Immunological Investigations最新文献_第10页

Upregulation, Functional Association, and Correlated Expressions of TRPV1 and TRPA1 During Telmisartan-Driven Immunosuppression of T Cells 替米沙坦驱动的 T 细胞免疫抑制过程中 TRPV1 和 TRPA1 的上调、功能关联和相关表达

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-07 DOI: 10.1080/08820139.2024.2329203

Tathagata Mukherjee, Kshyama Subhadarsini Tung, Parthasarathi Jena, Chandan Goswami, Subhasis Chattopadhyay

引用次数: 0

Immune Dysregulation in Chronic Obstructive Pulmonary Disease 慢性阻塞性肺病的免疫失调

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-04 DOI: 10.1080/08820139.2024.2334296

Xichen Pang, Xiaoju Liu

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Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis. 血小板/淋巴细胞、中性粒细胞/淋巴细胞和白细胞介素-37/白细胞介素-17 的比例在类风湿关节炎的发生和治疗中的作用。

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-03-13 DOI: 10.1080/08820139.2023.2299687

Yan Meng, Xuan-Lin Cai, Shan Cong, Jiao Sun, Yong-Wei Hu, Yan-Qin Gu, Xiu-Min Ma, Li Luo

{"title":"Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis.","authors":"Yan Meng, Xuan-Lin Cai, Shan Cong, Jiao Sun, Yong-Wei Hu, Yan-Qin Gu, Xiu-Min Ma, Li Luo","doi":"10.1080/08820139.2023.2299687","DOIUrl":"10.1080/08820139.2023.2299687","url":null,"abstract":"This study was designed to investigate the correlation of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and interleukin (IL)-37/IL-17 ratio with the incidence/treatment of rheumatoid arthritis (RA). Firstly, fifty-eight patients with RA treated at the first affiliated hospital of Xinjiang Medical University from January 2018 to January 2019 were selected as the RA group; forty-nine healthy volunteers were enrolled in the control group. RA patients were treated with disease-modifying anti-rheumatic drugs (DMARDs). Next, the NLR, PLR, IL-37, IL-17 and 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) were deleted in two groups. Subsequently, Spearman correlation analysis was adopted for the correlations of various indicators before and after treatment in two groups. According to the analysis results, the levels of NLR, PLR, IL-37, and IL-17 before treatment in the RA group were higher than those in the control group (P < .05), but the difference in the IL-37/IL-17 level between the two groups was not significant (P > .05). After treatment, NLR, PLR, and IL-37/IL-17 levels were significantly reduced in RA patients (P < .05). NLR and PLR were significantly positively correlated with DAS28-ESR, ESR and C-reactive protein (CRP), of which represented the disease activity of RA. NLP was strongly correlated with IL-37/IL-17. Collectively, NLR, PLR, IL-37, and IL-17 are closely related to the occurrence of RA. In addition, NLR and IL-37/IL-17 are more suitable than PLR in reflecting the therapeutic effect. Therefore, IL-37/IL-17 can be considered as a new indicator for reflecting the treatment effectiveness of RA.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"464-474"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Hydrogel Based Allergen-Coated Gold Nanoparticles for Topical Administration: A Possible Epicutaneous Immunotherapy in Pollen-Sensitized Mice? 用于局部给药的水凝胶过敏原包裹金纳米粒子：花粉过敏小鼠可能采用的表皮免疫疗法？

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-01-03 DOI: 10.1080/08820139.2023.2298397

