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Retraction: Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis. 撤回：CD14 基因的多态性可能改变可溶性 CD14 的水平并代表多发性硬化症的风险因素。
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-05-01 Epub Date: 2024-05-20 DOI: 10.1080/08820139.2024.2346369
{"title":"Retraction: Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis.","authors":"","doi":"10.1080/08820139.2024.2346369","DOIUrl":"10.1080/08820139.2024.2346369","url":null,"abstract":"","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"712"},"PeriodicalIF":2.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTED ARTICLE: Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis. CD14 基因的多态性可能会改变可溶性 CD14 的水平，并代表多发性硬化症的风险因素。
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-05-01 Epub Date: 2016-11-07 DOI: 10.1080/08820139.2016.1226897
Mehrdad Farrokhi, Pedram Moeini, Mohammad Fazilati, Habibollah Nazem, Shahla Faraji, Zahra Saadatpour, Elyas Fadaei, Leila Saadatpour, Ali Rezaei, Sadra Ansaripour, Ali Amani-Beni
{"title":"RETRACTED ARTICLE: Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis.","authors":"Mehrdad Farrokhi, Pedram Moeini, Mohammad Fazilati, Habibollah Nazem, Shahla Faraji, Zahra Saadatpour, Elyas Fadaei, Leila Saadatpour, Ali Rezaei, Sadra Ansaripour, Ali Amani-Beni","doi":"10.1080/08820139.2016.1226897","DOIUrl":"10.1080/08820139.2016.1226897","url":null,"abstract":"<p><p>Statement of RetractionWe, the Editors and Publisher of the journal <i>Immunological Investigations</i>, have retracted the following article:Merhdad Farrokhi, Pedram Moeini, Mohammada Fazilati, Habibollah Nazem, Shahla Faraji, Zahra Saadatpour, Elyas Fadaei, Leila Saadatpour, Ali Rezaei, Sadra Ansaripour and Ali Amani-Beni (2016) Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis, <i>Immunological Investigations</i>, DOI: https://doi.org/10.1080/08820139.2016.1226897Since publication, significant concerns have been raised about the author affiliations, ethical approval, and the integrity of the data in the article.When approached for an explanation, the authors provided responses to our queries regarding the flow cytometry data, but they have not sufficiently addressed all of our concerns. In particular, the authors and institution did not respond to our requests for proof that the research was conducted at the Isfahan University of Medical Sciences or provide proof of ethical approval.As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The corresponding author listed in this publication has been informed.We have been informed in our decision-making by our Editorial Policies and COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted'.</p>","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"1 1","pages":"I-VIII"},"PeriodicalIF":2.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59792696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL1RAP Exacerbates Sepsis-Induced Pulmonary and Spleen Injury Through Regulating CD4+ T Lymphocyte Differentiation. IL1RAP 通过调节 CD4+ T 淋巴细胞分化加剧败血症诱发的肺和脾损伤
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-05-01 Epub Date: 2024-02-08 DOI: 10.1080/08820139.2024.2312898
Liou Huang, Chunrong Wu, Dan Xu, Yuhui Cui, Jianguo Tang
{"title":"IL1RAP Exacerbates Sepsis-Induced Pulmonary and Spleen Injury Through Regulating CD4<sup>+</sup> T Lymphocyte Differentiation.","authors":"Liou Huang, Chunrong Wu, Dan Xu, Yuhui Cui, Jianguo Tang","doi":"10.1080/08820139.2024.2312898","DOIUrl":"10.1080/08820139.2024.2312898","url":null,"abstract":"<p><strong>Background: </strong>Complex pathophysiological the specific mechanism of sepsis on CD4<sup>+</sup> T-cell responses is less well understood. IL1 receptor accessory protein (IL1RAP) was found to be involved in activating host immune responses.</p><p><strong>Method: </strong>Cecum ligation and puncture (CLP) was utilized to build a mouse sepsis model. The experiment was randomly divided into four groups: Sham, CLP, CLP + shNC, and CLP + shIL1RAP group.