Indian Journal of Pharmacology最新文献

{"title":"Effect of dexmedetomidine combined with ropivacaine in ultrasound-guided paravertebral nerve block for acute herpes zoster neuralgia patients.","authors":"Cuicui Liu, Yanting Wang, Pei Wang, Chao Meng, Yanwei Yin","doi":"10.4103/ijp.ijp_434_23","DOIUrl":"10.4103/ijp.ijp_434_23","url":null,"abstract":"<p><strong>Purpose: </strong>Early and effective treatment of acute herpes zoster (AHZ) can relief the pain and prevent the occurrence of postherpetic neuralgia (PHN) in patients. The aim of this study is to investigate the efficacy of dexmedetomidine combined with ropivacaine in ultrasound-guided paravertebral nerve block for patients with AHZ neuralgia.</p><p><strong>Materials and methods: </strong>Seventy-four patients suffering from acute thoracic herpes zoster neuralgia were divided into two equal groups in a prospective, randomized, double-blind controlled manner. All patients received paravertebral nerve block under ultrasound guidance with different drugs: Group I: 0.2% ropivacaine with 1 μg/kg dexmedetomidine; Group II: 0.2% ropivacaine, all drugs were diluted with normal saline to a total of 20 ml. The patients' Visual Analog Scale (VAS) scores were used for assessing pain level while the quality of sleep (QS) scores were used for assessing sleep levels 1, 4, 8, and 12 weeks after the treatment, as well as the pregabalin consumption. Time to pain resolution and skin eruption, total times of block, complications within 24 h after block, and the incidence of persistent PHN at 3 and 6 months were analyzed.</p><p><strong>Results: </strong>There were no significant differences in the VAS scores between the two groups at various time points (P > 0.05). At the time point 1, 4, and 8 weeks after treatment, the QS scores in Group I were significantly lower than that in Group II (P < 0.05). The pregabalin consumption and the incidence of PHN between the two groups were not significantly different (P > 0.05). The total times of block in Group I were significantly less than Group II.</p><p><strong>Conclusion: </strong>Both interventions provided similar efficacy in minimizing the pain intensity and reducing the incidence of PHN in AHZ patients. Compared with ropivacaine only, the addition of dexmedetomidine significantly improved patients' sleep quality and reduced the times of block.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"385-391"},"PeriodicalIF":1.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of epigallocatechin-3-gallate against oleic acid-induced acute respiratory distress syndrome.","authors":"Subham Kumar Panda, Vadlamani Girish Shankar Sharma, Vishal L Sorathiya, Pratap Kumar Sahu","doi":"10.4103/ijp.ijp_518_24","DOIUrl":"10.4103/ijp.ijp_518_24","url":null,"abstract":"<p><strong>Objective: </strong>The objective is to induce acute respiratory distress syndrome (ARDS) in rats by oleic acid and evaluate the prophylactic and therapeutic effectiveness of epigallocatechin-3-gallate (EGCG) against ARDS.</p><p><strong>Background: </strong>ARDS is an acute, severe inflammatory lung injury. Clinically used anti-inflammatory medication and corticosteroids have side effects, infection risk, and increased treatment costs. Epigallocatechin-3-gallate (EGCG) from green tea is a flavonoid possessing antioxidant and anti-inflammatory properties. Intravenous injection of pure oleic acid causes respiratory distress in diverse animal species, leading to inflammation in the lungs. Hence, we used oleic acid to induce ARDS in rats to assess the prophylactic and therapeutic effectiveness of EGCG against ARDS.</p><p><strong>Materials and methods: </strong>A total of four groups were formed, with five animals allocated to each group. The control group (G1) was administered with normal saline 0.2 ml/kg, twice at an interval of 1 h, ARDS group (G2) with oleic acid 0.2 ml/kg intravenously, twice at 1-h interval. The prophylactic group (G3) was administered with EGCG 10 mg/kg i.p. 1 h before the administration of oleic acid, whereas therapeutic group (G4) was administered with same dose of EGCG but, 1 h after the administration of oleic acid.</p><p><strong>Results: </strong>Assessment of animal body and lungs weight, gross macroscopic and microscopic evaluation of lungs did not produce any significant treatment-related changes when compared with the control group. However, a substantial decrease in tumor necrosis factor-alpha levels was observed in G3 and G4 when compared to the G2 group.</p><p><strong>Conclusions: </strong>EGCG has both prophylactic and therapeutic effectiveness against ARDS.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"380-384"},"PeriodicalIF":1.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ponsegromab: The new miracle drug for cancer cachexia.","authors":"Elisha Paikray, Anima Rout, Ratikanta Tripathy","doi":"10.4103/ijp.ijp_347_25","DOIUrl":"10.4103/ijp.ijp_347_25","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"419-420"},"PeriodicalIF":1.