International Journal of Applied and Basic Medical Research最新文献

{"title":"Histopathological Profile of the Heart in Sudden Death: Forensic Perspectives on Cardiac and Noncardiac Mechanisms.","authors":"Amina Zorlak-Cavcic, Nina Camdžic, Enisa Hodžic, Sanita Maleškic Kapo, Elhana Maric, Emina Derviševic","doi":"10.4103/ijabmr.ijabmr_123_26","DOIUrl":"10.4103/ijabmr.ijabmr_123_26","url":null,"abstract":"<p><strong>Background: </strong>Sudden death is an unexpected natural fatal event that may arise from both cardiac and noncardiac causes. Differentiating true primary cardiac pathology from incidental or secondary myocardial changes remains a major challenge in forensic evaluation, particularly in clearly noncardiac sudden deaths.</p><p><strong>Aim: </strong>The aim of this study was to assess histopathological changes in the heart in cases of sudden death of cardiac and noncardiac origin and to compare the distribution of these findings across different certified causes of death. Additionally, the study aimed to evaluate the frequency and potential forensic relevance of these cardiac alterations.</p><p><strong>Materials and methods: </strong>A retrospective cross-sectional analysis was conducted on 78 medico-legal autopsy cases of sudden death examined at the Department of Forensic Medicine in Bosnia and Herzegovina (2016-2025). Paraffin-embedded cardiac tissue was evaluated histologically by three independent pathologists, while cases involving unnatural causes of death or significant autolysis were excluded.</p><p><strong>Results: </strong>Cardiac-origin deaths accounted for 76.9% of cases and were more common in males. Individuals who died from cardiac causes were significantly older than those with noncardiac causes (58.7 ± 19.2 vs. 45.7 ± 16.8 years; <i>P</i> = 0.012). Cardiac-origin deaths predominated in middle-aged and older adults, whereas noncardiac sudden deaths occurred more frequently in younger individuals. Myocardial infarction and scar tissue were significantly associated with cardiac-origin deaths (<i>P</i> = 0.017 and <i>P</i> = 0.038). Hypertrophy and dispersed fibrosis increased progressively with age.</p><p><strong>Conclusion: </strong>Cardiac sudden deaths were more frequent and mainly associated with chronic myocardial changes rather than acute ischemia. Middle-aged individuals were the most vulnerable group, highlighting the need for improved cardiovascular risk assessment and prevention.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 3","pages":"197-204"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Antral Vascular Ectasia as an Unusual Cause of Iron Deficiency Anemia in Primary Sjögren's Syndrome.","authors":"Shaikh Mohammed Aslam, H Aadithya Shyllesh, Ashwin Kulkarni, K Mohammed Suhail","doi":"10.4103/ijabmr.ijabmr_110_26","DOIUrl":"10.4103/ijabmr.ijabmr_110_26","url":null,"abstract":"<p><p>Gastric antral vascular ectasia (GAVE) is a cause of chronic gastrointestinal (GI) bleeding and is commonly associated with autoimmune disorders such as systemic lupus erythematosus and systemic sclerosis. We report an elderly woman with hypertension and hypothyroidism who presented with sicca symptoms and features of left parotitis. Evaluation revealed strong antinuclear antibody positivity with a specific anti-Ro-52 profile, and a lip biopsy confirmed chronic sialadenitis, consistent with primary Sjögren's syndrome (PSS). During evaluation, she was incidentally found to have iron deficiency anemia, prompting upper GI endoscopy, which demonstrated multiple oozing telangiectasias consistent with GAVE. The coexistence of GAVE with iron deficiency anemia in the setting of PSS is rare and clinically noteworthy. The patient underwent endoscopic band ligation for GAVE and was treated with steroids, methotrexate, and hydroxychloroquine for PSS, resulting in improvement of sicca symptoms and normalization of hematological parameters.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 3","pages":"223-225"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Susceptibility Pattern of <i>Staphylococcus aureus</i> with Special Reference to Inducible Clindamycin-resistant Isolates from Various Clinical Samples at a Tertiary Care Teaching Hospital.","authors":"Yash Khandelwal, Jigna Karia, Govind Ninama","doi":"10.4103/ijabmr.ijabmr_118_26","DOIUrl":"10.4103/ijabmr.ijabmr_118_26","url":null,"abstract":"<p><strong>Background: </strong><i>Staphylococcus aureus</i> is a major pathogenic organism responsible for various infections. The emergence of methicillin-resistant <i>S. aureus</i> (MRSA) and inducible clindamycin resistance (ICR) complicates treatment and highlights the importance of accurate detection of Macrolide-Lincosamide-Streptogramin B (MLSB) resistance mechanisms.</p><p><strong>Aims/objectives: </strong>This study aimed to assess the antimicrobial susceptibility pattern of <i>S. aureus</i>, detect ICR using the D-zone test, and evaluate its association with MRSA.