Safoora Pordel, MohammadAli Rezaee, Malihe Moghadam, Mojtaba Sankian

{"title":"The Hydrogel Based Allergen-Coated Gold Nanoparticles for Topical Administration: A Possible Epicutaneous Immunotherapy in Pollen-Sensitized Mice?","authors":"Safoora Pordel, MohammadAli Rezaee, Malihe Moghadam, Mojtaba Sankian","doi":"10.1080/08820139.2023.2298397","DOIUrl":"10.1080/08820139.2023.2298397","url":null,"abstract":"Background: The rapid uptake of antigens by antigen-presenting cells (APCs) and their migration to draining lymph nodes in the initial hours after antigen administration in epicutaneous allergen specific immunotherapy (EPIT) prompted us to investigate whether the topical administration of allergens without patch application could alleviate allergy in pollen-sensitized mice. We evaluated the immunotherapeutic effect of topically administering hydrogel-based Gold nanoparticles (AuNPs) loaded with a total extract of Platanus orientalis pollen (Pla. ext (50 μg)-AuNPs) on intact skin.Methods: Mice sensitized to P. orientalis pollen were divided into three groups and treated with Pla. ext (50 μg)-AuNPs: 1) patch with Pla. ext (50 μg)-AuNPs, 2) patch with Pla. ext (50 μg)-AuNPs in combination with hydrogel, and 3) topical application of Pla. ext (50 μg)-AuNPs in combination with hydrogel. The immunotherapeutic effects were evaluated by measuring serum specific and total IgE antibodies, total cell and eosinophil count in nasopharyngeal lavage fluid, cytokines in the supernatants of re-stimulated splenocytes by the total extract, and histological examination of lung and nasal mucosa.Results: Topical administration of Pla. ext (50 μg)-AuNPs, like patch-based administration, significantly downregulated specific and total IgE and IL-4 production, promoted secretion of IFN-γ and IL-10, markedly reduced the number of inflammatory cells, particularly eosinophils, in nasopharyngeal lavage fluid (p < .05), and inhibited inflammation and pathological damage in lung and nasal mucosa.Conclusion: Our results suggest that topical administration of AuNPs loaded with P. orientalis total pollen extract on intact skin could be a potential application for EPIT in the P. orientalis pollen -sensitized mice.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"523-539"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-98-5p Inhibits IFI44L-Mediated Differentiation of Dendritic Cells and Activation of Interferon Pathway in Systemic Lupus Erythematosus. MicroRNA-98-5p 可抑制 IFI44L 介导的树突状细胞分化和系统性红斑狼疮干扰素通路的激活

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-01-10 DOI: 10.1080/08820139.2023.2300346

Xin Huang, Yixin Tan, Ruifang Wu, Qianwen Li, Shuaihantian Luo

{"title":"MicroRNA-98-5p Inhibits IFI44L-Mediated Differentiation of Dendritic Cells and Activation of Interferon Pathway in Systemic Lupus Erythematosus.","authors":"Xin Huang, Yixin Tan, Ruifang Wu, Qianwen Li, Shuaihantian Luo","doi":"10.1080/08820139.2023.2300346","DOIUrl":"10.1080/08820139.2023.2300346","url":null,"abstract":"MicroRNA-98-5p (miR-98-5p) plays a protective role in the pathogenesis of autoimmune diseases through anti-inflammatory effects, but little is known about its role in Systemic lupus erythematosus (SLE). Our previous study suggested Interferon-inducible 44 like (IFI44L) overexpressed in monocytes which contributes to the pathogenesis of SLE by enhancing the maturation and functions of monocyte-derived dendritic cells (Mo-DCs), and miR-98-5p can regulate the expression of IFI44L. In this study, we identified miR-98-5p lowly expressed in both peripheral blood mononuclear cells (PBMCs) and monocytes of SLE patients along with high expression of IFI44L. IFI44L serves as target gene of miR-98-5p which inhibits differentiation of Mo-DCs and IFI44L-mediated activation of interferon pathway. We further showed that miR-98-5p promotes methylation of the IFI44L promoter to down-regulate its expression in SLE. Our results reveal an important role for miR-98-5p in the IFI44L-mediated immune imbalance of SLE and suggest a potential therapeutic target for SLE in the future.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"475-489"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139416926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Metabolic Regulation of Macrophage Polarization State. 巨噬细胞极化状态的代谢调节研究进展。

