International Journal of Applied and Basic Medical Research最新文献

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Use of Intraoperative Fluoroscopy for Brain Ventricular Catheter Insertion: Poor Man's Navigation. 术中透视在脑室导管置入中的应用:穷人的导航。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-07-01 Epub Date: 2025-08-20 DOI: 10.4103/ijabmr.ijabmr_559_24
Jagminder Singh, Saurabh Sharma, Shivender Sobti, Ashwani Kumar Chaudhary, Hanish Bansal, Manish Sharma
{"title":"Use of Intraoperative Fluoroscopy for Brain Ventricular Catheter Insertion: Poor Man's Navigation.","authors":"Jagminder Singh, Saurabh Sharma, Shivender Sobti, Ashwani Kumar Chaudhary, Hanish Bansal, Manish Sharma","doi":"10.4103/ijabmr.ijabmr_559_24","DOIUrl":"10.4103/ijabmr.ijabmr_559_24","url":null,"abstract":"<p><strong>Background: </strong>Ventricular catheter (VC) misplacement is one of the most common causes of ventriculoperitoneal (VP) shunt malfunction and revision surgery. Most of the VC placements are done by freehand method. We evaluated the use of intraoperative fluoroscopy for assessing VC placement.</p><p><strong>Materials and methods: </strong>A total of 70 patients were enrolled in the study. Patients with hydrocephalus who required cerebrospinal fluid diversion were enrolled in the study. Thirty-five patients were placed in the control group (patients in whom intraoperative fluoroscopy was not done), and 35 patients were placed in the test group (patients in whom intraoperative fluoroscopy was done). Patients with trapped ventricles and multiloculated hydrocephalus were excluded from the study. VP shunt insertion was done through standard Keen's point.</p><p><strong>Results: </strong>The positioning of VC was optimal in 40 patients, with a significant difference between the test group and the control group. Gross malpositioning was seen in seven patients: four in the test group and three in the control group. All gross malpositioned VCs in the test group were corrected intraoperatively. VC crossing midline was less in the test group as compared to the control group.</p><p><strong>Conclusion: </strong>Fluoroscopy is an easy and cheap method to assess VC position intraoperatively. It is readily available and helps us in avoiding resurgery due to VC misplacement and subsequent blockage.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 3","pages":"158-162"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing the Professionalism Mini-evaluation Exercise in Undergraduate Medical Training in India: A Validity and Feasibility Study. 在印度本科医学培训中引入专业精神小型评估练习:有效性和可行性研究。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-07-01 Epub Date: 2025-08-20 DOI: 10.4103/ijabmr.ijabmr_190_25
Rajiv Mahajan, Shital Bhandary, Purnima Barua, Sushanta Kumar Mishra, Priyanka Gupta, Sarika Gupta, Chandrika Rao, Roosy Aulakh, Tejinder Singh
{"title":"Introducing the Professionalism Mini-evaluation Exercise in Undergraduate Medical Training in India: A Validity and Feasibility Study.","authors":"Rajiv Mahajan, Shital Bhandary, Purnima Barua, Sushanta Kumar Mishra, Priyanka Gupta, Sarika Gupta, Chandrika Rao, Roosy Aulakh, Tejinder Singh","doi":"10.4103/ijabmr.ijabmr_190_25","DOIUrl":"10.4103/ijabmr.ijabmr_190_25","url":null,"abstract":"<p><strong>Context: </strong>Professionalism Mini-Evaluation Exercise (P-MEX) has demonstrated valid evidence in assessing the construct, professionalism, in resident training. As the Indian medical regulatory body has introduced \"professional\" as one of the seven roles of Indian Medical Graduate and as cultural and social differences affect professionalism of students' cohort across geographical regions, this study was undertaken to establish P-MEX's validity, reliability, and feasibility in assessing the construct, professionalism, in undergraduate medical students (UMSs) in India.</p><p><strong>Materials and methods: </strong>This multicentric study assessed the final phase-2 (5<sup>th</sup> year) UMSs for the construct of professionalism using a 24-item P-MEX questionnaire during various clinical encounters. Construct validity was established by performing exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) through structural equation modeling. Cronbach's alpha values defined the reliability of the questionnaire.