on the extent of mesenteric resection.</p><p><strong>Methods: </strong>A comprehensive literature research was conducted until November 2024 using PubMed (Medline), the Cochrane Central trials register, and Google Scholar databases. Studies before the biological era or with Kono-S anastomosis were excluded. Data from comparative studies with reported patient characteristics and outcome results of extended and limited mesenteric resections were extracted and subsequently entered into a pairwise meta-analysis model. Odds ratios (ORs) for dichotomous variables and standardized mean differences (SMDs) for continuous outcomes with 95% confidence intervals (CIs) were calculated. The risk of bias was rated according to ROBINS-I and Rob2 criteria, respectively.</p><p><strong>Results: </strong>Four non-randomized studies and one randomized trial with a total of 4358 patients (extended mesenteric resection: n = 993 versus mesenteric preservation: n = 3365) met eligibility criteria and were included. Extended mesenteric resection was significantly associated with reduced surgical recurrence rates compared to mesenteric preservation (OR = 4.94; 95% CI [2.22-10.97]; p < 0.001, I² = 0%). In terms of endoscopic recurrence, postoperative morbidity, and hospital stay, no significant differences between both groups were noted within the short follow-up period.</p><p><strong>Conclusion: </strong>Extended mesenteric resection demonstrated a lower surgical recurrence rate in Crohn's disease, while morbidity rates were comparable to the mesenteric sparing approach, whether extended mesenteric excision should be recommended requires further high-quality randomized trials with long-term follow-up data.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"51"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioleiomyoma originating from the ano-rectal wall presenting as a perineal mass: a case report.","authors":"Sayali Valiyeva, Elena Cicerone, Elisabetta Iacobelli, Gina R Quaglione, Renato Pietroletti","doi":"10.1007/s00384-025-04836-7","DOIUrl":"10.1007/s00384-025-04836-7","url":null,"abstract":"<p><strong>Introduction: </strong>Angioleiomyoma, a vascular leiomyoma is a rare, benign smooth-muscle tumor observed to occur anywhere in the body, most frequently in the lower extremities but very rarely in the digestive system. Angioleiomyoma in the hindgut is infrequent and in particular, rectal/perianal location has been observed very rarely.</p><p><strong>Case report: </strong>We describe herein a case of a 50-year-old male patient complaining of perineal discomfort and a swelling at the level of the left ischio-rectal fossa, moderately painful. This solid mass in the left ischio-rectal space was in close relationship with the wall of the ano-rectal junction. After surgical removal and histopathology, the mass resulted an angioleiomyoma, vascular type, desmin positive, a very rare neoplasm. Extensive immune-histochemical studies are fundamental for the correct diagnosis and to rule out other mesenchymal tumors.</p><p><strong>Discussion/conclusion: </strong>Angioleiomyoma is a very rare neoplasm of the gastrointestinal tract, and the fundamental problem of peri-rectal/perianal angioleiomyoma is represented by differential diagnosis from gastrointestinal stromal tumors (GISTs) and other perianal/perirectal swellings. For correct differential diagnosis, the histopathology supported by extensive immune-histochemical study adopting a panel of specific tissue markers is important. The surgical treatment is mandatory with complete excision and subsequent follow-up since local recurrence may occur.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"49"},"PeriodicalIF":2.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}