</p><p><strong>Results: </strong>qRT-PCR suggested mRNA levels of IL1RAP were decreased when IL1RAP was knocked down with the mRNA levels of IL-1β, NF-κB, and p38 decreased. Histopathology showed severe pathological damage with alveolar integrity lost, red blood cells in the alveoli, massive inflammatory cell infiltration, and the alveolar wall was thickening in the CLP group. The inflammatory cytokine levels of TNF-α, IL-1β, and IFN-γ were elevated in CLP mice by ELISA. The counts of CD4<sup>+</sup> T cells were decreased in sepsis mice in peripheral blood, spleen, and BALF by flow cytometry. However, the above was blocked down when using shIL1RAP. Western blot suggested sh IL1RAP inhibited IL-1β, NF-κB, and p38 protein expressions.</p><p><strong>Conclusions: </strong>We defined IL1RAP as a new target gene through NF-κB/MAPK pathways regulating CD4<sup>+</sup> T lymphocyte differentiation mediated the progression of sepsis, which is potentially exploitable for immunotherapy.</p>","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"574-585"},"PeriodicalIF":2.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Analysis of Innate Lymphoid Cells in Patients with ST-Segment Elevation Myocardial Infarction. ST段抬高型心肌梗死患者体内先天性淋巴细胞的定量分析
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-05-01 Epub Date: 2024-05-03 DOI: 10.1080/08820139.2024.2316052
Alma Celeste Ortega-Rodriguez, Paola Del Carmen Guerra de Blas, Ricardo Ramírez-Torres, Elena B Martínez-Shio, Adriana E Monsiváis-Urenda
{"title":"Quantitative Analysis of Innate Lymphoid Cells in Patients with ST-Segment Elevation Myocardial Infarction.","authors":"Alma Celeste Ortega-Rodriguez, Paola Del Carmen Guerra de Blas, Ricardo Ramírez-Torres, Elena B Martínez-Shio, Adriana E Monsiváis-Urenda","doi":"10.1080/08820139.2024.2316052","DOIUrl":"10.1080/08820139.2024.2316052","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) is one of the principal causes of death in Mexico and worldwide. AMI triggers an acute inflammatory process that induces the activation of different populations of the innate immune system. Innate lymphoid cells (ILCs) are an innate immunity, highly pleiotropic population, which have been observed to participate in tissue repair and polarization of the adaptive immune response.</p><p><strong>Objective: </strong>We aimed to analyze the levels of subsets of ILCs in patients with ST-segment elevation myocardial infarction (STEMI), immediately 3 and 6 months post-AMI, and analyze their correlation with clinical parameters.</p><p><strong>Results: </strong>We evaluated 29 STEMI patients and 15 healthy controls and analyzed the different subsets of circulating ILCs, immediately 3 and 6 months post-AMI. We observed higher levels of circulating ILCs in STEMI patients compared to control subjects and a significant correlation between ILC levels and cardiac function. We also found increased production of the cytokines interleukin 5 (IL-5) and interleukin 17A (IL-17A), produced by ILC2 cells and by ILC3 cells, respectively, in the STEMI patients.</p><p><strong>Conclusion: </strong>This study shows new evidence of the role of ILCs in the pathophysiology of AMI and their possible involvement in the maintenance of cardiac function.</p>","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":" ","pages":"586-603"},"PeriodicalIF":2.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Clinical Significance of Serum Interleukin-36α Levels in Patients with Gout 痛风患者血清白细胞介素-36α水平的临床意义
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-04-18 DOI: 10.1080/08820139.2024.2341233
Sicen Meng, Wubing Lu, Zhi Li, Yinxin Zhou, Shanjun Shi, Hui Zhao, Mingcai Li, Yan Li
{"title":"The Clinical Significance of Serum Interleukin-36α Levels in Patients with Gout","authors":"Sicen Meng, Wubing Lu, Zhi Li, Yinxin Zhou, Shanjun Shi, Hui Zhao, Mingcai Li, Yan Li","doi":"10.1080/08820139.2024.2341233","DOIUrl":"https://doi.org/10.1080/08820139.2024.2341233","url":null,"abstract":"Gout is a chronic inflammatory diseases caused by monosodium urate crystal deposition. However, the role of interleukin (IL)-36 in gout has not dbeen elucidated.We enrolled 75 subjects, including 2...","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"29 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis MSRB2 可改善 H2O2 诱导的软骨细胞氧化应激并抑制骨关节炎患者的细胞凋亡
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-04-18 DOI: 10.1080/08820139.2024.2343898
Keke Huang, Wenhan Fu, Anquan Wang, Gongwen Du, Hao Tang, Li Yin, Zongsheng Yin, Weilu Gao
