Biophytum sensitivum (L) DC叶片甲醇提取物的抗焦虑作用。

IF 1.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Indian Journal of Pharmacology Pub Date : 2025-05-01 Epub Date: 2025-07-09 DOI:10.4103/ijp.ijp_288_23

Anuska P Nair, Shailaja Mallya

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引用次数: 0

摘要

目的：本研究旨在评估Biophytum sensitivum (L) DC叶片甲醇提取物的抗焦虑作用。材料与方法：采用高架加迷宫模型、明暗室模型、镜室仪等体内筛选方法研究Wistar白化大鼠的焦虑行为。分别以200 mg和400 mg/kg的剂量给药。结果：白刺叶甲醇提取物具有剂量依赖性的抗焦虑活性。结论：MEBS具有抗焦虑活性，其效果与使用的标准药物相当。总黄酮含量测定证实了黄酮类化合物的存在，黄酮类化合物可能与抗焦虑活性有关。

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Anxiolytic action of a methanolic extract of Biophytum sensitivum (L) DC leaves.

Objective: The current study sought to assess the anxiolytic effects of a methanolic extract of Biophytum sensitivum (L) DC leaves.

Materials and methods: In vivo screening methods such as the elevated plus maze model, light and dark chamber model, and mirror chamber apparatus were used to study the anxiolytic behavior, using Wistar albino rats. Methanolic extract of B. sensitivum (MEBS) leaves and was administered orally at a dose of 200 mg and 400 mg/kg.

Results: The methanolic extract of the leaves of B. sensitivum exhibited a dose-dependent anxiolytic activity.

Conclusions: The MEBS showed anxiolytic activity and showed results which were comparable to the standard drugs used. The total flavonoid content test confirmed the presence of flavonoids, which may have a role in the anxiolytic activity.

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来源期刊

Indian Journal of Pharmacology 医学-药学

CiteScore

4.00

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Pharmacology accepts, in English, review articles, articles for educational forum, original research articles (full length and short communications), letter to editor, case reports and interesting fillers. Articles concerning all aspects of pharmacology will be considered. Articles of general interest (e.g. methods, therapeutics, medical education, interesting websites, new drug information and commentary on a recent topic) are also welcome.