Risk factors for postoperative acute kidney injury in colorectal cancer: a systematic review and meta-analysis.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

International Journal of Colorectal Disease Pub Date : 2025-03-18 DOI:10.1007/s00384-025-04860-7

Lumei Huang, Aifang Xiao, Yufeng Li

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引用次数: 0

Abstract

Purpose: To thoroughly examine the risk factors that may predispose patients with colorectal cancer to postoperative acute kidney injury (AKI).

Methods: To find relevant studies (from the beginning up to May 2024), two researchers searched PubMed, Web of Science, the Cochrane Library, and Embase databases. Two researchers evaluated the quality of the literature using the Newcastle-Ottawa Scale (NOS) and extracted data individually. Data analysis was performed using the Review Manager 5.4.

Results: Our meta-analysis included 23 studies, encompassing a total of 167,904 patients. The identified risk factors for postoperative AKI in colorectal cancer patients were male sex, older age, body mass index (BMI) ≥ 25 kg/m², hypertension, diabetes mellitus (DM), chronic kidney disease (CKD), hypoalbuminemia, emergency surgery, open surgery, prolonged operation time, American Society of Anesthesiologists (ASA) score ≥ 3, and intraoperative transfusion. In contrast, anemia and elevated creatinine levels did not emerge as significant risk factors for AKI in this population.

Conclusion: To mitigate the incidence of postoperative AKI among these patients, healthcare professionals must proactively identify these risk factors and implement appropriate preventive measures.

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结直肠癌术后急性肾损伤的风险因素：系统回顾和荟萃分析。

目的：深入探讨可能导致结直肠癌术后急性肾损伤（AKI）的危险因素。方法：两位研究者检索PubMed、Web of Science、Cochrane Library和Embase数据库查找相关研究（从年初到2024年5月）。两位研究人员使用纽卡斯尔-渥太华量表（NOS）评估文献的质量，并单独提取数据。使用Review Manager 5.4进行数据分析。结果：我们的荟萃分析包括23项研究，共包括167,904例患者。结直肠癌患者术后AKI的危险因素为男性、年龄较大、体重指数(BMI)≥25 kg/m2、高血压、糖尿病（DM）、慢性肾病（CKD）、低白蛋白血症、急诊手术、开放手术、手术时间延长、美国麻醉医师学会（ASA）评分≥3分、术中输血。相比之下，贫血和肌酐水平升高并未成为该人群AKI的重要危险因素。结论：为了降低这些患者术后AKI的发生率，医护人员必须积极识别这些危险因素并实施适当的预防措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Colorectal Disease 医学-外科

CiteScore

4.90

自引率

3.60%

发文量

206

审稿时长

3-8 weeks

期刊介绍： The International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery aims to publish novel and state-of-the-art papers which deal with the physiology and pathophysiology of diseases involving the entire gastrointestinal tract. In addition to original research articles, the following categories will be included: reviews (usually commissioned but may also be submitted), case reports, letters to the editor, and protocols on clinical studies. The journal offers its readers an interdisciplinary forum for clinical science and molecular research related to gastrointestinal disease.