Indian Journal of Pharmacology最新文献_第9页

Plasma drug concentration resulting from body surface area-based dosage. 基于体表面积的剂量产生的血浆药物浓度。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-09-01 DOI: 10.4103/ijp.ijp_470_23

Heng Wang, Song Xue

引用次数: 0

Genomic biomarkers: Unveiling the potential for precise cancer therapy response. 基因组生物标志物：揭示精确癌症治疗反应的潜力。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_442_23

Gurjeet Kaur, Paras Pahwa, Ajay Prakash, Bikash Medhi

引用次数: 0

A case series on tofacitinib-induced weight gain. 托法替尼诱导体重增加的病例系列。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_158_23

Kanisha Shah, Dhaiwat Shukla, Manish Patel, Supriya Malhotra

引用次数: 0

Microteaching: Overview and examination evaluation. 微格教学：概述和考试评估。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_912_21

Pugazhenthan Thangaraju, Bikash Medhi

引用次数: 0

Testing the knowledge and interpretation skills of ChatGPT in pharmacology examination of phase II MBBS. 在II期MBBS药理学考试中测试ChatGPT的知识和解释技能。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_188_23

Anitha Elango, Neevedha Kannan, Isswariya Anandan, Krishna Mohan Surapaneni

引用次数: 0

Fixed drug eruption - Experience from a tertiary care center in Uttarakhand. 修复药疹-北阿坎德邦三级护理中心的经验。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_177_23

Neirita Hazarika, Puneet Dhamija, Amrita Upadhyaya, Manisha Rauthan

引用次数: 0

Role of vascular endothelial growth factor in tuberculous meningitis: A prospective study from a tertiary care center in North India. 血管内皮生长因子在结核性脑膜炎中的作用：来自北印度一家三级护理中心的前瞻性研究。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_743_22

Devesh Kumar, Deependra Singh, Tanish Modi, Riya Sharma, Anand Keshav Awasthy, Ritu Shree, Manoj Kumar Goyal, Dhawal Narang, Siddharth Chand, Sameer Vyas, Kusum Sharma, Navneet Sharma, Rudresh Gowda, Abeer Goel, Rajeev Ranjan, Manish Modi

{"title":"Role of vascular endothelial growth factor in tuberculous meningitis: A prospective study from a tertiary care center in North India.","authors":"Devesh Kumar, Deependra Singh, Tanish Modi, Riya Sharma, Anand Keshav Awasthy, Ritu Shree, Manoj Kumar Goyal, Dhawal Narang, Siddharth Chand, Sameer Vyas, Kusum Sharma, Navneet Sharma, Rudresh Gowda, Abeer Goel, Rajeev Ranjan, Manish Modi","doi":"10.4103/ijp.ijp_743_22","DOIUrl":"10.4103/ijp.ijp_743_22","url":null,"abstract":"Introduction: The status of vascular endothelial-derived growth factor (VEGF) in the pathogenesis of tuberculous meningitis (TBM) remains far from clear. We prospectively evaluated the role of serum and cerebrospinal fluid (CSF) VEGF in TBM.Patients and methods: This prospective study was conducted at a tertiary care center in North India from January 2018 to June 2019. Consecutive drug-naive patients (n = 82) of TBM diagnosed on the basis of modified Ahuja's criteria were included in the study. The results were compared with 49 control subjects (n = 49). Serum and CSF VEGF were done in all the cases and controls. Follow-up serum VEGF levels were done in 34 patients after 3 months of completion of antitubercular therapy. The VEGF levels were estimated using the human VEGF enzyme-linked immunosorbent assay kit.Results: The mean age was 29.9 ± 13.1 years. The study group consisted of 33 (40.2%) men and 49 (59.8%) women. BACTEC MGIT960 was positive in 15 (18%) patients while multiplex tuberculosis polymerase chain reaction was positive in 73 (89%) patients. Levels of VEGF in serum and CSF of TBM patients were not elevated when compared to controls. There was no association between final outcome in TBM and decrease in serum levels of VEGF at follow-up.Conclusion: VEGF may not be playing a significant role in the pathogenesis of TBM. Future studies with larger sample size may clarify the status of VEGF further in TBM.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 4","pages":"216-222"},"PeriodicalIF":2.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41123029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Citicoline on the Barthel Index: Severe and moderate brain injury. Citicoline对Barthel指数的影响：严重和中度脑损伤。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_570_21

