IET nanobiotechnology最新文献

{"title":"Preparation of Fe3O4/Chitosan–Acrylic Acid Nanocomposite as an Adsorbent for the Removal of Cu2+ Ions From Real Water Samples","authors":"Arman Samadzadeh Mamaghani,&nbsp;Ali Moghimi,&nbsp;Milad Abniki","doi":"10.1049/nbt2/9919353","DOIUrl":"10.1049/nbt2/9919353","url":null,"abstract":"<p>This study presents an environmentally friendly and nontoxic method for the selective separation and removal of trace amounts. A magnetic nanocomposite made of Fe₃O₄/chitosan–acrylic acid was utilized to separate and remove Cu²⁺ ions using its magnetic properties. Various characterization techniques, including Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM), thermogravimetric analyzer (TGA), and VSM, were employed to investigate and identify the nanocomposite. Additionally, the research discusses adsorption isotherm models related to the adsorption of Cu²⁺ ions. The maximum adsorption capacity of the biodegradable Fe₃O₄/chitosan–acrylic acid nanocomposite for Cu²⁺ ions was found to be 30.68 mg/g. The adsorption process followed the Freundlich isotherm model when using the Fe₃O₄/chitosan–acrylic acid adsorbent. The method exhibited a linear range of 10–1000 µg/L for Cu²⁺ ions, with a limit of detection (LOD) of 0.15 μg/L for the adsorption of Cu²⁺ ions by the Fe₃O₄/chitosan–acrylic acid adsorbent. These findings indicate that Fe₃O₄/chitosan–acrylic is a high-performance adsorbent for removing Cu²⁺ ions from tap, well, river, and spring water samples.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/9919353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145619056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Algal Polysaccharides-Based Nanoparticles and Evaluation of Their Antioxidant and Anti-Inflammatory Potential","authors":"Cheng-Yuan Chen,&nbsp;Wei-Hao Huang,&nbsp;Pin-Yu Tsai,&nbsp;Chung-Hsiung Huang","doi":"10.1049/nbt2/8887357","DOIUrl":"10.1049/nbt2/8887357","url":null,"abstract":"<p>This study investigates the development of nanoparticles derived from algal polysaccharides and evaluates their physicochemical properties, antioxidant capacity, and anti-inflammatory activity in comparison to their native counterparts. Polysaccharides extracted from <i>Sargassum</i> (SP), <i>Ulva</i> (UP), and <i>Porphyra</i> (PP) were subjected to dry-heating at various temperatures to form nanoparticles. The prepared polysaccharides and nanoparticles were characterized by molecular weight distribution, monosaccharide composition, yield, morphology, particle size, sulfate content, and functional group profiles, respectively. The nanoparticles were spherical in form, with diameter less than 500 nm. Furthermore, their polydispersity index (PDI) was observed to be lower than 0.4, and their zeta potentials ranged from −5 to −30 mV. Dry-heating above 210°C induced notable alterations in functional groups, while temperatures above 150°C significantly enhanced DPPH radical scavenging and Fe²⁺ chelation activities. The nanoparticles showcased enhanced antioxidant and anti-inflammatory capabilities when juxtaposed with crude polysaccharides. Specifically, they led to a significant suppression of lipopolysaccharide (LPS)-induced generation of key pro-inflammatory molecules in macrophages. Importantly, the nanoparticles exhibited no cytotoxicity at concentrations below 1000 <i>μ</i>g/mL. These findings suggest that algal polysaccharide-based nanoparticles, particularly those formed at higher temperatures, hold considerable potential as bioactive agents in therapeutic applications.