Indian Journal of Pharmacology最新文献_第6页

Photosensitive dermatitis caused by nintedanib in a patient of chronic fibrosing interstitial lung disease already on pirfenidone. 一名已服用吡非尼酮的慢性纤维化间质性肺病患者因宁替尼而引发光敏性皮炎。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_371_24

Aurelia Goyal, Sharang Gupta, Dimple Chopra

引用次数: 0

Effect of glimepiride versus teneligliptin in combination with metformin in type 2 diabetes mellitus patients. 格列美脲与替尼格列汀联合二甲双胍治疗2型糖尿病的疗效比较。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_107_24

Razia Abdul Rasheed, G Venkatraman, S Vijayalakshmi, T A R Raja, G Senthil, P Renugadevi

{"title":"Effect of glimepiride versus teneligliptin in combination with metformin in type 2 diabetes mellitus patients.","authors":"Razia Abdul Rasheed, G Venkatraman, S Vijayalakshmi, T A R Raja, G Senthil, P Renugadevi","doi":"10.4103/ijp.ijp_107_24","DOIUrl":"10.4103/ijp.ijp_107_24","url":null,"abstract":"Background: Long-term metabolic disease type 2 diabetes mellitus (T2DM) is distinguished by elevated blood glucose, insulin resistance, and drought of insulin with dyslipidemia. Oral hypoglycemic agents lower blood glucose levels as well as prevent both short-term and long-term complications such as micro/macrovascular atherosclerosis, chronic kidney diseases, and chronic heart disease. This study aims to compare the effect of glimepiride versus teneligliptin in combination with metformin in T2DM patients attending a tertiary care hospital.Materials and methods: This prospective, randomized, open-label study was initiated in a tertiary care hospital after obtaining IEC approval. Written informed consent was obtained. The sample size was calculated using \"Statistics and sample size software.\" Ninety-seven patients satisfying the inclusion criteria were assigned to two groups using simple randomization with allocation 1:1. Group A received metformin + glimepiride while Group B received metformin + teneligliptin for 12 weeks. Fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), and lipid profile were recorded at the baseline and at the end of 12 weeks. This study was conducted for 1 year. Data were analyzed using SPSS version 23.0 software.Results: Out of 97 participants (Group A: 48 and Group B: 49), Group A showed a higher reduction in FBS (48.18 ± 9.64) whereas Group B showed 72.53 ± 5.01, 1.74 ± 0.42 of change in PPBS and HbA1c after 12 weeks.Conclusion: The study found that combining metformin with teneligliptin was better tolerated and improved glycemic control and lipid profile compared to metformin plus glimepiride.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"317-321"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piperacillin-tazobactam and nephrotoxicity: Myth busted? 哌拉西林-他唑巴坦与肾毒性：神话被打破？

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_113_24

Muhammad Momin Khan, Kundan Kumar Maheshwari, Maisam Ali Rajput, Farina Fatima Siddiqui

引用次数: 0

Effectiveness and safety of spesolimab in treating generalized pustular psoriasis: A comparative analysis of randomized controlled trials. 斯派索利单抗治疗泛发性脓疱型银屑病的有效性和安全性：随机对照试验对比分析。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_240_24

Sai Praneeth Duvvuri, Rithwik Goud Burri, Annie Monica Ch, Krishna Chaitanya Meduri, Ujwala Damineni

引用次数: 0

Training and education in pharmacovigilance: The experience from the Pharmacovigilance Programme of India. 药物警戒方面的培训和教育：印度药物警戒计划的经验。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_638_22

Rishi Kumar, Jai Prakash, Shashi Bhushan, Akash Deep Rawat, R S Ray, Rajeev Singh Raghuvanshi

