Immunological Investigations最新文献_第3页

The Role of Exosomes in Central Immune Tolerance and Myasthenia Gravis. 外泌体在中枢免疫耐受和重症肌无力中的作用

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1080/08820139.2024.2440772

Hanlu Zhang, Siyuan Luan, Fuqiang Wang, Lin Yang, Sicheng Chen, Zhiyang Li, Xuyang Wang, Wen-Ping Wang, Long-Qi Chen, Yun Wang

{"title":"The Role of Exosomes in Central Immune Tolerance and Myasthenia Gravis.","authors":"Hanlu Zhang, Siyuan Luan, Fuqiang Wang, Lin Yang, Sicheng Chen, Zhiyang Li, Xuyang Wang, Wen-Ping Wang, Long-Qi Chen, Yun Wang","doi":"10.1080/08820139.2024.2440772","DOIUrl":"10.1080/08820139.2024.2440772","url":null,"abstract":"Background: Immune homeostasis plays a crucial role in immunology andis dependent on both central and peripheral tolerance. Centraltolerance and peripheral tolerance occur in the thymus and thesecondary lymphoid tissues, respectively. Tolerance breakdown andimmune regulation defects can lead to autoimmune disorders. In thisreview article, we aimed to describe the role of exosomes inregulating central tolerance and provide a summary of their effectson the pathogenesis, diagnosis, and therapeutic potential inmyasthenia gravis (MG).Methods: Articles for this review wereidentified using the PubMed database.Results: As the primarylymphoid organ, the thymus is responsible for building an immunecompetent, yet self-tolerant of T-cell population. Thymic statesinclude thymoma, thymic hyperplasia, and thymic atrophy, which canexert a significant influence on the central immune tolerance andrepresent specific characteristics of MG. Previous studies have foundthat exosomes derived from human thymic epithelial cells carryantigen-presenting molecules and a wide range of tissue restrictedantigens, which may indicate a vital role of thymic exosomes in MG.Besides, exosomal miRNAs and lncRNAs may also play a critical role inthe pathophysiology of MG.Conclusion: This review provides thetherapeutic and diagnostic potential of exosomes in MG patients.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"412-434"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Differences Influence Depressive-Like Behaviour via Alterations in Microglial Expression of GIF-1, TREM2, and IL-1β in an Acute Lipopolysaccharide-Induced Murine Neuroinflammation Model. 在急性脂多糖诱导的小鼠神经炎症模型中，性别差异通过改变小胶质细胞中GIF-1、TREM2和IL-1β的表达影响抑郁样行为。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1080/08820139.2024.2440006

Rasha Alonaizan, Wafa K Alotaibi, Asma Alsulami, Fadwa M Alkhulaifi, Suliman Alomar

{"title":"Sex-Differences Influence Depressive-Like Behaviour via Alterations in Microglial Expression of GIF-1, TREM2, and IL-1β in an Acute Lipopolysaccharide-Induced Murine Neuroinflammation Model.","authors":"Rasha Alonaizan, Wafa K Alotaibi, Asma Alsulami, Fadwa M Alkhulaifi, Suliman Alomar","doi":"10.1080/08820139.2024.2440006","DOIUrl":"10.1080/08820139.2024.2440006","url":null,"abstract":"Background: Neurodegenerative diseases (NDs) have caused serious health issues worldwide. A growing body of evidence suggests a correlation between neuroinflammation and abnormal microglial activity with ND symptoms. Microglia survey play crucial roles in CNS during health and the injury. It is proposed that sex affects microglial roles during inflammation, resulting in mouse behavioural changes and expression alterations in key markers related to microglia functions.Methods: Male and female C57BL/6 mice were injected with a single dose of LPS (5 mg/kg, i.p.) or saline. After 48 h, an open field test was conducted, followed by brain tissues collection for measuring the expression of IGF-1, IL-1β and TREM2 and Immunohistochemistry (IHC) analysis for NLRP3 level.Results: Males displayed greater depressive-like behaviour in the OFT, with lower levels of IGF-1, IL-1β, and NLRP3 and high TREM2 expression. Female mice did not exhibit this behaviour, in contrast to male mice, they exhibited increased IL-1β and NLRP3 expression.Discussion: This study revealed that LPS-induced sex-specific changes in genes involved in neuronal cell survival caused behavioural alterations in male mice. Moreover, females had observed inflammatory responses that had no impact on behavioural alterations. Overall, both sexes exhibited sex-specific microglial activation states.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"317-333"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Control of T-Cell Subsets by Recombinant Human PLD2 in a Mouse Model of Allergic Asthma. 重组人PLD2对变应性哮喘小鼠模型t细胞亚群的差异控制。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-18 DOI: 10.1080/08820139.2024.2441468