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/8887357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Radiotherapy for Hypoxic Tumors: Integrative Strategies Using Bacteria and Nanoparticles","authors":"Abolfazl Bemidinezhad,&nbsp;Abbas Al-Baghdadi,&nbsp;Anwer Alsarray,&nbsp;Yasaman Abolhassani,&nbsp;Yodgor Kenjayev,&nbsp;Fatemeh Gheybi","doi":"10.1049/nbt2/2687439","DOIUrl":"10.1049/nbt2/2687439","url":null,"abstract":"<p>Cancer remains a major global health challenge, with radiotherapy (RT) being a cornerstone of treatment. However, the efficacy of RT is significantly hindered by hypoxic tumor microenvironments (TMEs) and nonselective toxicity to healthy tissues. Recent advancements in combining bacteria and nanoparticles have shown promise in addressing these limitations. Cyanobacteria, with their oxygen-producing capabilities, alleviate tumor hypoxia, while anaerobic bacteria selectively target hypoxic regions. Nanoparticles complement these approaches by enhancing bacterial localization and amplifying radiosensitization through reactive oxygen species (ROS) generation and other synergistic therapies. Unlike previous reviews that have mainly focused on either bacterial therapy or nanoparticle-assisted radiosensitization separately, this review provides a comparative and integrative perspective on their combined use, emphasizing the novelty of synergistic strategies. This review explores innovative bacterial–nanoparticle integrations, highlighting their roles in overcoming hypoxia and improving RT outcomes. The potential of these strategies to transform cancer treatment is discussed, alongside challenges and future directions.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/2687439","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145469794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Potential of Free Radical-Scavenging Nanoparticles in Addressing Inflammation and Obesity","authors":"Shampa Ghosh,&nbsp;Rakesh Bhaskar,&nbsp;Krishna Kumar Singh,&nbsp;Bhuvaneshwar Yarlagadda,&nbsp;Prashant Verma,&nbsp;Sung Soo Han,&nbsp;Shiv Dutt Purohit,&nbsp;Jitendra Kumar Sinha","doi":"10.1049/nbt2/6805313","DOIUrl":"10.1049/nbt2/6805313","url":null,"abstract":"<p>Neuroprotection is well known for its strategies and interventions that help preserve the structure and function of neurons during a myriad of neurological challenges. It is fundamental in managing the complex relationship between neuroinflammation and obesity, both of which are significant factors affecting our neurological health. In the present review, we try to merge nanoparticles with artificial intelligence (AI) to tackle the neurological implications of both conditions. This review summarizes prior studies of free radical-scavenging nanoparticles: polymeric, liposomal, ceria-based, and quantum dots, and evaluates their reported efficacy in attenuating markers of neuroinflammation and neuronal dysfunction in preclinical models. We have also discussed AI applications, such as predictive modeling and real-time monitoring, stating that they present a complementary role in themselves. There is recognition that the promise of nanoparticles in mitigating neurological problems underscores the potential of AI in upgrading neuroprotection. Early-phase clinical trials of free radical-scavenging nanoparticles have highlighted the importance of patient stratification to optimize personalized treatment regimens. Furthermore, we advocate coordinated efforts in education, awareness, and research to integrate scientific findings, public policy, and technology innovation, thereby holistically addressing neuroinflammation and obesity at the individual level.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/6805313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145406636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Study on Enhancing Microbicidal Activity of Pure and Ion-Exchanged Zeolites Through Structural and Chemical Determinants","authors":"Hadi Tabesh,&nbsp;Shabnam Kharrazi,&nbsp;Mostafa Bashiri Barazandeh,&nbsp;Parastoo Ebadoulah Poursafa,&nbsp;Ali Poorkhalil","doi":"10.1049/nbt2/7012728","DOIUrl":"10.1049/nbt2/7012728","url":null,"abstract":"<p>Zeolites are crystalline aluminosilicate materials known for their unique structures and small pores, making them highly suitable for various applications, including antimicrobial uses. Their porous surfaces enable them to act as carriers for metal ions, enhancing their antibacterial potential. A recent comprehensive review of the literature assessed the antibacterial activity of both natural and synthetic zeolites, with a specific focus on their performance after being modified with metal ions. The study confirmed that while unmodified zeolites