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicle fiasco - Unraveling the cause of sudden hair loss!","authors":"Sanyam Mehta, Kailash Bhatia, Chaitanya Namdeo, Lavin Bhatia","doi":"10.4103/ijp.ijp_919_24","DOIUrl":"10.4103/ijp.ijp_919_24","url":null,"abstract":"<p><strong>Abstract: </strong>Sudden excessive hair loss poses a diagnostic challenge when encountered in an otherwise healthy individual. We present a case study of a middle-aged female who presented with unexplained and sudden hair loss. After initial consideration of common causes of sudden hair loss, a dispensing error involving azathioprine was identified as the underlying cause. This case underscores the need for further research to elucidate the specific pathways through which azathioprine induces selective damage to the dermal papillae of the hair follicle. This case also emphasizes the importance of meticulous medication management and pharmacovigilance in clinical practice.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"414-416"},"PeriodicalIF":1.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roflumilast in dermatology: Revolutionizing inflammatory skin treatment.","authors":"Sharang Gupta","doi":"10.4103/ijp.ijp_161_25","DOIUrl":"10.4103/ijp.ijp_161_25","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"421-422"},"PeriodicalIF":1.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on cardiovascular and chronic kidney disease interplay, exploring biomarkers and algorithmic approaches in unraveling organ crosstalk.","authors":"Prashant Kumar, Yogendra Pal, Shiv Dev Singh, Shashi Bhooshan Tiwari","doi":"10.4103/ijp.ijp_66_24","DOIUrl":"10.4103/ijp.ijp_66_24","url":null,"abstract":"<p><strong>Abstract: </strong>This review article is based upon the findings of the role of different biomarkers in the progression of the diseases. These findings were from past studies and meta-analysis of the biomarker in cardiovascular and chronic kidney diseases (CKDs). It mainly focuses on the organ crosstalk of diseases because of different biomarkers such as proteomics, genomics, metabolomics, and bioinformatics. In this reviewing process, we analyzed some biomarkers responsible for various cardiovascular and CKDs, out of which we found few biomarkers which are responsible for indication and diagnosis of disease relating to both the systems. It was found that the MiR-21, a type of genomic biomarker C-reactive protein, N-terminal pro-B-type natriuretic peptide, high-sensitivity cardiac troponin T, and estimated glomerular filtration rate, types of proteomics biomarkers has shown role in the prediction of diseases. As well as we also reviewed research work from the past to analyze the relation between the disease and its clinical outcomes using machine learning, which can be used to create few models to predict the clinical outcomes. Out of all the algorithms used, they showing most promising results was XGBoost method. In the past, there were studies supporting the statement - algorithms created by the scientists gives variables relating to the disease. These variables can be used to predict the disease based on the levels of biomarkers present in the sample of the patients.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"371-379"},"PeriodicalIF":1.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of awareness and acceptability of the Medicines Side Effect Reporting Form for Consumer and the quality of data entered by consumers - An Indian perspective.","authors":"Ratinder Jhaj, Ajay Kumar Shukla, Sameer Uttamrao Khasbage, Deepa Chaudhary, Shah Newaz Ahmed","doi":"10.4103/ijp.ijp_464_24","DOIUrl":"10.4103/ijp.ijp_464_24","url":null,"abstract":"<p><strong>Background: </strong>Consumers are key stakeholders in drug safety, yet, till recently, their potential has remained untapped in terms of contributing to the drug safety data. The Medicines Side Effect Reporting Form for Consumer (MSERC), launched by the Pharmacovigilance Programme of India, is an important tool for the consumer to report adverse drug reactions (ADRs).</p><p><strong>Objective: </strong>Our objective was to evaluate the awareness and acceptability of the MSERC among the general population and the quality of data entered by the consumers.</p><p><strong>Methods: </strong>This was a cross-sectional study carried out at a tertiary healthcare center in Madhya Pradesh (Central India).</p><p><strong>Results: </strong>The study included 203 participants, with 115 self-reports and 88 reports of ADRs experienced by a relative. All mandatory fields were filled by 149 (73.4%) participants. More than half of the reporters (113, 55.57%) took <5 min to fill the form and found it easy to fill it (123, 60.59%). Most of the participants expressed a willingness (186, 91.63%) to fill the MSERC. The time taken to complete the form and the difficulty in filling the form were significantly greater in the elderly (age >60 years). Significantly more women were aware about the MSERC (P = 0.026), as compared to men. Participants with graduate, postgraduate, or professional degrees took significantly less time to fill the form (P < 0.001) and found it easier to fill it (P = 0.019).