IET nanobiotechnology最新文献

{"title":"Nanomedicines for Efficient Diagnosis and Treatment of Pediatric Respiratory Diseases: Prospects and Challenges","authors":"Yan Shi,&nbsp;Hui Ma,&nbsp;Han Wenchao,&nbsp;Dan Li","doi":"10.1049/nbt2/2692282","DOIUrl":"https://doi.org/10.1049/nbt2/2692282","url":null,"abstract":"<p>Pediatric respiratory diseases are a major burden of global disease because they are very common and their pathophysiological mechanisms are complex. Conventional therapies have suboptimal pulmonary deposition, systemic toxicity, and poor patient compliance in children. Nanomedicine based interventions provide targeted pulmonary delivery, promote increased bioavailability, controlled drug release and reduce toxicity. Pulmonary deposition, epithelial uptake and intracellular trafficking are regulated by the physicochemical properties and the functionalization of nanoparticles. Preclinical studies in juvenile animal models show superior pharmacokinetic (PK) properties, preclinical therapeutic efficacy and preliminary clinical studies in pediatric patients show favorable safety and tolerability characteristics. There are still challenges associated with translation, such as immunotoxicity, regulatory issues, and optimizing doses in children. New strategies that combine AI-assisted design and synthesis of nanoparticles, nanotheranostics, and biodegradable 2D nanomaterials have potential to address these challenges. In this review, recent advances in pediatric nanomedicine for respiratory diseases are discussed with special focus on mechanistic understanding, preclinical evidence, translation to the clinics and future directions of the therapeutic platforms.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/2692282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Macrophage-Camouflaged Oxygen-Self-Supplying Nanoplatform for Precision Synergistic Ablation of Breast Cancer","authors":"Yunwen Sun,&nbsp;Xun Gao,&nbsp;Juan Gao,&nbsp;Jiajia Chang,&nbsp;Xiaoqi Tan,&nbsp;Yue Yu,&nbsp;Yongping Lu,&nbsp;Da Huo","doi":"10.1049/nbt2/4933996","DOIUrl":"https://doi.org/10.1049/nbt2/4933996","url":null,"abstract":"<p>Breast cancer remains one of the most prevalent and life-threatening malignancies affecting women globally, and the development of precision therapeutic platforms capable of overcoming the inherent limitations of conventional monotherapies is a pressing clinical imperative. Here, we report the design, synthesis, and evaluation of a macrophage membrane-camouflaged IrO₂-IR808 nanoplatform (IrO₂-IR808@M1) that achieves precise and synergistic tumor ablation through the cooperative action of photothermal/photodynamic therapy (PDT). The IrO₂ nanocore provides efficient light-to-heat conversion and catalase-like activity that locally generates oxygen to sustain PDT efficacy in the hypoxic tumor microenvironment, while the covalently conjugated near-infrared (NIR) photosensitizer IR808 provides complementary NIR absorption and reactive oxygen species (ROS) generation. Under 808 nm NIR irradiation, IrO₂-IR808@M1 achieves rapid and reproducible temperature elevation with a high photothermal conversion efficiency (PCE) of 55.22%, translating into potent concentration-dependent cytotoxicity in MCF-7 breast cancer cells and pronounced tumor growth suppression in syngeneic 4T1 murine models without discernible systemic toxicity. The M1 macrophage membrane camouflage confers extended systemic circulation, enhanced colloidal stability, and strengthened tumor selectivity through immune-mimetic surface interactions. This bioinspired, self-oxygen-supplying nanoplatform establishes a concise and translatable blueprint for precision phototherapy in breast cancer, with implications for broader application across solid tumor indications.