Indian Journal of Pharmacology最新文献_第2页

Clozapine, pneumonia, and COVID-19. 氯氮平、肺炎和COVID-19。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/ijp.ijp_623_22

Pathum Sookaromdee, Viroj Wiwanitkit

引用次数: 0

Reporting and critical appraisal of evidence-based research: Making the journal club most effective. 基于证据的研究报告和批判性评价：使期刊俱乐部最有效。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/ijp.ijp_570_25

Rashmi Ranjan Das, Akash Bang

引用次数: 0

Rare manifestation of paclitaxel-induced cardiotoxicity: A case of restrictive cardiomyopathy in an elderly breast cancer patient. 紫杉醇致心脏毒性的罕见表现：一例老年乳腺癌患者的限制性心肌病。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/ijp.ijp_764_25

Kumar Masum, Sandeep Srinivas, Balakeshwa Ramaiah

{"title":"Rare manifestation of paclitaxel-induced cardiotoxicity: A case of restrictive cardiomyopathy in an elderly breast cancer patient.","authors":"Kumar Masum, Sandeep Srinivas, Balakeshwa Ramaiah","doi":"10.4103/ijp.ijp_764_25","DOIUrl":"10.4103/ijp.ijp_764_25","url":null,"abstract":"Abstract: Paclitaxel, a widely used taxane in the treatment of breast and other solid tumors, rarely causes cardiovascular complications such as restrictive cardiomyopathy and often underrecognized. A 78-year-old woman with estrogen receptor/progesterone receptor-positive, HER2-negative breast cancer who developed acute dyspnea and paroxysmal nocturnal dyspnea after her ninth weekly paclitaxel infusion. Cardiac evaluation revealed new-onset atrial fibrillation, elevated N-terminal pro-B-type natriuretic peptide, and multimodal imaging findings consistent with restrictive cardiomyopathy, including bi-atrial enlargement, severe valvular regurgitation, and myocardial fibrosis on cardiac magnetic resonance imaging. She had no prior cardiac history, and alternative etiologies were excluded. The temporal association with paclitaxel strongly implicated drug-induced cardiotoxicity. Proposed mechanisms include microtubule disruption, mitochondrial injury, calcium dysregulation, and potential toxicity from the solvent Cremophor EL. Prompt cessation of paclitaxel and initiation of heart failure therapy led to clinical improvement. This case highlights the need for vigilance for cardiac toxicities in chemotherapy patients with cardio-oncology collaboration.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"58 2","pages":"150-152"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse drug reaction due to concomitant vaccine administration of Covishield and Hepatitis-B in a patient with multidrug allergies. 多药过敏患者同时接种柯氏盾和乙型肝炎疫苗的不良反应。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/ijp.ijp_611_21

Abhishek Sharma, Gulnaz Bano

引用次数: 0

Therapy in diabetic dyslipidemia. 糖尿病性血脂异常的治疗。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/ijp.ijp_569_24

Uma Maheswari

引用次数: 0

A rare drug reaction: Toxic epidermal necrolysis following polymyxin B administration in a post-Bentall procedure. 一个罕见的药物反应：多粘菌素B在本特尔手术后给药后毒性表皮坏死松解。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/ijp.ijp_1139_25

Bhavin B Patel, Rachana B Patel, Nisarg R Hajariwala, Pankaj Maheshwari, Anil Ganju, Chetan Trivedi

{"title":"A rare drug reaction: Toxic epidermal necrolysis following polymyxin B administration in a post-Bentall procedure.","authors":"Bhavin B Patel, Rachana B Patel, Nisarg R Hajariwala, Pankaj Maheshwari, Anil Ganju, Chetan Trivedi","doi":"10.4103/ijp.ijp_1139_25","DOIUrl":"10.4103/ijp.ijp_1139_25","url":null,"abstract":"Abstract: Polymyxin B is a last-resort antibiotic used to treat multidrug-resistant (MDR) Gram-negative infections. While nephrotoxicity and neurotoxicity are well-documented, severe dermatologic adverse reactions such as toxic epidermal necrolysis (TEN) are exceedingly uncommon but clinically significant. A 54-year-old hypertensive male underwent an emergency Bentall procedure for DeBakey type I aortic dissection. The patient developed acute kidney injury requiring dialysis. The patient subsequently developed polymyxin B-sensitive Acinetobacter lwoffii septicemia, for which intravenous polymyxin B was initiated. On day 6 of therapy, the patient developed a widespread erythematous rash that progressed to bullous eruptions and skin sloughing involving over 30% body surface area. A clinical diagnosis of TEN was made. Polymyxin B was discontinued immediately, and the patient was managed with corticosteroids and wound care. The patient demonstrated complete clinical recovery. This case underscores the importance of heightened clinical suspicion for polymyxin B-induced toxic epidermal necrolysis and early withdrawal of the offending agent to ensure prompt detection and recovery.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"58 2","pages":"156-158"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breathing insights: Biomarkers as tools for chronic obstructive pulmonary disease assessment - A systematic review. 呼吸洞察：作为慢性阻塞性肺疾病评估工具的生物标志物-系统综述。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.4103/ijp.ijp_970_24

