International Journal of Biomaterials最新文献

{"title":"Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects.","authors":"Bharti Sharma,&nbsp;Sudeep Shukla,&nbsp;Rohit Rattan,&nbsp;Musarrat Fatima,&nbsp;Mayurika Goel,&nbsp;Mamta Bhat,&nbsp;Shruti Dutta,&nbsp;Rakesh Kumar Ranjan,&nbsp;Mamta Sharma","doi":"10.1155/2022/6819080","DOIUrl":"https://doi.org/10.1155/2022/6819080","url":null,"abstract":"<p><p>The rise in antimicrobial resistance is a cause of serious concern since the ages. Therefore, a dire need to explore new antimicrobial entities that can combat against the increasing threat of antibiotic resistance is realized. Studies have shown that the activity of the strongest antibiotics has reduced drastically against many microbes such as microfungi and bacteria (Gram-positive and Gram-negative). A ray of hope, however, was witnessed in early 1940s with the development of new drug discovery and use of metal complexes as antibiotics. Many new metal-based drugs were developed from the metal complexes which are potentially active against a number of ailments such as cancer, malaria, and neurodegenerative diseases. Therefore, this review is an attempt to describe the present scenario and future development of metal complexes as antibiotics against wide array of microbes.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2022 ","pages":"6819080"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10460746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microleakage Evaluation of Two Methacrylate-Based Composites (GC Kalore and Luna SDI) in Class II Restorations: A Laboratory Study.","authors":"Kooshan Moradi,&nbsp;Sadaf Sadat Mahmoudinezhad,&nbsp;Mehran Mapar","doi":"10.1155/2022/3835694","DOIUrl":"https://doi.org/10.1155/2022/3835694","url":null,"abstract":"<p><strong>Objective: </strong>In recent years, dental composite resins such as tooth-colored restoration are frequently used to restore dental cavities, coronal fractures, and congenital defects. This study aimed to evaluate the microleakage of two methacrylate-based composites (GC Kalore and Luna SDI) in class II restorations.</p><p><strong>Materials and methods: </strong>In this experimental study, a total of 18 intact human premolars previously extracted for periodontal and orthodontic reasons were randomly divided into two groups. Similar class II cavities (box only) were prepared on all teeth and restored with two different composites. In group 1, a bonding agent (Single Bond 2-SB2; 3M ESPE) and Luna SDI composite in mesial cavities and GC Kalore composite in distal cavities were used. In group 2, Single Bond 2 and GC Kalore composite in mesial cavities and Luna SDI composite in distal cavities were applied. They were then subjected to 2000 thermal cycles in a water bath between 5-55°C (dwell time: 30 seconds in every bath and transfer time: 10 seconds). Then, they were immersed in a 2% basic fuchsin dye solution for 24 hours. After rinsing with water, they were sectioned mesiodistally and evaluated for microleakage using a stereomicroscope.</p><p><strong>Results: </strong>Independent <i>t</i>-test (Mann-Whitney test) showed no statistically significant difference for microleakage in mesial and distal class II restorations between GC Kalore composite and Luna SDI composite (<i>p</i> = 1.000) (<i>p</i>= 0.852). A total of 83.4% of the Luna SDI composite samples and 66.6% of the GC Kalore composite had a microleakage score of ≤3 in class II cavities.</p><p><strong>Conclusion: </strong>In the present study, marginal microleakage was found mainly at the gingival floor extending to 1/3 of the axial wall for the Luna SDI composite and GC Kalore composite. Furthermore, no statistically significant difference was found between the microleakage of the Class II cavities restored with Luna SDI composite and GC Kalore composite.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2022 ","pages":"3835694"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10280571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID-19.","authors":"Viktor Kamkin,&nbsp;Aidana Kamarova,&nbsp;Baurzhan Shalabayev,&nbsp;Assyltas Kussainov,&nbsp;Marat Anuarbekov,&nbsp;Serik Abeuov","doi":"10.1155/2022/5943649","DOIUrl":"https://doi.org/10.1155/2022/5943649","url":null,"abstract":"<p><p>The COVID-19 pandemic has once again prompted people to resort to the remedies of folk and alternative medicine. Medicinal plants, because of their chemical composition, pharmacological properties, and the action of biologically active substances, can stop and relieve the symptoms of the disease. The purpose of the work is a comparative flora analysis of medicinal plants to identify the most prospective plant and further production of a remedy for the avoidance, treatment, and rehabilitation of COVID-19. The search for prospective medicinal plants was performed by analyzing the literature in online databases: Web of Science, Scopus, Google Scholar, and PubMed, including official WHO media sites. According to recent studies related to COVID-19, a significant number of medicinal plants with anti-inflammatory, antiviral, and immunostimulatory effects have been identified. A comparative study of nine medicinal plants was conducted to determine the most suitable medicinal plant to treat coronavirus infection. According to the results of the comparative analysis, <i>Chamaenerion angustifolium</i> Seg. showed itself as the most prospective medicinal plant with the greatest pharmacological effect compared with other types of medicinal plants. Its therapeutic properties allow physiological relief of 18 symptoms of coronavirus infection. It is advisable to conduct further clinical trials for the treatment and rehabilitation of COVID-19 using preparations from this plant.