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-01-11 DOI: 10.1080/08820139.2024.2302828

Xin Liu, Ruoxuan Xiang, Xue Fang, Guodong Wang, Yuyan Zhou

引用次数: 0

Etiopathogenesis of Psoriasis: Integration of Proposed Theories. 银屑病的发病机制：拟议理论的整合。

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-01-19 DOI: 10.1080/08820139.2024.2302823

Brenda Fernanda Hernandez-Nicols, Juan José Robledo-Pulido, Anabell Alvarado-Navarro

{"title":"Etiopathogenesis of Psoriasis: Integration of Proposed Theories.","authors":"Brenda Fernanda Hernandez-Nicols, Juan José Robledo-Pulido, Anabell Alvarado-Navarro","doi":"10.1080/08820139.2024.2302823","DOIUrl":"10.1080/08820139.2024.2302823","url":null,"abstract":"Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin and the involvement of the immune system. Global prevalence for psoriasis has been reported around 1-3% with a higher incidence in adults and similar proportions between men and women. The risk factors associated with psoriasis are both extrinsic and intrinsic, out of which a polygenic predisposition is a highlight out of the latter. Psoriasis etiology is not yet fully described, but several hypothesis have been proposed: 1) the autoimmunity hypothesis is based on the over-expression of antimicrobial peptides such as LL-37, the proteins ADAMTSL5, K17, and hsp27, or lipids synthesized by the PLA2G4D enzyme, all of which may serve as autoantigens to promote the differentiation of autoreactive lymphocytes T and unleash a chronic inflammatory response; 2) dysbiosis of skin microbiota hypothesis in psoriasis has gained relevance due to the observations of a loss of diversity and the participation of pathogenic bacteria such as Streptococcus spp. or Staphylococcus spp. the fungi Malassezia spp. or Candida spp. and the virus HPV, HCV, or HIV in psoriatic plaques; 3) the oxidative stress hypothesis, the most recent one, describes that the cell injury and the release of proinflammatory mediators and antimicrobial peptides that leads to activate of the Th1/Th17 axis observed in psoriasis is caused by a higher release of reactive oxygen species and the imbalance between oxidant and antioxidant mechanisms. This review aims to describe the mechanisms involved in the three hypotheses on the etiopathogeneses of psoriasis.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"348-415"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Mobility Group Box 1 Gene Polymorphism and Serum High Mobility Group Box 1, Interleukin 1 Beta, and Alpha-Klotho Crosstalk in Severe COVID-19 Patients. 严重 COVID-19 患者的高迁移率组 Box 1 基因多态性与血清高迁移率组 Box 1、白细胞介素 1 Beta 和 Alpha-Klotho 相互关系

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-02-06 DOI: 10.1080/08820139.2023.2299680

Maha Houssen, Rasha El-Mahdy, Nouran E Samra, Yousra Tera, Kamel Nayera Mostafa, Manal M El-Desoky, Fatma Azzahraa Hisham, Asem A Hewidy, Rehab A Elmorsey, Hala Samaha, Rasha Mahmoud, Mona S Abdelhafez

