Indian Journal of Pharmacology最新文献_第5页

Training and education in pharmacovigilance: The experience from the Pharmacovigilance Programme of India. 药物警戒方面的培训和教育：印度药物警戒计划的经验。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_638_22

Rishi Kumar, Jai Prakash, Shashi Bhushan, Akash Deep Rawat, R S Ray, Rajeev Singh Raghuvanshi

{"title":"Training and education in pharmacovigilance: The experience from the Pharmacovigilance Programme of India.","authors":"Rishi Kumar, Jai Prakash, Shashi Bhushan, Akash Deep Rawat, R S Ray, Rajeev Singh Raghuvanshi","doi":"10.4103/ijp.ijp_638_22","DOIUrl":"10.4103/ijp.ijp_638_22","url":null,"abstract":"Abstract: For a robust Pharmacovigilance system in a country, training of healthcare professionals is of utmost importance. The training is the integral part of continual improvement in any quality management system. The present article describes the different training modules and experience from the Pharmacovigilance Programme of India (PvPI) and emphasizes that if training and education elements with special reference to pharmacovigilance are implemented for all concerned stakeholders in a healthcare system, the efficiency of deliverables will be improved and objectives of the organization can easily be achieved. The PvPI has been putting its best efforts to train healthcare professionals in pharmacovigilance and it has achieved new heights in establishing best practices for the other countries to follow for the development of pharmacovigilance system in their respective countries or regions. The aim of this article is to suggest how capacity building in a pharmacovigilance system can help low- and middle-income countries in area of pharmacovigilance. The authors tried to conceptualize the process and implementation of the training program under PvPI.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"348-357"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the benefits of Drug Master File filing in the Indian pharmaceutical industries. 解锁药品主文件在印度制药业备案的好处。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_297_23

Rahul Pathak, Rajat Singal, Sandip Mitra, Sanjay Koul, Supriya Sharma

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Cardioprotective effect of S-adenosyl L-methionine due to antioxidant and anti-inflammatory properties on isoproterenol-induced chronic heart failure in Wistar rats. s -腺苷- l-蛋氨酸抗氧化和抗炎作用对异丙肾上腺素诱导的Wistar大鼠慢性心力衰竭的保护作用。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_407_24

Sharmila Vinayak Jalgaonkar, Raakhi Tripathi, Komal Gorakshanath Kurhade, Pradeep Chaudhari, Bhabani Shankar Mohanty, Pradeep Vaideeswar

{"title":"Cardioprotective effect of S-adenosyl L-methionine due to antioxidant and anti-inflammatory properties on isoproterenol-induced chronic heart failure in Wistar rats.","authors":"Sharmila Vinayak Jalgaonkar, Raakhi Tripathi, Komal Gorakshanath Kurhade, Pradeep Chaudhari, Bhabani Shankar Mohanty, Pradeep Vaideeswar","doi":"10.4103/ijp.ijp_407_24","DOIUrl":"10.4103/ijp.ijp_407_24","url":null,"abstract":"Objectives: The development and progression of chronic heart failure (CHF), hypertrophy, and remodeling strongly correlate with myocardial inflammation and oxidative stress. S-adenosylmethionine (SAMe), available as a dietary supplement, exerts anti-inflammatory and antioxidant effects. Previous reports show that by regulating angiogenesis and fibrosis, S-adenosyl-L-methionine improves ventricular remodeling. The study objectives were to investigate the cardioprotective effect of SAMe in isoproterenol (ISO)-induced CHF and explore the anti-inflammatory and antioxidant properties of SAMe in this model.Methodology: After animal ethics permission, CHF was induced using ISO of 10 mg/kg for 14 consecutive days in 24 Wistar rats. There were four groups of six rats in each group: Sham Control, Disease Control (DC), ISO + SAMe 100 mg, and ISO + SAMe 200 mg. The variables assessed were heart to body weight ratio (HW/BW mg/g), bio-distribution of Flourine 18-Fluorodeoxyglucose (18F-FDG) in heart tissue, tumor necrosis factor-α (TNF-α) and glutathione (GSH) levels in heart tissue, histopathology, and positron emission tomography imaging.Results: SAMe in ISO-induced CHF animals showed a significant decrease in the HW/BW compared to DC group (P < 0.001). 18F-FDG uptake was significantly reduced by SAMe in CHF-induced rats compared to DC rats for both doses (P < 0.001). SAMe showed significantly better values of both TNF-α and GSH than the DC group in both doses (P < 0.001). SAMe in both doses showed multifocal necrosis with scarring and minimal inflammatory cells.Conclusion: SAMe exerts a cardioprotective effect on ISO-induced CHF in rats because of its antioxidant and anti-inflammatory properties.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"335-341"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Symphony of planetary health and prescription medicine for a sustainable future. 地球健康交响曲和可持续未来的处方药。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_896_24