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2022 ","pages":"5943649"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10751291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study.","authors":"Muhammad Pandunugrahadi,&nbsp;Komang Agung Irianto,&nbsp;Oen Sindrawati","doi":"10.1155/2022/9601547","DOIUrl":"https://doi.org/10.1155/2022/9601547","url":null,"abstract":"<p><strong>Introduction: </strong>Without appropriate treatment, nerve injuries may result in permanent loss of function. Platelet-rich plasma (PRP) injection is found to help in nerve regeneration. PRP is a concentrated platelet derived from autologous blood with the potential to release various growth factors (GF) to promote nerve regeneration. This study aims to know the best time for PRP injection to promote nerve regeneration.</p><p><strong>Methods: </strong>This is an experimental in vivo research using male New Zealand white rabbits in the randomized control group posttest only design. Samples were divided into 5 groups (1 control group and 4 treatment groups). The control group without PRP injection and treated groups injected immediately after nerve injury, 3 days, 7 days, and 14 days afterward. Nerve regeneration was evaluated by the histology specimen sacrificed on day 21. Inflammation cells and endoneurium vacuoles were counted as mean percentage of five nerve fragments in each injured nerve sample specimen.</p><p><strong>Result: </strong>Inflammation cells and vacuole cells increased significantly when PRP was administered 3 days after injury (group 2) (respectively, 14 ± 6.7 and 56.6 ± 11.6) compared to all treatment groups (<i>p</i> < 0.005) (control group, respectively, 6 ± 2.6 and 15.7 ± 9.5). On the other hand, significantly lower endoneurium vacuoles and inflammation cells were found on \"the day 14\" sample group (respectively, 5 ± 1.3 and 5.2 ± 1.6) compared to all other groups (<i>p</i> < 0.005).</p><p><strong>Conclusion: </strong>This study found that the best time for injecting PRP for nerve regeneration is 14 days after injury.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2022 ","pages":"9601547"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Breast Implant Surface Finishing on Physicochemical and Mechanical Properties before and after Extreme Degradation Studies.","authors":"Izabelle de Mello Gindri, Lucas Kuth de Azambuja, Michele da Silva Barreto, Dionatha José do Prado, Gean Vitor Salmoria, Carlos Rodrigo de Mello Roesler","doi":"10.1155/2021/8850577","DOIUrl":"10.1155/2021/8850577","url":null,"abstract":"<p><p>The influence of the surface finishing of breast implants on physicochemical and mechanical properties, before and after extreme degradation experiments, was investigated in this study. Removal of superficial layers after degradation was verified for both smooth and rough membranes, in which local erosion was verified. FTIR results demonstrated the generation of low-molecular-weight structures in all samples due to exposure to acidic and basic environments. Furthermore, smooth samples presented higher degrees of crosslinking than rough samples. Considering the mechanical properties, no difference was verified between smooth and rough samples as received and after degradation studies. However, the pH of the degradation solution had an influence on mechanical properties of the material and a basic environment caused greater deterioration of the mechanical properties compared to acidic conditions.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2021 ","pages":"8850577"},"PeriodicalIF":3.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10436951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells.","authors":"Bernard Owusu Asimeng,&nbsp;Emmanuel Nyankson,&nbsp;Johnson Kwame Efavi,&nbsp;Amartey Nii Amarkai,&nbsp;Gloria Pokuaa Manu,&nbsp;Elvis Tiburu","doi":"10.1155/2020/2630735","DOIUrl":"https://doi.org/10.1155/2020/2630735","url":null,"abstract":"<p><p>Magnetic Fe₃O₄ nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that Fe₃O₄ NPs interaction with HeLa cells affected their electrochemical behavior. The nanoparticles formed with higher Fe³⁺/Fe²⁺ molar ratio (2.8 : 1) resulted in smaller crystallite sizes compared to those formed with lower Fe³⁺/Fe²⁺ molar ratio (1.4 : 1). The particles with the smallest crystallite size showed higher anodic peak currents, whereas the larger crystallite sizes resulted in lower anodic peak currents. The peak currents relate to cell inhibition and are confirmed by the half-maximum inhibitory concentration (IC₅₀). The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"2630735"},"PeriodicalIF":3.1,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2630735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38855467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis and Antibacterial Activity of HAp@Ag Nanocomposite Using <i>Centella asiatica</i> (L.) Urban Extract and Eggshell.","authors":"Xuan Nui Pham, Hoa Thi Nguyen, Ngan Thi Pham","doi":"10.1155/2020/8841221","DOIUrl":"10.1155/2020/8841221","url":null,"abstract":"<p><p>In