Indian Journal of Pharmacology最新文献

{"title":"Comparative evaluation of efficacy and tolerability of apremilast and methotrexate in patients of moderate-to-severe palmoplantar psoriasis: A randomized, parallel, open-label clinical trial","authors":"Mitali Wagh, Jayesh Mukhi, Smita Sontakke, Amit Dhok, Avinash Turankar, Mrunalini Kalikar","doi":"10.4103/ijp.ijp_190_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_190_23","url":null,"abstract":"<h3>BACKGROUND: </h3>\u0000<p>Variable results about efficacy as well as safety of apremilast compared to methotrexate are reported in different trials. Hence, it is necessary to collect more evidence to prove the role of Apremilast in palmoplantar psoriasis.</p>\u0000<h3>METHODOLOGY: </h3>\u0000<p>The study was a randomized, prospective, parallel-group, open-label study conducted in patients with moderate-to-severe palmoplantar psoriasis. They were randomized into two groups, methotrexate (<em xmlns:mrws=\"http://webservices.ovid.com/mrws/1.0\">n</em> = 19) or apremilast (22) for 16 weeks. Primary efficacy parameter was reduction in modified palmoplantar psoriasis area and severity index (mPPPASI) score from week 0 to week 16. Other parameters were proportion of patients attaining Static Physician Global Assessment score of 0 (clear) or 1 (almost clear), proportion of patients attaining mPPPASI75 (75% reduction in mPPPASI score) at the end of 16 weeks, and proportion of patients showing at least 5-point decline in dermatology life quality index from baseline.</p>\u0000<h3>RESULTS: </h3>\u0000<p>Decline in m-PPPASI score from 0 week to 16 weeks within the group was significant statistically though decline in score of m-PPPASI between these two groups was not statistically significant at 16 weeks. Similar results were obtained with the secondary efficacy parameters. In methotrexate group, there were 24 adverse events recorded including abnormal liver function tests in three patients. In apremilast group, 19 adverse events were recorded, in which two patients suffered from upper respiratory tract infection.</p>\u0000<h3>CONCLUSION: </h3>\u0000<p>Apremilast is as effective as methotrexate for the management of moderate-to-severe palmoplantar psoriasis with better tolerability. Hence, it can be considered alternative to established drugs in patients having palmoplantar psoriasis not responding to or tolerating other drugs.</p>\u0000<h3>REGISTRATION: </h3>\u0000<p>The study was registered with Clinical Trial Registry of India (CTRI/2020/05/025198).</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"62 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139068010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Asyogh’s rectangular device for learning and memory testing in Wistar rats","authors":"Yogesh Chand Yadav","doi":"10.4103/ijp.ijp_146_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_146_23","url":null,"abstract":"<p>This study aimed to design Asyogh’s rectangular device that is used for memory testing in rodents. It was found that scopolamine (3 mg/kg i.p.) and diazepam (1 mg/kg i.p.) caused significant memory deficits in rats, as evidenced by increased transfer latency times. However, these memory deficits were significantly reversed when the rats were pretreated with Donepezil. It further demonstrates that pretreated donepezil is able to effectively restore the memory deficits induced by scopolamine and diazepam, as indicated by the significant recovery in TLT. The present study showed that the device used to measure transfer latency time that was a valuable tool for assessing memory and cognitive function in rodents.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"37 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139053368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical effect of ossotide for injection in the treatment of condylar fracture.","authors":"Qian Jiang, Yifei Chen, Fangyong Zhu, Yujia Xie, Zhidan Zhu, Xiaojing Sun","doi":"10.4103/ijp.ijp_157_23","DOIUrl":"10.4103/ijp.ijp_157_23","url":null,"abstract":"<p><strong>Objectives: </strong>Patients with condylar fractures were treated with osteopeptide injections as an adjuvant therapy to assess pain control and changes in interleukin-1β (IL-1β) and bone G-gla protein (BGP) levels.</p><p><strong>Materials and methods: </strong>Eighty-two patients with a condylar neck fracture were randomly assigned to two groups. The control group received conventional surgical treatment, while the experimental group received osteopeptide injections in addition to surgery. Pain level, IL-1β, and BGP levels were evaluated at 1, 2, and 4 weeks postsurgery.</p><p><strong>Results: </strong>One and two weeks postsurgery, the experimental group had lower Numeric Rating Scale scores compared to the control group. In addition, the IL-1β level in patients receiving osteopeptide injections was lower than the control group at all three evaluation points (1, 2, and 4 weeks postsurgery) and the BGP level was higher with statistically significant differences (P < 0.05).</p><p><strong>Conclusions: </strong>The administration of osteopeptide injections as an adjuvant therapy for patients with condylar fractures can effectively reduce pain and facilitate faster initiation of muscle function training. In addition, the reduction of inflammatory factors and promotion of active osteogenesis leads to quicker wound healing.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"363-366"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does ketamine show tolerance?","authors":"Abhishek Bharadwaj","doi":"10.4103/ijp.ijp_230_23","DOIUrl":"10.4103/ijp.ijp_230_23","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"410-411"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective potential of erucic acid via inhibition of N2a cell lines and rotenone induced Parkinson's disease rat model.","authors":"Bhawna Sharma, Pankaj Gupta, Largee Biswas, Anita Kamra Verma, Arif Mohammad Pasha, Prasad Thota, Bikash Medhi","doi":"10.4103/ijp.ijp_314_23","DOIUrl":"10.4103/ijp.ijp_314_23","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to investigate the potential for erucic acid (EA), an omega-9 monounsaturated fatty acid, to act as a neuroprotective agent.