Inorganic Chemistry Communications最新文献

{"title":"Gold nanoparticles immobilized subtilisin as a novel nanoplatform for breast carcinoma control: Apoptosis induction and NF-kB suppression","authors":"Rua J. Kadhim ,&nbsp;Majid S. Jabir ,&nbsp;Ghassan M. Sulaiman ,&nbsp;Uday M. Nayef ,&nbsp;Suresh Ghotekar ,&nbsp;Hamdoon A. Mohammed","doi":"10.1016/j.inoche.2026.116307","DOIUrl":"10.1016/j.inoche.2026.116307","url":null,"abstract":"<div><h3>Background</h3><div>Subtilisin (serine protease) can be produced from <em>Bacillus subtilis</em>, to which the enzyme is named. Earlier research elucidated the high cytotoxicity of subtilisin toward cancer cell lines. This work aims to develop compounds with a new architecture to immobilize subtilisin and enhance its accessibility to target areas.</div></div><div><h3>Aim</h3><div>The aim is to assess the anticancer effects of Au NPs and Au/subtilisin nanocomposites on MCF-7 cells and examine their stability, binding strength, and toxicity.</div></div><div><h3>Methods</h3><div>We designed and characterized a new compound to immobilize subtilisin on gold nanoparticles GNPs coated with glutamic acid. Subtilisin was immobilized on AuNPs through the chemical reactions between their surfaces. The activity of Au/subtilisin nanocomposites against the breast cancer cells has been demonstrated, and a potential mechanism that stimulates apoptosis has also been identified. Molecular docking and dynamics studies were used to analyze binding behavior, stability, and potential toxicity.</div></div><div><h3>Results</h3><div>The results demonstrate the notable antiproliferative effect for MCF-7 cells induced by Au/subtilisin nanocomposites . The results also confirm the apoptotic effect of Au/subtilisin nanocomposites through activating caspase-8. The findings of this study confirm that Au/subtilisin nanocomposites exhibit a higher toxic effect on MCF-7 cells than GNPs alone.</div></div><div><h3>Conclusion</h3><div>Our work focuses on the efficiency of AuNPs immobilized with subtilisin inducing toxicity toward MCF-7 compared to AuNPs alone. Au/subtilisin nanocomposites are a therapeutic compound that can treat breast cancer cells through apoptosis stimulation.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116307"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon derived from sugarcane bagasse: A sustainable carbon source and its influence on the electrochemical performance of LiFe0.5Mn0.5PO4 cathode materials in lithium-ion batteries","authors":"Panyu Xiong ,&nbsp;Haoyun Luo ,&nbsp;Xiaolian Zhao ,&nbsp;Dawei Lan ,&nbsp;Hongkai Yan ,&nbsp;Zhipeng Li ,&nbsp;Yong Yang ,&nbsp;Haiqing Zhan ,&nbsp;Man Mo ,&nbsp;Tianshi Xiong ,&nbsp;Weichi Ye ,&nbsp;Gangli Zhao ,&nbsp;Liyun Zhang ,&nbsp;Chunxia Li ,&nbsp;Qingmeng Wei ,&nbsp;Qizhi Chen ,&nbsp;Zhijie Fang ,&nbsp;Feng Zhan","doi":"10.1016/j.inoche.2026.116301","DOIUrl":"10.1016/j.inoche.2026.116301","url":null,"abstract":"<div><div>LiFe_xMn_1-xPO₄ holds significant promise as a cathode for lithium-ion batteries. However, its development is constrained by poor conductivity and low ionic mobility. KOH-activated sugarcane bagasse is an abundant agricultural waste. It acted as a sustainable carbon precursor for synthesizing LFMP/B composites by hydrothermal-sintering. We took sucrose-derived LFMP/C as the reference, and investigated how 4 to 8 wt% bagasse-derived carbon affects LFMP. LFMP/B–3 performed best overall. It had a high specific surface area (30.0050 m² g⁻¹), low charge transfer resistance (57.48 Ω), and an elevated Li⁺ diffusion coefficient. Electrochemically, it delivered 146.6 mAh g⁻¹ (0.1C) and 62.3 mAh g⁻¹ (10C), with 99.5% capacity retention at restored 0.5C. After 500 cycles at 1C, its capacity retention rate reached 90.4%, which surpassed LFMP/C's 66.2%. It also maintained good stability over 800 cycles at 10C. Such performance superiority stems from bagasse-derived carbon. This carbon material improves electrical conductivity, reduces charge transfer impedance, and contributes significantly to pseudocapacitance (91.3%). This work realizes agricultural waste valorization and sustainable cathode design.