</p><p><strong>Methodology: </strong>A total of 212 nonduplicate <i>S. aureus</i> isolates were obtained from various clinical samples at Medical College Baroda. Identification was performed using standard microbiological techniques. Antimicrobial susceptibility was tested using the Kirby-Bauer disk diffusion method and interpreted as per the Clinical and Laboratory Standards Institute guidelines. MRSA was identified using cefoxitin (30 µg), and ICR was detected via the D-zone test.</p><p><strong>Results: </strong>Among 212 isolates, 124 (58.49%) were male and 88 (41.51%) were female. MRSA was detected in 40 (18.87%) isolates. ICR (inducible MLSB [iMLSB]) was seen in 48 (22.64%) isolates, MS phenotype in 21 (9.90%) and constitutive MLSB in 9 (4.24%). A significant association was found between MRSA and iMLSB (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Routine D-zone testing is essential to detect inducible resistance. Continued surveillance and rational antibiotic use are necessary to prevent resistance spread.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 3","pages":"205-209"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nontraumatic Acute Abdominal Pain in the Emergency Department: A Retrospective Study.","authors":"Haris Duljević, Amina Zorlak-Čavčić, Verica Mišanović, Emina Duljević, Fahrudin Husić, Mustafa Omanović, Emina Dervišević","doi":"10.4103/ijabmr.ijabmr_448_25","DOIUrl":"10.4103/ijabmr.ijabmr_448_25","url":null,"abstract":"<p><strong>Introduction: </strong>Acute abdominal pain (AAP) constitutes a frequent presenting complaint in the emergency department (ED). Distinguishing between mild and potentially life-threatening cases requires a structured approach and effective triage. This study aimed to describe the main nontraumatic causes of AAP, assess urgency, and analyze case distribution by age and gender, as well as admission and discharge patterns.</p><p><strong>Patients and methods: </strong>All records of adult patients presenting with abdominal pain between August and December 2023 were retrospectively analyzed. The entire patient sample (<i>n</i> = 257) was classified into 15 different diagnostic groups.</p><p><strong>Results: </strong>From the total count of patients, <i>n</i> = 257, there were 154 females (59.92%) and 103 males (40.08%). According to our study, the leading cause of AAP was renal colic (<i>n</i> = 67; 26.07%), followed by nonspecific abdominal pain (NSAP) (<i>n</i> = 48, 18.68%), urinary tract infections (UTIs) (<i>n</i> = 38, 14.79%), and biliary colic and cholecystitis (<i>n</i> = 32, 12.45%). In terms of hospitalization, 195 patients (75.88%) were discharged, and 62 patients (24.12%) were admitted. Logistic regression analysis revealed that the likelihood of hospitalization was approximately twofold higher in males (odds ratio [OR] = 2.03), whereas females exhibited a reduced probability (OR = 0.49).</p><p><strong>Conclusion: </strong>A higher proportion of AAP cases was observed among females in our ED sample, with renal colic, NSAP, UTI, and biliary disorders being the most common diagnoses. A high discharge rate (75.9%) reflects that most AAP cases were non-emergent; however, careful triage remains essential, particularly in male patients due to their higher admission risk.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"92-97"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Dental Commission - Toward a Collaborative and Outcome-driven Approach.","authors":"Kavita Sekhri, Ruchika Nandha","doi":"10.4103/ijabmr.ijabmr_128_26","DOIUrl":"10.4103/ijabmr.ijabmr_128_26","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"77-78"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pityriasis Lichenoides et Varioliformis Acuta: Diagnostic Enigma Unveiled with Clinicopathologic Insights into a Rare Dermatologic Entity.","authors":"Yash Thesiya, Parth Goswami, Garima Anandani, Yashdeep Singh Pathania","doi":"10.4103/ijabmr.ijabmr_56_26","DOIUrl":"10.4103/ijabmr.ijabmr_56_26","url":null,"abstract":"<p><p>Pityriasis Lichenoides et varioliformis acuta (PLEVA) is a rare, idiopathic, inflammatory dermatosis representing the acute end of the pityriasis lichenoides spectrum. It usually affects children and young adults, whereas occurrence in older individuals is distinctly uncommon. We report a 53-year-old male laborer who presented with multiple, discrete, erythematous, itchy papuloplaque lesions over the back and neck for 8 days. There were no systemic symptoms. Clinical differentials included pityriasis rosea and PLEVA. Histopathological examination of a punch biopsy revealed mild acanthosis, focal spongiosis, basal layer vacuolar degeneration, lymphocytic exocytosis, red blood cell extravasation, and a dense superficial perivascular lichenoid lymphocytic infiltrate, confirming the diagnosis of PLEVA. The patient responded well to a short course of systemic and topical therapy, with complete resolution of lesions within 6 weeks and no recurrence on follow-up. This case highlights that PLEVA can present even in older adults, an age group where it is exceptionally uncommon. Recognition of its variable clinical spectrum and careful histopathological evaluation are essential to distinguish it from other papulosquamous disorders. Reporting such atypical presentations expands current understanding of disease demographics and reinforces the need to consider PLEVA in the differential diagnosis of acute eruptive dermatoses across all age groups.