Indian Journal of Pharmacology最新文献

Targeted active surveillance of branded generic deferasirox in pediatric thalassemia patients in a tertiary care hospital of India: A pharmacovigilance study. 印度三级医院儿童地中海贫血患者对品牌非专利去铁宁的靶向主动监测：一项药物警戒研究

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_88_23

Mousumee Panigrahi, Trupti Rekha Swain, Rabindra Kumar Jena, Ashutosh Panigrahi, Nishant Debta

{"title":"Targeted active surveillance of branded generic deferasirox in pediatric thalassemia patients in a tertiary care hospital of India: A pharmacovigilance study.","authors":"Mousumee Panigrahi, Trupti Rekha Swain, Rabindra Kumar Jena, Ashutosh Panigrahi, Nishant Debta","doi":"10.4103/ijp.ijp_88_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_88_23","url":null,"abstract":"Introduction: Deferasirox is a newer oral iron chelator which needs to be given for at least 1 year to see a significant decrease in serum ferritin level in thalassemia patients with chronic iron overload. This study aimed to assess the safety profile of branded generic deferasirox in pediatric thalassemia cases, as it has not been studied in eastern India, especially in real-world settings.Subjects and methods: It was an observational hospital-based study in a government tertiary care teaching hospital where branded generic deferasirox is distributed free of cost to patients. One hundred and seventy-four patients were included. Safety assessment was done through active questioning about the symptoms starting after deferasirox therapy and through laboratory parameters and clinical examination.Results: Sixty percent of patients developed adverse drug reactions (ADRs) with deferasirox during the 1-year follow-up. ADRs were more common in males than females. The highest number of ADRs was related to the gastrointestinal and hepatobiliary system. The ADRs were either mild or moderate. Compliance and number of ADRs were found to be inversely correlated.Conclusion: ADRs of deferasirox are acceptable looking at the benefits. Regular monitoring and management of ADRs will facilitate patient compliance. However, healthcare professionals need to be alert while prescribing this drug and report any ADR, even if it is not labeled. This study found increased serum lipase and mouth ulcer as adverse effects, which are not yet labeled. These can be signals for further analysis by regulatory authorities.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 2","pages":"77-82"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imatinib attenuates neurobehavioral deficits and hippocampal neuronal damage after global cerebral ischemia in gerbils. 伊马替尼减轻沙鼠全脑缺血后的神经行为缺陷和海马神经元损伤。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_726_23

Hina Lateef Nizami, Krishnamoorthy Srinivasan, Shyam Sunder Sharma

{"title":"Imatinib attenuates neurobehavioral deficits and hippocampal neuronal damage after global cerebral ischemia in gerbils.","authors":"Hina Lateef Nizami, Krishnamoorthy Srinivasan, Shyam Sunder Sharma","doi":"10.4103/ijp.ijp_726_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_726_23","url":null,"abstract":"Abstract: Imatinib mesylate, a selective tyrosine kinase inhibitor, exhibited beneficial effects against various neurological diseases besides its anticancer activity. However, its effects on global cerebral ischemia in gerbils remain to be investigated. Global cerebral ischemia was induced by bilateral carotid artery occlusion (BCAO) in male Mongolian gerbils. Imatinib (3, 10, and 30 mg/kg BW) was administered intraperitoneally (i.p.) 30 min before BCAO. Imatinib (3 and 10 mg/kg) significantly ameliorated neurological deficits, locomotor hyperactivity, and cognitive deficits (Y-maze spontaneous alternations) at 4, 24, and 72 h, respectively, after reperfusion in gerbils. Imatinib caused reduction in neuronal cell death in CA1 hippocampal region of gerbils after BCAO and was associated with abrogation of elevated immunoreactivity of endoplasmic reticulum (ER) stress markers (GRP78 and CHOP). This study demonstrates the neuroprotective effect along with functional improvement by imatinib in global cerebral ischemia in gerbils that may be due to mitigation of ER stress.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 2","pages":"97-101"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the collective advantages of sodium-glucose cotransporter-2 inhibitors and GLP-1 analogs in addressing metabolic health issues linked to obese type 2 diabetes mellitus and related comorbidities. 研究钠-葡萄糖共转运蛋白-2抑制剂和GLP-1类似物在解决与肥胖2型糖尿病及相关合并症相关的代谢健康问题中的集体优势