{"title":"Training and education in pharmacovigilance: The experience from the Pharmacovigilance Programme of India.","authors":"Rishi Kumar, Jai Prakash, Shashi Bhushan, Akash Deep Rawat, R S Ray, Rajeev Singh Raghuvanshi","doi":"10.4103/ijp.ijp_638_22","DOIUrl":"10.4103/ijp.ijp_638_22","url":null,"abstract":"Abstract: For a robust Pharmacovigilance system in a country, training of healthcare professionals is of utmost importance. The training is the integral part of continual improvement in any quality management system. The present article describes the different training modules and experience from the Pharmacovigilance Programme of India (PvPI) and emphasizes that if training and education elements with special reference to pharmacovigilance are implemented for all concerned stakeholders in a healthcare system, the efficiency of deliverables will be improved and objectives of the organization can easily be achieved. The PvPI has been putting its best efforts to train healthcare professionals in pharmacovigilance and it has achieved new heights in establishing best practices for the other countries to follow for the development of pharmacovigilance system in their respective countries or regions. The aim of this article is to suggest how capacity building in a pharmacovigilance system can help low- and middle-income countries in area of pharmacovigilance. The authors tried to conceptualize the process and implementation of the training program under PvPI.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"348-357"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardioprotective effect of S-adenosyl L-methionine due to antioxidant and anti-inflammatory properties on isoproterenol-induced chronic heart failure in Wistar rats. s -腺苷- l-蛋氨酸抗氧化和抗炎作用对异丙肾上腺素诱导的Wistar大鼠慢性心力衰竭的保护作用。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_407_24

Sharmila Vinayak Jalgaonkar, Raakhi Tripathi, Komal Gorakshanath Kurhade, Pradeep Chaudhari, Bhabani Shankar Mohanty, Pradeep Vaideeswar

{"title":"Cardioprotective effect of S-adenosyl L-methionine due to antioxidant and anti-inflammatory properties on isoproterenol-induced chronic heart failure in Wistar rats.","authors":"Sharmila Vinayak Jalgaonkar, Raakhi Tripathi, Komal Gorakshanath Kurhade, Pradeep Chaudhari, Bhabani Shankar Mohanty, Pradeep Vaideeswar","doi":"10.4103/ijp.ijp_407_24","DOIUrl":"10.4103/ijp.ijp_407_24","url":null,"abstract":"Objectives: The development and progression of chronic heart failure (CHF), hypertrophy, and remodeling strongly correlate with myocardial inflammation and oxidative stress. S-adenosylmethionine (SAMe), available as a dietary supplement, exerts anti-inflammatory and antioxidant effects. Previous reports show that by regulating angiogenesis and fibrosis, S-adenosyl-L-methionine improves ventricular remodeling. The study objectives were to investigate the cardioprotective effect of SAMe in isoproterenol (ISO)-induced CHF and explore the anti-inflammatory and antioxidant properties of SAMe in this model.Methodology: After animal ethics permission, CHF was induced using ISO of 10 mg/kg for 14 consecutive days in 24 Wistar rats. There were four groups of six rats in each group: Sham Control, Disease Control (DC), ISO + SAMe 100 mg, and ISO + SAMe 200 mg. The variables assessed were heart to body weight ratio (HW/BW mg/g), bio-distribution of Flourine 18-Fluorodeoxyglucose (18F-FDG) in heart tissue, tumor necrosis factor-α (TNF-α) and glutathione (GSH) levels in heart tissue, histopathology, and positron emission tomography imaging.Results: SAMe in ISO-induced CHF animals showed a significant decrease in the HW/BW compared to DC group (P < 0.001). 18F-FDG uptake was significantly reduced by SAMe in CHF-induced rats compared to DC rats for both doses (P < 0.001). SAMe showed significantly better values of both TNF-α and GSH than the DC group in both doses (P < 0.001). SAMe in both doses showed multifocal necrosis with scarring and minimal inflammatory cells.Conclusion: SAMe exerts a cardioprotective effect on ISO-induced CHF in rats because of its antioxidant and anti-inflammatory properties.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"335-341"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the benefits of Drug Master File filing in the Indian pharmaceutical industries. 解锁药品主文件在印度制药业备案的好处。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_297_23

Rahul Pathak, Rajat Singal, Sandip Mitra, Sanjay Koul, Supriya Sharma

引用次数: 0

Symphony of planetary health and prescription medicine for a sustainable future. 地球健康交响曲和可持续未来的处方药。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_896_24

Sandhya Rajaram, Ajay Prakash, Bikash Medhi

引用次数: 0

In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae). 三叠纪（Agavaceae）乙醇叶提取物对结直肠癌细胞株的体外抗菌和细胞毒性潜力。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_564_24

Sheryar Afzal, Yuan Seng Wu, Aimi Syamaima Abdul Manap, Ali Attiq, Ibrahim Albokhadaim, Velaga Appalaraju, Ahmed Magzoub Khalid, Olorunfemi Eseyin

