Indian Journal of Pharmacology最新文献_第3页

Postvaccine "spikeopathy:" what is the long-term neurological risk? 疫苗后“刺突病”：长期神经风险是什么？

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_943_24

Jean-Marc Bugnicourt

引用次数: 0

Olanzapine-induced paraesthesia: A less reported side effect. 奥氮平诱导的感觉异常：较少报道的副作用。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_637_24

Sanyam Tyagi, Vishal Verma, Vijay Kumar Saini, Harmanpreet Kaur

引用次数: 0

How well do patients understand medication information written in prescriptions? A study from Eastern India. 病人对处方上的用药信息了解多少？一项来自东印度的研究。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_359_24

Debaleena Das, Shreya Kotal, Suparna Chatterjee

{"title":"How well do patients understand medication information written in prescriptions? A study from Eastern India.","authors":"Debaleena Das, Shreya Kotal, Suparna Chatterjee","doi":"10.4103/ijp.ijp_359_24","DOIUrl":"10.4103/ijp.ijp_359_24","url":null,"abstract":"Introduction: Appropriate understanding of medicine-related advice in a prescription by patients ensures therapeutic compliance and mitigates avoidable medication intake-related errors.Aims: This study assessed how well patients or their caregivers attending a tertiary care hospital have understood medicine-related information in their outpatient department (OPD) prescription.Materials and methods: This prospective questionnaire-based observational study was conducted on patients attending outpatient clinics of four departments of a tertiary care hospital. The questionnaire had both open and close-ended questions, which assessed understanding of written information related to the prescribed medicines.Results: A total of 380 patients were enrolled in the study. 59.21% (95% CI 54.2-64.04) respondents had an excellent or good understanding of drug dosage. Similarly, 40% (95% CI 35.2-45) about drug frequency and 59.77% (95% CI 54.66-64.7) had excellent understanding of drug duration. However, overall composite understanding of prescriptions was poor in 36.84% (95% CI 32.14-41.8) of study participants. Patients with a higher level of education or from higher socioeconomic groups had a better understanding compared to other educational and socioeconomic categories. Suggestions for better patient understanding included prescriptions in vernacular language and pictorial representations.Conclusions: The study conducted in a tertiary care public hospital in India, reveals suboptimal understanding of medication-related information in OPD prescriptions. Based on the study outcome, measures have been taken to address the issue. Furthermore, there is a need for designing tailored interventions based on the patient profile attending a healthcare facility to facilitate better understanding.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 2","pages":"83-89"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential application of the wolly mouse in future research. 狼鼠在未来研究中的潜在应用。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-03-01 Epub Date: 2025-06-13 DOI: 10.4103/ijp.ijp_376_25

Supriya Khanra, Aastha Datta, Shiv Charan, Rutweek Kulkarni, Ajay Prakash, Bikash Medhi

引用次数: 0

Pirfenidone-induced phototoxicity. Pirfenidone-induced光毒性。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.4103/ijp.ijp_601_24

Nazneen Bano, Anmol Batra, Shubham Kumar

引用次数: 0

Tuberculosis and comorbid depression: Association with serum indoleamine 2,3-dioxygenase activity. 结核病和共病抑郁症：与血清吲哚胺2,3-双加氧酶活性的关系。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.4103/ijp.ijp_252_23

Proteesh Rana, Bijo Varughese, Vandana Roy, Shreshth Khanna, Seema Kapoor, Ashwani Khanna