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116301"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption performance of Congo red and malachite green in binary system using Co3O4 and Fe2O3 co-doped g-C3N4","authors":"Mohamed R. Elamin ,&nbsp;Mohamed Ali Ben Aissa ,&nbsp;Abdullah S. Al-Ayed ,&nbsp;Abueliz Modwi","doi":"10.1016/j.inoche.2026.116258","DOIUrl":"10.1016/j.inoche.2026.116258","url":null,"abstract":"<div><div>Currently, the management of dyes and pigments is seen as a significant global concern. This investigation gives the fabrication, analysis, and application of a novel and efficient Fe₂O₃-Co₃O₄-g-C₃N₄ nanocomposite for the simultaneous sorption of Congo Red (CR) and Malachite Green (MG) dyes from a water-based binary solution. The characterization of the Fe₂O₃-Co₃O₄-g-C₃N₄ nanocomposite was conducted utilizing a range of techniques, including X-ray diffraction (XRD), transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDX), X-Ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller surface area (BET). The composite's calculated BET surface area is 36.30 m²/g, while its average volume and pore radius are 0.17 cm³/g and 17.05 Å, respectively. The obtained results indicate that the Fe₂O₃-Co₃O₄-g-C₃N₄ nanosorbent makes it a highly innovative adsorbent.The removal of MG and CR dyes was dissected through batch mode experiments. The effect of several operational parameters, including dye concentration, time contact, and pH, is examined comprehensively. Optimal removal occurred at pH 3.0 for CR dye and 12.0 for MG dye, and contact time of 101 min for CR and 159 min for MG dyes. The dye adsorption process demonstrated a superior fit with the Sips isotherm models for CR and MG dyes. The maximum adsorption capacity of Fe₂O₃-Co₃O₄-g-C₃N₄ was determined to be 804.9 mg/g for CR and 262.4 mg/g for MG. The adsorption mechanism of MG and CR involved electrostatic interactions, Lewis acid-base interactions, π − π stacking, and hydrogen bonding. The high sorption capacity and excellent reusability endow the ternary nanocomposite with significant prospects for the elimination of MG and CR dyes from aqueous environments.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116258"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel MXene/calcinated-MOF composite for electrochemical sensing of lead","authors":"Shavita ,&nbsp;Amit L. Sharma ,&nbsp;Suman Singh","doi":"10.1016/j.inoche.2026.116175","DOIUrl":"10.1016/j.inoche.2026.116175","url":null,"abstract":"<div><div>Heavy metals are particularly hazardous, causing various diseases and developmental issues even at low concentrations. Consequently, there is an urgent requirement for detection methods that are cost-effective, sensitive, and dependable. MXene has gained significant attention because of its electrical conductivity, surface modification, and larger surface area. However, their stability is poor in an aqueous medium because of the restacking of sheets. Herein, calcined nickel-metal Organic Framework and titanium carbide MXene composites (NiO@C-MOF/Ti₃C₂T_x) have been prepared using the calcination and sonication method. The NiO@C-MOF/Ti₃C₂T_x is intended for the electrochemical detection of lead (Pb²⁺) using the electrochemical method. Electrochemical detection of Pb²⁺ was performed using an electrode modified with NiO@C-MOF/Ti₃C₂T_x. Further parameters, such as deposition time, potential, and electrolyte pH, were optimized for better sensor performance. In the electrochemical experiments conducted with varying lead concentrations from 0 to 200 ppb, a rise in current values was noted as the concentration of lead ions increased. The findings revealed that the limit of detection (LOD) was determined to be 1.89 ppb, whereas the limit of quantification (LOQ) was established at 6.24 ppb. The prepared sample demonstrated reproducibility, showing a relative standard deviation of 9.8 %. The novel development of a NiO@C-MOF/Ti₃C₂T_x for lead detection enhances sensitivity and stability, offering a cost-effective solution with improved performance.