{"title":"In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae).","authors":"Sheryar Afzal, Yuan Seng Wu, Aimi Syamaima Abdul Manap, Ali Attiq, Ibrahim Albokhadaim, Velaga Appalaraju, Ahmed Magzoub Khalid, Olorunfemi Eseyin","doi":"10.4103/ijp.ijp_564_24","DOIUrl":"10.4103/ijp.ijp_564_24","url":null,"abstract":"Background: Sansevieria trifasciata, common name, mother-in-law's tongue, is a member of the Agavaceae family. We undertook this study to evaluate the cytotoxicity of S. trifasciata leaf extract against two cancer cell lines as well as its antibacterial activities against six bacterial strains.Materials and methods: The investigated cell lines include primary colon epithelial (PCE) cells and human colorectal cancer cells; the studied bacterial strains are Staphylococcus aureus, Proteus vulgaris, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Using the agar well-diffusion method, various doses (5, 10, and 20 mg/mL) of plant extracts (ethanol and petroleum ether) were evaluated against each kind of bacterial strain. The minimal inhibitory doses were found using the two-fold serial dilution approach, with a range of 0.156-5 mg/mL.Results: Comparing extracts of S. trifasciata leaves to tetracycline (0.05 mg/mL), a common antibiotic, revealed a wide range of antibacterial activity. P. vulgaris and S. aureus were the most sensitive bacterial strains to ethanol and petroleum ether extracts, respectively. The MTT test was employed to ascertain the viable cell count of PCE cells and HCT-116. When various ethanol extract concentrations (7.8, 15.63, 31.25, 62.5, 125, 250, 500, and 1000 μg/mL) were tested against the cell lines, HCT-116's IC50, values were lower as compared to PCE. The IC50 values for HCT-116 and PCE cells ranged from 10.0 to 14.07 μg/mL and 92.9-216.9 μg/mL, respectively.Conclusions: Ethanolic extract of S. trifasciata showed promising antibacterial and anticancer properties.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"329-334"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raw Ocimum sanctum L. leaf extract modulates the pharmacokinetic of ceftriaxone and increases its bioavailability in staphylococcal mastitis. 生欧琴圣树叶提取物可调节头孢曲松的药代动力学，并提高其在葡萄球菌性乳腺炎中的生物利用度。

IF 1.4 4区医学

Indian Journal of Pharmacology Pub Date : 2024-09-01 Epub Date: 2024-12-16 DOI: 10.4103/ijp.ijp_22_24

Jeevan Ranjan Dash, Tapas Kumar Sar, Indranil Samanta, Tapan Kumar Mandal

{"title":"Raw Ocimum sanctum L. leaf extract modulates the pharmacokinetic of ceftriaxone and increases its bioavailability in staphylococcal mastitis.","authors":"Jeevan Ranjan Dash, Tapas Kumar Sar, Indranil Samanta, Tapan Kumar Mandal","doi":"10.4103/ijp.ijp_22_24","DOIUrl":"10.4103/ijp.ijp_22_24","url":null,"abstract":"Background: To study the pharmacokinetic interaction of cephalosporin antibiotic ceftriaxone (CFT) with raw undiluted Ocimum sanctum L. leaf juice in chronic staphylococcal mastitis in caprine.Materials and methods: Chronic inflammation of the udder was evoked in goats by Staphylococcus aureus (J638) intracisternal inoculation 2000 cfu for 30 days into the left udder. Animals of Group I were given one single dose of CFT at 20 mg/kg i.v. Group II animals were given one single dose of CFT at 20 mg/kg i.v, and contemporary extracted fresh leaf juice of O. sanctum L. given at 5 ml/kg orally for 7 consecutive days.Results: O. sanctum L. at 5 ml/kg oral had synergistic herb-drug pharmacokinetic interaction with CFT antibiotic (i.v.) and increased its bioavailability. It prolonged its rate of elimination (β) and enhanced the volume of distribution (Vdarea) and mean residence time in the body. Bioavailability and persistence of the antibiotic CFT and its metabolite ceftizoxime were increased in the milk from the udder.Conclusion: Administration of O. sanctum L. at 5 ml/kg oral with intravenous CFT at 20 mg/kg may be advocated for effective treatment of S. aureus inflammation of the udder in caprine.","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"56 5","pages":"322-328"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0