IET nanobiotechnology最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148068554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect and Mechanism of Nanofiber Membrane Loaded With Curcumin Inclusion Compound in Periodontitis Oxidative Stress","authors":"Xinting Yang,&nbsp;Yingjie Xu,&nbsp;Shulong Guan,&nbsp;Ming Xu,&nbsp;Tengyu Ma,&nbsp;Yuanping Hao,&nbsp;Xinru Yang,&nbsp;Meihua Gao,&nbsp;Wanchun Wang,&nbsp;Yuguang Gao,&nbsp;Yuanfei Wang,&nbsp;Beibei Cong","doi":"10.1049/nbt2/6679414","DOIUrl":"10.1049/nbt2/6679414","url":null,"abstract":"<p>Periodontitis, a leading cause of tooth loss, is conventionally treated by mechanical curettage and antibiotics, which may cause adverse effects. Curcumin (Cur), a natural anti-inflammatory and antioxidant agent, shows therapeutic potential but suffers from low solubility and bioavailability. To overcome these limitations, we developed an electrospun nanofiber membrane (HP-Cur-IC/poly-L-lactone-co-ε-caprolactone [PLCL]) containing cyclodextrin-encapsulated Cur for localized sustained drug delivery within periodontal pockets. The resulting membrane exhibited improved water solubility, mechanical strength, and drug release profile. It demonstrated significant antioxidant and antibacterial effects, as evidenced by reductions in oxidative stress markers and bacterial viability. Furthermore, the membrane modulated the JAK2/STAT3 and ERK/JNK/p38 signaling pathways, alleviating oxidative damage in periodontal tissues. These findings suggest that the HP-Cur-IC/PLCL nanofiber membrane represents a promising nonsurgical strategy for periodontitis treatment.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/6679414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147686376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148092213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive and Cost-Effective Detection of Gamma Rays Using Cd-Functionalized QTF and MEMS–Based Microcantilever Sensors","authors":"Sawsan Aldusaymani,&nbsp;Shuruq Alotaibi,&nbsp;Khaled Shamma,&nbsp;Reem Alanazi,&nbsp;Mahmoud Algawati,&nbsp;Hamad Albrithen,&nbsp;Nadyah Alanazi,&nbsp;Abdullah N. Alodhayb","doi":"10.1049/nbt2/1902121","DOIUrl":"10.1049/nbt2/1902121","url":null,"abstract":"<p>Ionizing radiation poses a serious health risk to humans; therefore, sensitive detection is significant. Gamma rays are a form of ionizing radiation that can pass through the human body and interact with matter through ionization. Several techniques have been conventionally used to detect ionizing radiation. Despite the advantages of current methods, it is important to develop alternative approaches that can provide cost-effective, sensitive, and low-cost radiation detection. Quartz tuning fork (QTF) and microelectromechanical systems (MEMSs) sensors are some of these techniques that have drawn increasing interest. In this work, we aim to detect low doses of gamma radiation with fast response time using a QTF and MEMS sensors coated with cadmium chloride (CdCl₂) with different immersion times 2, 8, and 17 h. The structural and optical properties of quartz and silicon-coated CdCl₂ thin film were also investigated before and after gamma irradiation with different immersion times 2, 8, and 17 h. These properties were analyzed using X-ray photoelectron spectroscopy (XPS), ultraviolet–visible spectroscopy (UV–VIS), atomic force microscopy (AFM), and spectroscopic ellipsometry (SE). Comparing the resonance frequency shift (RFS) for the three QTFs–coated CdCl₂, measured using the Quester <i>Q</i>₁₀, the RFS of QTF₈ (8 h immersion time) had an excellent response and was about 1800 Hz in the irradiation region. The root mean square (RMS) roughness (Sq) using AFM and the transmittance using UV–VIS of the samples increase after gamma irradiation. On the other side, the MEMSs–coated CdCl₂ results illustrated that the RFS of MEMS₂ (2 h immersion time) was about 4.2 Hz in the irradiation region, measured using the Picomeasure PM3. AFM and SE supported MEMSs results. Both showed a clear increase in the surface roughness of the CdCl₂ as a coating layer onto the silicon substrate after irradiation. Finally, the QTF–based sensor (QTF₈) was more sensitive than the MEMS–based sensor (MEMS₂) which strongly makes a candidate to be a sensitive detector for low gamma rays.