</p><p><strong>Conclusion: </strong>Awareness about the form was found in only 6.4% of the responders, highlighting a need to generate more awareness among the consumers about the MSERC form to improve the ADR reporting.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 6","pages":"401-408"},"PeriodicalIF":1.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Over-the-counter drug development in developing countries.","authors":"Vipul Bharati, Sandhya Rajaram, Ajay Prakash, Bikash Medhi","doi":"10.4103/ijp.ijp_550_25","DOIUrl":"10.4103/ijp.ijp_550_25","url":null,"abstract":"","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 4","pages":"207-211"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-treatment of trigonelline and everolimus synergistically prevented chronic steatohepatitis induced by fast food diet and thioacetamide in a novel murine nonalcoholic steatohepatitis model.","authors":"Raghu Rai Sharma, Love Sharma, Haroon Rashid, Aalim Maqsood Bhat, Divya Gupta, Sheikh Abdullah Tasduq","doi":"10.4103/ijp.ijp_323_23","DOIUrl":"10.4103/ijp.ijp_323_23","url":null,"abstract":"<p><strong>Objectives: </strong>Nonalcoholic steatohepatitis (NASH) is a strong risk factor for end-stage liver disease. Trigonelline (TG) is a plant alkaloid with anti-oxidant, anti-dyslipidemic, and anti-insulin resistance activities. Everolimus (EV), a conventional drug and an mTOR inhibitor, has been demonstrated to improve metabolic outcomes. The synergistic effect of the co-treatment of TG and EV against NASH conditions remains unknown.</p><p><strong>Materials and methods: </strong>We have developed a fast food (FF)-diet and thioacetamide-induced chronic steatohepatitis in a C57BL/6J mice model of 24 weeks duration. We have evaluated the synergistic protective effect of TG and EV at reduced doses to avoid any undesired toxic manifestations of the FF and thioacetamide. The study was demonstrated by comparative analysis across different groups after 24 weeks.</p><p><strong>Results: </strong>Co-exposure to FF diet and thioacetamide resulted in chronic steatohepatitis, evident by focal necrosis, bridging fibrosis, loss of liver architecture, and excessive collagen deposition. Protein and gene analysis revealed enhanced de novo lipogenesis (SREBP-1, PPAR-Ƴ, CD36), inflammation (interleukin-6, tumor necrosis factor, CYP2E1), fibrosis (transforming growth factor beta, alpha-smooth muscle actin, tissue inhibitors of metalloproteinases-1), and extracellular matrix deposition (MMP-1, Col1A1). TG + EV at reduced doses showed marked synergistic effects in preventing inflammation, fibrosis, and lipogenesis markers.</p><p><strong>Conclusion: </strong>This study provides a novel 24-week FF diet and thioacetamide-induced murine NASH model for possible preclinical drug discovery studies. Furthermore, our treatment regimen discovered the synergistic effect of TG and EV at reduced doses in preventing chronic steatohepatitis.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 4","pages":"234-241"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of dextromethorphan-bupropion combination (AXS-05) in the treatment of depression: A systematic review and network meta-analysis.","authors":"J V Ashwin, Mohit Kumar Shahi, Astha Singh, S Theepan Kumar","doi":"10.4103/ijp.ijp_907_24","DOIUrl":"10.4103/ijp.ijp_907_24","url":null,"abstract":"<p><p>This network meta-analysis evaluated the efficacy and safety of the dextromethorphan-bupropion combination (AXS-05) in treating major depressive disorder (MDD). Data were retrieved from multiple databases, including PubMed, Embase, Scopus, Google Scholar, and ClinicalKey, yielding 60 records. After removing duplicates and excluding irrelevant studies, such as reviews, case reports, posters, and studies focusing on unrelated populations (e.g., Alzheimer's dementia), two randomized controlled trials (RCTs) - Tabuteau et al. (2022) and Iosifescu et al. (2022) - were selected for final analysis. The inclusion criteria focused on RCTs published between 2014 and 2024, involving adult participants (18-65 years) diagnosed with MDD, and reporting on the efficacy and safety of the dextromethorphan-bupropion combination. Studies that did not focus on MDD, were not in English, or lacked control groups were excluded. The findings indicate superior efficacy of the dextromethorphan-bupropion combination, with remission rates of 46.5% and 39.5%, compared to 16.2% for Bupropion alone and 17.3% for placebo. Despite a higher incidence of mild to moderate adverse events (72.9% vs. 64.6% for Bupropion), the combination's safety profile remained comparable, with no significant increase in treatment discontinuation. These results suggest that AXS-05 is a promising treatment for MDD, warranting further investigation in larger, diverse populations to confirm its long-term efficacy and safety.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 4","pages":"262-268"},"PeriodicalIF":1.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}