International Journal of Biomaterials最新文献

{"title":"Extracellular Enzyme of Endophytic Fungi Isolated from <i>Ziziphus spina</i> Leaves as Medicinal Plant.","authors":"Sumaiya Naeema Hawar","doi":"10.1155/2022/2135927","DOIUrl":"https://doi.org/10.1155/2022/2135927","url":null,"abstract":"<p><p>Endophytic fungi live inside plants or any part of them without creating any visible pathogenic signs. Endophytic fungi are found within medicinal plants and have shown strong biologic activity, such as anticancer and antioxidant activities, as well as producing extracellular enzymes. In this study, different fungal strains were isolated from the leaves of the medicinal plant Ziziphus spina, including <i>Aspergillus flavus</i>, <i>Aspergillus fumigatus</i>, <i>Aspergillus niger</i>, <i>Cladosporium</i> sp., <i>Rhizopus</i> sp., and <i>Mucor</i> sp. Extracellular enzymes have been quantified using agar plate-based methods in which fungi were grown in specified growth media to detect the enzymes produced. The results showed that <i>A. niger</i> has the highest ability to produce amylase, <i>Cladosporium</i> sp. has the highest ability to produce protease and pectinase, <i>Rhizopus</i> and <i>Mucor</i> sp. have the highest ability to produce cellulase, and <i>A. niger</i> and <i>Cladosporium</i> sp. have the same ability to produce lipase and laccase. The ability of medicinal plant endophytic fungi to produce extracellular enzymes has great therapeutic potential in clinical microbiology. Some of the isolates showed great activity in secreting particular enzymes, indicating that the enzymes of these fungi could be used in a variety of applications.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":"2135927"},"PeriodicalIF":3.1,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40513286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nanoparticles Additions on the Strength of Dental Composite Resin.","authors":"Emad Azmy,&nbsp;Mohamed Reda Zaki Al-Kholy,&nbsp;Mohamed Fattouh,&nbsp;Laila Mohamed Mohamed Kenawi,&nbsp;Mohamed Ahmed Helal","doi":"10.1155/2022/1165431","DOIUrl":"https://doi.org/10.1155/2022/1165431","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effect of nanoparticles, zirconium dioxide (ZrO₂), titanium dioxide (TiO₂), and silicon dioxide (SiO₂), on flexural strength (FS), hardness, and wear resistance of light cured dental composite resin.</p><p><strong>Materials and methods: </strong>210 rectangular and disc-shaped composite resin specimens were fabricated with dimensions (25 × 2 × 2 ± 0.03 mm) and (6×4 ± 0.03 mm) for FS, hardness, and wear resistance, respectively (70/test). Specimens of each test were divided according to nanofillers into four groups, unmodified as control, ZrO₂ (Z), TiO₂ (T), and SiO₂ (S) groups; each one was further subdivided into two subgroups according to nanoparticles concentration, 3wt.% and 7wt.% (Z3, Z7, T3, T7, S3, and S7), 10 specimens of each subgroup. A3-point bending test and Vickers hardness test were used for FS and hardness measurements, respectively. Wear resistance was evaluated by the differences in surface roughness of tested specimens before and after wear test. Two-way and 1-way ANOVA and Bonferroni's post hoc tests were done for data analysis (<i>α</i> = 0.05).</p><p><strong>Results: </strong>Two-way ANOVA for FS and wear resistance showed that there was a significant interaction between type of nanoparticles and concentration of nanoparticles (<i>p</i> < 0.001) while two-way ANOVA for hardness showed that both type of nanoparticles and concentration of nanoparticles had a significant effect (<i>p</i> < 0.001), while the effect of their interaction was not statistically significant (<i>p</i>=0.142). 1-way-ANOVA test showed significant increase in FS and wear resistance for all tested groups (<i>p</i> < 0.001 and <i>p</i> < 0.001, respectively) except T7 and S7. Also, there was a significant enhancement in hardness for all tested groups (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Modification of light cured composite resin with certain amounts of nanoparticles (3% and 7% of ZrO₂ and 3% of TiO₂ and SiO₂) can be beneficial in improving flexural strength and wear resistance while hardness of composite resin was increased with all NPs additions.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":"1165431"},"PeriodicalIF":3.1,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40513285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems.","authors":"Budi Mulyanti,&nbsp;Harbi Setyo Nugroho,&nbsp;Chandra Wulandari,&nbsp;Yuni Rahmawati,&nbsp;Lilik Hasanah,&nbsp;Ida Hamidah,&nbsp;Roer Eka Pawinanto,&nbsp;Burhanuddin Yeop Majlis","doi":"10.1155/2022/9135172","DOIUrl":"https://doi.org/10.1155/2022/9135172","url":null,"abstract":"<p><p>SPR-based technology has emerged as one of the most versatile optical tools for analyzing the binding mechanism of molecular interaction due to its inherent advantages in sensing applications, such as real-time, label-free, and high sensitivity characteristics. SPR is widely used in various fields, including healthcare, environmental management, and food-borne illness analysis. Meanwhile, kidney disease has grown to be one of the world's most serious public health problems in recent decades, resulting in physical degeneration and even death. As a result, several studies have published their findings regarding developing of reliable sensor technology based on the SPR phenomenon. However, an integrated and comprehensive discussion regarding the application of SPR-based sensors for detecting of kidney disease has not yet been found. Therefore, this review will discuss the recent advancements in the development of SPR-based sensors for monitoring kidney-related diseases. Numerous SPR configurations will be discussed, including Kretschmann, Otto, optical fiber-based SPR, and LSPR, which are all used to detect analytes associated with kidney disease, including urea, creatinine, glucose, uric acid, and dopamine. This review aims to show the broad application of SPR sensors which encouraged the development of SPR sensors for kidney problems monitoring.