Mehdi Mahmoodkhani, Bahram Aminmansour, Mehdi Shafiei, Mohammadreza Hasas, Donya Sheibani Tehrani

{"title":"Citicoline on the Barthel Index: Severe and moderate brain injury.","authors":"Mehdi Mahmoodkhani, Bahram Aminmansour, Mehdi Shafiei, Mohammadreza Hasas, Donya Sheibani Tehrani","doi":"10.4103/ijp.ijp_570_21","DOIUrl":"10.4103/ijp.ijp_570_21","url":null,"abstract":"Introduction: Traumatic brain injury (TBI) is a paramount factor in mortality and morbidity. The clinical trials conducted to investigate the efficacy of neuroprotective agents, such as citicoline, as a therapeutic alternative for TBI have presented divergent findings. Therefore, this study aimed to evaluate and compare citicoline's effect on the Barthel Index in patients with severe and moderate brain injury.Materials and methods: The study is a randomized clinical trial. Patients in the case group (35 patients) were treated with citicoline and the control group (34 patients) received a placebo. Data were analyzed using SPSS 16 software.Results: The results showed that changes in the Glasgow Coma Scale, changes in quadriceps muscle force score, Barthel Index score changes, achieving the status without intubation, and spontaneous breathing in patients treated with citicoline were not a statistically significant difference in the two groups (P > 0.05).Conclusion: Findings revealed that citicoline did not impact the recovery process of severe and moderate TBI patients.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 4","pages":"223-228"},"PeriodicalIF":2.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacovigilance in the medical education: In UG curriculum where do we stand? What can be done? 医学教育中的药物警戒：在UG课程中，我们的立场是什么？能做些什么？

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_145_23

Shiva Murthy Nanjundappa, Pratibha Durgesh Nadig, M K Jayanti, R M Veena, G N Manjunath

引用次数: 0

Potential use of Balanophora latisepala (V. Tiegh.) Lec. extract for the treatment of diabetes. latisepala Balanophora（V.Tiegh.）Lec的潜在用途。用于治疗糖尿病的提取物。

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2023-07-01 DOI: 10.4103/ijp.ijp_253_23

Nguyen Trong Hong Phuc, Nguyen Thi Yen Lan, Nguyen Van Ay

{"title":"Potential use of Balanophora latisepala (V. Tiegh.) Lec. extract for the treatment of diabetes.","authors":"Nguyen Trong Hong Phuc, Nguyen Thi Yen Lan, Nguyen Van Ay","doi":"10.4103/ijp.ijp_253_23","DOIUrl":"10.4103/ijp.ijp_253_23","url":null,"abstract":"Introduction: Balanophora latisepala (BL) is a chlorophyll-free and obligate parasitic plant found across mountainous areas of An Giang, Vietnam. This study was conducted to evaluate the effectiveness of extracts from BL, herbs mentioned in many traditional medicines in the treatment of diabetes, on laboratory mice.Materials and methods: The effects of BL aqueous, methanol, and ethanol extracts on the blood glucose levels, hematological indices, liver enzymes, and pancreatic tissue structure of normal, glucose-tolerant mice, and diabetic mice treated with streptozotocin (STZ) were assessed. Mice were orally administered extracts at a concentration of 500 mg/kg.Results and discussion: The aqueous and ethanol extracts did not affect the blood glucose levels of healthy and glucose-tolerant mice (P > 0.05). The methanol extract reduced the blood glucose of healthy mice (P < 0.05) but did not affect the blood glucose of glucose-tolerant mice 3 h after administration (P > 0.05). When taking the methanol and ethanol extracts, the diabetic mice experienced a 45.67% and a 40.33% decrease in blood glucose levels after 21 days of research, respectively. Aqueous extract and gliclazide (10 mg/kg) showed no effect on reducing blood glucose levels in diabetic mice over the 21 days of the study. Both methanol and ethanol extracts were effective in regulating liver enzyme levels in diabetic mice. In both untreated and treated diabetic mice, pancreatic islet structures were degraded with the appearance of gaps resulting from β-cell degeneration.Conclusion: This implies that ethanol extracts have potential applications in regulating blood glucose levels.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"55 4","pages":"237-242"},"PeriodicalIF":2.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0