Immunological Investigations最新文献_第2页

Differential Methylation Patterns Predict HBsAg Seroconversion in Hepatitis B Virus Reactivation Patients. 不同甲基化模式预测乙型肝炎病毒再激活患者HBsAg血清转化。

IF 2.4 4区医学

Immunological Investigations Pub Date : 2025-07-21 DOI: 10.1080/08820139.2025.2532630

Jayesh Kumar Sevak, Mojahidul Islam, Gayantika Verma, Anoushka Saxena, Preedia Babu E, Shahana Parveen, Ankur Jindal, Manoj Kumar Sharma, Gayatri Ramakrishna, Syed Naqui Kazim, Shiv Kumar Sarin, Nirupama Trehanpati

{"title":"Differential Methylation Patterns Predict HBsAg Seroconversion in Hepatitis B Virus Reactivation Patients.","authors":"Jayesh Kumar Sevak, Mojahidul Islam, Gayantika Verma, Anoushka Saxena, Preedia Babu E, Shahana Parveen, Ankur Jindal, Manoj Kumar Sharma, Gayatri Ramakrishna, Syed Naqui Kazim, Shiv Kumar Sarin, Nirupama Trehanpati","doi":"10.1080/08820139.2025.2532630","DOIUrl":"10.1080/08820139.2025.2532630","url":null,"abstract":"Background: Hepatitis B virus (HBV) modulates immune epigenetic landscape. Therefore, we investigated immune epigenetic landscape in HBsAg seroconverters and non-seroconverters.Methods: Sixteen rHBV patients including seroconverters (SC, n = 7) and non-seroconverters (NSC, n = 9) at baseline and week 24 were recruited. Age matched naïve chronic hepatitis B patients (nCHBV, n = 7) and healthy controls (HC, n = 6) were also included. PBMCs and plasma were subjected to genome-methylation, gene-expression, immunophenotyping, functionality, and cytokines analysis using Reduced Representation Bisulfite Sequencing (RRBS), qRT-PCR, flow-cytometry, and cytokine-bead-array.Results: In rHBV patients, as compared to nCHBV, there is significant hypomethylation (p < .05) of epigenetic remodellers and immune and metabolic genes like KDM2B, NCOR2 and GATA6, TGF-β, IL-6, IRF8, RPTOR, HK3, specifically at CpG islands. At baseline, HBsAg SC had hypomethylation of KDM2B, COX19, IRF8, TLR5, and hypermethylation of LAG3 compare to NSC. By week-24, SC demonstrated hypomethylation of IL17RA, IFN-γ, TGF-β, STAT5B (p < .05) and correlated with increased plasma IL-6 (p = .009) and decreased LAG3 (p = .01). At baseline and 24 weeks, SC depicted differentiation of HBV-specific CD8+, Tfh, and Th1/17 cells.Conclusion: This study identifies hypomethylation of immune genes suggesting enhanced immune response and viral clearance in SC. Conversely, nCHBV and NSC consistently exhibited hypomethylation of LAG3 and TOX, contributing to immune exhaustion.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-21"},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory T Cells in Colon Cancer: Implications for Pathogenesis, Prognosis and Emerging Therapeutic Strategies. 调节性T细胞在结肠癌中的作用：发病机制、预后和新出现的治疗策略。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-21 DOI: 10.1080/08820139.2025.2529970

Faris Anad Muhammad, Abdulkareem Shareef, S Renuka Jyothi, Sachin Kumar, Ashish Singh Chauhan, Apurav Gautam, Maksuda Ashurova, Hayder Naji Sameer, Ahmed Yaseen, Zainab H Athab, Mohaned Adil, Ayda Abrari, Mahyar Mohammadifard