Hui-Li Wang, Chuan-Xing Yu, Xiu-Ming Yu, Jun-Jin Lin, Yi-Zhong Chen, Ling Zhu

{"title":"Differential Control of T-Cell Subsets by Recombinant Human PLD2 in a Mouse Model of Allergic Asthma.","authors":"Hui-Li Wang, Chuan-Xing Yu, Xiu-Ming Yu, Jun-Jin Lin, Yi-Zhong Chen, Ling Zhu","doi":"10.1080/08820139.2024.2441468","DOIUrl":"10.1080/08820139.2024.2441468","url":null,"abstract":"Background: Phospholipase D2 (PLD2) enzymes are expressed on the cytoplasmic membrane of bacteria, fungi, plants, and animals. Recently, extensive research has linked PLD2 to the chronic inflammatory activity of cells. Allergic asthma is a chronic airway inflammation disease. In this context, a recombinant human phospholipase D2 (rhPLD2) was designed and modified from the wild-type PLD2 to study its effects in an ovalbumin (OVA) induced murine model of asthma.Methods: Hematoxylin and eosin staining was used for lung histopathology. Cytokine concentrations in bronchoalveolar lavage fluid (BALF) were measured using ELISA kits. The ratio of T-bet and GATA-3 expression level in spleen and lymph nodes following rhPLD2 administration was assessed through RT-PCR. Phenotyping analysis of Treg cells from peripheral blood was performed by flow cytometry.Results: It indicated that OVA-induced mice exhibited elevated pulmonary eosinophilia and allergic inflammation in the airways, along with increased expression of IFN-γ, IL-4 in the lung BALF. Administration of rhPLD2 alleviated lung inflammation and significantly reduce the number of eosinophils in peripheral blood and BALF. RhPLD2 also reversed the IFN-γ/IL-4 ratio at the molecular level in BALF and the T-bet/GATA-3 ratio in lymphocytes of the lung, spleen, lymph nodes at the genetic level. Furthermore, FACS analysis demonstrated that rhPLD2 increased the frequency of both IL-10+Treg cells and CD25+ Treg cells.Conclusion: From a therapeutic perspective, rhPLD2 alleviates allergic airway inflammation by balancing Th1/Th2 homeostasis and increasing Treg cells. It has been shown to function in immunoregulatory activities in OVA-induced asthma mice.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"334-351"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome. 血清白细胞介素-37对急性呼吸窘迫综合征患者预后的价值。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1080/08820139.2024.2443253

Zhaohui Lu, Jie Yang, Xiaoguang Liu, Juan Wang, Youjun Pan, Jinjin Zhong, Xin Su

{"title":"Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome.","authors":"Zhaohui Lu, Jie Yang, Xiaoguang Liu, Juan Wang, Youjun Pan, Jinjin Zhong, Xin Su","doi":"10.1080/08820139.2024.2443253","DOIUrl":"10.1080/08820139.2024.2443253","url":null,"abstract":"Background: Acute respiratory distress syndrome (ARDS) is prominently characterized by uncontrolled inflammation and high mortality. The effect of interleukin-37 (IL-37) on the prognosis of ARDS remains unclear.Methods: This prospective cohort study detected and analyzed serum IL-37 levels on day 1 (baseline) in 128 patients with ARDS and 40 healthy controls, and on day 7 in patients with ARDS. Clinical and laboratory parameters were assayed. Survival status was tracked within 28-d of enrollment.Results: BaselineIL-37 concentration was lower in non-survivors (135.00 [87.75, 198.75] pg/mL) than in survivors (250.50 [173.25, 382.75] pg/mL) (p < .05). Non-survivors displayed a greater reduction in IL-37 levels from day 1-7 than survivors (49.87% vs. 40.09%) (p < .05). Baseline IL-37 levels were negatively associated with C-reactive protein, procalcitonin, and IL-6 levels. The area under the receiver operating characteristic curve of the baseline level and percentage decline in IL-37 was 0.755 and 0.809, respectively, for predicting 28-d mortality. Combining IL-37 with the acute physiology and chronic health evaluation II score further improved mortality prediction capability. Patients with ARDS with low IL-37 concentrations (<143.00 pg/mL) or a high percentage decline (≥44.76%) had a poorer survival rate than those with a high concentration or low percentage decline. The baseline IL-37 level and percentage decline independently predicted mortality in a univariate Cox regression model (p < .05).Conclusions: A low IL-37 level or significantly declining rate predicts higher 28-d mortality in patients with ARDS, indicating that IL-37 may be a promising prognostic biomarker.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"368-381"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial Fluid-Derived Exosomes from Osteoarthritis Patients Modulate Cell Surface Phenotypes of Monocytes and Cytokine Secretions. 骨关节炎患者滑膜液来源的外泌体调节单核细胞表面表型和细胞因子分泌。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI: 10.1080/08820139.2024.2443244

