In vivo最新文献

{"title":"Sclerotherapy With Polidocanol Is Highly Effective for Treating Oral Cavernous Hemangiomas in Children.","authors":"Li-Na Han, Yu-Bo Wang, Rong-Xiang Tian, Wen-Ya Huang, Ralf Smeets, Martin Gosau, Lan Kluwe, Ming Yan, Rico Rutkowski, Reinhard E Friedrich","doi":"10.21873/invivo.14006","DOIUrl":"10.21873/invivo.14006","url":null,"abstract":"<p><strong>Background/aim: </strong>Cavernous hemangiomas in children older than 2 years will unlikely resolute and therefore, frequently require treatment. The aim of the study was to comparatively evaluated the outcome of the sclerotherapy with polidocanol and the conventional pingyangmycin therapy for thick cavernous hemangiomas in the oral cavity in children.</p><p><strong>Patients and methods: </strong>We treated a total of 21 cavernous hemangiomas in the oral cavity (majority on the tongue) of children aged 2-11 years by means of a sclerotherapy using an anesthetic agent polidocanol under ultra-sound monitoring.</p><p><strong>Results: </strong>Total regression of the tumors was achieved in 20 cases, corresponding to a success rate of 95%, significantly (<i>p</i>=0.0005) higher than that achieved by the conventional pingyangmycin therapy, which was <50%. No severe complication was observed, while mild and transit ones such as local swelling, pain, and ulceration were reported by both groups at similar frequency (10-20%).</p><p><strong>Conclusion: </strong>Sclerotherapy using polidocanol provides an effective, safe, and relatively simple treatment for hemangiomas in the oral cavity of children and may be recommended to replace the conventional pingyangmicine treatment.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2109-2114"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Preoperative Dry Eye Disease on the Outcome of Second (Visumax 800) Generation Keratorefractive Lenticule Extraction Surgery.","authors":"Chia-Yi Lee, Shun-Fa Yang, Ie-Bin Lian, Hung-Chi Chen, Jing-Yang Huang, Chao-Kai Chang","doi":"10.21873/invivo.14010","DOIUrl":"10.21873/invivo.14010","url":null,"abstract":"<p><strong>Background/aim: </strong>To evaluate the influence of preoperative dry eye disease (DED) on the postoperative outcome of second generation keratorefractive lenticule extraction (KLEx) surgery.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was performed and patients who received second generation KLEx surgery were enrolled. After the categorization, a total of 76, 59, and 65 eyes were put into the non-DED, DED without artificial tear (AT), and DED with AT groups, respectively. The primary outcomes were the uncorrected distance visual acuity (UDVA), spherical equivalent (SE), and postoperative complications. The one-way ANOVA was applied for the statistical analysis.</p><p><strong>Results: </strong>One day postoperatively, the DED without AT group demonstrated a significantly worse UDVA compared to the other two groups (<i>p</i>=0.002). At the final visit, the UDVA in this group was not significantly lower from that in the non-DED and DED with AT groups (<i>p</i>=0.129). The SE was significantly higher in the DED without AT group than the other two groups from postoperatively day one through three months (all <i>p</i><0.05). Moreover, the change in UDVA over time was significantly greater in the DED without AT group than in the other two groups (<i>p</i>=0.007). Regarding the vector analysis, the difference vector (DV), correction index (CoI), and angle of error (AE) was significantly higher in the DED without AT group compared to the other two groups (all <i>p</i><0.05). The rate of postoperative superficial keratitis and DED was significantly higher in the DED without AT group compared to the other two groups (both <i>p</i><0.05).</p><p><strong>Conclusion: </strong>The presence of preoperative DED is associated with worse postoperative UDVA recovery and refraction of second generation KLEx surgery, which can be prevented by preoperative AT application.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2144-2153"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Dyslipidemia on the Clinical Profile of Patients With Uncontrolled Diabetes.","authors":"Lorena Paduraru, Andrei Vasile Pascalau, Andreea Camarasan, Mihaela-Mirela Muresan, Ovidiu Laurean Pop, Roxana Brata","doi":"10.21873/invivo.14020","DOIUrl":"10.21873/invivo.14020","url":null,"abstract":"<p><strong>Background/aim: </strong>Current evidence suggests that dyslipidemia in patients with diabetes mellitus is associated with multiple microvascular and macrovascular complications. The prolonged failure to achieve glycemic and lipid profile targets increases cardiovascular risk, mortality, and the costs associated with medical care. This study aimed to explore the correlations between dyslipidemia and glycemic control in patients with diabetes, evaluate variations in lipid profiles, examine the impact of dyslipidemia on diabetes-related complications and assess the effectiveness of lipid-lowering treatments.