{"title":"Regulatory T Cells in Colon Cancer: Implications for Pathogenesis, Prognosis and Emerging Therapeutic Strategies.","authors":"Faris Anad Muhammad, Abdulkareem Shareef, S Renuka Jyothi, Sachin Kumar, Ashish Singh Chauhan, Apurav Gautam, Maksuda Ashurova, Hayder Naji Sameer, Ahmed Yaseen, Zainab H Athab, Mohaned Adil, Ayda Abrari, Mahyar Mohammadifard","doi":"10.1080/08820139.2025.2529970","DOIUrl":"https://doi.org/10.1080/08820139.2025.2529970","url":null,"abstract":"Introduction: Colon cancer is a highly heterogeneous malignancy with significant global incidence and mortality. The tumor microenvironment (TME) plays a pivotal role in disease progression and treatment response. Among key components of the TME are tumor-infiltrating lymphocytes (TILs), particularly regulatory T cells (Tregs) and effector T cells, whose balance influences cancer outcomes.Methods: This review analyzes recent findings regarding the role of Treg cells in colon cancer progression by evaluating preclinical and clinical studies that explore immune cell composition, function, and modulation within the TME.Results: Treg cells demonstrate a dual role in colon cancer. While they suppress effective anti-tumor immune responses, facilitating immune evasion, they may also mitigate chronic inflammation, which contributes to carcinogenesis. High intratumoral Treg levels are correlated with poor prognosis, reduced immunotherapy efficacy, and lower overall survival. Strategies to deplete or reprogram Tregs, such as immune checkpoint inhibition, modulation of T cell plasticity, and selective targeting, have shown promise in enhancing anti-tumor immunity.Discussion: Complete depletion of Tregs risks inducing autoimmune toxicity. Therefore, a precise understanding of Treg cell subsets and functions is essential. This review highlights the importance of developing targeted immunotherapeutic strategies that modulate Treg activity while preserving immune homeostasis in colon cancer treatment.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-52"},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIM-3 in Prostate Health: A Crucial Factor in the Microbiome-Immune Balance. 前列腺健康中的TIM-3：微生物群-免疫平衡的关键因素。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-21 DOI: 10.1080/08820139.2025.2533484

Elmira Davasaz Tabrizi, Mazdak Ganjalikhani Hakemi

{"title":"TIM-3 in Prostate Health: A Crucial Factor in the Microbiome-Immune Balance.","authors":"Elmira Davasaz Tabrizi, Mazdak Ganjalikhani Hakemi","doi":"10.1080/08820139.2025.2533484","DOIUrl":"https://doi.org/10.1080/08820139.2025.2533484","url":null,"abstract":"This review highlights the emerging role of the immune checkpoint receptor T cell immunoglobulin and mucin-domain containing-3 (TIM-3) as a crucial modulator in the prostate's microbiome-immune axis, with significant implications for prostate-related diseases such as prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer. These conditions reflect the prostate's susceptibility to immune dysregulation, which is influenced by microbial communities and their metabolites. TIM-3, already known for its role in immune regulation in cancer and chronic infections, is now recognized for its potential to shape immune responses within the prostate by modulating regulatory T cells (Tregs) and influencing inflammation and tolerance. Microbial metabolites, such as short-chain fatty acids (SCFAs), and pro-inflammatory bacterial components like lipoteichoic acid can alter TIM-3 expression, contributing to immune imbalance. Therapeutic strategies targeting TIM-3 aim to restore immune equilibrium, while complementary microbiome-focused approaches, such as probiotics, dietary interventions, pH modulation, and enhancement of epithelial antimicrobial peptides, may further prevent microbial overgrowth and inflammation. Drawing parallels with therapies for inflammatory bowel disease and other immune-related conditions, the integration of TIM-3 blockade with microbiota modulation presents a promising avenue for managing chronic prostate inflammation and cancer. This review proposes a multi-omics and bioinformatics-driven framework for developing TIM-3-centered diagnostic and therapeutic strategies.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-31"},"PeriodicalIF":2.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Immune Microenvironment on Osteoblast Differentiation. 免疫微环境在成骨细胞分化中的作用。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-14 DOI: 10.1080/08820139.2025.2527246

Mengtao Wang, Zhicheng Cao, Wenhui Hu, Zhiwen Dong, Yufeng Wang, Changyan Ma, Cheng Tang