Nur Azira Mohd Noor, Ng Jun Quan, Nur Ainn Adabiah Adibah Mazlan, Asma Abdullah Nurul, Muhammad Rajaei Ahmad Mohd Zain, Maryam Azlan

{"title":"Synovial Fluid-Derived Exosomes from Osteoarthritis Patients Modulate Cell Surface Phenotypes of Monocytes and Cytokine Secretions.","authors":"Nur Azira Mohd Noor, Ng Jun Quan, Nur Ainn Adabiah Adibah Mazlan, Asma Abdullah Nurul, Muhammad Rajaei Ahmad Mohd Zain, Maryam Azlan","doi":"10.1080/08820139.2024.2443244","DOIUrl":"10.1080/08820139.2024.2443244","url":null,"abstract":"Background: Exosomes can be found in the synovial fluid of inflamed knee joints, which play a significant role in osteoarthritis (OA) progression. However, their role - in modulating the cellular environment within the body, particularly monocytes remain unexplored. This study aimed to evaluate the immunomodulatory effect of exosomes on monocytes.Methods: Exosomes were isolated by ultracentrifugation and characterized using nanoparticle tracking analysis (NTA), scanning electron microscopy (SEM), and Western blot. The effect of exosomes in modulating monocyte phenotypes as well as cytokine secretion were further assessed in a co-culture condition using flow cytometry and ELISA accordingly.Results: Exosomes were identified as spherical particles with a size distribution ranging from 30 nm to 150 nm. These nanoparticles intensely expressed exosome protein markers including CD9, CD63, CD81, and HSP70. The expression of HLA-DR, CD14, and CD11b on monocytes decreased in the presence of exosomes after 24 h of incubation, regardless of the dose. Exosomes significantly induced the release of anti-inflammatory cytokines IL-1Ra in a time- and dose-dependent manner, while TNF-α secretion remains unchanged regardless of the presence or absence of exosomes.Conclusion: This study highlights the immunoregulatory role of exosomes on monocytes, emphasizing the need for further studies into the underlying mechanism.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"352-367"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-142-3p Regulates Airway Inflammation Through PTEN/AKT in Children and Mice with Asthma. miR-142-3p通过PTEN/AKT调控哮喘儿童和小鼠气道炎症

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-05 DOI: 10.1080/08820139.2024.2438339

Huiman Huang, Bo Sun, Bo Li, Bing Wei

{"title":"miR-142-3p Regulates Airway Inflammation Through PTEN/AKT in Children and Mice with Asthma.","authors":"Huiman Huang, Bo Sun, Bo Li, Bing Wei","doi":"10.1080/08820139.2024.2438339","DOIUrl":"10.1080/08820139.2024.2438339","url":null,"abstract":"Background: Asthma is the most common chronic pulmonary disease in children. MicroRNAs (miRNAs) play a regulatory role in the occurrence and development of asthma. We aimed to explore the differential expression of miRNAs in the peripheral blood of children with asthma and identify a miRNA that can alleviate asthma inflammation.Methods: We used high-throughput sequencing to analyze differences in peripheral blood miRNA between children with acute asthma and healthy children, followed by target gene prediction and functional enrichment analysis. We inhibited miR-142-3p's expression in asthmatic mice to observe asthma symptoms. Inflammatory changes in lung tissue were assessed using hematoxylin and eosin staining and ELISA. Subsequently, the target gene of miR-142-3p was identified through a dual-luciferase reporter assay, and PTEN and AKT expression levels in mice lung tissue were determined using qPCR and western blot.Results: Fifty one differentially expressed miRNAs were identified. Inhibition of miR-142-3p expression in asthmatic mice reversed the downregulation of PTEN and activation of AKT in lung tissue, while also significantly alleviating symptoms and pulmonary inflammation in the asthmatic mice.Conclusion: miRNAs were differentially expressed in the peripheral blood of children with asthma. miR-142-3p regulates airway inflammation via the PTEN/AKT pathway.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"297-316"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological Mechanisms of Sensorineural Hearing Impairment in Patients with Different Clinical Phenotypes of Chronic Rhinosinusitis: A Narrative Review. 慢性鼻窦炎不同临床表型患者感音神经性听力障碍的免疫学机制：述评

