Serum YKL-40 and Serum Krebs von den Lungen-6 as Potential Predictive Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Immunological Investigations Pub Date : 2024-08-01 Epub Date: 2024-06-20 DOI:10.1080/08820139.2024.2366966

Bo Liang, Yan Zhang, Dan Ke, Rui Yan, Min-Na Jiang, Li Li, Li-Xia Zhang, Xue-Gang Zhao, Guan-Ping Yuan, Bing Xu, Xiao-Min Liu

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引用次数: 0

Abstract

Background: Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA) and is associated with a poor prognosis. However, the role of blood biomarkers in RA-associated interstitial lung disease (RA-ILD) is ill-defined. We aim to evaluate the role of YKL-40 and Krebs von den Lungen-6 (KL-6) in the diagnosis and severity evaluation of RA-ILD.

Methods: 45 RA-non-ILD patients and 38 RA-ILD patients were included. The clinical data and the levels of YKL-40 and KL-6 were measured and collected for all patients. The risk factors for RA-ILD were analyzed and their correlation with relevant indicators and predictive value for RA-ILD was explored.

Results: The levels of YKL-40 and KL-6 in RA-ILD patients were higher than RA-non-ILD patients (p < .001). Both YKL-40 and KL-6 were correlated with the incidence of RA-ILD. The predictive power of combined KL-6 and YKL-40 for the presence of ILD was 0.789, with a sensitivity and specificity at 73.7% and 73.3%, respectively. In RA-ILD patients, both YKL-40 and KL-6 were positively correlated with the Scleroderma Lung Study (SLS) I score and negatively correlated with pulmonary function.

Conclusions: KL-6 and YKL-40 might be a useful biomarker in the diagnosis and severity evaluation of RA-ILD.

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血清 YKL-40 和血清 Krebs von den Lungen-6 作为类风湿性关节炎相关间质性肺病的潜在预测性生物标记物。

背景：间质性肺病（ILD）是类风湿性关节炎（RA）常见的肺部表现，预后较差。然而，血液生物标志物在 RA 相关间质性肺病（RA-ILD）中的作用尚不明确。我们旨在评估 YKL-40 和 Krebs von den Lungen-6 (KL-6) 在 RA-ILD 诊断和严重程度评估中的作用。方法：纳入 45 名 RA 非 ILD 患者和 38 名 RA-ILD 患者，测量并收集所有患者的临床数据以及 YKL-40 和 KL-6 的水平。分析了RA-ILD的危险因素，并探讨了这些因素与相关指标的相关性以及对RA-ILD的预测价值：结果：RA-ILD 患者的 YKL-40 和 KL-6 水平高于非 RA-ILD 患者（P < .001）。YKL-40和KL-6均与RA-ILD的发病率相关。KL-6和YKL-40联合检测对ILD的预测能力为0.789，敏感性和特异性分别为73.7%和73.3%。在RA-ILD患者中，YKL-40和KL-6均与硬皮病肺研究（SLS）I评分呈正相关，而与肺功能呈负相关：结论：KL-6和YKL-40可能是诊断和评估RA-ILD严重程度的有用生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunological Investigations 医学-免疫学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.