</p><p><strong>Results: </strong>The item mean score for the 697 collected P-MEX questionnaires ranged from 2.57 to 3.24 out of 4. EFA conducted using principal component analysis with item-component loading of 0.5 and above with Varimax rotation gave a 5-factor, 21-item solution. However, the CFA suggested a 4-factor, 18-item solution which was then confirmed by a rerun of the CFA.</p><p><strong>Conclusion: </strong>The CFA suggests that the 18-item, 4-factor questionnaire is a good fit solution for assessing the construct, professionalism, in UMSs in Indian context.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 3","pages":"171-177"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hidden Impact of Vision Loss: A Cross-sectional Study Assessing Caregiver Burden and Depression at a Tertiary Ophthalmology Center in India. 视力丧失的隐性影响:一项评估印度三级眼科中心看护者负担和抑郁的横断面研究。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-07-01 Epub Date: 2025-08-20 DOI: 10.4103/ijabmr.ijabmr_158_25
Kavita Rajan Bhatnagar, Anirban Pradhan, Kirti Jaisingh, Seema Meena, Nikhil Agrawal, Tapasya Rajpurohit, Naresh Nebhinani
{"title":"The Hidden Impact of Vision Loss: A Cross-sectional Study Assessing Caregiver Burden and Depression at a Tertiary Ophthalmology Center in India.","authors":"Kavita Rajan Bhatnagar, Anirban Pradhan, Kirti Jaisingh, Seema Meena, Nikhil Agrawal, Tapasya Rajpurohit, Naresh Nebhinani","doi":"10.4103/ijabmr.ijabmr_158_25","DOIUrl":"10.4103/ijabmr.ijabmr_158_25","url":null,"abstract":"<p><strong>Background: </strong>Caregivers of visually impaired individuals often endure significant physical, emotional, and financial challenges, yet their burden and depression remain understudied, particularly in resource-limited settings like India. This study examines the prevalence and associated factors of caregiver burden and depression.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted at a tertiary care institution in India from July 2022 to December 2023, involving 270 caregivers of 109 patients with permanent visual impairment (Category III or higher). Caregivers were assessed using the Zarit Caregiver Burden Scale (ZCBS) and the Center for Epidemiologic Studies Depression Scale (CES-D). Statistical analyses included Chi-Square tests and Pearson's correlation, with <i>P</i> < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Caregiver burden was prevalent, with 54.07% experiencing mild-to-moderate burden, 42.60% moderate to severe, and 3.33% severe burden. Depression affected 30% of caregivers (18.15% mild to moderate and 11.85% at risk of major depression). Burden was significantly associated with care duration (<i>P</i> < 0.001), female caregivers (<i>P</i> = 0.016), illiteracy (<i>P</i> = 0.002), patient relationship (<i>P</i> < 0.001), and patient employment status (<i>P</i> = 0.016). Depression was significantly linked to care duration (<i>P</i> < 0.001), female caregivers (<i>P</i> = 0.012), female patients (<i>P</i> = 0.009), married caregivers (<i>P</i> = 0.021), and nuclear families (<i>P</i> = 0.006). A moderate positive correlation between burden and depression was observed (<i>R</i> = 0.648, <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Caregivers of visually impaired individuals experience a substantial burden and depression, influenced by demographic and socioeconomic factors. Targeted interventions, including financial support, coping skills training, and psychiatric referrals, are essential to alleviate caregiver distress and enhance well-being.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 3","pages":"213-220"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic Gallbladder Carcinoma to Pleura with Gallbladder Tuberculosis - Case Report with Literature Review. 胆囊癌转移至胸膜并胆囊结核1例并文献复习。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_412_24
Anjum Ara, Mohammad Saleem, Kafil Akhtar