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/4933996","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPRESSION OF CONCERN: Apoptotic Efficacy and Antiproliferative Potential of Silver Nanoparticles Synthesised From Aqueous Extract of Sumac (Rhus coriaria L.)","authors":"","doi":"10.1049/nbt2/9856498","DOIUrl":"https://doi.org/10.1049/nbt2/9856498","url":null,"abstract":"<p>EXPRESSION OF CONCERN: P. Ghorbani, F. Namvar, M. Homayouni-Tabrizi, et al., “Apoptotic Efficacy and Antiproliferative Potential of Silver Nanoparticles Synthesised From Aqueous Extract of Sumac (<i>Rhus coriaria</i> L.),” IET Nanobiotechnology, 12, (2018): 600–603. https://doi.org/10.1049/iet-nbt.2017.0080.</p><p>This Expression of Concern is for the above article, published online on 27 March 2018 in Wiley Online Library (wileyonlinelibrary.com) and has been issued by agreement between the journal Editor-in-Chief, Duo Lin; and John Wiley &amp; Sons Ltd. The Expression of Concern has been agreed due to an error identified in Figure 2b, in which unexpected, repeated elements are shared between the 5 and 15 µM panels [<span>1</span>].</p><p>During an investigation by the publisher, the authors were unable to provide the raw data or original images. The authors insisted that the duplication was a result of an error in image preparation, and it was determined that the error did not significantly affect the conclusions of the study. Therefore, the journal has decided to issue an Expression of Concern to inform and alert readers.</p><p>The authors have been informed about this Expression of Concern.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/9856498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Cytotoxicity of Aqueous Aloe–Silver Nanoparticles Against Human Glioma U-87 MG Cell Line","authors":"Neha Saini,&nbsp;Gajanan Sonawane,&nbsp;Kyunghee Yun,&nbsp;Hyeshin Hwang,&nbsp;Kyungmin Kim,&nbsp;Bumho Yoo,&nbsp;Smita Zinjarde,&nbsp;Atul Kulkarni","doi":"10.1049/nbt2/1937831","DOIUrl":"https://doi.org/10.1049/nbt2/1937831","url":null,"abstract":"<p>The heterogeneity of glioblastoma and recurrence pose a major threat to the life of brain cancer patients. The failure of the current therapeutic regime in preventing its recurrence leads to a growing need for effective cancer treatments with lesser side effects. Previous studies have shown the potential of plants extract to synthesize silver nanoparticles (AgNPs) against U-87 MG cell line. However, the need for optimum sized and effective nanoparticles is still not fulfilled. Hence, the current work aimed to utilize size controlled bioavailable AgNPs capped with <i>Aloe barbadensis</i> (aqueous extracts) and study their effectiveness against U-87 MG cells. Two different concentrations of <i>Aloe vera</i> extract (ALE) viz. ALE1 and ALE2, were used. Their physiochemistry was characterized via UV–Vis, dynamic light scattering (DLS), FE-SEM (50–60 nm diameter), and energy dispersive X-ray (EDX). The observed zeta potentials were −8 and −16 mV for ALE1– and ALE2–AgNPs, respectively. This indicated that ALE2–AgNPs were more stable. Further, the anticancer potency of both ALE–AgNPs at 0, 24, and 48 h was evaluated. MTT-assay revealed ALE2–AgNPs were more cytotoxic, significantly inhibiting the proliferation of U-87 MG, indicating their dose-dependent cytotoxicity. At an effective concentration of ALE2–AgNPs, (i.e., 10 µg/mL) viability of cancer cell line decreased significantly to 40% after 24 h of treatment. In apoptotic analysis pronounced elevation in early apoptotic cells was noted (5.1% and 9.9% for ALE1– and ALE2–AgNPs, respectively). The significant cytotoxicity and observed apoptosis induction shows ALE–AgNPs’s therapeutic potential against glioblastoma and aqueous extract shows its high biocompatibility, thus having significant probability to be translated in clinical settings.