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_559_24

Sulthan Al-Rashid, Monisha Prasad, Rajkapoor Balasubramanian, Naina Mohamed Pakkir Maideen

引用次数: 0

Effectiveness of disease-modifying agents in ameliorating multiple sclerosis - A cross-sectional observational study. 疾病调节剂改善多发性硬化症的有效性-一项横断面观察性研究。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_493_23

Mamatha Jayachandran, Dhanya Sacheendran, Sanitha Kuriachan, Princy Louis Palatty, Greeshma C Ravindran

{"title":"Effectiveness of disease-modifying agents in ameliorating multiple sclerosis - A cross-sectional observational study.","authors":"Mamatha Jayachandran, Dhanya Sacheendran, Sanitha Kuriachan, Princy Louis Palatty, Greeshma C Ravindran","doi":"10.4103/ijp.ijp_493_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_493_23","url":null,"abstract":"Background: Multiple sclerosis (MS) - A chronic inflammatory demyelinating disorder of the central nervous system is notorious for causing progressive neurological deterioration. This affects the quality of life of these patients and their productivity. Various oral and injectable disease-modifying drugs (DMDs) are available for the treatment of MS. In spite of availability of many drugs, the quality of life of these patients continues to be perturbing. The present study was undertaken to assess the effectiveness of common therapy in MS.Methods: A single-center cross-sectional study was conducted from 2020 to 2021. Seventy-one MS patients on DMDs were recruited. Relevant clinical details were collected from the electronic medical records, and a quality-of-life questionnaire was administered telephonically. Assessment of drugs being prescribed, treatment effectiveness, and adverse drug reactions were calculated as frequency and percentage.Results: Female cases were 64.8%. 77.5% were relapsing-remitting type of MS. The initial presenting complaints varied from visual disturbances in 28.16%, paresthesia in 25.35%, and ataxia in 21.12%. No relapse episodes were reported in 21.12% of cases. 33.8% faced physical disabilities and 9.9% cognitive disabilities. 2.81% cases opined that their quality of life is good.Conclusions: Drug therapy is beneficial in providing remission and reducing relapse rates in MS. DMDs are effective in reducing the debilitating symptoms and preventing the progression of the disease, when begun immediately after the diagnosis is made.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 2","pages":"90-96"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eyelid hyperpigmentation: Rare involvement following intake of common drug. 眼睑色素沉着：摄取普通药物后极少受累。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_565_24

Ankur Singh, Shiva Manwatkar, Abhishek Abhinay, Rajniti Prasad

引用次数: 0

Effect of recombinant human parathyroid hormone and zoledronic acid on osteoblast gene expression using multifaceted approach: An in vitro study. 重组人甲状旁腺激素和唑来膦酸对成骨细胞基因表达影响的体外研究。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_582_23

Vandana Dhiman, Sanjay Kumar Bhadada, Poonam Kanta, Gurjeet Kaur, Swati Bhat, Amanjit Bal, Naresh Sachdeva, Anil Bhansali, Devinder Kumar Dhawan, Ravi Pratap Barnwal, Gurpal Singh, Sudhaker Dhanwada Rao