{"title":"Metastatic Gallbladder Carcinoma to Pleura with Gallbladder Tuberculosis - Case Report with Literature Review.","authors":"Anjum Ara, Mohammad Saleem, Kafil Akhtar","doi":"10.4103/ijabmr.ijabmr_412_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_412_24","url":null,"abstract":"<p><p>Gallbladder carcinoma (GBC) is the most common malignant tumor of the biliary system and presents with frequent locoregional lymphadenopathy and distant metastasis. Gallbladder tuberculosis (GT) is rare abdominal tuberculosis (TB). GBC and GT mimic each other. The clinical examinations and radiographic investigations sometimes fail to exhibit the difference between these two which are confirmed only after postoperative histopathological assessment. Herein, we report a patient of GBC with coexistent GT with pleural metastasis and pleural effusion. We emphasize the importance of differential diagnosis of the two conditions, with similar signs and symptoms. The pleura is an extremely rare site of spread of GBC as seen in our patient.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"125-127"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Intraoperative Efficacy of Preoperative Single-Dose Corticosteroid Over Short Course in Functional Endoscopic Sinus Surgery for Nasal Polyposis. 术中单剂量皮质类固醇在功能性鼻内镜手术治疗鼻息肉病的疗效比较。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_431_24
Sahil Maingi, Ankur Sharma
{"title":"Comparison of Intraoperative Efficacy of Preoperative Single-Dose Corticosteroid Over Short Course in Functional Endoscopic Sinus Surgery for Nasal Polyposis.","authors":"Sahil Maingi, Ankur Sharma","doi":"10.4103/ijabmr.ijabmr_431_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_431_24","url":null,"abstract":"<p><strong>Background: </strong>Patients having nasal polyposis who do not respond to medical management are subjected for functional endoscopic sinus surgery (FESS). One of the most common complications of surgery is bleeding. One of the strategies to reduce bleeding and securing a dry operating field during surgery is the use of preoperative corticosteroids which shrink the polyps and decrease mucosal inflammation.</p><p><strong>Aim: </strong>The current study is designed to assess whether preoperative single-dose steroids 24 h before surgery can be a substitute for a 5-day regimen.</p><p><strong>Methods: </strong>The proposed study was conducted on 60 patients of unilateral/bilateral nasal polyposis divided into two random groups. Group A was given a single oral dose of 1 mg/kg/dose of prednisolone on the day before surgery. Group B was given 1 mg/kg/day of oral prednisolone for 5 days before surgery. Side effects of steroids in both groups were assessed. Outcome measures were the amount of blood loss, quality of the surgical field, and time taken for the surgery.</p><p><strong>Results: </strong>The mean age in both groups was similar with the majority of patients being male in both groups. Patients receiving a single dose of corticosteroid have almost no side effects as compared to patients receiving 5-day course. However, patients receiving single doses of corticosteroid preoperatively had significantly more blood loss during surgery. The surgical field in the single dose group was poor and the time taken for surgery was also significantly more.</p><p><strong>Conclusion: </strong>Preoperative single dose of oral corticosteroid can reduce side effects but it is not as effective as short course of preoperative corticosteroid 5-day regimen in case of FESS for nasal polyposis.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"104-108"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Diversity of Carbapenemases-producing Acinetobacter baumannii Isolates at a Tertiary Teaching Hospital in Western India. 印度西部某三级教学医院产碳青霉烯酶鲍曼不动杆菌分离株的遗传多样性
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_498_24
Amitesh Datta, Nageswari Gandham, Chanda R Vyawahare, Shahzad Mirza, Savita Bhatia, Prajakta B Shinde
{"title":"Genetic Diversity of Carbapenemases-producing <i>Acinetobacter baumannii</i> Isolates at a Tertiary Teaching Hospital in Western India.","authors":"Amitesh Datta, Nageswari Gandham, Chanda R Vyawahare, Shahzad Mirza, Savita Bhatia, Prajakta B Shinde","doi":"10.4103/ijabmr.ijabmr_498_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_498_24","url":null,"abstract":"<p><strong>Background: </strong><i>Acinetobacter baumannii</i> is an alarming pathogen in hospital-acquired infections, particularly in the intensive care units (ICUs). Carbapenemases production and biofilm formation contribute significantly to the pathogenicity of the organism. Carbapenem resistance in <i>A. baumannii</i> is primarily due to the production of carbapenemases.