{"title":"High Mobility Group Box 1 Gene Polymorphism and Serum High Mobility Group Box 1, Interleukin 1 Beta, and Alpha-Klotho Crosstalk in Severe COVID-19 Patients.","authors":"Maha Houssen, Rasha El-Mahdy, Nouran E Samra, Yousra Tera, Kamel Nayera Mostafa, Manal M El-Desoky, Fatma Azzahraa Hisham, Asem A Hewidy, Rehab A Elmorsey, Hala Samaha, Rasha Mahmoud, Mona S Abdelhafez","doi":"10.1080/08820139.2023.2299680","DOIUrl":"10.1080/08820139.2023.2299680","url":null,"abstract":"Aim: To evaluate the serum levels of HMGB1, IL1β, and α-klotho in COVID-19 patients with different disease severity, investigate their association with clinicopathological parameters, and to assess HMGB1 rs1045411 polymorphism and its relation with clinical severity.Methods: 120 COVID-19 patients (89 critically ill, 15 severe, and 16 moderately severe) along with 80 healthy control were enrolled.The serum levels of HMGB1,IL1β, and α-klotho were determined by ELISA. The HMGB1 rs1045411 polymorphism was detected by RT- PCR.Results: The serum levels of HMGB1, IL1β, and α-klotho were significantly higher in critically ill COVID-19 patients compared to other groups. The HMGB1rs1045411 polymorphism revealed a significant decrease in the percentage of T/T genotypes in COVID-19 patients compared to controls. The (ROC) analysis showed moderate diagnostic potential for serum HMGB1, IL1β, and α-klotho.Conclusion: The serum HMGB1, IL1β, and α-klotho may be severity markers and promising therapeutic targets for COVID-19 patients.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"450-463"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis. 对用于治疗类风湿性关节炎的姜黄素-环孢素载体纳米凝胶的体外和体内评估

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-01-10 DOI: 10.1080/08820139.2024.2301997

Sankalp Gharat, Vivek Basudkar, Munira Momin

{"title":"In-Vitro and in-Vivo Evaluation of the Developed Curcumin-Cyclosporine-Loaded Nanoemulgel for the Management of Rheumatoid Arthritis.","authors":"Sankalp Gharat, Vivek Basudkar, Munira Momin","doi":"10.1080/08820139.2024.2301997","DOIUrl":"10.1080/08820139.2024.2301997","url":null,"abstract":"Background: Topical nanogel-based formulations have shown potential in the management of rheumatoid arthritis (RA). The aim of this research work was to explore the synergistic effect of Curcumin (CUR) and Cyclosporine (CYC) in combination via a topical route for the management of RA.Methods: The CUR+CYC loaded nanoemulsion was developed using the spontaneous emulsification technique and was subsequently incorporated into Carbopol® Ultrez 30-NF gel. The effect of the developed formulation on levels of proinflammatory cytokines (IL-6, TNF-α) and anti-inflammatory cytokine (IL-10) was evaluated using lipopolysaccharide (LPS) induced RAW 264.7 cell culture model. The anti-arthritic activity was evaluated in a Complete Freund's Adjuvant (CFA) induced arthritic rat model.Results: The optimized nanoemulgel (CUR + CYC NE gel) exhibited average globule size of 15.32 nm ±2.7 nm, poly-dispersity index of 0.181 ± 0.034 and zeta potential of -16.3 mV ± 0.9 mV. The cumulative drug release from ex-vivo diffusion studies on porcine ear skin was 99.189% ± 1.419% at the of 24 h and 99.177% ± 1.234% at the end of 18 h for CUR and CYC, respectively. The cell culture studies revealed that the formulation was able to significantly lower (p < .001) the levels of IL-6 and TNF-α, inhibited prostaglandin E2 (PGE2) while significantly elevating (p < .001) the levels of anti-inflammatory cytokine (IL-10). The gel was found to be non-irritating and showed the inhibition of paw edema and substantial reduction of arthritic symptoms in an arthritic rat model as compared to commercial and other conventional alternatives.Conclusion: This study highlights the potential of the developed nanoemulgel for the management of RA by enhancing the topical permeation of CUR and CYC.","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"490-522"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine at the Pulmonary Frontier: Immune-Centric Approaches for Respiratory Disease Treatment. 肺部前沿的纳米医学：以免疫为中心的呼吸系统疾病治疗方法。

IF 2.8 4区医学

Immunological Investigations Pub Date : 2024-04-01 Epub Date: 2024-01-11 DOI: 10.1080/08820139.2023.2298398

Jatinder Kaur, Akanksha Sharma, Gautam Passi, Piyush Dey, Akhil Khajuria, Hema Kumari Alajangi, Pradeep Kumar Jaiswal, Ravi Pratap Barnwal, Gurpal Singh

引用次数: 0