Sandhya Rajaram, Ajay Prakash, Bikash Medhi

引用次数: 0

In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae). 三叠纪（Agavaceae）乙醇叶提取物对结直肠癌细胞株的体外抗菌和细胞毒性潜力。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_564_24

Sheryar Afzal, Yuan Seng Wu, Aimi Syamaima Abdul Manap, Ali Attiq, Ibrahim Albokhadaim, Velaga Appalaraju, Ahmed Magzoub Khalid, Olorunfemi Eseyin

{"title":"In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae).","authors":"Sheryar Afzal, Yuan Seng Wu, Aimi Syamaima Abdul Manap, Ali Attiq, Ibrahim Albokhadaim, Velaga Appalaraju, Ahmed Magzoub Khalid, Olorunfemi Eseyin","doi":"10.4103/ijp.ijp_564_24","DOIUrl":"10.4103/ijp.ijp_564_24","url":null,"abstract":"Background: Sansevieria trifasciata, common name, mother-in-law's tongue, is a member of the Agavaceae family. We undertook this study to evaluate the cytotoxicity of S. trifasciata leaf extract against two cancer cell lines as well as its antibacterial activities against six bacterial strains.Materials and methods: The investigated cell lines include primary colon epithelial (PCE) cells and human colorectal cancer cells; the studied bacterial strains are Staphylococcus aureus, Proteus vulgaris, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Using the agar well-diffusion method, various doses (5, 10, and 20 mg/mL) of plant extracts (ethanol and petroleum ether) were evaluated against each kind of bacterial strain. The minimal inhibitory doses were found using the two-fold serial dilution approach, with a range of 0.156-5 mg/mL.Results: Comparing extracts of S. trifasciata leaves to tetracycline (0.05 mg/mL), a common antibiotic, revealed a wide range of antibacterial activity. P. vulgaris and S. aureus were the most sensitive bacterial strains to ethanol and petroleum ether extracts, respectively. The MTT test was employed to ascertain the viable cell count of PCE cells and HCT-116. When various ethanol extract concentrations (7.8, 15.63, 31.25, 62.5, 125, 250, 500, and 1000 μg/mL) were tested against the cell lines, HCT-116's IC50, values were lower as compared to PCE. The IC50 values for HCT-116 and PCE cells ranged from 10.0 to 14.07 μg/mL and 92.9-216.9 μg/mL, respectively.Conclusions: Ethanolic extract of S. trifasciata showed promising antibacterial and anticancer properties.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"329-334"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raw Ocimum sanctum L. leaf extract modulates the pharmacokinetic of ceftriaxone and increases its bioavailability in staphylococcal mastitis. 生欧琴圣树叶提取物可调节头孢曲松的药代动力学，并提高其在葡萄球菌性乳腺炎中的生物利用度。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_22_24

Jeevan Ranjan Dash, Tapas Kumar Sar, Indranil Samanta, Tapan Kumar Mandal

{"title":"Raw Ocimum sanctum L. leaf extract modulates the pharmacokinetic of ceftriaxone and increases its bioavailability in staphylococcal mastitis.","authors":"Jeevan Ranjan Dash, Tapas Kumar Sar, Indranil Samanta, Tapan Kumar Mandal","doi":"10.4103/ijp.ijp_22_24","DOIUrl":"10.4103/ijp.ijp_22_24","url":null,"abstract":"Background: To study the pharmacokinetic interaction of cephalosporin antibiotic ceftriaxone (CFT) with raw undiluted Ocimum sanctum L. leaf juice in chronic staphylococcal mastitis in caprine.Materials and methods: Chronic inflammation of the udder was evoked in goats by Staphylococcus aureus (J638) intracisternal inoculation 2000 cfu for 30 days into the left udder. Animals of Group I were given one single dose of CFT at 20 mg/kg i.v. Group II animals were given one single dose of CFT at 20 mg/kg i.v, and contemporary extracted fresh leaf juice of O. sanctum L. given at 5 ml/kg orally for 7 consecutive days.Results: O. sanctum L. at 5 ml/kg oral had synergistic herb-drug pharmacokinetic interaction with CFT antibiotic (i.v.) and increased its bioavailability. It prolonged its rate of elimination (β) and enhanced the volume of distribution (Vdarea) and mean residence time in the body. Bioavailability and persistence of the antibiotic CFT and its metabolite ceftizoxime were increased in the milk from the udder.Conclusion: Administration of O. sanctum L. at 5 ml/kg oral with intravenous CFT at 20 mg/kg may be advocated for effective treatment of S. aureus inflammation of the udder in caprine.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"322-328"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of paracetamol in the management of hemodynamically significant patent ductus arteriosus in preterm newborns 扑热息痛治疗早产新生儿血流动力学显著性动脉导管未闭的疗效