</p><p><strong>Patients and methods: </strong>A cohort observational study was conducted on 304 patients hospitalized at the Emergency County Hospital in Oradea, Bihor, located in Northwest Romania, over a two-year period from 2022 to 2023. The study included data on diabetes control (fasting blood glucose, HbA1c), associated conditions including diabetes complications, laboratory analyses-lipid profile, creatinine, urea, albuminuria-anthropometric data, and home medication.</p><p><strong>Results: </strong>In the group without dyslipidemia, the mean HbA1c value was 8.96±2.81, compared to 9.70±2.80 in the dyslipidemia group. The mean blood glucose level was 207.44±126.09 in the group without dyslipidemia and 257.77±140.68 in the dyslipidemia group (<i>p</i>=0.048). Coronary artery disease was significantly more common in patients with dyslipidemia (58.9%) than in those without (4.6%) (<i>p</i>=0.004). Uric acid levels were higher in patients with dyslipidemia (<i>p</i>=0.048). Lipid-lowering therapy reduced high lipid values, but a significant percentage of patients on treatment still exhibited elevated cholesterol, LDL, and triglyceride levels.</p><p><strong>Conclusion: </strong>In patients with poorly controlled diabetes, dyslipidemia associates with poorer glycemic control, greater obesity levels, cardiovascular diseases, particularly coronary artery disease and peripheral arterial disease, as well as chronic kidney disease. Despite treatment, the lipid profile continues to remain elevated.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2243-2258"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of Proteinuria and Nephrotic Syndrome Using the Japanese Adverse Drug Event Reporting Database.","authors":"Sho Masago, Kenta Yamaoka, Mayako Uchida, Yoshihiro Uesawa, Kennosuke Yorifuji, Tadashi Shimizu","doi":"10.21873/invivo.14002","DOIUrl":"10.21873/invivo.14002","url":null,"abstract":"<p><strong>Background/aim: </strong>This study aimed to identify potential drug associations between proteinuria and nephrotic syndrome (NS) using the Japanese Adverse Drug Event Report (JADER) database.</p><p><strong>Patients and methods: </strong>We extracted data reported in JADER between April 2004 and May 2023, and conducted a comprehensive disproportionality analysis of spontaneous adverse event reports to identify drugs potentially linked to proteinuria and NS.</p><p><strong>Results: </strong>Our analysis identified 20 and 32 drugs associated with proteinuria and NS, respectively. Notably, anti-vascular endothelial growth factor (anti-VEGF) agents represented 45% (9/20) of proteinuria-associated drugs and 34% (11/32) of NS-associated drugs. Furthermore, the association between anti-VEGF agents and these adverse events appeared to be independent of the route of administration, sex, or clinical background.</p><p><strong>Conclusion: </strong>These findings suggest that anti-VEGF agents play a significant role in the development of proteinuria and NS. Given the widespread use of anti-VEGF therapy, heightened vigilance, routine monitoring, and timely interventions are crucial to mitigate these risks and improve patient outcomes.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2073-2084"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and Risk Factors of Inappropriate Bladder Filling in Patients Irradiated for High-risk Prostate Cancer.","authors":"Dirk Rades, Laura Doehring, Jan-Dirk Küter, Justus Domschikowski, Jon Cacicedo, Stefan Janssen","doi":"10.21873/invivo.14030","DOIUrl":"10.21873/invivo.14030","url":null,"abstract":"<p><strong>Background/aim: </strong>Many patients with high-risk prostate cancer receive normo-fractionated irradiation. Previously, high-risk cancer and pre-treatment bladder volumes <200 ml were associated with inappropriate bladder filling during the radiotherapy course. A prospective trial will investigate the value of an app reminding patients to drink water before each radiotherapy session. This study provides information regarding magnitude of inappropriate bladder filling and risk factors required for the prospective trial.</p><p><strong>Patients and methods: </strong>In 23 patients with high-risk prostate cancer and inappropriate pre-treatment bladder filling, mean and median numbers of radiation fractions with bladder volumes less than 200 ml and potential risk factors were retrospectively investigated.</p><p><strong>Results: </strong>Mean and median numbers of fractions with volumes less than 200 ml were 29.2±6.6 and 32.0 (interquartile range=24.0-35.0) of 35 fractions. Higher numbers were significantly associated with a lower performance score (<i>p</i> <0.029).</p><p><strong>Conclusion: </strong>Bladder filling was inappropriate during most radiotherapy fractions and, therefore, must be considered a significant problem. Our results are relevant for a subsequent prospective trial.