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-09 DOI: 10.1080/08820139.2024.2437638

Aleksandar Peric, Dragoslava Djeric

{"title":"Immunological Mechanisms of Sensorineural Hearing Impairment in Patients with Different Clinical Phenotypes of Chronic Rhinosinusitis: A Narrative Review.","authors":"Aleksandar Peric, Dragoslava Djeric","doi":"10.1080/08820139.2024.2437638","DOIUrl":"10.1080/08820139.2024.2437638","url":null,"abstract":"Background: In this review article, we aimed to discuss the pathogenesis of sensorineural hearing loss (SNHL) in patients with different forms of chronic rhinosinusitis (CRS), with special reference to the connection of the immune response of the nasal and middle ear mucosa and inner ear structures.Methods: Articles for this review were identified using PubMed and Google© Scholar databases.Results: Different phenotypes of CRS may be associated with impaired function of the inner and outer cells of the organ of Corti. This is primarily due to the secondary CRS, which occurs within systemic diseases, such as granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Also, the tetrad, which includes CRS with nasal polyps, non-allergic asthma, hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), and so-called eosinophilic otitis media can lead to SNHL.Conclusion: Previous studies suggest that disrupted harmony between the immune response in the nasal and middle ear mucosa and inner ear structures may contribute to developing SNHL in CRS patients. This especially applies to CRS as part of NSAID-exacerbated respiratory disease and systemic necrotizing vasculitis, including GPA and EGPA. However, the exact mechanisms of development of SNHL in different forms of CRS have not been sufficiently investigated and new studies are necessary soon. Apart from the pathophysiological basis of SNHL, different therapeutic approaches in the clinical phenotypes of CRS have also been discussed.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"396-411"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Markers of Endotoxemia and Inflammation are Associated with Digital Ulcers in Systemic Sclerosis Patients. 内毒素血症和炎症标志物与系统性硬化症患者手指溃疡相关。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-03-18 DOI: 10.1080/08820139.2025.2478932

Chiara Pellicano, Alessandra Oliva, Amalia Colalillo, Cristina Luceri, Antonietta Gigante, Claudio Maria Mastroianni, Daniela Tornese, Valeria Carnazzo, Valerio Basile, Edoardo Rosato, Umberto Basile

{"title":"Markers of Endotoxemia and Inflammation are Associated with Digital Ulcers in Systemic Sclerosis Patients.","authors":"Chiara Pellicano, Alessandra Oliva, Amalia Colalillo, Cristina Luceri, Antonietta Gigante, Claudio Maria Mastroianni, Daniela Tornese, Valeria Carnazzo, Valerio Basile, Edoardo Rosato, Umberto Basile","doi":"10.1080/08820139.2025.2478932","DOIUrl":"https://doi.org/10.1080/08820139.2025.2478932","url":null,"abstract":"Background: The aim of this study was to evaluate the possible role of lipopolysaccharide-binding protein (LBP) and interleukin 6 (IL-6) in the development of digital ulcers (DUs) in Systemic sclerosis (SSc).Methods: 60 SSc patients were enrolled and tested for serum levels of LBP and IL-6. The development of DUs was assessed in a 12-month follow-up period.Results: Median LBP and IL-6 were 107.445 ng/mL and 10.8 pg/mL whilst 33.3% patients had LBP ≥ 11995 ng/mL and 51.7% patients had IL-6 ≥ 12.5 pg/mL. DUs history were present in 41.7% SSc patients and at follow-up 23.3% patients developed new DUs. Baseline LBP (14105 ng/mL vs 10355 ng/mL, p < .001) and IL-6 (195 pg/mL vs 9.4 ng/mL, p < .001) were higher in SSc patients with new DUs. The ROC curves showed a good diagnostic accuracy for a cut-off of LBP ≥ 11995 ng/mL [AUC = 0.804 (95% CI = 0.656-0.951), p < .001] and for a cut-off of IL-6 ≥ 12.5 pg/mL [AUC = 0.897 (95% CI = 0.783-1.000), p < .001]. Free survival from new DUs was shorter in SSc patients with increased LBP (p < .001) or IL-6 (p = .003).Conclusions: LPB or IL-6 could play a role in digital microvascular damage of SSc patients.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-14"},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Lasting Impact of IL-2: Approaching 50 Years of Advancing Immune Tolerance, Cancer Immunotherapies, and Autoimmune Diseases. IL-2 的持久影响：推动免疫耐受、癌症免疫疗法和自身免疫疾病发展的 50 年历程。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-03-17 DOI: 10.1080/08820139.2025.2479609