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/1937831","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Nanoparticles in Microbial Biotechnology: Multisector Mechanisms, Applications, and Future Frontiers","authors":"Kaveh Rahimi Mamaghani,&nbsp;Marzieh Alikarami,&nbsp;Hossein Saremi,&nbsp;Nader Parvin","doi":"10.1049/nbt2/7866252","DOIUrl":"https://doi.org/10.1049/nbt2/7866252","url":null,"abstract":"<p>Fungal pathogens threaten global food security, ecosystem stability, and human health, while the overuse of conventional fungicides accelerates resistance and disrupts beneficial microbiota. Nanotechnology offers a powerful new paradigm for fungal control, but its greatest potential lies at the interface with microbial biotechnology. Here, we critically review advances in antifungal nanoparticles (NPs) with a focus on their integration into microbiome-aware and microbe-assisted systems. We discuss biogenic NP synthesis by bacteria, fungi, and yeast; synergistic nanobiofungicides that combine NPs with biocontrol agents such as <i>Trichoderma</i> and <i>Bacillus</i>; and NP-enabled strategies that selectively suppress pathogens while preserving beneficial taxa. Mechanistic insights include NP-mediated membrane disruption, reactive oxygen species (ROS) generation, ion release, and biofilm inhibition, with special attention to how these processes modulate plant-microbe interactions in the rhizosphere. Translational applications span pre- and postharvest agriculture, seed treatments, microbial inoculant stabilization, and smart delivery systems for agrochemicals. We also examine the ecological implications of NP deployment, highlighting safe-by-design (SbD) strategies, biodegradability, and microbiome resilience as key design criteria. Finally, we outline a future roadmap where nanotechnology converges with synthetic biology, microbial engineering, and AI-guided design to enable precision antifungal systems that are adaptive, ecologically compatible, and scalable. Together, these insights position antifungal nanotechnology as a next-generation tool in microbial biotechnology, with the potential to reshape crop protection, soil health management, and sustainable fungal control.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/7866252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148087318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of Paclitaxel-Loaded Self-Nanoemulsifying Drug Delivery System for Enhanced Cancer Therapy: A Promising Alternative to Cremophor EL–Based Formulation","authors":"Alshaimaa M. Almehmady,&nbsp;Amerh A. Alahmadi,&nbsp;Abrar Hakami,&nbsp;Ehab M. M. Ali,&nbsp;Abdulaziz A. Kalantan,&nbsp;Amjad Aljagthmi,&nbsp;Tarek A. Ahmed","doi":"10.1049/nbt2/4890307","DOIUrl":"https://doi.org/10.1049/nbt2/4890307","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Paclitaxel’s clinical use is limited by poor aqueous solubility and Cremophor EL–related toxicity in commercial formulations. This study aimed to develop a self-nanoemulsifying drug delivery system (SNEDDS) to improve paclitaxel solubility, bioavailability, and anticancer efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Experimental Approach</h3>\u0000 \u0000 <p>Paclitaxel-loaded SNEDDSs were prepared using oleic acid, Tween 80, and polyethylene glycol (PEG) 400 in different ratios and characterized for particle size, polydispersity index (PDI), zeta potential, and solubility. The optimized formulation (F1) was assessed for cytotoxicity, cell cycle distribution, apoptosis, mitochondrial membrane potential (MMP), and nuclear morphology in MCF-7 breast cancer cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Results</h3>\u0000 \u0000 <p>Formulation F1 (10% oleic acid, 10% PEG 400, and 80% Tween 80) exhibited the highest solubility, smallest particle size, and lowest PDI, with near-neutral zeta potential ensuring stability. F1 demonstrated superior cytotoxic activity, inducing G₂/M arrest (41.8%) and total apoptosis of 70.6%, mainly in the early phase (64.4%), compared to pure paclitaxel and Paxol. MMP and 4^′, 6-diamidino-2-phenylindole (DAPI) assays confirmed mitochondrial-mediated apoptosis and nuclear fragmentation, consistent with paclitaxel’s mechanism of microtubule stabilization and mitotic catastrophe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion and Implications</h3>\u0000 \u0000 <p>Encapsulation of paclitaxel into SNEDDS significantly enhanced solubility, cellular uptake, and proapoptotic activity. The optimized F1 formulation provides a promising nanocarrier platform for improving paclitaxel’s therapeutic performance and may serve as a safer, more effective alternative to