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2333-2339"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Challenges and Advancements in the Management of Pivotal Porcine/Swine Viral Diseases.","authors":"Taeho Kwon, Gyu-Seo Bae, Eunsu Jeon, Philyong Kang, Hee Chang Son, You Jung An, Bon-Sang Koo, Sun-Uk Kim, Kyung-Seob Lim","doi":"10.21873/invivo.13982","DOIUrl":"10.21873/invivo.13982","url":null,"abstract":"<p><p>Porcine/swine viral diseases pose substantial challenges to the global pig industry by affecting animal health and economic stability. This comprehensive review examines four major viral diseases impacting swine populations worldwide: Porcine reproductive and respiratory syndrome (PRRS), African swine fever (ASF), classical swine fever (CSF), and porcine circovirus type 2 (PCV2). We investigated the etiology, epidemiology, clinical signs, and diagnostic methods for each disease, thereby providing an in-depth understanding of their complexities. Additionally, we assessed their global distribution, transmission dynamics, and the economic repercussions they entail. We also discuss current management and control strategies, including vaccination, biosecurity measures, and regulatory policies. Special attention is given to the evolving nature of these diseases, with a focus on emerging strains, new insights into their pathogenesis, and the latest advancements in vaccine development. This review intends to be a valuable resource for veterinarians, researchers, and policymakers, presenting a thorough and current overview of the challenges and developments in managing these swine viral diseases at the international level.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"1810-1832"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Gerontosurgery\": Evaluation of Multidimensional Assessment Scales for Elderly Patients Undergoing Major Abdominal Surgery. What Is the Best Prediction Model?","authors":"Marta Goglia, Diana Ronconi, Andrea DE Zanna, Arianna Cicolani, Gaetano Gallo, Niccolò Petrucciani, Matteo Pavone, Francesco D'Angelo, Giuseppe Nigri, Paolo Aurello","doi":"10.21873/invivo.14040","DOIUrl":"10.21873/invivo.14040","url":null,"abstract":"<p><strong>Background/aim: </strong>The aging population poses unique challenges in oncogeriatric surgery, particularly regarding risk stratification and postoperative outcome prediction. The impact of frailty on surgical decision-making reports should be noted. Geriatric assessment scales are recommended for preoperative objective evaluations to optimize surgical outcomes, but their accuracy remains unclear. This study evaluates the effectiveness of five multidimensional geriatric assessment scales - Charlson Comorbidity Index (CCI), APACHE II, Cumulative Illness Rating Scale (CIRS), Identification of Seniors at Risk (ISAR), and G8 - in predicting postoperative complications in elderly patients undergoing major oncological surgery.</p><p><strong>Patients and methods: </strong>A retrospective observational study was conducted on 69 patients aged ≥75 years who underwent major abdominal surgery for neoplastic conditions between December 2018 and July 2020. Preoperative assessments using the five scoring systems were performed, and postoperative complications were classified according to the Clavien-Dindo system. The study compared the predictive validity of each scale through correlation analysis with postoperative outcomes.</p><p><strong>Results: </strong>The study found weak correlations between predictive scores and postoperative complications. The G8 scale showed the strongest association with Clavien-Dindo scores (<i>ρ</i>=0.267, <i>p</i>=0.027), while other scales exhibited limited predictive value. Despite the widespread use of these scales in clinical practice, none of them accurately predicted postoperative morbidity in this cohort of patients.</p><p><strong>Conclusion: </strong>This study highlights the limitations of existing geriatric assessment scales in predicting postoperative complications for elderly patients undergoing major oncological surgery. Among the evaluated tools, only the G8 score showed an association with complications. However, the results suggest a need for more tailored risk stratification models that incorporate comorbidities, frailty, nutritional status, and physiological reserves. Further research with larger sample sizes is necessary to validate these findings and improve preoperative decision-making in geriatric oncologic surgery.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2410-2418"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternate-day S-1 Oral Therapy for Frail Patients With Metastatic Colorectal and Pancreatic Cancer.","authors":"Naoki Odaira, Junkichi Kanda, Masataka Sasaki, Katsuki Muneoka","doi":"10.21873/invivo.14044","DOIUrl":"10.21873/invivo.14044","url":null,"abstract":"<p><strong>Background/aim: </strong>Standard therapies are difficult to implement in vulnerable patients. S-1 alternative daily therapy has been reported to be a low-burden drug therapy for metastatic colorectal cancer in elderly patients. The vulnerable elders survey-13 (VES-13) is a tool to identify vulnerable elderly patients. In this study, we investigated the utility of simultaneous and serial measurements of the VES-13 and cancer prognostic factors, neutrophil-to-lymphocyte ratio (NLR) and tumor markers (TM), during chemotherapy in patients receiving S-1 every other day.