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":"9135172"},"PeriodicalIF":3.1,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40397153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Disinfection Methods on the Color Stability of Precolored and Hand-Colored Maxillofacial Silicone: An In Vitro Study.","authors":"Natdhanai Chotprasert,&nbsp;Binit Shrestha,&nbsp;Kawin Sipiyaruk","doi":"10.1155/2022/7744744","DOIUrl":"https://doi.org/10.1155/2022/7744744","url":null,"abstract":"<p><p>Maxillofacial prostheses are used in rehabilitation of patients with facial defects. Typically, these prostheses are fabricated with medical grade silicone and are tinted corresponding to the patients' natural skin color. However, exposure to environment and disinfectants can result in color changes. This study aimed to evaluate the effects of four different disinfection methods on the color stability of precolored and hand-colored maxillofacial silicones. Forty specimens each of precolored and hand-colored silicone were prepared. The specimens were randomly divided into eight groups (<i>n</i> = 10) and cleansed with four different disinfection methods. Disinfection was carried out six times/day for 60 days, simulating once-a-day disinfection for a year. Color evaluation was carried out at day 0 and day 60 using a UV-vis spectrophotometer. Color alterations were calculated by the CIE <i>L</i> ^<i>∗</i> <i>a</i> ^<i>∗</i> <i>b</i> ^<i>∗</i> system. Data were analyzed by two-way ANOVA with post hoc Tukey HSD and <i>t</i>-tests (<i>α</i> = 0.05). Disinfectants can affect the color stability of maxillofacial silicone. In our study, chlorhexidine solution and liquid soap resulted in the highest color change. Precolored silicone showed higher color stability than its hand-colored counterpart.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":"7744744"},"PeriodicalIF":3.1,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40224641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Properties and Color Stainability by Coffee and Red Wine of Opaque and High Translucency Zirconia Dental Ceramics after Hydrothermal Degradation","authors":"Ana Lúcia Nascimento Oliveira, C. Elias, Heraldo Elias Salomão Dos Santos, Claudinei dos Santos, R. de Biasi","doi":"10.1155/2022/1571729","DOIUrl":"https://doi.org/10.1155/2022/1571729","url":null,"abstract":"The objective was to evaluate the bending strength, phase transformation, roughness, and color stainability by coffee and red wine of opaque and high translucency yttria-stabilized zirconia before and after hydrothermal degradation in saline solution or oral mouthwash. Presintered zirconia blocks with medium opacity (ZrO2-3 mol. % of Y2O3) designed as ZrOp and high translucency zirconia (5.2 mol. % of Y2O3) designed as ZrTrans were used. Specimens (n = 80/group) were cut and sintered at 1500°C for 2 h. The specimens were hydrothermally degraded in an autoclave (134°C–1.8 kg/cm2) for 20 h in saline solution (0.5 g/L) and oral mouthwash solution (0.02% sodium fluoride, without alcohol and with 21.6% alcohol). After hydrothermal degradation, the samples were immersed in containers with coffee or red wine for 14 days to determine their color stainability. The results showed that the ZrOp had a higher bending strength than the ZrTrans before and after hydrothermal aging. In ZrOp and ZrTrans, the roughness increased after hydrothermal degradation. ZrOp samples had a higher Ra roughness than the ZrTrans samples. Roughness did not change after immersion in coffee or red wine. The X-ray diffraction (XRD) results showed that ZrOp samples underwent a tetragonal to monoclinic phase transformation, while ZrTrans samples were unchanged. Both ZrOp and ZrTrans samples changed color after immersion in coffee and red wine.","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43886841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and Biochemical Comparative Study of Copper Oxide Nanoparticles and Copper Sulphate Toxicity in Male Albino Mice Reproductive System","authors":"Manal M. S. AL-Musawi, Hanady S Al-Shmgani, G. Al-Bairuty","doi":"10.1155/2022/4877637","DOIUrl":"https://doi.org/10.1155/2022/4877637","url":null,"abstract":"Copper (Cu) is an essential trace element for the efficient functioning of living organisms. Cu can enter the body in different ways, and when it surpasses the range of biological tolerance, it can have negative consequences. The use of different nanoparticles, especially metal oxide nanoparticles, is increasingly being expanded in the fields of industry and biomedical materials. However, the impact of these