Sonali Singh, Atul Kabra, Pradeep Goyal

{"title":"Breathing insights: Biomarkers as tools for chronic obstructive pulmonary disease assessment - A systematic review.","authors":"Sonali Singh, Atul Kabra, Pradeep Goyal","doi":"10.4103/ijp.ijp_970_24","DOIUrl":"10.4103/ijp.ijp_970_24","url":null,"abstract":"Abstract: Chronic obstructive pulmonary disease (COPD) remains a major global health burden, posing ongoing challenges in diagnosis and management. This systematic review examines current evidence on biomarkers relevant to COPD, emphasizing their diagnostic, prognostic, and therapeutic potential. A comprehensive search of PubMed and Scopus identified studies published from January 2019 to April 2025 involving adult COPD patients. Two independent reviewers screened observational and randomized studies, with duplicates (n = 24) removed using Mendeley and verified manually. Due to heterogeneity in methodology and outcomes, data were synthesized narratively. Risk of bias was assessed using RoB 2.0 for randomized trials and the Newcastle-Ottawa Scale for observational studies. Traditional biomarkers such as C-reactive protein and fibrinogen were consistently associated with exacerbation risk and disease severity. Interleukins-6 and -8 were elevated in frequent exacerbators, while surfactant proteins showed potential in distinguishing COPD from other chronic lung diseases. Emerging genetic and multiomics markers - such as matrix metalloproteinase-9, chitinase-3-like protein 1, and various microRNAs - demonstrated associations with disease phenotypes and treatment response. The findings highlight that while individual biomarkers offer valuable insights, a combined multimarker approach integrated with clinical parameters may enhance the precision of COPD management. This review provides clinicians and researchers with an updated perspective on the utility and limitations of current biomarkers, supporting the move toward more personalized and effective strategies in COPD care.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"58 1","pages":"11-23"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outer membrane protein LipL21 as a potential candidate against Leptospira interrogans: An in silico prediction. 外膜蛋白LipL21作为抗钩端螺旋体的潜在候选物：一个计算机预测。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.4103/ijp.ijp_540_23

Anita Kumari, Devinder Toor

{"title":"Outer membrane protein LipL21 as a potential candidate against Leptospira interrogans: An in silico prediction.","authors":"Anita Kumari, Devinder Toor","doi":"10.4103/ijp.ijp_540_23","DOIUrl":"10.4103/ijp.ijp_540_23","url":null,"abstract":"Abstract: Leptospirosis is one of the most widespread zoonotic diseases caused by Leptospira interrogans, characterized by mild febrile illness to severe multiorgan failure. The conventional vaccines against Leptospira have several drawbacks, including short-term immunity and serovar-based protection. The current study focuses on determining the most effective outer membrane protein (OMP) as a potential antigen using various computational approaches in providing protection against leptospirosis, as they are conserved within pathogenic serovars. Out of OmpL1, LipL21, LipL32, and LipL41, the VaxiJen analysis revealed LipL21 to be the most antigenic with a score of 0.7848. The antigenic epitopes of LipL21 were further analyzed using BCPred and MHCPred. It is conserved among all the pathogenic serovars while being absent in nonpathogenic. LipL21 had both B-cell and T-cell epitopes, suggesting that it is immunogenic. The VaxiJen score, localization of protein, Clustal Omega, and confirmational analysis of B-cell epitopes were studied for defining a better immunogenic and conserved OMP. This study holds importance as the surface proteins are a potential vaccine candidate for the development of new and effective vaccines in the prevention of leptospirosis hold. An ideal protein, which has its entire conserved immunogenic domain, would confer cross-protection against heterologous serovars. Thus, using bioinformatic approaches, we for the first time predict that LipL21 is a promising, effective vaccine candidate in providing protection against Leptospira.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"58 1","pages":"68-73"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12875520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedicine and digital health: The future for pharmaceutical companies and health care. 远程医疗和数字健康：制药公司和医疗保健的未来。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.4103/ijp.ijp_452_24

Pathan Azher Khan, Payal Jayendra Badole, Darakshan Shaikh

{"title":"Telemedicine and digital health: The future for pharmaceutical companies and health care.","authors":"Pathan Azher Khan, Payal Jayendra Badole, Darakshan Shaikh","doi":"10.4103/ijp.ijp_452_24","DOIUrl":"10.4103/ijp.ijp_452_24","url":null,"abstract":"Abstract: In today's fast-paced world, demand for convenient patient care is high, prompting the rise of telemedicine and digital health platforms. These platforms offer quick solutions for health management, aligning with the trend of utilizing online tools for various needs. Integrating these technologies into health care ensures top-notch facilities without disrupting busy lifestyles. This review provides a comprehensive view of their benefits, enhancing patient access and streamlining processes. The paper explores diverse applications such as electronic health records and mobile health apps, empowering patients and enabling real-time decision-making for healthcare providers. It emphasizes the role of big data analytics in managing vast health-related data. Government initiatives and regulatory frameworks are also discussed. Through case studies, the review illustrates the tangible impact of these technologies on patient outcomes and healthcare efficiency. Embracing digital health and telemedicine is crucial for pharmaceutical stakeholders to adapt to evolving patient needs and drive innovation in modern health care.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"58 1","pages":"24-34"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced mania and parkinsonism in substance use disorder patient: A case report. 物质使用障碍患者药物性躁狂症和帕金森症1例。

IF 1.2 4区医学

Indian Journal of Pharmacology Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.4103/ijp.ijp_1041_24

Ragesh Gurumoorthi, Ramakrishnan Subbaraya Rajendran, Akila Murugan, Karthik Thiyagarajan, Muhasaparur Ganesan Rajanandh

引用次数: 0