{"title":"Effect of recombinant human parathyroid hormone and zoledronic acid on osteoblast gene expression using multifaceted approach: An in vitro study.","authors":"Vandana Dhiman, Sanjay Kumar Bhadada, Poonam Kanta, Gurjeet Kaur, Swati Bhat, Amanjit Bal, Naresh Sachdeva, Anil Bhansali, Devinder Kumar Dhawan, Ravi Pratap Barnwal, Gurpal Singh, Sudhaker Dhanwada Rao","doi":"10.4103/ijp.ijp_582_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_582_23","url":null,"abstract":"Background: Bone is an endocrine organ that despite being inert in appearance constantly undergoes remodeling, in which wear and tear of bone cells occur. With more than two decades of clinical experience, the molecular mechanisms of anti-fracture drugs are not completely understood because they inhibit osteoclastic activity and differentiate the osteoblast cells. Recent studies suggest fundamentally different mechanisms of action for key anti-fracture drugs, bisphosphonates, and recombinant human parathyroid hormone (rhPTH) at the tissue level; however, their molecular basis of action has not been explored completely. Here, we showed the effect of varying concentrations of zoledronic acid (ZOL) and rhPTH on human osteogenic sarcoma cells (U2OS cells).Materials and methods: Cellular viability, mineralization, and osteogenic gene expressions were assessed to elucidate the effects of these two prototypic drugs with diametrically different mechanisms of action.Results: Cellular viability was not affected either by ZOL or rhPTH alone or in tandem treatments. Osteoblastic activity increased significantly with rhPTH followed by ZOL. Further, alkaline phosphatase activity increased significantly with tandem treatment of rhPTH followed by ZOL both at the mRNA and protein levels. Moreover, osteoblastic genes (COL1A1 and osteocalcin) were significantly modulated by sequential treatment with rhPTH followed by ZOL.Conclusions: We conclude that rhPTH (5 μg) treatment followed by ZOL (1 μM) showed the best anabolic or bone-forming effect. Our results warrant further research in assessing similar combinations of anti-fracture drugs, which augment osteogenesis to maximize their anabolic effects in preventing osteoporosis in susceptible individuals.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 2","pages":"69-76"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olanzapine-induced paraesthesia: A less reported side effect. 奥氮平诱导的感觉异常：较少报道的副作用。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_637_24

Sanyam Tyagi, Vishal Verma, Vijay Kumar Saini, Harmanpreet Kaur

引用次数: 0

Postvaccine "spikeopathy:" what is the long-term neurological risk? 疫苗后“刺突病”：长期神经风险是什么？

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_943_24

Jean-Marc Bugnicourt

引用次数: 0

How well do patients understand medication information written in prescriptions? A study from Eastern India. 病人对处方上的用药信息了解多少？一项来自东印度的研究。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_359_24

Debaleena Das, Shreya Kotal, Suparna Chatterjee

{"title":"How well do patients understand medication information written in prescriptions? A study from Eastern India.","authors":"Debaleena Das, Shreya Kotal, Suparna Chatterjee","doi":"10.4103/ijp.ijp_359_24","DOIUrl":"https://doi.org/10.4103/ijp.ijp_359_24","url":null,"abstract":"Introduction: Appropriate understanding of medicine-related advice in a prescription by patients ensures therapeutic compliance and mitigates avoidable medication intake-related errors.Aims: This study assessed how well patients or their caregivers attending a tertiary care hospital have understood medicine-related information in their outpatient department (OPD) prescription.Materials and methods: This prospective questionnaire-based observational study was conducted on patients attending outpatient clinics of four departments of a tertiary care hospital. The questionnaire had both open and close-ended questions, which assessed understanding of written information related to the prescribed medicines.Results: A total of 380 patients were enrolled in the study. 59.21% (95% CI 54.2-64.04) respondents had an excellent or good understanding of drug dosage. Similarly, 40% (95% CI 35.2-45) about drug frequency and 59.77% (95% CI 54.66-64.7) had excellent understanding of drug duration. However, overall composite understanding of prescriptions was poor in 36.84% (95% CI 32.14-41.8) of study participants. Patients with a higher level of education or from higher socioeconomic groups had a better understanding compared to other educational and socioeconomic categories. Suggestions for better patient understanding included prescriptions in vernacular language and pictorial representations.Conclusions: The study conducted in a tertiary care public hospital in India, reveals suboptimal understanding of medication-related information in OPD prescriptions. Based on the study outcome, measures have been taken to address the issue. Furthermore, there is a need for designing tailored interventions based on the patient profile attending a healthcare facility to facilitate better understanding.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 2","pages":"83-89"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential application of the wolly mouse in future research. 狼鼠在未来研究中的潜在应用。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_376_25

Supriya Khanra, Aastha Datta, Shiv Charan, Rutweek Kulkarni, Ajay Prakash, Bikash Medhi

引用次数: 0