International Journal of Colorectal Disease最新文献

{"title":"Letter to the Editor regarding \"Lymph node yield does not affect the cancer-specific survival of patients with T1 colorectal cancer: a population‑based retrospective study of the U.S. database and a Chinese registry\".","authors":"Sung Hwan Hwang, Jun Ho Lee","doi":"10.1007/s00384-025-04879-w","DOIUrl":"10.1007/s00384-025-04879-w","url":null,"abstract":"","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"80"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic versus laparoscopic colectomy for transverse colon cancer: a systematic review and meta-analysis.","authors":"Andrea Morini, Maurizio Zizzo, Magda Zanelli, Francesca Sanguedolce, Andrea Palicelli, Candida Bonelli, Lucia Mangone, Massimiliano Fabozzi","doi":"10.1007/s00384-025-04859-0","DOIUrl":"10.1007/s00384-025-04859-0","url":null,"abstract":"<p><strong>Purpose: </strong>Transverse colon cancer, which accounts for approximately 10% of all colon cancers, has a significant gap in the available scientific literature regarding the optimal minimally invasive surgical approach. This meta-analysis aims to compare the robotic and laparoscopic approaches for the surgical management of transverse colon cancer.</p><p><strong>Methods: </strong>Our systematic review made use of Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, in addition to Cochrane Handbook for Systematic Reviews of Interventions. Articles of interest turned out from a search with PubMed/MEDLINE, Cochrane Library (Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials-CENTRAL), Web of Science (Science and Social Science Citation Index), and Embase databases. A comprehensive literature search was conducted for comparative population studies concerning patients who underwent robotic or laparoscopic colectomy for transverse colon cancer). The risk of bias was assessed by the Cochrane Risk-of-Bias tool for randomized trials (Version 2) (RoB 2) and the Risk Of Bias In Non-randomized Studies - of Interventions (Version 2) ROBINS-I. We evaluated two groups of outcomes: intraoperative and postoperative. RevMan (Computer program) Version 5.4.1 was used to perform the meta-analysis. The heterogeneity of the included studies in the meta-analysis was assessed by using the I² statist.</p><p><strong>Results: </strong>The 4 included comparative studies (373 patients: 116 robotic colectomy versus 257 laparoscopic colectomy) had a time frame of approximately 26 years (2005-2021) and an observational nature. Meta-analysis showed a longer operative time (MD: 62.47, 95% CI: 18.17, 106.76, I² = 92%, P = 0.006) and a shorter hospital stay (MD:-1.11, 95% CI: -2.05, -0.18, I² = 63%, P = 0.002) for the robotic group. No differences in terms of conversion to laparotomy, estimated blood loss, time to flatus, time to solid diet, overall postoperative complications rate, minor (Clavien-Dindo or CD I-II) and major (Clavien-Dindo or CD ≥ III) postoperative complications rate, anastomotic leakage, surgical site infections, bleeding, lymph nodes harvested, were shown between robotic and laparoscopic groups.</p><p><strong>Conclusions: </strong>Our meta-analysis revealed that the robotic approach to transverse colon cancer appears to be a safe and feasible option, with results comparable to those of laparoscopic surgery, with longer operating times but a shorter hospital stay. Further high-quality methodological studies are needed to evaluate and compare the short- and long-term outcomes, healthcare costs, and the learning curve between the robotic and laparoscopic surgical approaches.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"79"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of radiomic and clinical characteristics to predict mortality in patients with colorectal perforation.","authors":"Jiaqing Lin, Zhaopu Li, Wei Jiang, Yang Li, Wei Zhu, Shixiong Yang, Kun Yang","doi":"10.1007/s00384-025-04872-3","DOIUrl":"10.1007/s00384-025-04872-3","url":null,"abstract":"<p><strong>Purpose: </strong>We aim to construct and verify a model combining radiomic and clinical data to predict early mortality in patients with colorectal perforation in a two-center study.