</p><p><strong>Patients and methods: </strong>We studied five patients with metastatic colorectal cancer and eight patients with pancreatic cancer who received S-1 on alternate days. The NLR, TM levels, and VES-13 scores were measured monthly before and during chemotherapy. A scatterplot of NLR on the horizontal axis and TM levels on the vertical axis was plotted together with the VES-13.</p><p><strong>Results: </strong>The NLR and VES-13 scores showed a positive correlation, and both increased in cases of bowel obstruction or enteritis. Following the evaluation of progressive disease, two patients with colon cancer and two with pancreatic cancer were eligible to switch to the standard treatment regimen.</p><p><strong>Conclusion: </strong>Alternate-day S-1 therapy appears to be a feasible and effective treatment option for frail patients with metastatic colorectal and pancreatic cancer. Continuous monitoring of the NLR and VES-13 scores can aid in the stratification of patients, ensuring that treatment intensity is appropriately matched to the patient's condition.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2441-2448"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymph Cyst After Robotic-assisted Lateral Lymph Node Dissection for Rectal Cancer Treated With Lymphangiography: A Case Report.","authors":"Ken Yonemitsu, Hiroaki Kasashima, Tatsunari Fukuoka, Shintaro Ozawa, Yuki Seki, Takemi Ishidate, Masatsune Shibutani, Kiyoshi Maeda","doi":"10.21873/invivo.14039","DOIUrl":"10.21873/invivo.14039","url":null,"abstract":"<p><strong>Background/aim: </strong>With the increasing use of robotic-assisted surgery, postoperative lymphatic leakage has become a more frequent challenge. Lymph cysts following lateral lymph node dissection (LLND) for rectal cancer can lead to complications, such as infection, compression of adjacent structures, and impaired lymphatic drainage. Conservative treatments, including percutaneous drainage, are often used, but refractory cases require alternative strategies.</p><p><strong>Case report: </strong>A 78-year-old woman underwent robotic-assisted abdominoperineal resection with right LLND for lower rectal cancer. She was discharged on postoperative day 12 but developed right lower abdominal pain on day 7 after discharge. Computed tomography revealed a fluid collection in the LLND area, diagnosed as a lymph cyst. Despite computed tomography-guided percutaneous drainage, the output remained high, and symptoms persisted. On hospital day 18, lymphangiography was performed using Lipiodol <i>via</i> right inguinal lymph node puncture. Within 3 days, the drainage output significantly decreased, and her symptoms improved.</p><p><strong>Conclusion: </strong>Lymphangiography with Lipiodol is a minimally invasive and effective treatment for refractory lymph cysts following LLND. As robotic-assisted surgery becomes more common, understanding and managing postoperative lymphatic complications are increasingly important.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2405-2409"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Invasive Lobular Breast Carcinoma Involving Tamoxifen-related Endometrial Polyp in a Patient With Metachronous Bilateral Breast Carcinomas: A Case Report.","authors":"Ha Young Woo, Yoon Yang Jung, Hyun-Soo Kim","doi":"10.21873/invivo.14046","DOIUrl":"10.21873/invivo.14046","url":null,"abstract":"<p><strong>Background/aim: </strong>Metastasis of extragenital malignancies to the female genital tract, particularly the uterus, is exceedingly rare. Invasive lobular carcinoma (ILC) is the most common histological type of breast carcinoma that metastasizes to gynecologic organs.</p><p><strong>Case report: </strong>A 42-year-old woman receiving tamoxifen presented with an irregularly thickened endometrium on transvaginal ultrasonography. She had previously undergone bilateral partial mastectomies - eight years prior for right-sided invasive ductal carcinoma, and three years prior for left-sided ILC. Hysteroscopic evaluation revealed an endometrial polyp. Microscopic examination of the polypectomy specimen showed variably sized, irregularly shaped branching glands embedded in densely fibrotic stroma. Within the stroma, monomorphic tumor cells with hyperchromatic, eccentrically located nuclei were arranged in single files, thin cords, or nests. Immunostaining revealed that the tumor cells were positive for GATA-binding protein 3 and negative for paired box 8, supporting a diagnosis of metastatic carcinoma from the breast. The final pathological diagnosis was metastatic ILC involving a tamoxifen-associated endometrial polyp.</p><p><strong>Conclusion: </strong>Although rare, breast carcinoma may metastasize to endometrial polyps. Clinicians and pathologists should consider this possibility when evaluating abnormal ultrasonographic findings in the female genital tract, particularly in patients with a history of breast carcinoma receiving tamoxifen therapy. Abnormal ultrasonographic findings in the uterus of such patients warrant a comprehensive diagnostic workup to exclude metastatic disease.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2456-2463"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}