nanoparticles on human health is still not completely elucidated. This comparative study was conducted to evaluate the impacts of copper oxide nanoparticles (CuO NPs) and copper sulphate (CuSO4 0.5 (H2O)) on infertility and reproductive function in male albino mice BALB/c. Body weight, the weight of male reproductive organs, malondialdehyde (MDA) level, caspase-3 level, and the presence of Ki67 and CD68, as detected using the amino-histochemistry technique, were investigated. Animals were treated with 25 and 35 mg/kg of CuO NPs and CuSO4 0.5 (H2O) by oral gavage for 14 days. The control group was given distilled water by oral gavage. Body weight significantly decreased at the end of experiments in both treated groups in a concentration- and time-dependent manner compared with the control group. Weights of testes and epididymis (head and tail), as well as the weight of the seminal vesicle, showed a significant decrease compared with the control. However, the average weights of the seminal vesicle and prostate significantly increased. Caspase-3 and MDA levels increased in the CuO NP and CuSO4 0.5 (H2O) groups compared with the control group, and there was a significant difference between the two concentrations used. Immunohistochemical results detected a significant decrease in Ki67 protein in the treatment groups compared with the control. However, increase in CD68 protein was found in groups treated with CuO NPs and CuSO4 0.5 (H2O) compared with the control group. Overall, this in vivo comparative study of CuO NPs and CuSO4 0.5 (H2O) showed that oral intake of copper NPs at 25 and 23 mg/kg was safer to the mice reproductive system than CuSO4 0.5 (H2O) at the same dose. CuSO4 0.5 (H2O) significantly influenced the histopathological and toxicological alteration responses.","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42545806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Biomechanical and Chemical Properties of Gamma-Irradiated Polycaprolactone Microfilaments for Musculoskeletal Tissue Engineering Applications","authors":"Laura Rojas-Rojas, Andrea Ulloa-Fernández, Silvia Castro-Piedra, Walter Vargas-Segura, T. Guillén-Girón","doi":"10.1155/2022/5266349","DOIUrl":"https://doi.org/10.1155/2022/5266349","url":null,"abstract":"An appropriate and reliable sterilization technique is crucial for tissue engineering scaffolds. Skeletal muscle scaffolds are often fabricated using microfilaments of a wide variety of polymers. One method for sterilization is 25 kGy of gamma irradiation. In addition, sterilization through irradiation should administer a dose within a specific range. Radiation directly affects the chemical and mechanical properties of scaffolds. The accuracy and effects of irradiation are often not considered during sterilization procedures; however, these are important since they provide insight on whether the sterilization procedure is reliable and reproducible. This study focused on the chemical and mechanical characterization of 25 kGy gamma-irradiated scaffold. The accuracy and uncertainty of the irradiation procedure were also obtained. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analyses were performed to determine whether the crystallinity of the polymer changed after irradiation and whether gamma rays influenced its thermal properties. The tensile parameters of the microfilaments were analyzed by comparing irradiated and nonirradiated scaffolds to determine whether gamma radiation changed their elastic behavior. Dose distribution and uncertainty were recorded with several dosimeters. The results showed that the irradiation process slightly affected the mechanical parameters of the scaffold; however, it did not modify its crystallinity or thermal properties. The irradiation was uniform, since the measured uncertainty was low. The scaffold was pathogen-free after 7 days; this meant sterilization was achieved. These results indicated that gamma-sterilized scaffolds were a promising material for use as a skeletal muscle analog material for tissue-engineering applications because they can be sterilized with gamma rays without changing their chemical structure and mechanical properties. This study provided the dose distribution measurement and uncertainty calculations for the sterilization procedure.","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42802188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effect of Incorporation of ZrO2, TiO2, and SiO2 Nanoparticles on the Strength and Surface Properties of PMMA Denture Base Material: An In Vitro Study","authors":"Emad Azmy, M. R. Al-kholy, Ahmad M. Al-Thobity, M. Gad, M. A. Helal","doi":"10.1155/2022/5856545","DOIUrl":"https://doi.org/10.1155/2022/5856545","url":null,"abstract":"Objective This study aimed to investigate the effects of nanoparticles (zirconium dioxide (ZrO2), titanium dioxide (TiO2), and silicon dioxide (SiO2)) on the flexural strength, impact strength, hardness, and wear resistance of the acrylic resin denture base material. Materials and Methods Acrylic resin specimens were fabricated in dimensions according to American Dental Association (ADA) specifications per test. Specimens were divided according to nanofiller into four groups; unmodified as control, ZrO2 (Z), TiO2, (T), and SiO2 (S) groups. Each one was subdivided into two subgroups according to nanoparticle concentrations; 3% and 