</p><p><strong>Methods: </strong>Data from 147 patients at Xiaogan Central Hospital (2014-2024) and 52 patients at Southern Hospital of Southern Medical University (2021-2023) were collected for model training and validation. Univariate and multivariate analyses were performed to identify risk factors associated with mortality. Radiomic characteristics from CT scans were extracted via least absolute shrinkage and selection operator (LASSO) regression to construct an imaging score. A nomogram was developed by integrating the findings from the multivariate analysis. Predictive performance was evaluated via the area under the receiver operating characteristic curve (AUC), and clinical utility was assessed via decision curve analysis (DCA).</p><p><strong>Results: </strong>Univariate analysis highlighted age, ASA classification, shock index, rad-score, white blood cell (WBC) count, neutrophil (N) and lymphocyte (L) counts, sodium (Na⁺), creatinine (Cr), and procalcitonin (PCT) as significant prognostic indicators for mortality (p < 0.05). Multivariate analysis confirmed age, ASA classification, PCT, and rad-score as independent prognostic factors. The radiomic combined with clinical characteristics nomogram (RCCCN) includes four variables: the patient's age, ASA classification, PCT level, and rad-score. The RCCCN model demonstrated excellent predictive performance for mortality risk in the validation cohort (AUC: 0.92, 95% CI: 0.84-0.99) with good calibration.</p><p><strong>Conclusion: </strong>A nomogram combining radiomic features and clinical characteristics effectively predicts mortality in patients with colorectal perforation, providing a valuable tool for clinical decision-making and patient management.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"78"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Current evidence on powered versus manual circular staplers in colorectal surgery: a systematic review and meta‑analysis.","authors":"José Martín-Arévalo, David Moro-Valdezate, Leticia Pérez-Santiago, Fernando López-Mozos, Carlos Javier Peña, Juan Antonio Carbonell Asins, David Casado Rodrigo, Stephanie García-Botello, Claudia Gil-Alfosea, Vicente Pla-Martí","doi":"10.1007/s00384-025-04874-1","DOIUrl":"10.1007/s00384-025-04874-1","url":null,"abstract":"","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"77"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative chemoradiotherapy with the TEGAFIRI regimen achieves significant local control in locally advanced rectal cancer.","authors":"Shigenobu Emoto, Kazushige Kawai, Koji Oba, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Yuichiro Yokoyama, Shinya Abe, Kensuke Kaneko, Yuzo Nagai, Takahide Shinagawa, Yuichi Tachikawa, Satoshi Okada, Soichiro Ishihara","doi":"10.1007/s00384-025-04867-0","DOIUrl":"10.1007/s00384-025-04867-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate both the short- and long-term outcomes of preoperative chemoradiotherapy (CRT) using the tegafur-uracil/calcium folinate/irinotecan (TEGAFIRI) regimen in patients with locally advanced rectal cancer (LARC). While total neoadjuvant therapy (TNT) is becoming more common, CRT may still be the optimal approach in certain cases to improve prognosis and reduce adverse events.</p><p><strong>Methods: </strong>This single-center, retrospective cohort study included patients with histologically confirmed nonmetastatic primary adenocarcinoma of the lower rectum treated with preoperative CRT using the TEGAFIRI regimen (TEGAFIRI group). The control group comprised patients treated with tegafur-uracil/calcium folinate (UFT group). The primary endpoint was the pathologic complete response (pCR) rate. Secondary endpoints included adverse events, overall survival (OS), disease-free survival (DFS), distant recurrence-free survival (DRFS), and local recurrence-free survival (LRFS). The background was adjusted using inverse probability weighting (IPW) calculated with the propensity score.</p><p><strong>Results: </strong>The TEGAFIRI group consisted of 79 patients, while the UFT group included 264. The standardized pCR rates through the IPW were as follows: TEGAFIRI group: 24.3%, UFT group: 8.8%, and the difference in pCR was 15.4% (P = 0.01). Adverse events of grade 3 or higher were observed in 15.2% vs. 8.7% (adjusted) (13.6% vs. 9.1% crude) in the TEGAFIRI group and the UFT group. The standardized LRFS was significantly higher in the TEGAFIRI group (HR = 0.39, (95% CI 0.16-0.98), P = 0.045). There were no significant differences in OS, DFS, or DRFS between groups.