Nanoparticles as an Alternative Strategy for the Rapid Detection of Mycobacterium tuberculosis Complex (MTBC): A Systematic Literature Review of In Vitro Studies

IF 4.9 4区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Abayeneh Girma, Fentaye Kassawmar, Yeshiwas Kassa, Yeshwas Asrat
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引用次数: 0

Abstract

Worldwide, tuberculosis (TB) ranks as a second leading cause of death. The End TB strategy targets eliminating TB by 2030. Achieving this goal requires an early, accurate, and affordable diagnosis applicable in low- and middle-income countries; increasing the reach of point-of-care (POC) diagnostics is essential. Nanodiagnostics aims to enhance clinical diagnostic procedures with heightened sensitivity and accuracy by focusing on distinctive markers for early detection. A systematic search of research articles was conducted in four databases (PubMed, Scopus, Web of Science, and ScienceDirect) independently by two researchers. Publications retrieved in the independent search were mixed and imported into a single EndNote X8. The extraction of characteristics from the selected studies were carried out step by step by two independent researcher groups Abayeneh Girma and Fentaye Kassawmar and Yeshiwas Kassa and Yeshwas Asrat using a standardized data extraction format in Microsoft Excel 2021. Finally, the extracted data were combined and clearly presented in the table with the key information and findings. Inconsistencies between reviewers were resolved by discussion, and articles were included after consensus was reached. Totally, 2740 articles were retrieved, and 69 TB nanoparticle (NP)-based assays have fulfilled the inclusion criteria and included in this systematic review. The proposed platforms share the characteristics of accuracy, affordability, and swift time-to-result. Nanodiagnostics for TB now cover all clinical presentations of the disease, including active, drug-resistant, HIV-related, latent, and extrapulmonary TB. These advancements not only enhance the diagnostic landscape but also facilitate timely and effective treatment strategies, ultimately aiming to reduce the burden of TB worldwide. This review summarizes state-of-the-art knowledge of TB nanodiagnostics for the last 18 years. For fabrication concepts, detection strategies, and clinical performance, special consideration is given using various clinical specimens, and the suitability of TB nanodiagnostics for optimal MTB testing is evaluated. TB nanodiagnostics present a promising solution for meeting the stringent demands to end the TB epidemic by 2030.

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纳米颗粒作为快速检测结核分枝杆菌复合体(MTBC)的替代策略:体外研究的系统文献综述
在世界范围内,结核病是第二大死因。终止结核病战略的目标是到2030年消除结核病。实现这一目标需要适用于低收入和中等收入国家的早期、准确和负担得起的诊断;扩大即时诊断的覆盖范围至关重要。纳米诊断旨在提高临床诊断程序的灵敏度和准确性,重点关注早期检测的独特标记。两名研究人员分别在PubMed、Scopus、Web of Science和ScienceDirect四个数据库中对研究论文进行了系统的检索。在独立搜索中检索到的出版物被混合并导入到单个EndNote X8中。两个独立研究小组Abayeneh Girma和Fentaye Kassawmar以及Yeshiwas Kassa和Yeshwas Asrat使用Microsoft Excel 2021中的标准化数据提取格式逐步从所选研究中提取特征。最后,将提取的数据进行合并,并在表格中清晰地呈现出关键信息和发现。审稿人之间的不一致通过讨论解决,达成一致意见后纳入文章。共检索到2740篇文献,其中69项基于TB纳米颗粒(NP)的检测符合纳入标准并被纳入本系统综述。所提出的平台具有准确性、可负担性和快速得出结果的特点。结核病的纳米诊断现在涵盖了该病的所有临床表现,包括活动性、耐药性、艾滋病毒相关、潜伏性和肺外结核。这些进展不仅改善了诊断环境,而且促进了及时和有效的治疗战略,最终旨在减轻全世界结核病的负担。这篇综述总结了过去18年来结核病纳米诊断的最新知识。对于制造概念、检测策略和临床性能,使用各种临床标本进行了特别考虑,并评估了结核纳米诊断对最佳结核分枝杆菌检测的适用性。结核病纳米诊断为满足到2030年结束结核病流行的严格要求提供了一个有希望的解决方案。
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来源期刊
IET nanobiotechnology
IET nanobiotechnology 工程技术-纳米科技
CiteScore
6.20
自引率
4.30%
发文量
34
审稿时长
1 months
期刊介绍: Electrical and electronic engineers have a long and illustrious history of contributing new theories and technologies to the biomedical sciences. This includes the cable theory for understanding the transmission of electrical signals in nerve axons and muscle fibres; dielectric techniques that advanced the understanding of cell membrane structures and membrane ion channels; electron and atomic force microscopy for investigating cells at the molecular level. Other engineering disciplines, along with contributions from the biological, chemical, materials and physical sciences, continue to provide groundbreaking contributions to this subject at the molecular and submolecular level. Our subject now extends from single molecule measurements using scanning probe techniques, through to interactions between cells and microstructures, micro- and nano-fluidics, and aspects of lab-on-chip technologies. The primary aim of IET Nanobiotechnology is to provide a vital resource for academic and industrial researchers operating in this exciting cross-disciplinary activity. We can only achieve this by publishing cutting edge research papers and expert review articles from the international engineering and scientific community. To attract such contributions we will exercise a commitment to our authors by ensuring that their manuscripts receive rapid constructive peer opinions and feedback across interdisciplinary boundaries. IET Nanobiotechnology covers all aspects of research and emerging technologies including, but not limited to: Fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale (including methods that employ electrokinetic, electrohydrodynamic, and optical trapping techniques) Micromachining and microfabrication tools and techniques applied to the top-down approach to nanobiotechnology Nanomachining and nanofabrication tools and techniques directed towards biomedical and biotechnological applications (e.g. applications of atomic force microscopy, scanning probe microscopy and related tools) Colloid chemistry applied to nanobiotechnology (e.g. cosmetics, suntan lotions, bio-active nanoparticles) Biosynthesis (also known as green synthesis) of nanoparticles; to be considered for publication, research papers in this area must be directed principally towards biomedical research and especially if they encompass in vivo models or proofs of concept. We welcome papers that are application-orientated or offer new concepts of substantial biomedical importance Techniques for probing cell physiology, cell adhesion sites and cell-cell communication Molecular self-assembly, including concepts of supramolecular chemistry, molecular recognition, and DNA nanotechnology Societal issues such as health and the environment Special issues. Call for papers: Smart Nanobiosensors for Next-generation Biomedical Applications - https://digital-library.theiet.org/files/IET_NBT_CFP_SNNBA.pdf Selected extended papers from the International conference of the 19th Asian BioCeramic Symposium - https://digital-library.theiet.org/files/IET_NBT_CFP_ABS.pdf
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