Cremophor EL–based products for breast cancer treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/4890307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148088672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-Friendly ZnO–Chitosan Nanocomposite-Embedded Sodium Alginate/Polyvinyl Alcohol/Saffron Hydrogel for Enhanced Antibacterial Applications","authors":"Fatemeh Karampour,&nbsp;Saba Zendehcheshm","doi":"10.1049/nbt2/7756674","DOIUrl":"https://doi.org/10.1049/nbt2/7756674","url":null,"abstract":"<p>This study reports the green synthesis, development, and characterization of novel eco-friendly zinc oxide nanoparticles (ZnO NPs) coated with chitosan (ZnO NPs–Chsn) and their incorporation into a polyvinyl alcohol/sodium alginate/saffron (PSS) hydrogel for enhanced antibacterial applications. ZnO NPs were biosynthesized using quince (<i>Cydonia oblonga</i>) peel extract, yielding semi-spherical particles with an average size of ~72 nm. The Chsn coating improved particle dispersion, surface uniformity, and colloidal stability while modifying the surface charge (zeta potential from −27 to −11.6 mV), thereby enhancing biocompatibility and antibacterial potential. The ZnO NPs–Chsn were integrated into the PSS hydrogel matrix via a freeze–thaw method to improve biocompatibility and generate a highly porous structure. Incorporation of ZnO NPs–Chsn increased the maximum swelling ratio from 220.91% ± 1.89% (PSS) to 589.39% ± 1.77% and enhanced hydrophilicity, as confirmed by contact angle (CA) measurements. Antibacterial assays (disc diffusion) showed that the PSS/ZnO NPs–Chsn hydrogel produced inhibition zones of 4.64 ± 0.20 mm (<i>S. aureus</i>), 1.55 ± 0.10 mm (<i>E. coli</i>), and 4.94 ± 0.14 mm (<i>B. cereus</i>), compared with negligible inhibition for the base PSS hydrogel. The enhanced antibacterial effect is attributed to the synergistic action of ZnO NPs and Chsn through bacterial membrane disruption, reactive oxygen species (ROS) generation, and metabolic impairment, potentially boosted by the bioactive compounds in saffron (crocin and safranal). These findings highlight the potential of PSS/ZnO NPs–Chsn hydrogels as eco-friendly antibacterial biomaterials; however, further evaluations are required to confirm clinical applicability.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/7756674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148068543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148068554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect and Mechanism of Nanofiber Membrane Loaded With Curcumin Inclusion Compound in Periodontitis Oxidative Stress","authors":"Xinting Yang,&nbsp;Yingjie Xu,&nbsp;Shulong Guan,&nbsp;Ming Xu,&nbsp;Tengyu Ma,&nbsp;Yuanping Hao,&nbsp;Xinru Yang,&nbsp;Meihua Gao,&nbsp;Wanchun Wang,&nbsp;Yuguang Gao,&nbsp;Yuanfei Wang,&nbsp;Beibei Cong","doi":"10.1049/nbt2/6679414","DOIUrl":"10.1049/nbt2/6679414","url":null,"abstract":"<p>Periodontitis, a leading cause of tooth loss, is conventionally treated by mechanical curettage and antibiotics, which may cause adverse effects. Curcumin (Cur), a natural anti-inflammatory and antioxidant agent, shows therapeutic potential but suffers from low solubility and bioavailability. To overcome these limitations, we developed an electrospun nanofiber membrane (HP-Cur-IC/poly-L-lactone-co-ε-caprolactone [PLCL]) containing cyclodextrin-encapsulated Cur for localized sustained drug delivery within periodontal pockets. The resulting membrane exhibited improved water solubility, mechanical strength, and drug release profile. It demonstrated significant antioxidant and antibacterial effects, as evidenced by reductions in oxidative stress markers and bacterial viability. Furthermore, the membrane modulated the JAK2/STAT3 and ERK/JNK/p38 signaling pathways, alleviating oxidative damage in periodontal tissues. These findings suggest that the HP-Cur-IC/PLCL nanofiber membrane represents a promising nonsurgical strategy for periodontitis treatment.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/6679414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}