</p><p><strong>Conclusions: </strong>The TEGAFIRI regimen for preoperative CRT in LARC demonstrated a high pCR rate and reduced local recurrence, with manageable adverse events.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"76"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lysyl oxidase expression with clinicopathological features in colorectal adenocarcinomas.","authors":"Ayça Dilşad Çağlayan, Seda Kahraman, Doğukan Çanakçı, Mustafa Tahtacı, Ayşegül Aksoy Altınboğa, Hayriye Tatlı Doğan","doi":"10.1007/s00384-025-04852-7","DOIUrl":"10.1007/s00384-025-04852-7","url":null,"abstract":"<p><strong>Purpose: </strong>Colorectal adenocarcinoma (CRC) is one of the leading causes of cancer-related mortality worldwide. Within the tumor microenvironment, neoplastic cells, along with tumor-promoting fibroblasts, contribute to the progression of CRC. Lysyl oxidase (LOX), an enzyme involved in this process facilitates collagen cross-linking within the extracellular matrix and plays a crucial role in remodeling the tumor microenvironment (TME) and promoting metastasis through epithelial-mesenchymal transition (EMT). This study investigates LOX expression in both tumor cells and the tumor stroma in relation with clinicopathological features in CRC patients.</p><p><strong>Method: </strong>Immunohistochemical staining of LOX proteins was performed on tissue microarrays from colorectal tumor samples taken from resection specimens. LOX expression was quantified in tumor cells and stroma. The correlation between the expression of LOX and clinicopathological parameters was analyzed.</p><p><strong>Results: </strong>A positive correlation was observed between peritumoral stromal LOX expression and LOX expression in the tumor epithelium. High expression of LOX in tumor cells was significantly associated with poorer progression-free survival (PFS) among patients. Low tumor budding was observed in tumors with low stromal LOX expression.</p><p><strong>Conclusion: </strong>The current study indicates that LOX may be an important contributor to CRC progression. The findings of this series, in which LOX expression correlated with tumor budding and survival, support a contribution for LOX to EMT and metastasis. Furthermore, LOX expression in both the tumor cell and stromal compartment may add information to improve prognosis in CRC management. These findings, however, have to be validated in further studies, as does also the investigation of LOX as a potential therapeutic target in CRC.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"75"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival analysis and prediction of early-onset colorectal cancer patients post-chemotherapy: an analysis based on the SEER database.","authors":"Zhiguo Tang, Guojia Zhou, Yu Xu, Yinxu Zhang","doi":"10.1007/s00384-025-04853-6","DOIUrl":"10.1007/s00384-025-04853-6","url":null,"abstract":"<p><strong>Background: </strong>The incidence of Early-Onset Colorectal Cancer (EOCRC) has risen markedly in recent years, garnering widespread attention due to its distinctive clinical and biological features. However, systematic research on prognostic risk factors and long-term survival prediction for EOCRC patients undergoing postoperative chemotherapy remains scarce. This study seeks to pinpoint critical prognostic factors for EOCRC patients receiving postoperative chemotherapy and to devise a survival prediction tool employing a Nomogram model.</p><p><strong>Methods: </strong>Patients diagnosed with EOCRC between 2010 and 2015, who underwent postoperative chemotherapy, were extracted from the SEER (Surveillance, Epidemiology, and End Results) database. Only those meeting the inclusion criteria were included. Univariate and multivariate Cox regression analyses were performed to determine independent risk factors influencing overall survival (OS). A Nomogram model was then developed using significant variables. The model's predictive accuracy and clinical utility were assessed through the concordance index (C-index), calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>A cohort of 9,205 patients was analyzed, with 6,445 randomly allocated to the training group and 2,760 to the