7% (Z3, Z7, T3, T7, S3, and S7). A 3-point bending test, Charpy impact test, and Vickers hardness test were used for flexural strength, impact strength, and hardness measurements, respectively. Wear resistance was measured by the differences in surface roughness of tested specimens before and after the wear test. A scanning electron microscope was used to assess nanoparticle specifications and distributions and for fracture surfaces analysis. ANOVA, Bonferroni's post hoc test, and the Kruskal–Wallis test were applied for data analysis (α = 0.05). Results Regarding the flexural and impact strength, there was a statistically remarkable increase for all tested groups compared with the control group, except for the T7 and S7 groups (P value <0.001, effect size = 0.893) and (P value <0.001, effect size = 0.759), respectively. There was a statistically significant improvement in the hardness of all tested groups compared with the control group (P value <0.001, effect size = 0.67) except T3 and S3. Regarding wear, a statistically significant enhancement was noticed in the wear resistance of all tested groups (P value <0.001, effect size = 0.685), except for the T7 and S7 groups. Conclusion The flexural strength, impact strength, and wear resistance improved with both concentrations of ZrO2 and low TiO2 and SiO2 concentrations. The hardness increased with both concentrations of ZrO2 and high TiO2 and SiO2 concentrations.","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46601263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of CO2 Extract of Portulaca oleracea for Antioxidant Activity from Raw Material Cultivated in Kazakhstan","authors":"Meruyert I Tleubayeva, R. Abdullabekova, U. Datkhayev, M. Ishmuratova, M. Alimzhanova, K. Kozhanova, Aida M. Seitaliyeva, K. Zhakipbekov, Zhanar Iskakova, E. Serikbayeva, E. Flisyuk","doi":"10.1155/2022/6478977","DOIUrl":"https://doi.org/10.1155/2022/6478977","url":null,"abstract":"Medicinal plants remain as an important resource in the fight against many diseases, especially in developing countries. Antioxidants are substances capable of delaying, retarding, and preventing the oxidation of lipids or substances that delay or prevent free radical reactions during lipid oxidation. Natural antioxidants such as ascorbic acid, tocopherol, phenolic compounds, and flavonoids are a safe alternative to chemical antioxidants. In present work, results of antioxidant activity of raw materials from the cultivated plant Portulaca oleracea are presented. The extraction time was optimized to 780 minutes; the yield of extractive substances was 1.25% in the production of CO2 extract under subcritical conditions. For the first time, the antioxidant activity of Portulaca oleracea CO2 extract was determined by the amperometric method. Gas chromatography-mass spectrometry (GC-MS) chemical analysis of Portulaca oleracea CO2 extract dissolved in hexane revealed 37 components, including a complex mixture of aldehydes, alkanes, alkenes, esters, diterpenes, steroids, vitamin E, and carbohydrates. The investigation results showed that the Portulaca oleracea CO2 extract was promising for pharmaceutical, cosmetic, and food industries and had great potential for the prevention and treatment of diseases caused by oxidative stress.","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2022 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41533629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers","authors":"E. Varghese, Dhanasekaran Sihivahanan, K. Venkatesh","doi":"10.1155/2022/3912290","DOIUrl":"https://doi.org/10.1155/2022/3912290","url":null,"abstract":"Objectives To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers. Methods The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO2 nanoparticles were added to the composite resin as antibacterial filler. Experimental composite resin was manually prepared by adding ingredients. The resin matrix consisted of two mixed monomers, bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate, diketone as the photo initiator, and N, N-dimethylaminoethyl methacrylate as a coinitiator. The antibacterial efficacy against Streptococcus mutans, Streptococcus mitis, Streptococcus aureus, and Lactobacillus spp. bacterial strains was tested using the microdilution method keeping commercially available 3M Filtek Z250 restorative composite as control. Results The experimental dental composite demonstrated 99.503% efficacy against Streptococcus mutans, 99.441% efficacy against Streptococcus mitis, 99.416% efficacy against Streptococcus aureus, and 99.233% efficacy against Lactobacillus spp. Conclusion Integrating cerium oxide nanoparticles as fillers into dental composite resin can be promising in terms of antibacterial activity, provided furthermore study has to be conducted to examine other properties. Clinical Significance. Previous studies attempted adding CeO2 nanoparticles into acrylic resins that showed improvement in mechanical properties, but literature is nil on the dental composite resin and cerium oxide nanoparticles. This study demonstrates the development of an experimental antibacterial dental composite resin that can resolve most of the problems related to secondary caries around dental composite restorations.","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44692572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}