Prajita Paul, Cherry Choong, Joseph Heinemann, Rafid Al-Hallaf, Zainab Agha, Shaan Ganatra, Lina Abdulrahman, Agastya Sinha, Harrsha Kumar, Bardia Nourbakhsh, Abdel Rahim A Hamad

{"title":"The Lasting Impact of IL-2: Approaching 50 Years of Advancing Immune Tolerance, Cancer Immunotherapies, and Autoimmune Diseases.","authors":"Prajita Paul, Cherry Choong, Joseph Heinemann, Rafid Al-Hallaf, Zainab Agha, Shaan Ganatra, Lina Abdulrahman, Agastya Sinha, Harrsha Kumar, Bardia Nourbakhsh, Abdel Rahim A Hamad","doi":"10.1080/08820139.2025.2479609","DOIUrl":"https://doi.org/10.1080/08820139.2025.2479609","url":null,"abstract":"Background: The discovery of interleukin-2 (IL-2) and its receptor (IL-2R) almost 50 years ago revolutionized immunology, marking a pivotal moment in understanding T cell biology and immune regulation. Initially identified as a T cell growth factor, IL-2 unveiled critical insights into cytokine-mediated immune cell proliferation and differentiation.Methods: This review highlighted the characterization of IL-2R as a multi-chain receptor complex set a precedent for decoding cytokine receptor signaling. The unique interplay between IL-2 and its high-affinity receptor component, IL-2Rα, epitomizes the principle of specificity and efficiency in cytokine signaling, enabling precise immune modulation. Regulatory T cells (Tregs) exploit IL-2Rα high affinity to outcompete effector T cells for IL-2, ensuring immune tolerance and preventing autoimmunity.Results: Despite its foundational role in immune homeostasis, leveraging IL-2 for therapeutic purposes has proven challenging.Conclusion: IL-2-based therapies hold transformative potential in autoimmunity, cancer immunology, and transplantation, yet they remain elusive due to the complex balance between immunostimulatory and immunosuppressive effects. This review explores the milestones in IL-2 biology, its dualistic functions, and the ongoing quest to harness its therapeutic promise.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-15"},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Role and Therapeutic Potential of HLA-DR⁺ Regulatory T Cells in Systemic Lupus Erythematosus. HLA-DR+调节性T细胞在系统性红斑狼疮中的免疫调节作用和治疗潜力。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-03-11 DOI: 10.1080/08820139.2025.2475816

Jing Zhang, Bei Liao, Xiaobing Wang, Weijun Liu

{"title":"Immunomodulatory Role and Therapeutic Potential of HLA-DR+ Regulatory T Cells in Systemic Lupus Erythematosus.","authors":"Jing Zhang, Bei Liao, Xiaobing Wang, Weijun Liu","doi":"10.1080/08820139.2025.2475816","DOIUrl":"https://doi.org/10.1080/08820139.2025.2475816","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems. A key element in maintaining immune tolerance and preventing autoimmunity is the role of regulatory T cells (Treg cells). Among these, HLA-DR+ Treg cells represent a distinct subset, and their altered expression and functionality in SLE are closely associated with the progression of the disease. This review explores the biological characteristics of HLA-DR+ Treg cells, their mechanisms of action in SLE, as well as their potential and the challenges they pose as therapeutic targets.Methods and results: This review offers a comprehensive analysis of the mechanisms by which HLA-DR+ Treg cells regulate immune responses. It highlights their direct interactions with autoreactive T cells and antigen-presenting cells, which contribute to the suppression of autoimmunity. Additionally, the review explores the critical role of these cells in maintaining immune tolerance and their promising potential in the context of antigen-specific immunotherapy.Discussion: The potential of HLA-DR+ Treg cells in the treatment of systemic lupus erythematosus (SLE) is considerable, particularly due to their capacity to generate antigen-specific Tregs. The development of Treg-based therapies, including the expansion of both polyclonal and antigen-specific Tregs, is an area of active investigation. Nonetheless, several challenges persist, such as the need to optimize protocols for Treg generation and expansion, ensure the stability of the Treg phenotype, and address potential safety concerns associated with cellular therapies.Continued research is essential to fully harness the potential of HLA-DR+ Treg cells in the treatment of SLE and other autoimmune diseases.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-18"},"PeriodicalIF":2.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0