possess some inherent antibacterial properties, their effectiveness is generally limited to high concentrations. In contrast, zeolites modified with metal ions, such as silver (Ag), copper (Cu), or zinc (Zn), demonstrate significantly enhanced antimicrobial effects at much lower concentrations. Among the metal-modified zeolites, Ag-treated zeolite A (ZA) emerged as the most effective, exhibiting a remarkably low minimum inhibitory concentration (MIC) of just 16 µg/mL against various bacterial strains. This heightened activity is attributed to the controlled release of Ag ions and the high ion-exchange capacity of ZA, which allows for sustained antimicrobial action. These findings suggest that metal-exchanged zeolites, particularly those with high ion-retention capabilities, hold strong potential as long-lasting and efficient antimicrobial agents. Such materials could be valuable in medical, environmental, and industrial applications, especially where bacterial resistance is a growing concern.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/7012728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multiomic Study of Platelet-Derived Extracellular Vesicles and Impact of Platelet Concentrate Sources","authors":"Andreu Miquel Amengual-Tugores,&nbsp;Carmen Ráez-Meseguer,&nbsp;Maria Antònia Forteza-Genestra,&nbsp;Javier Calvo,&nbsp;Antoni Gayà,&nbsp;Marta Monjo,&nbsp;Joana Maria Ramis","doi":"10.1049/nbt2/8358424","DOIUrl":"10.1049/nbt2/8358424","url":null,"abstract":"<p>Platelet-derived extracellular vesicles (pEVs) are a potent fraction of platelet concentrates, enhancing their therapeutic potential in regenerative medicine. This study evaluates pEV from three platelet sources: platelet lysate (PL), fresh platelets (fPs), and aged platelets (aPs), to determine how activation and storage conditions affect pEV characteristics, functionality, and molecular content. pEV are isolated using size exclusion chromatography (SEC) and characterized by transmission electron microscopy (TEM), western blot, and nanoparticle tracking analysis (NTA). Functional assays include wound healing, metabolic activity, and cytotoxicity. Protein and miRNA profiles are obtained through LC-MS/MS and miRNA arrays, followed by bioinformatic analysis. Findings show that PL-derived pEV exhibits the highest yield and purity, containing markers CD63 and CD9. Enhanced fibroblast migration in wound healing assays suggest a critical role for PL-pEV in hemostasis, proliferation, and remodeling phases. Multiomics analysis identifies upregulated miRNAs, particularly miR-210-3p and the miR-320 family, associated with wound healing. Differential protein analysis reveals an enrichment in immune response and wound healing pathways within PL-pEV. These results demonstrate the impact of platelet preparation methods on pEV molecular cargo and efficacy, with hsa-miR-320a, hsa-miR-320b, and hsa-miR-210-3p identified as key mediators supporting the clinical potential of PL-pEV in regenerative medicine.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/8358424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells","authors":"Zeinab Hormozi-Moghaddam,&nbsp;Ali Neshasteh-Riz,&nbsp;Seyedeh Mona Taheri,&nbsp;Seyed Mohammad Amini,&nbsp;Ehsan Sedghinezhad","doi":"10.1049/nbt2/7036856","DOIUrl":"10.1049/nbt2/7036856","url":null,"abstract":"<p><b>Introduction:</b> Sonodynamic therapy (SDT) is a promising approach that combines low-intensity ultrasound (LIUS) with a sensitizing agent to induce therapeutic effects. Curcumin-coated silver nanoparticles (Cur@AgNPs) have shown potential as a sensitizer, demonstrating adverse effects on cancer cell survival. This study examined the apoptotic effects of US waves in the presence of Cur@AgNPs on MCF7 breast cancer cells.