{"title":"The Role of the Immune Microenvironment on Osteoblast Differentiation.","authors":"Mengtao Wang, Zhicheng Cao, Wenhui Hu, Zhiwen Dong, Yufeng Wang, Changyan Ma, Cheng Tang","doi":"10.1080/08820139.2025.2527246","DOIUrl":"https://doi.org/10.1080/08820139.2025.2527246","url":null,"abstract":"Background: Osteoblasts, derived from mesenchymal stem cells (MSCs) in the bone marrow, are responsible for bone formation. Osteoblast differentiation is orchestrated by a spectrum of biological signals, with immune-derived components serving as indispensable regulators in this network. Dysfunctional osteoblast differentiation underlies bone-related pathologies such as osteoarthritis, rheumatoid arthritis, and osteoporosis, where immune dysregulation drives inflammatory cascades that disrupt the osteoblast-osteoclast equilibrium. This bidirectional crosstalk has propelled the emergence of osteoimmunology as a pivotal discipline.Methods: By analyzing immune cells and cytokines in the immune microenvironment, we synthesize evidence on their roles in regulating osteoblast differentiation, with focus on inflammatory bone disorders, particularly in osteoarthritis.Results: Thus, bone growth, development, and healing are intrinsically coupled with the dynamics of the immune microenvironment, which contributes to subchondral bone sclerosis and disease progression in osteoarthritis. Therefore, targeting immune-osteoblast crosstalk offers therapeutic potential for bone pathologies.Conclusion: This review consolidates recent advances in understanding how the immune microenvironment impacts osteoblast differentiation, aiming to provide novel insights for clinical strategies targeting bone repair and disease mitigation.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-50"},"PeriodicalIF":2.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between UBQLN Family Gene and Systemic Lupus Erythematosus: A Case Control Study. UBQLN家族基因与系统性红斑狼疮的关系：一项病例对照研究

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-08 DOI: 10.1080/08820139.2025.2530726

Qing Wu, Yong Liu, Xinyi Zhao, Qin Zhang

{"title":"Association between UBQLN Family Gene and Systemic Lupus Erythematosus: A Case Control Study.","authors":"Qing Wu, Yong Liu, Xinyi Zhao, Qin Zhang","doi":"10.1080/08820139.2025.2530726","DOIUrl":"https://doi.org/10.1080/08820139.2025.2530726","url":null,"abstract":"Objective: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder. This study aims to investigate the association between UBQLN family genes and the systemic lupus erythematosus (SLE).Methods: In the present study, plasma levels of UBQLN family genes were evaluated in 113 SLE patients and 115 healthy controls. The relative mRNA expression levels of UBQLN family genes in peripheral blood lymphocytes were quantified using qRT-PCR. Additionally, UBQLN protein levels in serum were measured using enzyme-linked immunosorbent assay (ELISA). The diagnostic potential of UBQLN family genes was evaluated by calculating the area under the receiver operating characteristic (ROC) curve. Correlation analysis was conducted using Pearson and Spearman methods, while logistic regression was employed for one-way analysis.Results: The mRNA expression levels of UBQLN4 and UBQLN2 SLE patients were significantly lower than those in the control group (both p < .05). Moreover, the combined diagnostic performance of UBQLN4 and UBQLN2 surpassed that of each gene alone, with a combined AUC of 0.697. The protein expression levels of UBQLN1, UBQLN2, and UBQLN4 were also significantly reduced in SLE patients compared to controls (all p < .05).Conclusion: These findings suggest that UBQLN family genes in peripheral blood lymphocytes may play a role in the pathogenesis of SLE and hold promise as biomarkers for the diagnosis and treatment of the disease.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superloaded Multiplexed scRNA-seq Data Preserves Primary Immune Cell Heterogeneity but Necessitates Stringent Doublet Removal. 过载多路scRNA-seq数据保留了原代免疫细胞的异质性，但需要严格的双偶去除。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-01 Epub Date: 2025-01-30 DOI: 10.1080/08820139.2025.2457039

Henry Sserwadda, Jung Ho Lee, Brian H Lee, Sunyoung Jung, Yoon Ji Bang, Beom Keun Cho, Hyo Jeong Nam, So-Jung Choi, Jeong-Ryeol Gong, Hyun Seung Choi, Chong Wook Jung, Hyeyeon Chung, Hyunsung Nam, Eung Re Kim, Hyun Je Kim, Chung-Gyu Park, Yong-Hee Kim