{"title":"Tuberculosis and comorbid depression: Association with serum indoleamine 2,3-dioxygenase activity.","authors":"Proteesh Rana, Bijo Varughese, Vandana Roy, Shreshth Khanna, Seema Kapoor, Ashwani Khanna","doi":"10.4103/ijp.ijp_252_23","DOIUrl":"10.4103/ijp.ijp_252_23","url":null,"abstract":"Introduction: Patients with tuberculosis (TB) may have depression as a comorbidity, which may be associated with poor treatment outcomes. Increased production of pro-inflammatory cytokines activating enzyme indoleamine 2,3-dioxygenase (IDO) has been reported in TB. We studied the association of IDO activity and comorbid depression in TB patients.Materials and methods: Newly diagnosed, treatment-naïve TB patients were evaluated for symptoms of depression using the Patient Health Questionnaire (PHQ)-9 scale. A PHQ-9 score of ≥5 was taken as an indicator for depression. Patients were further categorized into two groups based on their PHQ-9 scores, Group-I with a PHQ-9 score of <5 and Group-II with a PHQ-9 score ≥5. The serum kynurenine (KYN) and tryptophan (TRP) levels were determined using liquid chromatography-mass spectrometry (LC-MS) and the KYN/TRP ratio was taken as a measure for IDO activity.Results: A total of 106 TB patients and 106 healthy controls were enrolled in this study. Over 73.5% of TB patients had PHQ-9 scores of above 5 with an average score of 7.09 ± 2.83, a significant difference (P < 0.05) as compared to the average PHQ-9 scores of healthy controls (2.93 ± 1.20). Group-II TB patients had lower serum TRP 539.55 ± 194.31 ng/mL versus 1109.45 ± 186.04 ng/mL (P < 0.01) in Group-I; higher serum KYN 425.81 ± 65.51 ng/mL versus 250.06 ± 40.28 ng/mL (P < 0.01) and higher K/T ratio 0.906 ± 0.56 versus 0.251 ± 0.052 (P < 0.01). There was a significant linear correlation between PHQ-9 and serum KYN (r: 0.969; P: <0.01; R2: 0.909); serum TRP (r: 0.841; P: <0.01; R2: 0.745); and KYN/TRP ratio (r: 0.745; P < 0.01; R2: 0.618).Conclusion: These findings suggest that in TB patients, induction of IDO activity may be relevant to the development of comorbid depression.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 1","pages":"21-26"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac glycosides: Looking beyond heart failure and atrial fibrillation. 心脏糖苷：超越心力衰竭和心房颤动。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.4103/ijp.ijp_934_24

Joseph G Omole, Godswill J Udom, Ayodeji Aturamu, Richard D Agbana, Omoirri Moses Aziakpono, Benjamin Oritsemuelebi, Sarad Pawar Naik Bukke, Idara A Okon, Omoniyi K Yemitan

引用次数: 0

A rare case of tamsulosin-induced recurrent ischemic priapism. 坦索罗辛致复发性缺血性阴茎勃起症1例。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.4103/ijp.ijp_456_24

Hitesh Taleja, Mohit Pateriya, Abhishek Mishra, Shalendra Singh

引用次数: 0

Cardiac physiological changes induced by cardiovascular drugs from different chemical classes in zebrafish mirrored in mice: A predictive tool for comprehensive risk assessment. 不同化学类别的心血管药物在斑马鱼中引起的心脏生理变化反映在小鼠身上：一种综合风险评估的预测工具。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.4103/ijp.ijp_566_24

Rohan Takawale, Deeksha Singh, Vandana S Nikam

{"title":"Cardiac physiological changes induced by cardiovascular drugs from different chemical classes in zebrafish mirrored in mice: A predictive tool for comprehensive risk assessment.","authors":"Rohan Takawale, Deeksha Singh, Vandana S Nikam","doi":"10.4103/ijp.ijp_566_24","DOIUrl":"10.4103/ijp.ijp_566_24","url":null,"abstract":"Objective: Our study investigated the impact of various cardiovascular drug on the cardiac physiology of zebrafish embryos and validated these findings in mice.Background: Cardiotoxicity has significantly contributed to the high drug attrition rate over the last two decades, underscoring the cardiac risk assessment in drug discovery and development. Although regulatory authority's guidelines specified the cell-based assays for the safety assessment of drugs, the current requirements fall short due to a lack of in vivo biology. The use of zebrafish experimental system has surged in developmental and pathophysiological investigation due to their striking resemblance to mammals. Hence, we used the zebrafish model system for cardiovascular drug studies and validated it in the mice model.Materials and methods: The zebrafish embryos of 72 hours post-fertilization (hpf) were exposed to different CVS drug and, recorded their heart rate, and further validated in mice.Results: We observed that exposure to amlodipine (a calcium channel blocker), atenolol (a class II antiarrhythmic), and amiodarone (a class III antiarrhythmic) led to dose-dependent reductions in heart rate in zebrafish embryos, with effects varying based on drug concentration and mechanism of action. Specifically, amiodarone treatment resulted in a dose-dependent decrease in heart rate (0.001-100 μM) and atrioventricular block starting at a 10 μM concentration. Each class of cardiovascular drug demonstrated unique cardiac effects in zebrafish embryos, reflecting similar patterns in mice treated with these drugs.Conclusions: Our findings highlight the zebrafish model's utility for early-phase cardiac risk assessment in drug discovery due to its high throughput capabilities and other beneficial features.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 1","pages":"12-20"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual and interesting case of sequential serious adverse event. 一个不寻常和有趣的连续严重不良事件的病例。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.4103/ijp.ijp_675_22

Trupti Rekha Swain, Lorika Sahu, Jyotishree Mallik

引用次数: 0