{"title":"MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis","authors":"Keke Huang, Wenhan Fu, Anquan Wang, Gongwen Du, Hao Tang, Li Yin, Zongsheng Yin, Weilu Gao","doi":"10.1080/08820139.2024.2343898","DOIUrl":"https://doi.org/10.1080/08820139.2024.2343898","url":null,"abstract":"Chondrocyte oxidative stress and apoptosis are critical factors contributing to the pathogenesis of osteoarthritis (OA). Methionine sulfoxide reductase B2 (MSRB2) is a mitochondrial protein that pr...","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"38 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140623736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GBM Immunotherapy: Macrophage Impacts GBM 免疫疗法：巨噬细胞的影响
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-04-18 DOI: 10.1080/08820139.2024.2337022
Nina Loginova, Denis Aniskin, Peter Timashev, Ilya Ulasov, Rajesh Kumar Kharwar
{"title":"GBM Immunotherapy: Macrophage Impacts","authors":"Nina Loginova, Denis Aniskin, Peter Timashev, Ilya Ulasov, Rajesh Kumar Kharwar","doi":"10.1080/08820139.2024.2337022","DOIUrl":"https://doi.org/10.1080/08820139.2024.2337022","url":null,"abstract":"Glioblastoma (GBM) is an extremely aggressive form of brain tumor with low survival rates. Current treatments such as chemotherapy, radiation, and surgery are problematic due to tumor growth, invas...","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"23 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study 冠状动脉疾病中的甘露糖结合凝集素和 C3 血清水平：一项横断面研究
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-04-18 DOI: 10.1080/08820139.2024.2337023
Juliana Meneghetti da Rosa, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Léia Sena, Renato Nisihara, Altair Rogerio Ambrosio, Iara J. Messias-Reason
{"title":"Mannose Binding Lectin and C3 Serum Levels in Coronary Artery Disease: A Cross-Sectional Study","authors":"Juliana Meneghetti da Rosa, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Léia Sena, Renato Nisihara, Altair Rogerio Ambrosio, Iara J. Messias-Reason","doi":"10.1080/08820139.2024.2337023","DOIUrl":"https://doi.org/10.1080/08820139.2024.2337023","url":null,"abstract":"The process of tissue injury in coronary artery disease (CAD) has been associated with activation of the complement system, partly due to the action of mannose-binding lectin (MBL) and C3, which ar...","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"33 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the Roles of Natural Killer Cells in Osteoarthritis 洞察自然杀伤细胞在骨关节炎中的作用
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-04-15 DOI: 10.1080/08820139.2024.2337025
Chang-Qing Zheng, Ling-Jun Zeng, Zhi-Hong Liu, Chen-Fang Miao, Ling-Yan Yao, Hong-Tao Song, Xiao-Mu Hu, Xin Zhou
{"title":"Insights into the Roles of Natural Killer Cells in Osteoarthritis","authors":"Chang-Qing Zheng, Ling-Jun Zeng, Zhi-Hong Liu, Chen-Fang Miao, Ling-Yan Yao, Hong-Tao Song, Xiao-Mu Hu, Xin Zhou","doi":"10.1080/08820139.2024.2337025","DOIUrl":"https://doi.org/10.1080/08820139.2024.2337025","url":null,"abstract":"Osteoarthritis (OA) is now widely acknowledged as a low-grade inflammatory condition, in which the intrinsic immune system plays a significant role in its pathogenesis. While the involvement of mac...","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"58 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis LINC00265 是一种潜在的生物标记物，可用于预测败血症的疾病风险增加、全身炎症、疾病严重程度和不良预后
IF 2.8 4区 医学
Immunological Investigations Pub Date : 2024-04-08 DOI: 10.1080/08820139.2024.2332791
Yiming Cui, Nan Jiang, Xin Liu, Jianyuan Huang, Wei Chen
{"title":"LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis","authors":"Yiming Cui, Nan Jiang, Xin Liu, Jianyuan Huang, Wei Chen","doi":"10.1080/08820139.2024.2332791","DOIUrl":"https://doi.org/10.1080/08820139.2024.2332791","url":null,"abstract":"Identifying effective therapeutic targets is of great significance for improving early diagnosis and prognosis of sepsis. This study aims to explore the role of LINC00265 in sepsis.This is a retros...","PeriodicalId":13387,"journal":{"name":"Immunological Investigations","volume":"33 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140592529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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