recent years, the green synthesis of nanoparticles via biological processes has attracted considerable attention. Herein, we introduce a facile and green approach for the synthesis of poriferous silver nanoparticles (Ag-NPs) decorated hydroxylapatite (HAp@Ag) nanoparticles with excellent antibacterial properties. All the nanocomposites were fully characterized in the solid state via various techniques such as X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectrometer (EDX), in which the synthesized Ag-NPs (24 nm in diameter) and their homogeneous incorporation on HAp have been studied by ultraviolet-visible (UV-vis) technique, transmission electron microscopy (TEM), and dynamic light scattering (DLS) analysis. The obtained results indicate that the structure and morphology of HAp have no significant changes after the incorporation of Ag-NPs on its surface. Moreover, an impressive antibacterial activity of HAp@Ag nanocomposite against Gram-positive bacterium <i>Staphylococcus aureus</i> and Gram-negative bacteria <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> has been recorded by using the agar well diffusion method. As a result, the HAp@Ag nanocomposite promises to be a great biomedical material with high antibacterial properties.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"8841221"},"PeriodicalIF":3.1,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38494281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Comment on \"The Use of Pulsed Electromagnetic Fields to Promote Bone Responses to Biomaterials In Vitro and In Vivo\".","authors":"G Pedrazzi,&nbsp;C Galli,&nbsp;M Mattioli-Belmonte,&nbsp;S Guizzardi","doi":"10.1155/2020/9801420","DOIUrl":"https://doi.org/10.1155/2020/9801420","url":null,"abstract":"<p />","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"9801420"},"PeriodicalIF":3.1,"publicationDate":"2020-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9801420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38494282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized Glutathione on Chitosan-Genipin Cross-Linked Beads Used for the Removal of Trace Metals from Water.","authors":"Samira R Akaji, David Dewez","doi":"10.1155/2020/4158086","DOIUrl":"10.1155/2020/4158086","url":null,"abstract":"<p><p>Functionalized glutathione on chitosan-genipin cross-linked beads (CS-GG) was synthesized and tested as an adsorbent for the removal of Fe(II) and Cu(II) from aqueous solution. The beads were characterized by several techniques, including Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), CNS elementary analysis, scanning electron microscopy (SEM), and atomic force microscopy (AFM). The effect of several parameters such as the pH, the temperature, and the contact time was tested to optimize the condition for the adsorption reaction. The beads were incubated in aqueous solutions contaminated with different concentrations of Fe(II) and Cu(II) (under the range concentration from 10 to 400 mg·L^-1), and the adsorption capacity was evaluated by inductively coupled plasma optical emission spectrometry (ICP-OES). The adsorption equilibrium was reached after 120 min of incubation under optimal pH 5 for Fe(II) and after 180 min under optimal pH 6 for Cu(II). According to the <i>Langmuir</i> isotherm, the maximum adsorption capacities (<i>q</i> _max) for Fe(II) and Cu(II) were 208 mg·g^-1 and 217 mg·g^-1, respectively. Our results showed that the adsorption efficiency of both metals on CS-GG beads was correlated with the degree of temperature. In addition, the adsorption reaction was spontaneous and endothermic, indicated by the positive values of Δ<i>G</i> ⁰ and Δ<i>H</i> ⁰. Therefore, the present study demonstrated that the new synthesized CS-GG beads had a strong adsorption capacity for Fe(II) and Cu(II) and were efficient to remove these trace metals from aqueous solution.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"4158086"},"PeriodicalIF":3.1,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction and Characterization of Novel Natural Hydroxyapatite Bioceramic by Thermal Decomposition of Waste Ostrich Bone.","authors":"Komal Prasad Malla,&nbsp;Sagar Regmi,&nbsp;Achyut Nepal,&nbsp;Sitaram Bhattarai,&nbsp;Ram Jeewan Yadav,&nbsp;Shinichi Sakurai,&nbsp;Rameshwar Adhikari","doi":"10.1155/2020/1690178","DOIUrl":"https://doi.org/10.1155/2020/1690178","url":null,"abstract":"<p><p>A novel natural hydroxyapatite (HAp) bioceramic was extracted from the ostrich cortical bone by the thermal decomposition method. HAp was characterized by different analytical tools such as thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM). Removal of organic impurities from the bone powder was confirmed by TGA analysis. FTIR spectra of HAp confirmed the presence of the major functional groups such as phosphate (PO₄ ^3-), hydroxyl (OH^-), and carbonate (CO₃ ^2-) in the bioceramic. The XRD data revealed that the HAp was the crystalline phase obtained by calcination of the bone powder at 950°C, and the SEM analyses confirmed the typical plate-like texture of the nanosized HAp crystals.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"1690178"},"PeriodicalIF":3.1,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1690178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38364079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}