{"title":"Superloaded Multiplexed scRNA-seq Data Preserves Primary Immune Cell Heterogeneity but Necessitates Stringent Doublet Removal.","authors":"Henry Sserwadda, Jung Ho Lee, Brian H Lee, Sunyoung Jung, Yoon Ji Bang, Beom Keun Cho, Hyo Jeong Nam, So-Jung Choi, Jeong-Ryeol Gong, Hyun Seung Choi, Chong Wook Jung, Hyeyeon Chung, Hyunsung Nam, Eung Re Kim, Hyun Je Kim, Chung-Gyu Park, Yong-Hee Kim","doi":"10.1080/08820139.2025.2457039","DOIUrl":"10.1080/08820139.2025.2457039","url":null,"abstract":"Background: Single-cell RNA sequencing (scRNA-seq) has improved our ability to characterize rare cell populations. In practice, cells from different tissues or donors are simultaneously loaded onto the instrument (multiplexed) at the recommended (standard loading) or higher (superloading) numbers to save time and money. Although cost-effective, superloading can stymie computational analyses owing to high multiplet rates and sample complexity.Methods: We compared the effects of superloading on multiplexed single-cell gene expression and T cell receptor (TCR) data generated from human thymus and blood samples from different donors.Results: Minimal transcriptomic differences were observed between the data generated by either standard or superloading. Irrespective of the loading cell number, we found that over 50% of the T cells expressing multiple TCR chains were doublets.Conclusion: Multiple samples can be run simultaneously without compromising data quality and subsequent analyses. However, an additional doublet removal step based on TCR configuration may improve the accuracy of T cell analysis.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"695-711"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-7 Immunotherapies: Current Applications and Engineering Opportunities. IL-7免疫疗法：目前的应用和工程机会。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-01 Epub Date: 2025-02-21 DOI: 10.1080/08820139.2025.2464055

Emily Ariail, Benjamin Biggs, Rowan O'Flanagan, Jonathan P Schneck

{"title":"IL-7 Immunotherapies: Current Applications and Engineering Opportunities.","authors":"Emily Ariail, Benjamin Biggs, Rowan O'Flanagan, Jonathan P Schneck","doi":"10.1080/08820139.2025.2464055","DOIUrl":"10.1080/08820139.2025.2464055","url":null,"abstract":"Background: IL-7 is a cytokine that plays a critical role in the development and proliferation of many different immune cells. IL-7 is notably important for the proper development and activity of T cells and B cells. Additionally, the cytokine plays a role in the function of natural killer cells and dendritic cells. Because of this innate biological activity, IL-7 has gained traction as a potential immunotherapy for multiple applications.Methods: We conducted a comprehensive literature review to explore the physiological role of IL-7 and current applications harnessing the biology of IL-7 as a therapeutic. We also investigated the ways in which IL-7 is being engineered to enhance its therapeutic potential.Results: Notably, IL-7 has demonstrated efficacy in adoptive cell therapy models and as a vaccine adjuvant. The cytokine has also been used as a treatment for sepsis and other chronic infections. To further enhance its therapeutic efficacy, IL-7 has been engineered by fusing the cytokine to antibody fragments or other bioactive or targeting molecules. These engineered IL-7 therapeutics seek to improve the cytokine's pharmacokinetic and immunological properties and reduce off-target effects.Conclusion: IL-7 immunotherapies largely remain at the preclinical stage, but there is growing interest in IL-7's many therapeutic applications and increasing opportunities to further engineer the molecule for future clinical translation.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"604-622"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal Tubular Epithelial Cell-Derived IL-7 Drives Expansion and Protective Effects of Double-Negative T Cells in Acute Kidney Injury. 肾小管上皮细胞来源的IL-7驱动急性肾损伤中双阴性T细胞的扩增和保护作用。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-01 Epub Date: 2025-02-06 DOI: 10.1080/08820139.2025.2462537

Mohanraj Sadasivam, Sanjeev Noel, Kyungho Lee, Sepideh Gharaie, Hamid Rabb, Abdel Rahim A Hamad

{"title":"Renal Tubular Epithelial Cell-Derived IL-7 Drives Expansion and Protective Effects of Double-Negative T Cells in Acute Kidney Injury.","authors":"Mohanraj Sadasivam, Sanjeev Noel, Kyungho Lee, Sepideh Gharaie, Hamid Rabb, Abdel Rahim A Hamad","doi":"10.1080/08820139.2025.2462537","DOIUrl":"10.1080/08820139.2025.2462537","url":null,"abstract":"Background: Previous studies have demonstrated that double-negative (DN) αβ T cells play an important role in immune responses during ischemic acute kidney injury (AKI). Here, we investigate the role of γ-chain cytokines in driving DN T cell proliferation in steady state and AKI, focusing on IL-2, IL-7, and IL-15.Methods: We assessed DN T cell proliferation in vitro in response to IL-2, IL-7, and IL-15, with co-culture experiments using renal tubular epithelial cells (RTECs) and IL-7 blockade. In vivo, wild-type and IL-7r knockout mice were studied to evaluate the impact of IL-7 on DN T cell expansion and kidney function during AKI. Human RTECs confirmed the relevance of these findings.Results: All three cytokines promoted DN T cell proliferation in vitro, with IL-7 inducing the most robust expansion. Co-culture experiments showed RTECs as a key IL-7 source, and blockade reduced DN T cell expansion. In vivo, IL-7 complexes administered to wild-type mice increased DN T cells and selectively expanded the PD-1+ subset. IL-7 deficiency worsened renal outcomes during AKI. Human RTECs activated peripheral human DN T cells in vitro.Conclusion: These results establish IL-7 as pivotal for DN T cell expansion and highlight RTECs' role in DN T cell homeostasis.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"623-636"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Role and Therapeutic Potential of HLA-DR⁺ Regulatory T Cells in Systemic Lupus Erythematosus. HLA-DR+调节性T细胞在系统性红斑狼疮中的免疫调节作用和治疗潜力。