validation group from the SEER database. Independent prognostic factors, including gender, race, marital status, primary tumor location, histological type, TNM stage, CEA levels, bone metastasis, liver metastasis, and lung metastasis, were identified through univariate and multivariate Cox regression analyses. A Nomogram model constructed from these factors yielded a C-index of 0.76 (0.75, 0.77) in the training group and 0.76 (0.75, 0.78) in the validation group, reflecting robust discriminative ability and consistency. The area under the curve (AUC) for predicting 1-year OS was calculated as 0.84 (0.81, 0.86) in the training group and 0.82 (0.78, 0.85) in the validation group. For 3-year OS, AUCs were recorded at 0.83 (0.82, 0.84) and 0.82 (0.80, 0.84), respectively, while for 5-year OS, AUCs reached 0.81 (0.80, 0.82) and 0.82 (0.80, 0.84). Calibration curves demonstrated close alignment between predicted and observed survival rates. Additionally, DCA affirmed the model's clinical decision-making value.</p><p><strong>Conclusion: </strong>Prognostic risk factors for EOCRC patients receiving postoperative chemotherapy were systematically evaluated in this study, leading to the development of a Nomogram-based survival prediction model. This tool offers a robust scientific foundation for tailoring individualized treatment and guiding follow-up strategies.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"74"},"PeriodicalIF":2.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of negative pressure wound therapy following stoma reversal: a systematic review and meta-analysis of randomized controlled trials.","authors":"Caroline Drumm, Ben Creavin, Iva Pranjic Previsic, Maeve O'Neill, John Larkin, Brian J Mehigan, Dara Kavanagh, Paul McCormick, Michael Eamon Kelly","doi":"10.1007/s00384-025-04865-2","DOIUrl":"10.1007/s00384-025-04865-2","url":null,"abstract":"<p><strong>Introduction: </strong>Stoma reversal is a contaminated surgery with many patients experiencing significant wound complications that contribute to patient morbidity. It is believed that the use of prophylactic negative pressure wound therapy (NPWT) may enhance wound healing and help reduce the risk of developing surgical site infections (SSI). However, there is conflicting research regarding its effectiveness following stoma reversal. Our systematic review aims to evaluate the available randomized data to determine if the use of prophylactic NPWT after stoma reversal improves the duration of wound healing and reduces rates of postoperative complications.</p><p><strong>Methods: </strong>A comprehensive search of literature published up to January 2025 was conducted using the following databases: PubMed, Embase, Medline, and Cochrane Library. The included trials were randomized controlled trials that investigated the effect of NPWT following stoma reversal. The primary outcome was the time to complete wound healing. Secondary outcomes included the incidence of wound complications, SSI, hematomas, and the length of hospital stay.</p><p><strong>Results: </strong>Six randomised control trials were included, with 332 patients, of which 171 of these underwent NPWT. There was a significant reduction in time to complete wound healing (OR - 2.53, 95% CI - 3.82 to - 1.24, p = 0.0001, I² = 45%) and wound healing at 42 days (OR 0.36, 95% CI 0.14 - 0.88, p = 0.03, I² = 0%) in the NPWT group. There was no significant difference in any wound complications (OR 0.72, 95% CI 0.23-2.28, p = 0.58, I² = 42%), SSI rates (OR 0.95, 95% CI 0.27-3.29, p = 0.94, I² = 38%) or haematoma rates (OR 0.21, 95% CI 0.03-1.27, p = 0.09, I² = 0%) between the groups. There was no significant difference in length of stay (OR - 0.02, 95% CI - 1.21-1.18, p = 0.98, I² = 66%).</p><p><strong>Conclusion: </strong>The use of NPWT after stoma reversal significantly reduces the time needed for complete wound healing while maintaining a comparable rate of wound complications and length of hospital stay. Therefore, NPWT may be valuable in optimizing postoperative recovery and enhancing patient outcomes.