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-07-05 DOI: 10.4103/ijp.ijp_45_21

Sanjay Kumar Tanti, Waseem Uddin, Asit Kumar Mishra, Sudhir Mishra

{"title":"Efficacy of paracetamol in the management of hemodynamically significant patent ductus arteriosus in preterm newborns","authors":"Sanjay Kumar Tanti, Waseem Uddin, Asit Kumar Mishra, Sudhir Mishra","doi":"10.4103/ijp.ijp_45_21","DOIUrl":"https://doi.org/10.4103/ijp.ijp_45_21","url":null,"abstract":"<h3>OBJECTIVE: </h3>\u0000The objective is to determine the efficacy and safety of paracetamol in preterm babies with hemodynamically significant patent ductus arteriosus (hsPDA).\u0000<h3>BACKGROUND: </h3>\u0000In preterm babies, patent ductus arteriosus, when hemodynamically significant, causes considerable morbidity and mortality and also affects 20% of very low birth weight infants. Medical therapy is the mainstay of treatment. Currently used drug cyclooxygenase inhibitor has multiple serious adverse effects, including gastrointestinal perforation, bleeding, and renal failure. Hence, an alternative drug like paracetamol has been proposed for the treatment of hsPDA for fewer side effects. Hence, we used paracetamol in our neonatal intensive care unit in preterm neonates with hsPDA.\u0000<h3>METHODS: </h3>\u0000A total of 14 preterm babies diagnosed to have hsPDA on clinical and echocardiographic evaluation in neonatal ICU on days 3–14 of life during 13 months were included. Birth weight was between 1000 g and 1650 g and gestation was between 28 weeks and 33 weeks. Paracetamol in a dose of 15 mg/kg/dose every six hourly given to all the included babies for 3 days and re-evaluated echocardiographically after 3 days of treatment.\u0000<h3>RESULTS: </h3>\u0000In 12 (86%) out of 14 cases, PDA was closed, whereas in 2 (14%) hemodynamic closure with insignificant residual flow was achieved. Paracetamol was effective in 100% of cases. No adverse event was observed during treatment.\u0000<h3>CONCLUSIONS: </h3>\u0000Paracetamol is a very safe and efficacious drug for treating hemodynamically significant patent ductus arteriosus in premature babies.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"30 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141572966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Spice components as modulating agents of P-glycoprotein – An in silico study 作为 P-糖蛋白调节剂的香料成分--一项硅学研究

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-07-05 DOI: 10.4103/ijp.ijp_299_23

Swagata Mukhopadhyay, Chandana Roy, Pratiti Ghosh

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Acitretin induced primary hypothyroidism in Darier’s disease: A rare case report 达里尔病中阿曲汀诱发的原发性甲状腺功能减退症：罕见病例报告

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-07-05 DOI: 10.4103/ijp.ijp_250_23

Betsy Susan Babu, Carol Z. Fernandes, Balachandra Bhat

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Reevaluating the epinephrine myth: A comprehensive review 重新评估肾上腺素神话：全面回顾

IF 2.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-07-05 DOI: 10.4103/ijp.ijp_308_23

Sreeganesh Krishnaprabhu, Joe M. Das

{"title":"Reevaluating the epinephrine myth: A comprehensive review","authors":"Sreeganesh Krishnaprabhu, Joe M. Das","doi":"10.4103/ijp.ijp_308_23","DOIUrl":"https://doi.org/10.4103/ijp.ijp_308_23","url":null,"abstract":"The combination of local anesthetic drugs with epinephrine has conventionally been contraindicated in acral regions due to concerns of potential necrosis caused by compromised blood flow. However, this belief has been challenged since 2001, when studies demonstrated the safety and effectiveness of the combination. This review aims to analyze reported cases of acral area necrosis following the use of local anesthesia with epinephrine since 2001. A thorough search was conducted on PubMed and Google Scholar using specific keywords to identify articles reporting acral area necrosis caused using local anesthesia and epinephrine. Our search yielded eight publications describing a total of 13 cases of ischemic events in acral areas. These cases involved finger necrosis (five cases), scrotal skin necrosis (two cases), and eyelid necrosis (six cases), following the injection of a combination of epinephrine and lignocaine. The majority of affected patients were female who underwent surgical intervention and reconstruction. The use of epinephrine in local anesthesia offers significant advantages and is generally safe for acral areas. However, the risk of necrosis cannot be entirely eliminated, particularly in patients with compromised vascular function. Adhering to proper guidelines and selecting suitable patients can help mitigate the risk. Phentolamine serves as a potential rescue agent if vascular compromise occurs. Precautionary measures must be taken when using this combination in high-risk patients.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"16 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141572967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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