</p><p><strong>Aim: </strong>The study was conducted to detect the presence of carbapenemase-encoding genes in <i>A. baumannii</i> along with their ability to form biofilm. In addition, this study also investigated the association between biofilm formation and carbapenemase genes harboring <i>A. baumannii</i> isolates.</p><p><strong>Materials and methods: </strong>One hundred and forty isolates of <i>A. baumannii</i> were collected from the various specimens. Of these, this study included 36 isolates that were carbapenem-resistant, metallo-β-lactamases (MBLs) producing, and extensively drug-resistant (XDR) obtained from ICUs. Identification and antibiotic susceptibility determination was done using VITEK 2. Further, the isolates were confirmed by detecting the <i><sup>bla</sup></i> OXA-51 carbapenemase gene intrinsic to <i>A. baumannii</i>. Polymerase chain reaction was performed to detect carbapenemase-encoding genes, and biofilm formation was examined using the tube method.</p><p><strong>Results: </strong>The <i><sup>bla</sup></i> OXA-51 gene was present in all isolates (<i>n</i> = 36). <i>A. baumannii</i> showed highest sensitivity against colistin (100%) and minocycline (25%). Out of 36 isolates, acquired carbapenemase encoding genes were detected in 35 (97.22%) isolates, as follows: <i><sup>bla</sup></i> OXA-23 (35/36, 97.22%), <i><sup>bla</sup></i> NDM (18/36, 50%), <i><sup>bla</sup></i> IMP (1/36, 2.78%), and <i><sup>bla</sup></i> VIM (28/36, 77.78%). In 33 (91.67%) isolates, oxacillinase (OXA) and MBL genes coexisted. Among the 36 isolates, 30 (83.33%) formed biofilm.</p><p><strong>Conclusion: </strong>The study highlights that colistin and minocycline are the viable antibiotics for treating carbapenem-resistant MBL-producing XDR <i>A. baumannii</i> infections. <i><sup>bla</sup></i> OXA-23 is the commonest carbapenemase gene, and <i><sup>bla</sup></i> VIM is the most frequently found MBL gene prevalent in our hospital and contributes to carbapenem resistance in <i>A. baumannii</i>. The study also showed a higher frequency of co-occurrence of multiple carbapenemase genes in single isolates, and most of these isolates formed biofilm. However, no statistically significant association was found between biofilm formation and carbapenemase genes in <i>A. baumannii</i>. This study emphasizes the molecular diagnostic value of carbapenemase gene detection to reduce the resistance rate in <i>A. baumannii</i> isolates.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"91-97"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Carcinoid Tumor of the Central Nervous System: A Rare Case Report with a Diagnostic Challenge. 原发性中枢神经系统类癌:一罕见病例报告与诊断挑战。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_523_24
Anurag Singh, Alka Singh, Kamlesh Singh Bhaisora, Narendra Krishnani
{"title":"Primary Carcinoid Tumor of the Central Nervous System: A Rare Case Report with a Diagnostic Challenge.","authors":"Anurag Singh, Alka Singh, Kamlesh Singh Bhaisora, Narendra Krishnani","doi":"10.4103/ijabmr.ijabmr_523_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_523_24","url":null,"abstract":"<p><p>Carcinoid tumors (CTs) are slow-growing neuroendocrine neoplasms that may arise in any part of the body. They usually affect the lungs or gut. Primary intradural extramedullary CTs of the central nervous system are rare; few cases have been reported. This case report describes a 36-year-old patient with lower back discomfort, weakness, and lower leg pain for 8 months. Contrast-enhanced magnetic resonance imaging of the lumbosacral spine, from the lower L3 vertebral level to the L4-5 disc level, revealed a 4.5 cm × 2.5 cm × 1.5 cm intradural mass lesion. The main differential diagnoses were on clinical and radiographic examination: nerve sheath tumors, meningiomas, and myxopapillary ependymomas. The tumor was excised en bloc after an L3-L5 lumbar laminectomy. Histomorphology and immunohistochemistry made a definitive diagnosis of CT of the lumbar spine. Two years after surgery, there was no clinical or radiological evidence of tumor recurrence or metastasis. The present case study is intended to effectively diagnose and treat spinal intradural extramedullary CTs.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"128-131"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Antidiabetic Potential of Methanolic Extract of Clerodendrum infortunatum Compared to Metformin in Streptozotocin-induced Diabetic Rats. 链脲佐菌素诱导的糖尿病大鼠对喜藤醇提物与二甲双胍降糖潜能的评价。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_580_24