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116175"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of Cu(II), Co(II), Fe(III), and Zn(II) complexes utilizing a Schiff base: dual functions in biomedical activity and Zn(II) chemosensing","authors":"Mayar Elsherbeny,&nbsp;Usama El-Ayaan,&nbsp;Gaber M. Abu El-Reash","doi":"10.1016/j.inoche.2026.116174","DOIUrl":"10.1016/j.inoche.2026.116174","url":null,"abstract":"<div><div>The formulation of metal-based complexes and Schiff base derivatives is crucial for the progress of medicinal and environmental applications. In this study, two methodologies were investigated: (i) Synthesis of four innovative Cu(II), Co(II), Fe(III) and Zn(II)compounds of ((4-oxo-4H-chromen-3-yl)methylene)isonicotinohydrazone (HL), as well as (ii) the creation of this Schiff base (HL) serving as a selective chemosensor. The four complexes underwent structural characterization through elemental analysis, spectroscopy, thermal studies, magnetism and EPR for the Cu(II) complex. Biological evaluations demonstrated significant antioxidant, anticancer and antibacterial properties, with Zn(II) complex exhibiting the highest efficacy (75% and 72% bacterial and fungal activity within 24 h). Concurrently, the Schiff base chemosensor displayed remarkable colorimetric and fluorometric selectivity towards Zn(II) ions. These results underscore the dual potential of such metal complexes and Schiff base derivatives as promising candidates for biomedical, sensing, and environmental applications. To ascertain whether the synthesized complexes may function as agents for HeLa carcinoma, molecular docking investigations were performed in the study's last portion. These four recently synthesized complexes showed that the complexes' initial cytotoxic and binding potential, rather than their potential for therapeutic use, according to the results.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116174"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silatrane-chalcone-triazole hybrid as a rationally designed NakedEye sensor and turn-on fluorescent probe for selective Zr(IV) detection and anticancer evaluation","authors":"Gurjaspreet Singh ,&nbsp;Poonam ,&nbsp;Manraj Singh ,&nbsp;Amanpreet Singh ,&nbsp;Priyanka ,&nbsp;Parul ,&nbsp;Baljinder Singh Gill ,&nbsp;Shipra Goyal ,&nbsp;Aman Bhalla","doi":"10.1016/j.inoche.2026.116202","DOIUrl":"10.1016/j.inoche.2026.116202","url":null,"abstract":"<div><div>The present study details the copper(I) catalyzed azide-alkyne cycloaddition (CuAAC)based construction of a Silatrane-Chalcone-Triazole conjugate (Quan et al., 2025 (6)), which exhibits selective and efficient colorimetric recognition of Zr(IV).The emission properties of compound (Quan et al., 2025 (6)) were investigated, revealing high selectivity toward Zr(IV) with a detection limit of 2.7 × 10⁻⁷ M.The excellent linear correlation (R² value) obtained from the titration data indicates a 1:1 binding stoichiometry ratio between compound (Quan et al., 2025 (6)) and the Zr(IV). The possible binding site of (6) for Zr(IV) was further elucidated through the ¹H NMR,FT-IR,ESR andmass spectrometric evaluation of the metal-ligand complex was carried out.A marked reduction in cell viability (94.81%) relative to untreated controls was observed upon exposure to compound (Quan et al., 2025 (6)), underscoring its strong anticancer activity. Real sample analysis was carried out using wheat flour to demonstrate practical applicability. Furthermore, molecular docking studies of (Quan et al., 2025 (6)) with 5HU9has been performed, showing a binding energy of −12.66 kcal/mol.