Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome.

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Immunological Investigations Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI:10.1080/08820139.2024.2443253
Zhaohui Lu, Jie Yang, Xiaoguang Liu, Juan Wang, Youjun Pan, Jinjin Zhong, Xin Su
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引用次数: 0

Abstract

Background: Acute respiratory distress syndrome (ARDS) is prominently characterized by uncontrolled inflammation and high mortality. The effect of interleukin-37 (IL-37) on the prognosis of ARDS remains unclear.

Methods: This prospective cohort study detected and analyzed serum IL-37 levels on day 1 (baseline) in 128 patients with ARDS and 40 healthy controls, and on day 7 in patients with ARDS. Clinical and laboratory parameters were assayed. Survival status was tracked within 28-d of enrollment.

Results: BaselineIL-37 concentration was lower in non-survivors (135.00 [87.75, 198.75] pg/mL) than in survivors (250.50 [173.25, 382.75] pg/mL) (p < .05). Non-survivors displayed a greater reduction in IL-37 levels from day 1-7 than survivors (49.87% vs. 40.09%) (p < .05). Baseline IL-37 levels were negatively associated with C-reactive protein, procalcitonin, and IL-6 levels. The area under the receiver operating characteristic curve of the baseline level and percentage decline in IL-37 was 0.755 and 0.809, respectively, for predicting 28-d mortality. Combining IL-37 with the acute physiology and chronic health evaluation II score further improved mortality prediction capability. Patients with ARDS with low IL-37 concentrations (<143.00 pg/mL) or a high percentage decline (≥44.76%) had a poorer survival rate than those with a high concentration or low percentage decline. The baseline IL-37 level and percentage decline independently predicted mortality in a univariate Cox regression model (p < .05).

Conclusions: A low IL-37 level or significantly declining rate predicts higher 28-d mortality in patients with ARDS, indicating that IL-37 may be a promising prognostic biomarker.

血清白细胞介素-37对急性呼吸窘迫综合征患者预后的价值。
背景:急性呼吸窘迫综合征(ARDS)的显著特征是炎症不受控制和高死亡率。白细胞介素-37 (IL-37)对ARDS预后的影响尚不清楚。方法:本前瞻性队列研究检测并分析了128例ARDS患者和40例健康对照者第1天(基线)和ARDS患者第7天的血清IL-37水平。测定临床及实验室参数。在入组后28天内追踪生存状况。结果:BaselineIL-37浓度在非幸存者组(135.00 [87.75,198.75]pg/mL)低于幸存者组(250.50 [173.25,382.75]pg/mL) (p p p)。结论:IL-37水平低或明显下降预示着ARDS患者28天死亡率较高,提示IL-37可能是一种有前景的预后生物标志物。
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来源期刊
Immunological Investigations
Immunological Investigations 医学-免疫学
CiteScore
5.50
自引率
7.10%
发文量
49
审稿时长
3 months
期刊介绍: Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.
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