</p><p><strong>Materials and methods: </strong>In this study, EA was investigated against N2a cell lines and a rotenone (ROT)-induced model of Parkinson's disease for its neuroprotective potential. The N2a cell line was incubated with fetal bovine serum, penicillin, and streptomycin supplemented with Dulbecco's Modified Eagle's Medium, and the following assays were carried out: (i) MTT, (ii) biocompatibility, (iii) DCFDA, and (iv) diphenylamine. A cell morphology study was also performed. Further, ROT 1 mg/kg s.c. and EA 3 and 10 mg/kg p.o. were given to rats on a daily basis for 21 days, and the following parameters were assessed: (i) neurobehavioral studies, (ii) oxidative stress markers, (iii) neuroinflammatory markers, (iv) neurotransmitters, and (v) histopathological study.</p><p><strong>Results: </strong>The cell viability assay revealed that EA showed protection against ROT-induced toxicity in N2a cells, which was confirmed by a cell morphology study. EA decreased oxidative stress and % DNA fragmentation significantly. EA also prevented ROT-induced motor impairment and altered levels of oxidative stress markers, neurotransmitters, and neuroinflammatory markers significantly. When compared to the ROT group, a histological investigation of the EA group showed partial neuronal loss with the existence of intact neurons in between the vacuolated gaps.</p><p><strong>Conclusion: </strong>This study revealed that EA possesses profound neuroprotective properties in in vitro and in vivo studies. Additional research can be carried out to study the mechanism of EA with respect to its neuroprotective potential.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"376-384"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Pistia stratiotes</i> has renoprotective potentials in ischemia reperfusion injury in normal and diabetic rats.","authors":"Vashisth Pankajkumar Bhavsar, Ashish Patel, Jitendra D Vaghasiya, Shantilal Padhiyar, Tejas B Patel","doi":"10.4103/ijp.ijp_272_23","DOIUrl":"10.4103/ijp.ijp_272_23","url":null,"abstract":"<p><strong>Objective: </strong>Even though oxidative and inflammatory bursts are a big part of renal reperfusion injury (RI/R), Pistia stratiotes (PS) has been used for a long time to stop these overreactions. People have said that it can drop both blood sugar and cholesterol. Hence, the goal of this study was to show how PS changed kidney reperfusion damage in both diabetic and normal rats.</p><p><strong>Materials and methods: </strong>In the study, 30 min of renal ischemia (RI) was followed by 1 h of recovery for each rat. Before the test, PS (100 mg/kg p. o.) was given to the animals for 7 days. Then, using the mixture from the separated kidney tissues, the antioxidant, inflammation, and histopathological effects were determined.</p><p><strong>Results: </strong>When compared to RI/R, diabetic rats given PS had lower blood sugar, aspartate aminotransferase, blood urea nitrogen, and creatinine, myeloperoxidase, C-reactive protein, and tumor necrosis factor-alpha levels in their urine.</p><p><strong>Conclusion: </strong>PS potentially worked in hyperglycemic rats protecting them against RI/R. It is possible that PS's ability to protect the kidneys of the test rats is due to its ability to fight free radicals, lower blood sugar, and stop inflammation.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"367-375"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin popping with tapentadol: New challenges in the ongoing opioid crisis.","authors":"Poojari Yogitha, Hima Gopinath","doi":"10.4103/ijp.ijp_382_23","DOIUrl":"10.4103/ijp.ijp_382_23","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"412-413"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracetamol-induced generalized fixed-drug eruption with localized bullous variant in a 15-year-old boy.","authors":"Shree Dhanani, Mauli M Shah, Pragya Ashok Nair","doi":"10.4103/ijp.ijp_552_23","DOIUrl":"10.4103/ijp.ijp_552_23","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"416-417"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug resistance profile in postbiliary and gastrointestinal surgical-site infection cases from a tertiary care hospital.","authors":"Deepjyoti Kalita, Madhab Chandra Rajbangshi, Sumi Deka, Ridip Kumar Sarma, Sangeeta Deka","doi":"10.4103/ijp.ijp_783_21","DOIUrl":"10.4103/ijp.ijp_783_21","url":null,"abstract":"<p><p>In the developing world, surgical-site infection (SSI)-associated pathogens are becoming more drug resistant implicating higher morbidity and management cost. Here, we tried to analyze the drug resistance pattern in our SSI-related isolates. Over 2 years, 191 clinically diagnosed SSIs (postbiliary tract and postgastrointestinal surgery) were included, and wound swabs were processed by conventional aerobic and anaerobic culture. Antibiotic minimum inhibitory concentration (MIC) was determined by the Epsilometer testing. Multidrug-resistant phenotypes were detected as per guidelines. The rate of SSI was 5.3% with Klebsiella, Staphylococcus, and Pseudomonas, growing predominantly, and no anaerobe detectable. About 19.4% of Staphylococcus aureus were methicillin-resistant S. aureus, and one-third of them had raised macrolide MIC. About 58.2% of Enterobacteriaceae isolates were extended-spectrum beta-lactamase producers. Isolates with raised meropenem MIC were observed. Antibiotic-resistant level in SSI cases is alarmingly high, and in susceptible strains, MIC is approaching the resistant level. Urgent corrective action is an emergency necessity.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"399-404"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of topically administered progesterone for the treatment of retinitis pigmentosa <i>in vivo</i>.","authors":"Yethindra Vityala, Afreen Begum Kaggallu, Sameena Sultana, Krishna Priya Kanteti, Tugolbai Tagaev","doi":"10.4103/ijp.ijp_429_23","DOIUrl":"10.4103/ijp.ijp_429_23","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 6","pages":"414-415"},"PeriodicalIF":1.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}