Manish Kumar, Pankaj Prabhakar, Saajid Hameed, Manoj Kumar, Ravi Shekhar, Bipin Kumar, Harihar Dikshit
{"title":"Evaluation of the Antidiabetic Potential of Methanolic Extract of <i>Clerodendrum infortunatum</i> Compared to Metformin in Streptozotocin-induced Diabetic Rats.","authors":"Manish Kumar, Pankaj Prabhakar, Saajid Hameed, Manoj Kumar, Ravi Shekhar, Bipin Kumar, Harihar Dikshit","doi":"10.4103/ijabmr.ijabmr_580_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_580_24","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus is a prevalent metabolic disorder characterized by reduced insulin activity leading to hyperglycemia, affecting over 425 million people globally. Traditional treatments, including sulfonylureas and biguanides, often have undesirable side effects, prompting a shift toward herbal remedies for diabetes management and prevention.</p><p><strong>Objective: </strong>This study aims to evaluate the antidiabetic effects of budding leaves from <i>Clerodendrum infortunatum</i> compared to metformin in preventing streptozotocin (STZ)-induced hyperglycemia in rats.</p><p><strong>Materials and methods: </strong>An <i>in vivo</i> study was conducted using adult male Wistar albino rats. STZ was administered on day 15 and was followed till day 18. Methanolic extract of <i>C. infortunatum</i> (MECI) at different dosages (250, 500, and 1000 mg), metformin (500 mg), and normal saline were administered to different groups of rats. Blood glucose levels (at day 1, 15, and 18) and biochemical parameters (lipid profile, hepatic and renal parameters, and oxidative stress markers) were measured at days 1 and 18. At the end, a histopathological examination of the pancreas, liver, and kidney was done. Statistical analyses were performed to determine significance.</p><p><strong>Results: </strong>The study found that while the MECI at 500 mg/kg showed a significant reduction in blood glucose levels compared to the diabetic control group (<i>P</i> < 0.0001), it was less effective than metformin (<i>P</i> > 0.05). Higher doses of MECI demonstrated potential in improving liver and renal parameters (<i>P</i> < 0.0001), as well as reducing oxidative stress (<i>P</i> < 0.0001) compared to metformin indicating its beneficial effects in diabetic conditions.</p><p><strong>Conclusion: </strong><i>C. infortunatum</i> shows promise as an adjunctive therapy for the prevention of diabetes due to its multifaceted mechanisms, including enhancing insulin secretion and reducing oxidative stress. However, further clinical trials are needed to confirm these findings and establish optimal dosages.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"78-84"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Immunohistochemical Expression of Beta-catenin and E-cadherin as Epithelial-Mesenchymal Transition Markers in Colorectal Carcinoma - An Analytical Retrospective Study in a Tertiary Care Center. 评价结直肠癌中β -连环蛋白和e -钙粘蛋白作为上皮-间质转化标志物的免疫组织化学表达-三级保健中心的回顾性分析研究
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_535_24
Ramya Katta, Sindhura Nugala, Madhavi Kolakonda, Aparna Chinnam
{"title":"Evaluation of Immunohistochemical Expression of Beta-catenin and E-cadherin as Epithelial-Mesenchymal Transition Markers in Colorectal Carcinoma - An Analytical Retrospective Study in a Tertiary Care Center.","authors":"Ramya Katta, Sindhura Nugala, Madhavi Kolakonda, Aparna Chinnam","doi":"10.4103/ijabmr.ijabmr_535_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_535_24","url":null,"abstract":"<p><strong>Context: </strong>Colorectal carcinoma is a major health concern globally, with varying prognostic outcomes influenced by molecular markers. E-cadherin and beta-catenin are proteins involved in cellular adhesion and signaling pathways, and their aberrant expression has been implicated in tumor progression and metastasis.</p><p><strong>Aims: </strong>This study aims to evaluate the association between abnormal immunohistochemical expression of E-cadherin and beta-catenin with various clinicopathological parameters in colorectal carcinomas.