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"147-149"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Drainage Dilemma in Thyroid Surgeries: A Randomized Controlled Trial to Evaluate Necessity of Drain Following Thyroidectomy.","authors":"Toshikala Khiamn, Siddharth P Dubhashi, Divish Saxena","doi":"10.4103/ijabmr.ijabmr_15_26","DOIUrl":"10.4103/ijabmr.ijabmr_15_26","url":null,"abstract":"<p><strong>Background: </strong>Draining the thyroid bed after thyroid surgery is a matter of apprehension and anxiety for the operating surgeon rather than its necessity. This study aims to evaluate the evidence-based evaluation of the necessity of a drain following thyroidectomy.</p><p><strong>Materials and methods: </strong>A randomized-controlled trial was conducted at a tertiary care center in Central India for 2 years with a sample size of 80 patients undergoing thyroidectomy, with 40 patients in both thyroidectomy with drain and thyroidectomy without drain group each. The postoperative protocol and standard of care were similar in both groups. The patients were assessed for pain, seroma formation, and wound infection on postoperative day 1, 3, and 5, and patient-rated satisfaction scoring was done using a 5-point Likert scoring.</p><p><strong>Results: </strong>The age distribution in both the groups was comparable with a mean age of presentation in Group A was 42.1 ± 11.6 years and for Group B was 43.4 ± 14.2 years. Patients with a drain experienced significantly more pain (<i>P</i> < 0.00001) and increased length of hospital stay (<i>P</i> < 0.0001). The patients in the group without a drain were significantly more satisfied (significant <i>P</i> < 0.022). Only 4 patients in the group without a drain developed seroma. None of the patients had hematoma or surgical site infection in the postoperative period.</p><p><strong>Conclusion: </strong>Drain placement after thyroid surgeries has no additional benefits in preventing postoperative risk of seroma/hematoma formation or occurrence of surgical site infection. Rather, the use of drains is usually associated with postoperative discomfort, increased length of hospital stays, and leaves an additional scar affecting overall esthetics for patients.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"130-134"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin Potentiates 5-fluorouracil Cytotoxicity in HT-29 Colon Cancer Cells through Enhanced Apoptosis and Transcriptional Modulation of Adenosine Monophosphate-activated Protein Kinase/Mammalian Target of Rapamycin Signaling.","authors":"Bassem Refaat","doi":"10.4103/ijabmr.ijabmr_477_25","DOIUrl":"10.4103/ijabmr.ijabmr_477_25","url":null,"abstract":"<p><strong>Background: </strong>Although 5-fluorouracil (5-FU) is a standard chemotherapeutic agent for colorectal cancer (CRC), its efficacy is often limited by chemoresistance. Irisin, an exercise-induced myokine, has demonstrated anticancer potential; however, its role in CRC remains incompletely defined.</p><p><strong>Materials and methods: </strong>Human HT-29 CRC cells were treated for 12 h with irisin (2, 20, and 200 ng/mL) alone or combined with 5-FU (50 μM). Cell cycle progression and apoptosis were assessed by flow cytometry. Expression of cell cycle regulators (CCND1, CCND3, p21, and p27), apoptotic markers (BCL2, Bcl-2-associated X protein, cytochrome c, caspase-8, caspase-9, and caspase-3), and metabolic mediators (protein kinase B [Akt], mammalian target of rapamycin [mTOR], adenosine monophosphate-activated protein kinase [AMPK], and phosphatase and tensin homolog [PTEN]) was analyzed by quantitative reverse transcription-polymerase chain reaction.</p><p><strong>Results: </strong>While 5-FU induced G0/G1 arrest with p21/p27 upregulation, irisin alone or in combination exerted minimal additional effects on cell cycle progression. In contrast, high-dose irisin (200 ng/mL) significantly increased apoptotic cell fractions and upregulated caspase-8 and caspase-3 without significant alteration of mitochondrial apoptotic gene expression. Combination treatment further enhanced apoptosis. Co-treatment also increased AMPK and PTEN mRNA levels while reducing Akt and mTOR mRNA levels.</p><p><strong>Conclusion: </strong>Under the experimental conditions used, irisin potentiated 5-FU cytotoxicity in HT-29 CRC cells primarily through enhanced apoptosis and transcriptional modulation of metabolic signaling components. These findings suggest a potential chemosensitizing role for irisin, warranting further validation at the protein and functional levels.