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116202"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146189689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular hydrogel implanting nanotubule channels inside microporous metal–organic frameworks for flexible solid-state supercapacitors with ultra-high areal capacity","authors":"Yingjun Chen ,&nbsp;Zhen Cheng ,&nbsp;Xueli Jin ,&nbsp;Linghai Xie ,&nbsp;Min Han ,&nbsp;Naien Shi","doi":"10.1016/j.inoche.2026.116213","DOIUrl":"10.1016/j.inoche.2026.116213","url":null,"abstract":"<div><div>Fabrication of interconnected composites from conductive polymers and highly porous materials is effective to increase the energy and power densities of supercapacitors. However, the effective energy storage of metal–organic frameworks are limited by their intrinsic microporous structure which blocks the interpenetration of electrolyte ions. This study proposes “implant nanotubule charge channel” strategy via supramolecular hydrogel engineering on ZIF-67, achieves a type of highly porous material with one-dimensional nanotubule pores, and it leads to exceptional energy storage performance. Herein, small molecular weight hydrogel of N,N′,N″-tris(3-pyridyl)trimesic amide (TPTA) was employed to engineer the microstructure of ZIF-67 and obtain ZIF-67-TPTA, then TPTA was etched away to achieve the Implanted Tubule Pored ZIF-67 (ITP-ZIF-67) with one-dimensional pore channels. Finally, the conductive polymer polyaniline was electrodeposited and the pore of ITP-ZIF-67 was modified to get the composite of ITP-ZIF-67/PANI. The electrochemical test of ITP-ZIF-67/PANI electrode material shows that its flexible solid-state supercapacitor achieves a high specific capacitance of 2116 mF cm⁻² with an energy density of 293.97 μWh cm⁻² at a power density of 5 W cm⁻², superior to most of the all-solid-state flexible supercapacitors. Moreover, after 5000 cycles, it maintains more than 70% of the initial capacitance value and it can power LED devices. The synthesis strategy in this work provides a new template for preparing MOF mesoporous composite materials with ion and electron conductive properties for further applications in flexible energy storage and electronic devices.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116213"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the performance of photoelectrochemical water splitting using zinc oxide nanorod through UV-Ozone treatment","authors":"Liszulfah Roza ,&nbsp;Vivi Fauzia ,&nbsp;Razin Sabil Asy'tada ,&nbsp;Murni Handayani ,&nbsp;Osi Arutanti ,&nbsp;Rahmat S. Mohar ,&nbsp;M.Y.A. Rahman","doi":"10.1016/j.inoche.2026.116247","DOIUrl":"10.1016/j.inoche.2026.116247","url":null,"abstract":"<div><div>This study investigates the effect of UV/Ozone (UVO) treatment on the photoelectrochemical water splitting (PECWS) using ZnO nanorods (NRs) as photocatalyst. ZnO NRs are recognized as an efficient semiconductor material for PECWS due to their outstanding properties and low cost. The UVO treatment was applied with irradiation times varying from 0 to 15 min to enhance the morphological and optical properties of ZnO NRs. The application of UVO treatment is found to significantly enhance the performance of the PECWS by increasing the density of oxygen vacancies (VO), which improves light-induced electron generation and separation. The variation of the UVO irradiation time led to the decrease in the NRs size, and improved optical properties, such as enhanced absorbance and photoluminescence (PL) emission, leading to significantly improved PEC activity. Among the treated samples, the UVO-10 treatment exhibited significant improvement in the PEC performance with the highest photocurrent density (<em>J</em>_ph) of 0.239 mAcm⁻² at 1.23 V vs. RHE under AM 1.5G illumination. This sample also yielded the highest applied bias photon-to-electron efficiency (<em>ABPE</em>) with the value of 0.059% at a bias voltage of 0.857 V vs. RHE. However, extended UVO treatment time led to the formation of oxygen interstitials (Oi) by accelerating photocatalytic degradation. The findings highlight the critical balance needed in UVO treatment duration to achieve optimal performance while avoiding detrimental defects. This study provides valuable insights for refining treatment protocols and advancing the development of efficient ZnO-based PECWS.