</p><p><b>Methods and Materials:</b> MCF7 cells were cultured and divided into different treatment groups. Cur@AgNPs were synthesized and characterized using various techniques, confirming their size to be approximately 29.3 ± 5.6 nm. The IC50 of Cur@AgNPs in MCF7 cells was determined to be 48.23 µg/ml through the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. LIUS radiation was applied to the cells in different modes, both with and without Cur@AgNPs. Cell viability was evaluated using the MTT assay and reactive oxygen species (ROS) production was measured. Colony formation assay and real-time PCR were conducted to evaluate cell death and changes in gene expression of Bcl-2-associated X protein (Bax), B-cell lymphoma-2 (Bcl-2), and Caspase-3, respectively.</p><p><b>Results:</b> The findings confirmed the successful synthesis of Cur@AgNPs with a uniform size of approximately 29.3 ± 5.6 nm. In the continuous wave (CW) and pulse wave (PW) modes, 50% and 25%, cell viability was measured at 65.01% ± 1.35%, 73.75% ± 1.80%, and 80.76% ± 1.57%, respectively. Cell viability in CW with Cur@AgNPs was 16.9% ± 4%. The plating efficiency (PE) of the combined treatment group was 13.66 ± 1.24, compared to 39.33 ± 1.24 for the US.CW group and 68.66 ± 2.62 for the Cur@AgNPs group. Also, the expression of proapoptotic genes, such as Bax and Caspase-3, increased, while the expression of the antiapoptotic gene Bcl-2 decreased in MCF7 cells treated with the SDT. Flow cytometry analysis revealed increased rates of early apoptosis (21.22% ± 3.82%) and late apoptosis (36.59% ± 4.5%) in the US.CW + Cur@AgNPs.</p><p><b>Conclusion:</b> This study provides novel insights into the induction of apoptosis in MCF7 breast cancer cells through SDT in the presence of Cur@AgNPs as a sonosensitizer. These findings support the potential of SDT as an effective therapeutic approach for breast cancer treatment using nonionizing and noninvasive methods.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/7036856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrafast and Deep Saliva Proteome Reveals the Dynamic of Human Saliva With Aging by Orbitrap Astral Mass Spectrometer","authors":"Lingling Jiao,&nbsp;Huilin Dong,&nbsp;Changjian Wu,&nbsp;Jing Liu,&nbsp;Chenhui Wang,&nbsp;Yi Cao,&nbsp;Fan Cao,&nbsp;Ying Zhu,&nbsp;Huaiyuan Zhu","doi":"10.1049/nbt2/6616433","DOIUrl":"10.1049/nbt2/6616433","url":null,"abstract":"<p>Saliva has already proven to be a prospective diagnostic bioresource for both early disease detection and timely intervention due to its easy accessibility, noninvasiveness, and reproducibility. However, the in-depth identification of salivary proteins needs to be further improved. Until now, only 3427 proteins are included in the human salivary proteome (HSP), which is far from the millions of proteins that make up humans. Here, we set out to quantitatively map the HSP in rapid and in-depth Orbitrap Astral mass spectrometer (MS) and coronal nanomagnetic bead–based proteomics workflow. Our study reported 5937 salivary proteins, which was about 73% more than that recorded in HSP. Moreover, we compared the differences between the young and aged salivary proteins. The predominant functions of the upregulated proteins in the young were related to motor proteins and cardiomyopathy, whereas those of the aged were primarily upregulated with oxidation reaction, as well as neurodegenerative disorders. It is the first study to carry out salivary proteomics using a fast and deep Orbitrap Astral MS and remarkably enlarged the number of proteins with HSP, furthermore, salivary proteomics was found to be characterized in the young and aged. With the rapidly advancing MS and proteomics technologies, we believe that salivary protein biomarkers will be more promising for clinical diagnosis and prognosis of human diseases in the future.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/6616433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles as an Alternative Strategy for the Rapid Detection of Mycobacterium tuberculosis Complex (MTBC): A Systematic Literature Review of In Vitro Studies","authors":"Abayeneh Girma,&nbsp;Fentaye Kassawmar,&nbsp;Yeshiwas Kassa,&nbsp;Yeshwas Asrat","doi":"10.1049/nbt2/4639233","DOIUrl":"10.1049/nbt2/4639233","url":null,"abstract":"<p>Worldwide, tuberculosis (TB) ranks as a second leading cause of death. The End TB strategy targets eliminating TB by 2030. Achieving this goal requires an early, accurate, and affordable diagnosis applicable in low- and middle-income