Pistia stratiotes has renoprotective potentials in ischemia reperfusion injury in normal and diabetic rats.

IF 1.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Indian Journal of Pharmacology Pub Date : 2023-11-01 DOI:10.4103/ijp.ijp_272_23

Vashisth Pankajkumar Bhavsar, Ashish Patel, Jitendra D Vaghasiya, Shantilal Padhiyar, Tejas B Patel

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引用次数: 0

Abstract

Objective: Even though oxidative and inflammatory bursts are a big part of renal reperfusion injury (RI/R), Pistia stratiotes (PS) has been used for a long time to stop these overreactions. People have said that it can drop both blood sugar and cholesterol. Hence, the goal of this study was to show how PS changed kidney reperfusion damage in both diabetic and normal rats.

Materials and methods: In the study, 30 min of renal ischemia (RI) was followed by 1 h of recovery for each rat. Before the test, PS (100 mg/kg p. o.) was given to the animals for 7 days. Then, using the mixture from the separated kidney tissues, the antioxidant, inflammation, and histopathological effects were determined.

Results: When compared to RI/R, diabetic rats given PS had lower blood sugar, aspartate aminotransferase, blood urea nitrogen, and creatinine, myeloperoxidase, C-reactive protein, and tumor necrosis factor-alpha levels in their urine.

Conclusion: PS potentially worked in hyperglycemic rats protecting them against RI/R. It is possible that PS's ability to protect the kidneys of the test rats is due to its ability to fight free radicals, lower blood sugar, and stop inflammation.

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肉苁蓉对正常大鼠和糖尿病大鼠的缺血再灌注损伤具有肾脏保护潜力。

目的：尽管氧化和炎症爆发是肾脏再灌注损伤（RI/R）的一个重要组成部分，但长期以来，人们一直使用地肤子（Pistia stratiotes，PS）来阻止这些过度反应。人们说它能降低血糖和胆固醇。因此，本研究的目的是展示 PS 如何改变糖尿病大鼠和正常大鼠肾脏再灌注损伤：研究中，每只大鼠肾缺血（RI）30 分钟，然后恢复 1 小时。试验前，动物连续 7 天服用 PS（100 毫克/千克 p.o.）。然后，使用分离肾组织的混合物测定抗氧化、炎症和组织病理学效应：结果：与 RI/R 相比，服用 PS 的糖尿病大鼠尿液中的血糖、天冬氨酸氨基转移酶、血尿素氮、肌酐、髓过氧化物酶、C 反应蛋白和肿瘤坏死因子-α 水平均较低：结论：PS 对高血糖大鼠具有潜在的保护作用，使其免受 RI/R 的影响。PS 能够保护试验大鼠的肾脏，可能是因为它具有抗自由基、降低血糖和阻止炎症的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Pharmacology 医学-药学

CiteScore

4.00

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Pharmacology accepts, in English, review articles, articles for educational forum, original research articles (full length and short communications), letter to editor, case reports and interesting fillers. Articles concerning all aspects of pharmacology will be considered. Articles of general interest (e.g. methods, therapeutics, medical education, interesting websites, new drug information and commentary on a recent topic) are also welcome.