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/1902121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148093279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stellera chamaejasme-Driven Green Nanosilver for Catalysis of Bacteria and Toxic Dye","authors":"Yaxin Hu,&nbsp;Bingbing Li,&nbsp;Yonglin Sun,&nbsp;Sakil Mahmud","doi":"10.1049/nbt2/1723949","DOIUrl":"10.1049/nbt2/1723949","url":null,"abstract":"<p>Metal nanoparticles produced via green chemistry routes offer broad potential for nanotechnology, yet their practical deployment is often constrained by colloidal instability and aggregation. Herein, silver nanoparticles (AgNPs) were biosynthesized using phytonutrients in <i>Stellera chamaejasme</i> L. <i>S. chamaejasme</i> root extract (SCRE), which served as both reducing and stabilizing agents. The synthesis was optimized through a one-variable-at-a-time (OVAT) approach, enabling precise control of reaction conditions. A characteristic surface plasmon resonance peak at 402 nm confirmed the formation of AgNPs and the appearance of a distinct yellow coloration. Under optimal conditions, the AgNPs were spherical, uniformly dispersed, and highly crystalline, with an average size of 23.3 ± 3.3 nm and a d-spacing of 0.236 nm. Selected-area electron diffraction (SAED) patterns confirmed a face-centered cubic (FCC) structure. The biogenic AgNPs demonstrated strong antibacterial efficacy, achieving &gt;98.5% reductions in <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and <i>Escherichia coli</i> (<i>E. coli</i>) with inhibition zones of 14.25 ± 1.43 mm and 12.34 ± 1.2 mm, respectively. Furthermore, they catalyzed the degradation of reactive yellow 179 dye, achieving nearly 100% removal within 30 min, following pseudo-first-order kinetics (<i>k</i> = 0.11155 min⁻¹, <i>R</i>² = 0.9973). These results highlight the potential of SCRE-mediated AgNPs for applications in antimicrobial coatings and sustainable wastewater treatment, particularly in textile effluents.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/1723949","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naïve Edible PVLNs: Emerging Versatile Biomaterial in Clinical Strategy","authors":"Le Zhou,&nbsp;Junqiu Ma,&nbsp;Jiawei Tian,&nbsp;Yao Xue,&nbsp;Chenyang Hu,&nbsp;Xueyan Zang,&nbsp;Wenrong Xu,&nbsp;Jiajia Jiang","doi":"10.1049/nbt2/3584549","DOIUrl":"10.1049/nbt2/3584549","url":null,"abstract":"<p>Naïve edible plant vesicle-like nanoparticles (PVLNs) could be acted as innovative therapeutic strategies due to their versatile role, such as antitumor, antiaging, anti-inflammation, and drug delivery. The advantages of edible PVLNs have displayed notable benefits including low toxicity, minimal side effects, nonimmunogenicity, and cost-effective scalability for large-scale production. In this review, we systematically summarize the methods including the extraction, isolation, and characterization of PVLNs; demonstrate a variety of bioactive components; and evaluate the application potential in disease treatment. PVLNs present promising potential as safe, sustainable, and multifunctional delivery systems for future applications in clinics and health.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/3584549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148087707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zn-Conjugated Graphene Oxide Nanoparticle–Mediated Inhibition of Human Islet Amyloid Polypeptide (hIAPP) Amyloid Formation: Their Synergistic Effects","authors":"Mahboobeh Nazari,&nbsp;Rahman Emamzadeh,&nbsp;Marzieh Rezaei,&nbsp;Maryam Yousefi,&nbsp;Soheila Mohammadi,&nbsp;Mansour Shahedi,&nbsp;Arash Minai-Tehrani,&nbsp;Ali Akbar Moosavi-Movahedi","doi":"10.1049/nbt2/6621537","DOIUrl":"10.1049/nbt2/6621537","url":null,"abstract":"<p>Human islet amyloid polypeptide (hIAPP) oligomers, formed through an accumulation pathway, are toxic to insulin-secreting pancreatic β-cells and are considered to contribute for β-cell death and insulin deficiency commonly observed in type 2 diabetes (T2D) patients. In this study, we investigated and compared the antiaggregation effects of several nanoparticles (NPs) including zinc acetate, graphene oxide (GO), and zinc-conjugated GO (GO–NH₂–Zn) on their interactions with hIAPP. For this purpose, GO was purchased and subsequently conjugated with zinc acetate. Recombinant hIAPP was produced and its amyloidogenic behavior was evaluated in the presence of different concentrations of GO, zinc acetate, and GO–NH₂–Zn. Thioflavin T (ThT) fluorescence spectroscopy was applied to examine the amyloid behavior of the protein. Additionally, the transmission electron microscopy (TEM) images of amyloid particles alone and in the presence of GO–NH₂–Zn NP were recorded. A cell toxicity assay revealed these NPs protected insulin-secreting NIT-1 pancreatic β-cells from hIAPP–induced toxicity. TEM images and ThT fluorescence spectra confirmed the reduction in hIAPP aggregation in the presence of GO–NH₂–Zn. Our results clearly demonstrated that both zinc acetate and GO extended the lag-phase latency to form amyloid fibrils, while GO–NH₂–Zn exerted a synergistic inhibitory effect on fibril formation. Furthermore, when GO–NH₂–Zn was incubated with fetal bovine serum (FBS) to form a hard corona mimicking in vivo circumstances, it effectively prevented the formation of amyloid as expected. Our study suggests that the GO–NH₂–Zn, as an antiaggregation NP, has potential for use in designing new nanomedicine agents to inhibit hIAPP fibril formation and treat T2D disease.</p>","PeriodicalId":13393,"journal":{"name":"IET nanobiotechnology","volume":"2026 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/nbt2/6621537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}