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"98-107"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world Effectiveness and Safety of Brentuximab Vedotin: A Retrospective Cohort Study from a Tertiary Care Hospital.","authors":"Roberto Lozano, Carina Bona","doi":"10.4103/ijabmr.ijabmr_68_26","DOIUrl":"10.4103/ijabmr.ijabmr_68_26","url":null,"abstract":"<p><strong>Background: </strong>Brentuximab vedotin (BV) is widely used in CD30-positive lymphomas, but real-world outcomes may differ from clinical trials due to patient heterogeneity and prior treatment exposure. This study evaluated effectiveness, safety, and survival outcomes of BV in routine clinical practice at a tertiary care hospital.</p><p><strong>Methods: </strong>A retrospective cohort study included 37 consecutive patients treated between January 2018 and February 2026. Complete remission (CR) rates were assessed in intention-to-treat (ITT) and evaluable populations. Overall survival and progression-free survival (PFS) was estimated using the Kaplan-Meier analysis. Adverse events were identified from the clinical records. Peripheral neuropathy was additionally assessed through a systematic narrative text search of clinical summaries.</p><p><strong>Results: </strong>The overall CR rate was 24.3% (95% confidence interval [CI], 11.8-41.2) in the ITT population and 33.3% (95% CI, 16.5-54.0) among evaluable patients. CR was numerically higher in Hodgkin lymphoma (HL) than non-HLs (28.6% vs. 21.7%; <i>P</i> = 0.71). Median PFS was 579 days, while median OS was not reached. Peripheral neuropathy was the most frequent adverse event (32.4%).</p><p><strong>Conclusion: </strong>BV shows clinically meaningful real-world effectiveness with a safety profile consistent with previous studies. Peripheral neuropathy remains the principal toxicity. The findings should be interpreted cautiously because of the limited cohort size and potential type II error in subgroup analyses. Larger real-world cohorts are needed to better define the outcomes.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"141-146"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Psychiatric Morbidity and Its Association with Marital Satisfaction and Quality of Life in Spouses of Patients with Alcohol Use Disorders.","authors":"Jivesh Arora, Pir Dutt Bansal, Amit Jain, Bhavneesh Saini, Sumit Saini, Jivitesh Singh Chahal, Gurpreet Choudhary","doi":"10.4103/ijabmr.ijabmr_378_25","DOIUrl":"10.4103/ijabmr.ijabmr_378_25","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorders (AUDs) pose significant public health challenges, profoundly affecting family members, particularly spouses, due to emotional, social, and psychological strain. Wives of alcohol-dependent individuals frequently experience mood and anxiety disorders, reduced marital satisfaction, and compromised quality of life (QoL). Addressing these issues can enhance coping, improve well-being, and positively influence treatment outcomes for patients.</p><p><strong>Objectives: </strong>The objective of this study was to determine the prevalence of psychiatric morbidity among spouses of AUD patients and its association with marital satisfaction and QoL.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted at a tertiary care hospital in Faridkot after ethical approval. Couples meeting the inclusion and exclusion criteria provided informed consent. Alcohol dependence severity in male patients was assessed using the Severity of Alcohol Dependence Questionnaire (SADQ). Spouses were evaluated using the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Positive and Negative Syndrome Scale, Kansas Marital Satisfaction Scale (KMSS), and World Health Organization QOL (WHOQOL-BREF). Data were analyzed for the degree of psychiatric morbidity and correlations with marital satisfaction and QoL.</p><p><strong>Results: </strong>Among patients, 51% had moderate alcohol dependence. Spouses exhibited predominantly mild depression (60%) and anxiety (45%). Severity of depression and anxiety significantly correlated with husbands' alcohol dependence (<i>P</i> < 0.001). KMSS scores demonstrated a strong negative correlation with SADQ (<i>r</i> = -0.804, <i>P</i> < 0.001). WHOQOL-BREF domain scores were highest in spouses of mildly dependent patients and lowest in the severe group, with environmental health showing the strongest negative correlation (<i>r</i> = -0.722, <i>P</i> < 0.001). Psychiatric morbidity negatively correlated with both marital satisfaction and all QoL domains (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>AUDs significantly impair spouses' mental health, marital satisfaction, and QoL. Integrating family-centered interventions in AUD management is crucial to reduce burden and improve outcomes.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"16 2","pages":"114-118"},"PeriodicalIF":1.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13327383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}