Surgical Treatment and Prognosis of Soft Tissue Sarcoma in Patients Aged 85 Years and Older.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-05-01 DOI:10.21873/invivo.13967

Hiroyuki Tsuchie, Makoto Emori, Shohei Murata, Yasutaka Murahashi, Emi Mizushima, Junya Shimizu, Hiroyuki Nagasawa, Atsushi Teramoto, Naohisa Miyakoshi

{"title":"Surgical Treatment and Prognosis of Soft Tissue Sarcoma in Patients Aged 85 Years and Older.","authors":"Hiroyuki Tsuchie, Makoto Emori, Shohei Murata, Yasutaka Murahashi, Emi Mizushima, Junya Shimizu, Hiroyuki Nagasawa, Atsushi Teramoto, Naohisa Miyakoshi","doi":"10.21873/invivo.13967","DOIUrl":null,"url":null,"abstract":"Background/aim: The incidence of soft tissue sarcomas (STSs) among older patients is increasing. Although it has been reported that surgical treatment of elderly patients with STS improves prognosis, most of these studies included patients aged <85 years. This study aimed to analyze the clinical features and prognostic factors of STS in excessively elderly patients aged ≥85 or ≥90 years.Patients and methods: We retrospectively identified 398 patients with STS who were treated at our two hospitals between 1994 and 2022. Only histological types that existed in ≥20 cases were included. Data on clinical information and detailed assessments were collected. We divided the patients into two subgroups according to 85 or 90 years of age and compared the groups within each subgroup. Furthermore, we examined the factors affecting the prognosis of all and older patients.Results: Patients ≥85 or ≥90 years old comprised 12.1% and 4.0% of the study population, respectively. In all patients, Kaplan-Meier curves for overall survival demonstrated a significantly poorer prognosis in elderly patients with STS aged ≥85 years (p=0.0476) and ≥90 years (p=0.0164). However, no significant differences were observed when analyzing only patients who underwent surgical treatment without distant metastasis at diagnosis. In the multivariate analyses, surgical treatment for the primary tumor improved prognosis exclusively in patients ≥85 years old (p =0.0300).Conclusion: Surgical treatment improves the prognosis in elderly STS patients aged ≥85 years and possibly among those aged ≥90 years.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1661-1668"},"PeriodicalIF":1.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041974/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"In vivo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/invivo.13967","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aim: The incidence of soft tissue sarcomas (STSs) among older patients is increasing. Although it has been reported that surgical treatment of elderly patients with STS improves prognosis, most of these studies included patients aged <85 years. This study aimed to analyze the clinical features and prognostic factors of STS in excessively elderly patients aged ≥85 or ≥90 years.

Patients and methods: We retrospectively identified 398 patients with STS who were treated at our two hospitals between 1994 and 2022. Only histological types that existed in ≥20 cases were included. Data on clinical information and detailed assessments were collected. We divided the patients into two subgroups according to 85 or 90 years of age and compared the groups within each subgroup. Furthermore, we examined the factors affecting the prognosis of all and older patients.

Results: Patients ≥85 or ≥90 years old comprised 12.1% and 4.0% of the study population, respectively. In all patients, Kaplan-Meier curves for overall survival demonstrated a significantly poorer prognosis in elderly patients with STS aged ≥85 years (p=0.0476) and ≥90 years (p=0.0164). However, no significant differences were observed when analyzing only patients who underwent surgical treatment without distant metastasis at diagnosis. In the multivariate analyses, surgical treatment for the primary tumor improved prognosis exclusively in patients ≥85 years old (p =0.0300).

Conclusion: Surgical treatment improves the prognosis in elderly STS patients aged ≥85 years and possibly among those aged ≥90 years.

查看原文本刊更多论文

85岁及以上患者软组织肉瘤的手术治疗及预后。

背景/目的：老年患者中软组织肉瘤（STSs）的发病率正在上升。虽然有报道称手术治疗老年STS患者可改善预后，但这些研究大多包括老年患者。患者和方法：我们回顾性分析了1994年至2022年在我们两家医院治疗的398例STS患者。仅纳入≥20例存在的组织学类型。收集临床资料和详细评估数据。我们将患者按85岁和90岁分为两个亚组，并对每个亚组内的组进行比较。此外，我们检查了影响所有和老年患者预后的因素。结果：≥85岁和≥90岁的患者分别占研究人群的12.1%和4.0%。在所有患者中，Kaplan-Meier总生存曲线显示≥85岁（p=0.0476）和≥90岁（p=0.0164）的老年STS患者预后明显较差。然而，当仅分析诊断时没有远处转移的接受手术治疗的患者时，没有观察到显著差异。在多因素分析中，原发性肿瘤的手术治疗仅在≥85岁的患者中改善预后（p =0.0300）。结论：手术治疗可改善≥85岁、≥90岁老年STS患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.