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-01 Epub Date: 2025-03-11 DOI: 10.1080/08820139.2025.2475816

Jing Zhang, Bei Liao, Xiaobing Wang, Weijun Liu

{"title":"Immunomodulatory Role and Therapeutic Potential of HLA-DR+ Regulatory T Cells in Systemic Lupus Erythematosus.","authors":"Jing Zhang, Bei Liao, Xiaobing Wang, Weijun Liu","doi":"10.1080/08820139.2025.2475816","DOIUrl":"10.1080/08820139.2025.2475816","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems. A key element in maintaining immune tolerance and preventing autoimmunity is the role of regulatory T cells (Treg cells). Among these, HLA-DR+ Treg cells represent a distinct subset, and their altered expression and functionality in SLE are closely associated with the progression of the disease. This review explores the biological characteristics of HLA-DR+ Treg cells, their mechanisms of action in SLE, as well as their potential and the challenges they pose as therapeutic targets.Methods and results: This review offers a comprehensive analysis of the mechanisms by which HLA-DR+ Treg cells regulate immune responses. It highlights their direct interactions with autoreactive T cells and antigen-presenting cells, which contribute to the suppression of autoimmunity. Additionally, the review explores the critical role of these cells in maintaining immune tolerance and their promising potential in the context of antigen-specific immunotherapy.Discussion: The potential of HLA-DR+ Treg cells in the treatment of systemic lupus erythematosus (SLE) is considerable, particularly due to their capacity to generate antigen-specific Tregs. The development of Treg-based therapies, including the expansion of both polyclonal and antigen-specific Tregs, is an area of active investigation. Nonetheless, several challenges persist, such as the need to optimize protocols for Treg generation and expansion, ensure the stability of the Treg phenotype, and address potential safety concerns associated with cellular therapies.Continued research is essential to fully harness the potential of HLA-DR+ Treg cells in the treatment of SLE and other autoimmune diseases.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"677-694"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of TAK-242-Induced Histone Lactylation in Modulating Repair Macrophage Transformation in Ulcerative Colitis. tak -242诱导组蛋白乳酸化在溃疡性结肠炎修复巨噬细胞转化中的作用

IF 2.9 4区医学

Immunological Investigations Pub Date : 2025-07-01 Epub Date: 2025-02-17 DOI: 10.1080/08820139.2025.2465644

Chenfei Zhang, Xiaoling Huang

{"title":"Role of TAK-242-Induced Histone Lactylation in Modulating Repair Macrophage Transformation in Ulcerative Colitis.","authors":"Chenfei Zhang, Xiaoling Huang","doi":"10.1080/08820139.2025.2465644","DOIUrl":"10.1080/08820139.2025.2465644","url":null,"abstract":"Background: Ulcerative Colitis (UC) is a condition that causes ulceration and inflammation of the intestinal epithelium. UC treatment depends on macrophages' phenotypic switch from pro-inflammatory (M1) to anti-inflammatory and tissue-repairing (M2). It has been reported that the epigenetic alteration of histone lactylation affects macrophage activity and phenotype. TAK-242, a TLR4 inhibitor, stimulates histone lactylation to generate reparative M2 UC macrophages.Methods: This review highlighted the significance in terms of introduction, an overview of histone lactylation, the mechanism of action of TAK-242 in regulating inflammatory responses, the relationship between TAK-242 to histone lactylation, the potential role of TAK-242-dependent histone lactylation in macrophage polarization, the role of repair macrophages in ulcerative colitis and regulation of repair macrophages by histone lactylation.Results: Novel treatments for ulcerative colitis involve the use of TAK-242 to enhance histone lactylation, which in turn boosts macrophage function and promotes mucosal healing.Conclusion: TAK-242 exhibits therapeutic potential in the treatment of UC, and this research suggests further investigation and clinical trials to enhance patient outcomes.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"658-676"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0