</p><p><strong>Setting and design: </strong>A retrospective cross-sectional 3-year analytical study.</p><p><strong>Materials and methods: </strong>A total of 52 colorectal carcinoma tissue samples were analyzed using immunohistochemistry to assess the expression levels of E-cadherin and beta-catenin. Clinicopathological parameters including age, gender, tumor location, tumor differentiation, depth of invasion, perineural invasion, lymphovascular invasion, and nodal involvement were assessed and correlated with protein expression patterns.</p><p><strong>Statistical analysis: </strong>SPSS version 24 was used for calculating <i>P</i> values using the Chi-squared test.</p><p><strong>Results: </strong>Aberrant expression of E-cadherin and beta-catenin was observed in a significant proportion of the tumors. Poorly differentiated tumors showed a marked loss of E-cadherin and abnormal beta-catenin localization. In addition, increased lymphovascular and nodal involvement were significantly associated with these aberrant expression patterns.</p><p><strong>Conclusion: </strong>The findings suggest that abnormal expression of E-cadherin and beta-catenin is linked to poor tumor differentiation and higher rates of lymphovascular and nodal involvement. These markers may serve as potential biomarkers for assessing prognosis in colorectal carcinoma patients.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"98-103"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Project-based Learning for Enhancing Neuroanatomy Understanding in 1st-year MBBS Students. 探索基于项目的学习增强MBBS一年级学生的神经解剖学理解。
IF 0.8
International Journal of Applied and Basic Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-07 DOI: 10.4103/ijabmr.ijabmr_364_24
Ranjana Verma, Sonu, Pragati Sheel Mittal, Suchismita Sarkar
{"title":"Exploring Project-based Learning for Enhancing Neuroanatomy Understanding in 1<sup>st</sup>-year MBBS Students.","authors":"Ranjana Verma, Sonu, Pragati Sheel Mittal, Suchismita Sarkar","doi":"10.4103/ijabmr.ijabmr_364_24","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_364_24","url":null,"abstract":"<p><strong>Background: </strong>Neuroanatomy has always been considered a difficult topic for 1<sup>st</sup>-year MBBS students. Project-based Learning (PjBL) is a comprehensive approach to classroom teaching and learning that is designed to engage students in solving clinical scenario-based questions. This innovative learning method employs real-world work assignments on time-limited projects to achieve mandated performance, facilitating a collaborative and collective learning experience. This engaging pedagogy is designed to enhance the understanding of neuroanatomy.</p><p><strong>Aim and objectives: </strong>To implement and innovate PjBL sessions in neuroanatomy, and to analyze student's perceptions following each session.</p><p><strong>Materials and methods: </strong>The phase I MBBS students and faculty involved in the teaching were sensitized regarding the projects. A baseline lecture on the topic was taken by the faculty in charge. Students were divided into four groups of 25 each and were assigned a topic and instructed to present a seminar on the given topic with the help of self-made models. Learner satisfaction survey was taken on the Likert Scale from the students regarding understanding of the given topic and faculty feedback for the same was also taken.</p><p><strong>Results: </strong>Students testified that the project was helpful in improving their understanding of neuroanatomy and enhancing classroom engagement, collaborative learning in preparation of projects, and boosting their critical and collateral thinking.</p><p><strong>Conclusion: </strong>Students were satisfied with the application of PjBL sessions in better understanding of neuroanatomy. It also helped them in developing concepts for various neurological disorders. The faculty involved was satisfied with the performance of students and looking forward to incorporating this teaching-learning method in the future.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"15 2","pages":"72-77"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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