countries; increasing the reach of point-of-care (POC) diagnostics is essential. Nanodiagnostics aims to enhance clinical diagnostic procedures with heightened sensitivity and accuracy by focusing on distinctive markers for early detection. A systematic search of research articles was conducted in four databases (PubMed, Scopus, Web of Science, and ScienceDirect) independently by two researchers. Publications retrieved in the independent search were mixed and imported into a single EndNote X8. The extraction of characteristics from the selected studies were carried out step by step by two independent researcher groups Abayeneh Girma and Fentaye Kassawmar and Yeshiwas Kassa and Yeshwas Asrat using a standardized data extraction format in Microsoft Excel 2021. Finally, the extracted data were combined and clearly presented in the table with the key information and findings. Inconsistencies between reviewers were resolved by discussion, and articles were included after consensus was reached. Totally, 2740 articles were retrieved, and 69 TB nanoparticle (NP)-based assays have fulfilled the inclusion criteria and included in this systematic review. The proposed platforms share the characteristics of accuracy, affordability, and swift time-to-result. Nanodiagnostics for TB now cover all clinical presentations of the disease, including active, drug-resistant, HIV-related, latent, and extrapulmonary TB. These advancements not only enhance the diagnostic landscape but also facilitate timely and effective treatment strategies, ultimately aiming to reduce the burden of TB worldwide. This review summarizes state-of-the-art knowledge of TB nanodiagnostics for the last 18 years. For fabrication concepts, detection strategies, and clinical performance, special consideration is given using various clinical specimens, and the suitability of TB nanodiagnostics for optimal MTB testing is evaluated. TB nanodiagnostics present a promising solution for meeting the stringent demands to end the TB epidemic by 2030.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/4639233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: In vitro and in vivo studies”","authors":"","doi":"10.1049/nbt2/9824354","DOIUrl":"10.1049/nbt2/9824354","url":null,"abstract":"<p>[Montazeri, S., et al.: Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: in vitro and in vivo studies. <i>IET Nanobiotechnol</i>. 17(3), 204–211 (2023). https://doi.org/10.1049/nbt2.12116]</p><p>In Section 2.9 [In vivo wound healing study], the statement “In the present study, 20 mature Sprague-Dawley rats weighing 200–300 g were used” was incorrect. This should have read: “In the present study, 25 mature Sprague-Dawley rats weighing 200–300 g were used.”</p><p>In Section 2.9 [In vivo wound healing study], the statement “The treatment started on day 0, wound dressing of each group was changed every day until the 14th day.” Was missing and is now included in the paragraph.</p><p>In Section 2.9 [In vivo wound healing study], the ethical approval statement was missing. The statement has now been provided below:</p><p>“All animal experiments in this study were performed with the approval of the Animal Ethics Committee of the Avicenna Research Institute under reference number IR.ACECR.Avicenna.REC.1396.19.”</p><p>In Section 2.10 [Wound histological analysis], the statement “After 14 days, the animals were sacrificed by spinal cord injury under anaesthesia” was incorrect. This should have read: “After 14 days, the animals were euthanized using carbon dioxide (CO₂).”</p><p>In Table 1, the standard deviation (SD) values were missing. The correct version of the table [with the SD values] is provided below:</p><p>The quality of the images in Figure 5a was inadvertently altered and decreased during the preparation and publication process. They have been replaced with images of higher quality.</p><p>The conclusions reached within the study remain unaffected. The authors apologize for these errors.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2025 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/9824354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}