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"73"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No operation after short-course radiotherapy followed by consolidation chemotherapy in locally advanced rectal cancer (NOAHS-ARC): study protocol for a prospective, phase II trial.","authors":"Felipe F Quezada-Díaz, Aron Bercz, Jose L Escobar, Nicole Caire, Lucia E Díaz-Feldman, Erik Manriquez, Gonzalo Carvajal","doi":"10.1007/s00384-025-04850-9","DOIUrl":"10.1007/s00384-025-04850-9","url":null,"abstract":"<p><strong>Purpose: </strong>Organ preservation through a watch-and-wait (W&W) strategy has become a viable option for select rectal cancer patients with clinical complete responses (cCR) to total neoadjuvant therapy (TNT). This approach limits the morbidity associated with multimodal treatment. However, the optimal treatment strategy and predictors of treatment response are still unresolved. Rectal cancer incidence is rising, particularly in developing countries, and the disease is a major public health concern in Chile. Prior to the no operation after short-course radiotherapy followed by consolidation chemotherapy in locally advanced rectal cancer (NOAHS-ARC) trial, TNT-based treatments and W&W programs had not been implemented in Chile.</p><p><strong>Methods/design: </strong>This single-arm, multicenter, phase II prospective trial, conducted in Santiago, Chile, will enroll patients with stage II/III rectal adenocarcinoma. Treatment involves induction short-course radiotherapy (25 Gy in 5 fractions) followed by consolidation chemotherapy (FOLFOX × 9 or CAPOX × 6 cycles). The response will be assessed 4-8 weeks after chemotherapy completion. Patients achieving cCR will be offered W&W, while those with incomplete responses will undergo total mesorectal excision. The primary endpoint is the rate of complete tumor response, combining pathologic complete responses (pCR) and sustained cCR (> 1 year), compared to a matched cohort treated with neoadjuvant chemoradiation alone. The trial aims to recruit 48 patients, assuming a combined pCR/sustained cCR rate of 12%. Quality of life measures will be assessed, and a biorepository of tissue and plasma samples will be established for future research, alongside serial endoscopic and MRI images.</p><p><strong>Discussion: </strong>NOAHS-ARC seeks to advance organ preservation strategies in rectal cancer while pioneering TNT and W&W protocols in Chile. The study will also focus on functional outcomes and provide valuable data for improving patient care both locally and globally.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier NCT04864067. Registered on April 28, 2021.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"69"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for postoperative acute kidney injury in colorectal cancer: a systematic review and meta-analysis.","authors":"Lumei Huang, Aifang Xiao, Yufeng Li","doi":"10.1007/s00384-025-04860-7","DOIUrl":"10.1007/s00384-025-04860-7","url":null,"abstract":"<p><strong>Purpose: </strong>To thoroughly examine the risk factors that may predispose patients with colorectal cancer to postoperative acute kidney injury (AKI).</p><p><strong>Methods: </strong>To find relevant studies (from the beginning up to May 2024), two researchers searched PubMed, Web of Science, the Cochrane Library, and Embase databases. Two researchers evaluated the quality of the literature using the Newcastle-Ottawa Scale (NOS) and extracted data individually. Data analysis was performed using the Review Manager 5.4.</p><p><strong>Results: </strong>Our meta-analysis included 23 studies, encompassing a total of 167,904 patients. The identified risk factors for postoperative AKI in colorectal cancer patients were male sex, older age, body mass index (BMI) ≥ 25 kg/m², hypertension, diabetes mellitus (DM), chronic kidney disease (CKD), hypoalbuminemia, emergency surgery, open surgery, prolonged operation time, American Society of Anesthesiologists (ASA) score ≥ 3, and intraoperative transfusion. In contrast, anemia and elevated creatinine levels did not emerge as significant risk factors for AKI in this population.</p><p><strong>Conclusion: </strong>To mitigate the incidence of postoperative AKI among these patients, healthcare professionals must proactively identify these risk factors and implement appropriate preventive measures.</p>","PeriodicalId":13789,"journal":{"name":"International Journal of Colorectal Disease","volume":"40 1","pages":"70"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}