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116247"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible β-carboline–derived fluorescent probes for nanomolar detection and intracellular Zn2+ imaging","authors":"Muhammad Ashraf ,&nbsp;Mochamad L. Firmansyah ,&nbsp;Safwat Abdel-Azeim ,&nbsp;Nisar Ullah","doi":"10.1016/j.inoche.2026.116294","DOIUrl":"10.1016/j.inoche.2026.116294","url":null,"abstract":"<div><div>Two novel β-carboline–based fluorescent probes (<strong>P1</strong> and <strong>P2</strong>) were synthesized through a concise, high-yielding route for the selective detection of Zn²⁺ ions. Structural and photophysical analyses revealed that both probes exhibit remarkable sensitivity and selectivity toward Zn²⁺ over competing metal ions, showing fluorescence “turn-on” responses of 5.6-fold (P1) and 10.5-fold (P2). The detection limits were determined to be 27.2 nM and 55.1 nM, respectively. Both probes demonstrated excellent anti-interference properties and operated optimally under physiological pH (7.4). DFT and TD-DFT calculations revealed that both probes form stable hexacoordinate Zn²⁺ complexes, with Zn²⁺ binding leading to a reduction in the HOMO–LUMO gap and orbital stabilization. These results support a photoinduced electron transfer (PET) inhibition mechanism, explaining the fluorescence “turn-on” response and the stronger Zn²⁺ affinity of P2. Moreover, the ¹H NMR spectra provided evidence for the formation of probe/Zn²⁺ complexes, as distinct differences were observed between the free probes and their complexed forms. The probes also exhibited low cytotoxicity and high biocompatibility, enabling their successful application in monitoring Zn²⁺ in WiDr cells using confocal fluorescence microscopy. Overall, these findings demonstrate that P1 and P2 are promising fluorescent probes for highly sensitive Zn²⁺ monitoring in biological and environmental systems</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116294"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial engineering of an NH₂-MIL-101(Fe)@COF core-shell structure for superior diclofenac sodium adsorption","authors":"Yangyang Li ,&nbsp;Meiqi Zhou ,&nbsp;Fei Zeng ,&nbsp;Jiafan Wang ,&nbsp;Bingzhen Ma","doi":"10.1016/j.inoche.2026.116315","DOIUrl":"10.1016/j.inoche.2026.116315","url":null,"abstract":"<div><div>The development of advanced drug contaminant adsorbents requires innovative material design and sustainable synthesis strategies. Herein, we report a room-temperature in situ growth method to construct NH₂-MIL-101(Fe)@COF core-shell hybrid materials, overcoming the limitations of conventional high-energy synthesis while achieving exceptional adsorption performance for diclofenac sodium (DCF). The precisely engineered interface between NH₂-MIL-101(Fe) and the COF layer creates synergistic adsorption sites, combining Fe<img>O chelation, electrostatic attraction, and π–π stacking interactions, as revealed by in situ FTIR and XPS studies. The hierarchical pore structure (micropores: 1.97 nm; mesopores: 7.44 nm) enables rapid diffusion kinetics (The adsorption equilibrium was reached within 45 min) and delivers an adsorption capacity of 399.77 mg·g⁻¹, surpassing most reported MOF@COF-based adsorbents. Remarkably, the material retains an adsorption capacity of 216.6 mg·g⁻¹ after five regeneration cycles and demonstrates strong resistance to interference from coexisting ions, highlighting its potential for real-world aqueous applications. This study presents a feasible strategy for the in situ room-temperature synthesis of MOF@COF composites, offering a mild route to fabricate COF-based hybrids with NH₂-MIL-101(Fe).</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"186 ","pages":"Article 116315"},"PeriodicalIF":5.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}